Lista de obras - J Rokach - Dominio Público Uruguay

15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils.

artículo científico publicado en 2003

5-Oxo-ETE and the OXE receptor

artículo científico publicado en 2009

5-Oxo-ETE receptor antagonists

artículo científico publicado en 2013

5-Oxo-ETE regulates tone of guinea pig airway smooth muscle via activation of Ca2+ pools and Rho-kinase pathway

artículo científico publicado en 2004

5-oxo-15-HETE: total synthesis and bioactivity

artículo científico publicado en 2011

5-oxo-6,8,11,14-eicosatetraenoic acid stimulates the release of the eosinophil survival factor granulocyte/macrophage colony-stimulating factor from monocytes.

artículo científico publicado en 2004

A new approach to the synthesis of polyunsaturated deuterated isoprostanes: total synthesis of d4-5-epi-8,12-iso-iPF3alpha-VI and d4-8,12-iso-iPF3alpha-VI.

artículo científico publicado en 2009

Actions of synthetic leukotrienes on platelets and blood vessels in the anesthetised pig: the release of a platelet derived vasodilator

scientific article published on 01 June 1985

Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and 11-Methylene-PGD2 on Human Eosinophils and Basophils

artículo científico publicado en 2006

Analogs of leukotriene B4: effects of modification of the hydroxyl groups on leukocyte aggregation and binding to leukocyte leukotriene B4 receptors

artículo científico publicado en 1987

Analysis of leukotrienes by high-pressure liquid chromatography

scientific article published on 01 November 1981

Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists

artículo científico publicado en 2014

Biliary and urinary excretion of peptide leukotrienes in the domestic pig

artículo científico publicado en 1987

Biological activities of isomers of 8, 15-dihydroxyeicosatetraenoic acid ⬇️

artículo científico publicado el 1 de septiembre de 1984

Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?

artículo científico

Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning.

artículo científico publicado en 2005

Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes

artículo científico publicado en 2015

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

artículo científico publicado en 2015

Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation.

artículo científico publicado en 1999

C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.

artículo científico publicado en 2011

Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: evidence for the involvement of the leukotriene B4 receptor.

artículo científico publicado en 1991

Calcium/Calmodulin-dependent Conversion of 5-Oxoeicosanoids to 6,7-Dihydro Metabolites by a Cytosolic Olefin Reductase in Human Neutrophils ⬇️

artículo científico publicado el 14 de agosto de 1998

Catabolism of leukotriene A4 into B4, C4, and D4 by rat liver subcellular fractions

scientific article published on 01 August 1985

Comparative Actions of Biologic and Synthetic Leukotrienes on Isolated Human Bronchus and Rat Mast Cells ⬇️

artículo científico publicado el 1 de enero de 1984

Comparative biological activities of synthetic leukotriene B4 and its omega-oxidation products

artículo científico publicado en 1983

Comparison of biological-derived and synthetic leukotriene C4 by fast atom bombardment mass spectrometry

scientific article published on 01 February 1982

Cyclic amidine inhibitors of indolamine N-methyltransferase

artículo científico publicado el 1 de marzo de 1979

Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase

artículo científico publicado en 2016

Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils.

artículo científico publicado en 2004

Eicosapentaenoic-acid-derived isoprostanes: synthesis and discovery of two major isoprostanes

artículo científico publicado en 2008

Enantio- and Stereospecific Syntheses of 15(R)-Me-PGD2, A Potent and Selective DP2−Receptor Agonist

scientific article published on 14 August 2008

Evidence of in-vivo omega-oxidation of peptide leukotrienes in the rat: biliary excretion of 20-CO2H N-acetyl LTE4

artículo científico publicado en 1987

F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases.

artículo científico publicado en 2004

Formation of lipoxin B by the pure reticulocyte lipoxygenase via sequential oxygenation of the substrate

scientific article in 1987

Fractional conversion of thromboxane A2 and B2 to urinary 2,3-dinor-thromboxane B2 and 11-dehydrothromboxane B2 in the cynomolgus monkey

scientific article published on 01 July 1989

Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha.

artículo científico publicado en 1997

IPF2alpha-I: an index of lipid peroxidation in humans

artículo científico publicado en 1998

Identification of two major F2 isoprostanes, 8,12-iso- and 5-epi-8, 12-iso-isoprostane F2alpha-VI, in human urine

artículo científico publicado en 1998

Inhibition of 5-Oxo-6,8,11,14-eicosatetraenoic Acid-Induced Activation of Neutrophils and Eosinophils by Novel Indole OXE Receptor Antagonists

article

Kojic amine--a novel gamma-aminobutyric acid analogue

artículo científico publicado el 1 de enero de 1979

Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leukocytes

artículo científico publicado en 1987

Metabolism and excretion of exogenous [3H]-LTC4 in primates

scientific article published on 01 June 1989

Metabolism and excretion of peptide leukotrienes in the anesthetized rat

artículo científico publicado en 1987

Metabolism of 5-hydroxy-6,8,11,14-eicosatetraenoic acid by human endothelial cells

article

NAD(P)H-dependent reduction of 12-ketoeicosatetraenoic acid to 12(R)- and 12(S)-hydroxyeicosatetraenoic acid by rat liver microsomes.

artículo científico publicado en 1988

Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid

artículo científico publicado en 2008

No evidence for lipid peroxidation in severe preeclampsia.

artículo científico publicado en 2001

Nomenclature of isoprostanes: a proposal.

artículo científico publicado en 1997

Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE)

artículo científico publicado en 2018

Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation.

artículo científico publicado en 2009

Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys

artículo científico publicado en 2020

Oxidative stress stimulates the synthesis of the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid by inflammatory cells.

artículo científico publicado en 2004

Oxidative stress-induced changes in pyridine nucleotides and chemoattractant 5-lipoxygenase products in aging neutrophils.

artículo científico publicado en 2009

Oxidized derivatives of ω-3 fatty acids: identification of IPF3α-VI in human urine

article

Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys.

artículo científico publicado en 2016

Photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor

artículo científico publicado en 1989

Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

artículo científico publicado en 2001

Prostaglandin F2alpha (PGF2alpha) and the isoprostane, 8, 12-iso-isoprostane F2alpha-III, induce cardiomyocyte hypertrophy. Differential activation of downstream signaling pathways

scientific article published on 01 August 1998

Prothrombinase acceleration by oxidatively damaged phospholipids

artículo científico publicado en 2000

Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement.

artículo científico publicado en 2013

Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F(2)-isoprostanes in human urine

artículo científico publicado en 1999

Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid hydroperoxides

artículo científico publicado en 1989

Slow reacting substance of anaphylaxis, SRS-A; assignment of the stereochemistry.

artículo científico publicado en 1980

Specific analysis in plasma and urine of 2,3-dinor-5, 6-dihydro-isoprostane F(2alpha)-III, a metabolite of isoprostane F(2alpha)-III and an oxidation product of gamma-linolenic acid

artículo científico publicado en 2000

Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity.

artículo científico publicado en 2008

Studies on L-640,035: a novel antagonist of contractile prostanoids in the lung

artículo científico publicado en 1984

Studies on the conjugation of leukotriene B4 with proteins for development of a radioimmunoassay for leukotriene B4

artículo científico publicado en 1983

Studies on the preparation of conjugates of leukotriene C4 with proteins for development of an immunoassay for SRS-A (1).

artículo científico publicado en 1982

Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids.

artículo científico publicado en 2009

Synthesis of 10,11-Dihydro-12-oxo-LTB4, a Key Biochemical Intermediate

artículo científico publicado en 1997

Synthesis of 15R-PGD2: a potential DP2 receptor agonist

artículo científico publicado en 2005

Synthesis of beta-oxidation products as potential leukotriene metabolites and their detection in bile of anesthetized rat

artículo científico publicado en 1988

Synthetic leukotriene B4 is a potent chemotaxin but a weak secretagogue for human PMN

scientific article published on 01 February 1983

The Isoprostanes: A Perspective ⬇️

artículo científico publicado el 1 de diciembre de 1997

The development of sensitive and specific radioimmunoassays for leukotrienes

scientific article published on 01 January 1984

The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor

artículo científico publicado en 2013

The lipoxins: determination of their biosynthesis

artículo científico publicado en 1986

The synthesis of leukotrienes

artículo científico publicado en 1981

Total synthesis of 17,17,18,18-d4-iPF2alpha-VI and quantification of iPF2alpha-VI in human urine by gas chromatography/mass spectrometry

artículo científico publicado en 1998

Total synthesis of 8,12-iso-iPF3alpha-VI, an EPA-derived isoprostane: stereoselective introduction of the fifth asymmetric center.

artículo científico publicado en 2006

Total synthesis of isoprostanes: discovery and quantitation in biological systems.

artículo científico publicado en 2004

Two Potent OXE-R Antagonists: Assignment of Stereochemistry

artículo científico publicado en 2014

Urinary leukotriene E4 levels during early and late asthmatic responses†

artículo científico publicado en 1990

Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury.

artículo científico publicado en 2004

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

artículo científico publicado en 1998

iPF2α-III-17,18,19,20-d4: Total synthesis and metabolism

article

Lista de obras de J Rokach

15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils.

5-Oxo-ETE and the OXE receptor

5-Oxo-ETE receptor antagonists

5-Oxo-ETE regulates tone of guinea pig airway smooth muscle via activation of Ca2+ pools and Rho-kinase pathway

5-oxo-15-HETE: total synthesis and bioactivity

5-oxo-6,8,11,14-eicosatetraenoic acid stimulates the release of the eosinophil survival factor granulocyte/macrophage colony-stimulating factor from monocytes.

A new approach to the synthesis of polyunsaturated deuterated isoprostanes: total synthesis of d4-5-epi-8,12-iso-iPF3alpha-VI and d4-8,12-iso-iPF3alpha-VI.

Actions of synthetic leukotrienes on platelets and blood vessels in the anesthetised pig: the release of a platelet derived vasodilator

Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and 11-Methylene-PGD2 on Human Eosinophils and Basophils

Analogs of leukotriene B4: effects of modification of the hydroxyl groups on leukocyte aggregation and binding to leukocyte leukotriene B4 receptors

Analysis of leukotrienes by high-pressure liquid chromatography

Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists

Biliary and urinary excretion of peptide leukotrienes in the domestic pig

Biological activities of isomers of 8, 15-dihydroxyeicosatetraenoic acid ⬇️

Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?

Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning.

Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation.

C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.

Calcium mobilization and right-angle light scatter responses to 12-oxo-derivatives of arachidonic acid in neutrophils: evidence for the involvement of the leukotriene B4 receptor.

Calcium/Calmodulin-dependent Conversion of 5-Oxoeicosanoids to 6,7-Dihydro Metabolites by a Cytosolic Olefin Reductase in Human Neutrophils ⬇️

Catabolism of leukotriene A4 into B4, C4, and D4 by rat liver subcellular fractions

Comparative Actions of Biologic and Synthetic Leukotrienes on Isolated Human Bronchus and Rat Mast Cells ⬇️

Comparative biological activities of synthetic leukotriene B4 and its omega-oxidation products

Comparison of biological-derived and synthetic leukotriene C4 by fast atom bombardment mass spectrometry

Cyclic amidine inhibitors of indolamine N-methyltransferase

Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase

Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils.

Eicosapentaenoic-acid-derived isoprostanes: synthesis and discovery of two major isoprostanes

Enantio- and Stereospecific Syntheses of 15(R)-Me-PGD2, A Potent and Selective DP2−Receptor Agonist

Evidence of in-vivo omega-oxidation of peptide leukotrienes in the rat: biliary excretion of 20-CO2H N-acetyl LTE4

F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases.

Formation of lipoxin B by the pure reticulocyte lipoxygenase via sequential oxygenation of the substrate

Fractional conversion of thromboxane A2 and B2 to urinary 2,3-dinor-thromboxane B2 and 11-dehydrothromboxane B2 in the cynomolgus monkey

Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha.

IPF2alpha-I: an index of lipid peroxidation in humans

Identification of two major F2 isoprostanes, 8,12-iso- and 5-epi-8, 12-iso-isoprostane F2alpha-VI, in human urine

Inhibition of 5-Oxo-6,8,11,14-eicosatetraenoic Acid-Induced Activation of Neutrophils and Eosinophils by Novel Indole OXE Receptor Antagonists

Kojic amine--a novel gamma-aminobutyric acid analogue

Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leukocytes

Metabolism and excretion of exogenous [3H]-LTC4 in primates

Metabolism and excretion of peptide leukotrienes in the anesthetized rat

Metabolism of 5-hydroxy-6,8,11,14-eicosatetraenoic acid by human endothelial cells

NAD(P)H-dependent reduction of 12-ketoeicosatetraenoic acid to 12(R)- and 12(S)-hydroxyeicosatetraenoic acid by rat liver microsomes.

Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid

No evidence for lipid peroxidation in severe preeclampsia.

Nomenclature of isoprostanes: a proposal.

Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE)

Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation.

Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys

Oxidative stress stimulates the synthesis of the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid by inflammatory cells.

Oxidative stress-induced changes in pyridine nucleotides and chemoattractant 5-lipoxygenase products in aging neutrophils.

Oxidized derivatives of ω-3 fatty acids: identification of IPF3α-VI in human urine

Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys.

Photoaffinity labelling of the human platelet thromboxane A2/prostaglandin H2 receptor

Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

Prostaglandin F2alpha (PGF2alpha) and the isoprostane, 8, 12-iso-isoprostane F2alpha-III, induce cardiomyocyte hypertrophy. Differential activation of downstream signaling pathways

Prothrombinase acceleration by oxidatively damaged phospholipids

Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement.

Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F(2)-isoprostanes in human urine

Sensitivity of immunoaffinity-purified porcine 5-lipoxygenase to inhibitors and activating lipid hydroperoxides

Slow reacting substance of anaphylaxis, SRS-A; assignment of the stereochemistry.

Specific analysis in plasma and urine of 2,3-dinor-5, 6-dihydro-isoprostane F(2alpha)-III, a metabolite of isoprostane F(2alpha)-III and an oxidation product of gamma-linolenic acid

Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity.

Studies on L-640,035: a novel antagonist of contractile prostanoids in the lung

Studies on the conjugation of leukotriene B4 with proteins for development of a radioimmunoassay for leukotriene B4

Studies on the preparation of conjugates of leukotriene C4 with proteins for development of an immunoassay for SRS-A (1).

Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids.

Synthesis of 10,11-Dihydro-12-oxo-LTB4, a Key Biochemical Intermediate

Synthesis of 15R-PGD2: a potential DP2 receptor agonist

Synthesis of beta-oxidation products as potential leukotriene metabolites and their detection in bile of anesthetized rat

Synthetic leukotriene B4 is a potent chemotaxin but a weak secretagogue for human PMN

The Isoprostanes: A Perspective ⬇️

The development of sensitive and specific radioimmunoassays for leukotrienes

The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor

The lipoxins: determination of their biosynthesis

The synthesis of leukotrienes

Total synthesis of 17,17,18,18-d4-iPF2alpha-VI and quantification of iPF2alpha-VI in human urine by gas chromatography/mass spectrometry