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Lista de obras de Lars Lannfelt

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

artículo científico publicado en 2017

A bispecific Tribody PET radioligand for visualization of amyloid-beta protofibrils - a new concept for neuroimaging

artículo científico publicado en 2017

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

artículo científico publicado en 2015

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

artículo científico publicado en 2012

A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice

artículo científico publicado en 2008

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status

artículo científico publicado en 2015

APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations

artículo científico publicado en 2003

Abstract 4683: Smoking is associated with mosaic loss of chromosome Y

Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease

artículo científico publicado en 2014

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

artículo científico publicado en 2016

Acute sleep deprivation increases serum levels of neuron-specific enolase (NSE) and S100 calcium binding protein B (S-100B) in healthy young men.

artículo científico publicado en 2014

Age-related somatic structural changes in the nuclear genome of human blood cells

artículo científico publicado en 2012

Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

artículo científico publicado en 2017

Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers.

artículo científico publicado en 2018

Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay

artículo científico publicado en 2005

Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice

artículo científico publicado en 2009

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

artículo científico publicado en 2017

An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease

artículo científico publicado en 2009

Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease

artículo científico publicado en 2016

Animal models of amyloid-beta-related pathologies in Alzheimer's disease

artículo científico publicado en 2010

Antibodies against alpha-synuclein reduce oligomerization in living cells

artículo científico publicado en 2011

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition

artículo científico publicado en 2018

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease

artículo científico

Apolipoprotein E epsilon4 genotype is independently associated with increased intima-media thickness in a recessive pattern

artículo científico publicado en 2007

Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways

artículo científico publicado en 2014

Apolipoprotein epsilon 4 allele in Swedish twins and siblings with Alzheimer disease.

artículo científico publicado en 1995

Appearance of Cxcl10-expressing cell clusters is common for traumatic brain injury and neurodegenerative disorders

artículo científico publicado en 2010

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

artículo científico publicado en 2014

Association study of cholesterol-related genes in Alzheimer's disease

artículo científico publicado en 2007

Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation

artículo científico publicado en 2007

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain

scientific article published on 01 May 2019

Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models

artículo científico publicado en 2014

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor.

artículo científico publicado en 2017

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [11C]ABP688 PET imaging and ex vivo immunoblotting.

artículo científico publicado en 2016

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

artículo científico publicado en 2009

CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.

artículo científico publicado en 2018

CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease

artículo científico publicado en 2016

Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors

artículo científico publicado en 2016

Cerebrospinal fluid levels of heart fatty acid binding protein are elevated prodromally in Alzheimer's disease and vascular dementia

artículo científico publicado en 2013

Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease

artículo científico publicado en 2014

Changes in secondary structure of α-synuclein during oligomerization induced by reactive aldehydes

artículo científico publicado en 2015

Characterization of monomeric and soluble aggregated Aβ in Down’s syndrome and Alzheimer’s disease brains

artículo científico publicado en 2021

Characterization of monomeric and soluble aggregated Aβ in Down’s syndrome and Alzheimer’s disease brains

artículo científico publicado en 2020

Circulating immune complexes of Abeta and IgM in plasma of patients with Alzheimer's disease

artículo científico publicado en 2009

Clinical and molecular aspects of frontotemporal dementia

artículo científico publicado en 2004

Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease

artículo científico publicado en 2008

Clinical findings in nondemented mutation carriers predisposed to Alzheimer's disease: a model of mild cognitive impairment

artículo científico publicado en 2003

Conformationally altered proteins cause neurodegenerative diseases

artículo científico publicado en 2005

Construction of a Detailed Physical and Transcript Map of the FTDP-17 Candidate Region on Chromosome 17q21

Correction: A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody

artículo científico publicado en 2022

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Cystatin C Levels are Positively Correlated with both Aβ42 and Tau Levels in Cerebrospinal Fluid in Persons with Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Controls

scholarly article by Johan Sundelöf et al published 11 August 2010 in Journal of Alzheimer's Disease

Decreased HHV-6 IgG in Alzheimer's Disease

scientific article published on 20 February 2017

Decreased proportion of cytomegalovirus specific CD8 T-cells but no signs of general immunosenescence in Alzheimer's disease

artículo científico publicado en 2013

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models

artículo científico publicado en 2016

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

artículo científico publicado en 2020

Docosahexaenoic acid stabilizes soluble amyloid-β protofibrils and sustains amyloid-β-induced neurotoxicity in vitro

scientific article published on 12 January 2007

Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease.

artículo científico publicado en 2007

Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13?

artículo científico publicado en 2008

Don't underestimate the value of transgenic animal models of Alzheimer disease

artículo científico publicado en 2007

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells.

artículo científico publicado en 2017

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody.

artículo científico publicado en 2018

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

artículo científico publicado en 2017

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2018

Extended investigation of tau and mutation screening of other candidate genes on chromosome 17q21 in a Swedish FTDP-17 family

artículo científico publicado en 2003

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

artículo científico publicado en 2012

Extreme stability of chitotriosidase in cerebrospinal fluid makes it a suitable marker for microglial activation in clinical trials

artículo científico publicado en 2012

Familial presenile dementia with bitemporal atrophy

artículo científico publicado en 2004

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

artículo científico publicado en 2020

Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation

artículo científico publicado en 2008

Frontotemporal dementia-amyotrophic lateral sclerosis complex is simulated by neurodegeneration with brain iron accumulation.

artículo científico publicado en 2009

Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs

artículo científico publicado en 2009

Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro ⬇️

artículo científico publicado el 21 de julio de 2011

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease

artículo científico publicado en 2014

Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men.

artículo científico publicado en 2009

Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice

artículo científico publicado en 2009

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

artículo científico publicado en 2019

Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation

artículo científico publicado en 2009

Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-Aβ Antibodies

scientific article published on 13 August 2010

Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells

artículo científico publicado en 2008

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

artículo científico publicado en 2010

Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain ⬇️

artículo científico publicado el 13 de junio de 2012

High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease

artículo científico publicado en 2016

Higher Cathepsin B Levels in Plasma in Alzheimer's Disease Compared to Healthy Controls

scholarly article by Johan Sundelöf et al published 7 January 2011 in Journal of Alzheimer's Disease

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

artículo científico publicado en 2015

Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis

artículo científico publicado en 2010

Identification of novel biomarker candidates by differential peptidomics analysis of cerebrospinal fluid in Alzheimer's disease

artículo científico publicado en 2005

Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes

artículo científico publicado en 2007

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

artículo científico publicado en 2014

Immunotherapy targeting α-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders

artículo científico

Impaired behavior of female tg-ArcSwe APP mice in the IntelliCage: A longitudinal study

artículo científico publicado en 2010

Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers

In vivo amyloid imaging with PET in frontotemporal dementia

artículo científico publicado en 2007

In vivo imaging of astrocytosis in Alzheimer's disease: an ¹¹C-L-deuteriodeprenyl and PIB PET study

artículo científico publicado en 2011

Increase in beta-amyloid levels in cerebrospinal fluid of children with Down syndrome

artículo científico publicado en 2007

Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain

artículo científico publicado en 2016

Increased Number of Plasma B Cells Producing Autoantibodies Against Aβ42 Protofibrils in Alzheimer's Disease.

artículo científico publicado en 2015

Increased inflammatory response in cytomegalovirus seropositive patients with Alzheimer's disease

artículo científico publicado en 2014

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

artículo científico publicado en 2010

Interference from heterophilic antibodies in amyloid-β oligomer ELISAs

artículo científico publicado en 2010

Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging

artículo científico publicado en 2013

Large aggregates are the major soluble Aβ species in AD brain fractionated with density gradient ultracentrifugation

artículo científico publicado en 2012

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

artículo científico publicado en 2017

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

artículo científico publicado en 2017

Life situation, coping and quality of life in people with high and low risk of developing Alzheimer's disease

artículo científico publicado en 2003

Longitudinal changes in the frequency of mosaic chromosome Y loss in peripheral blood cells of aging men varies profoundly between individuals

artículo científico publicado en 2019

Longitudinal cognitive decline in autosomal-dominant Alzheimer's disease varies with mutations in APP and PSEN1 genes

scientific article published on 04 July 2019

Longitudinal stability evaluation of biomarkers and their correlation in cerebrospinal fluid and plasma from patients with Alzheimer's disease

artículo científico publicado en 2012

Longitudinal stability of CSF biomarkers in Alzheimer's disease

artículo científico publicado en 2007

Loss of astrocyte polarization in the tg-ArcSwe mouse model of Alzheimer's disease

artículo científico publicado en 2011

Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease

artículo científico publicado en 2007

Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein

artículo científico publicado en 2016

Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients

artículo científico publicado en 2003

Micellar extraction possesses a new advantage for the analysis of Alzheimer's disease brain proteome.

artículo científico publicado en 2014

Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response

artículo científico publicado en 2015

Microglial markers are elevated in the prodromal phase of Alzheimer's disease and vascular dementia

artículo científico publicado en 2013

Modulation byDLST of the genetic risk of Alzheimer's disease in a very elderly population

artículo científico publicado en 1999

Monoclonal antibodies selective for α‐synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α‐synuclein transgenic mice with the disease‐causing A30P mutation ⬇️

artículo científico publicado el 27 de febrero de 2013

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

artículo científico publicado en 2016

Mosaic loss of chromosome Y in leukocytes matters

artículo científico publicado en 2019

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

artículo científico publicado en 2014

Mutagenesis. Smoking is associated with mosaic loss of chromosome Y.

artículo científico publicado en 2014

N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody

artículo científico publicado en 2013

Neurofilament ELISA validation

artículo científico publicado en 2009

No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain

artículo científico publicado en 2006

No association between CALHM1 and Alzheimer's disease risk

artículo científico publicado en 2008

No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found

artículo científico publicado en 2004

No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration

scientific article published on 23 November 2009

No evidence of linkage to chromosome 9q21-22 in a Swedish family with frontotemporal dementia and amyotrophic lateral sclerosis

artículo científico publicado en 2003

Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

artículo científico publicado en 2021

Novel progranulin mutation detected in 2 patients with FTLD.

artículo científico publicado en 2011

Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo.

artículo científico publicado en 2013

Oligomerization partially explains the lowering of Abeta42 in Alzheimer's disease cerebrospinal fluid

artículo científico publicado en 2009

P4-070 Is APOE exclusively responsible for the AD linkage peak on chromosome 19?

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

artículo científico publicado en 2010

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

artículo científico publicado en 2004

Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease

artículo científico

Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation

artículo científico publicado en 2005

Physiochemical characterization of the Alzheimer's disease-related peptides A beta 1-42Arctic and A beta 1-42wt

artículo científico publicado en 2006

Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study

artículo científico publicado en 2008

Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine

scientific article published on 01 January 2002

Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity.

artículo científico publicado en 2007

Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease

artículo científico publicado en 2017

Prediction of mild cognitive impairment that evolves into Alzheimer's disease dementia within two years using a gene expression signature in blood: a pilot study

artículo científico publicado en 2013

Proteasome-mediated effects on amyloid precursor protein processing at the gamma-secretase site

artículo científico publicado en 2005

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases

artículo científico publicado en 2009

Quantification of the brain proteome in Alzheimer's disease using multiplexed mass spectrometry

artículo científico publicado en 2014

Quantitative interaction proteomics of neurodegenerative disease proteins

artículo científico publicado en 2015

Rapid amyloid-β oligomer and protofibril accumulation in traumatic brain injury

artículo científico publicado en 2017

Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype

artículo científico publicado en 2009

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

artículo científico publicado en 2017

Rare mutations aim toward future treatment

artículo científico publicado en 2009

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis

artículo científico publicado en 2013

Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer's disease

artículo científico publicado en 2009

Reduced plasma desmosterol-to-cholesterol ratio and longitudinal cognitive decline in Alzheimer's disease

artículo científico publicado en 2015

Safety and tolerability of BAN2401--a clinical study in Alzheimer's disease with a protofibril selective Aβ antibody

artículo científico publicado en 2016

Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

artículo científico publicado en 2008

Self-reported sleep disturbance is associated with Alzheimer's disease risk in men.

artículo científico publicado en 2014

Sensitive ELISA detection of amyloid-beta protofibrils in biological samples

artículo científico publicado en 2007

Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease

artículo científico publicado en 2010

Separation and characterization of aggregated species of amyloid-beta peptides

artículo científico publicado en 2010

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

artículo científico publicado en 2017

Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients

artículo científico publicado en 2014

Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain.

artículo científico publicado en 2013

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

artículo científico publicado en 2010

Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease

artículo científico publicado en 2018

Systemic inflammation and the risk of Alzheimer's disease and dementia: a prospective population-based study

artículo científico publicado en 2009

Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia: a prospective population-based study

artículo científico publicado en 2009

The Arctic Alzheimer mutation enhances sensitivity to toxic stress in human neuroblastoma cells

artículo científico publicado en 2002

The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice

artículo científico publicado en 2005

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

artículo científico publicado en 2007

The Arctic AβPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aβ

artículo científico publicado en 2013

The Arctic amyloid-β precursor protein (AβPP) mutation results in distinct plaques and accumulation of N- and C-truncated Aβ.

artículo científico publicado en 2011

The Arctic mutation interferes with processing of the amyloid precursor protein

artículo científico publicado en 2002

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death.

artículo científico publicado en 2018

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

artículo científico publicado en 2010

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The amyloid-β degradation pattern in plasma--a possible tool for clinical trials in Alzheimer's disease

artículo científico publicado en 2014

The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924.

artículo científico publicado en 2009

The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men

artículo científico publicado en 2011

The genetic architecture of type 2 diabetes

artículo científico publicado en 2016

The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers

artículo científico publicado en 2008

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties ⬇️

artículo científico publicado el 1 de febrero de 2011

The murine version of BAN2401 (mAb158) selectively reduces amyloid-β protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice

artículo científico publicado en 2015

The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease

artículo científico publicado en 2007

The tau R406W mutation causes progressive presenile dementia with bitemporal atrophy

artículo científico publicado en 2004

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

artículo científico publicado en 2016

Translating research on brain aging into public health: a new type of immunotherapy for Alzheimer's disease ⬇️

artículo científico publicado el 1 de diciembre de 2010

Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort ⬇️

artículo científico publicado el 27 de julio de 2011

[Alzheimer's disease - the most common cause of dementia]

scientific article published on 09 March 2020

mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts

artículo científico publicado en 2016

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

artículo científico publicado en 2015

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