Lista de obras - Fabrice Anizon - Dominio Público Uruguay

A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia

artículo científico publicado en 2019

A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor

artículo científico publicado en 2008

Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

artículo científico publicado en 2011

Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.

artículo científico publicado en 2006

Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.

artículo científico publicado en 2000

DNA targeting of two new antitumour rebeccamycin derivatives.

artículo científico publicado en 2002

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

artículo científico publicado en 2016

Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue

artículo científico publicado en 1999

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors

artículo científico publicado en 2010

Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.

artículo científico publicado en 2000

Heteroaromatic Pim Kinase Inhibitors Containing a Pyrazole Moiety.

artículo científico publicado en 2016

Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors

artículo científico publicado en 2013

Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.

artículo científico publicado en 2013

In-vitro antiproliferative activities and kinase inhibitory potencies of glycosyl-isoindigo derivatives.

artículo científico publicado en 2007

In-vitro antiproliferative activities and kinase inhibitory potencies of meridianin derivatives

artículo científico publicado en 2008

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies

scientific article published on 04 April 2019

Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives.

artículo científico publicado en 2012

New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities

artículo científico publicado en 2014

New potent and selective inhibitor of Pim-1/3 protein kinases sensitizes human colon carcinoma cells to doxorubicin

artículo científico publicado en 2014

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

artículo científico publicado en 2019

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

artículo científico publicado en 2015

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

artículo científico publicado en 2010

Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety

artículo científico publicado en 2003

Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.

artículo científico publicado en 2008

Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.

artículo científico publicado en 2003

Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens

artículo científico publicado en 2002

Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.

artículo científico publicado en 1997

Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent

artículo científico publicado en 1999

Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle

artículo científico publicado en 1998

Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin

artículo científico publicado en 1998

Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells

artículo científico publicado en 2015

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.

artículo científico publicado en 2005

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.

artículo científico publicado en 2007

Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

artículo científico publicado en 2012

Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.

artículo científico publicado en 2006

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

artículo científico publicado en 2009

Synthesis and biological activities of isogranulatimide analogues.

artículo científico publicado en 2007

Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.

artículo científico publicado en 2007

Synthesis and biological activities of new di- and trimeric quinoline derivatives.

artículo científico publicado en 2010

Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators

artículo científico publicado en 2012

Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives.

artículo científico publicado en 2010

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

artículo científico publicado en 2016

Synthesis and biological evaluation of diversely substituted indolin-2-ones

artículo científico publicado en 2008

Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions

artículo científico publicado en 2006

Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework

artículo científico publicado en 2005

Synthesis and in vitro antiproliferative activities of quinoline derivatives.

artículo científico publicado en 2010

Synthesis and molecular modeling study of new trimeric quinoline derivatives

artículo científico publicado en 2011

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives

artículo científico publicado en 2016

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

artículo científico publicado en 2014

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.

artículo científico publicado en 2010

Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.

artículo científico publicado en 2008

Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone.

artículo científico publicado en 2007

Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7'-azaisoindigo derivatives substituted by Sonogashira cross-coupling.

artículo científico publicado en 2009

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors

artículo científico publicado en 2009

Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives

artículo científico publicado en 1999

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

artículo científico publicado en 2011

Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

artículo científico publicado en 2012

Lista de obras de Fabrice Anizon

A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia

A three-step synthesis from rebeccamycin of an efficient checkpoint kinase 1 inhibitor

Biological evaluation of glycosyl-isoindigo derivatives against the pathogenic agents of tropical diseases (malaria, Chagas disease, leishmaniasis and human African trypanosomiasis).

Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.

Cellular uptake and interaction with purified membranes of rebeccamycin derivatives.

DNA targeting of two new antitumour rebeccamycin derivatives.

Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

Enhanced binding to DNA and topoisomerase I inhibition by an analog of the antitumor antibiotic rebeccamycin containing an amino sugar residue

Fighting tumor cell survival: advances in the design and evaluation of Pim inhibitors

Formaldehyde-induced alkylation of a 2'-aminoglucose rebeccamycin derivative to both A.T and G.C base pairs in DNA.

Heteroaromatic Pim Kinase Inhibitors Containing a Pyrazole Moiety.

Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors

Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.

In-vitro antiproliferative activities and kinase inhibitory potencies of glycosyl-isoindigo derivatives.

In-vitro antiproliferative activities and kinase inhibitory potencies of meridianin derivatives

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies

Kinase inhibitory potencies and in vitro antiproliferative activities of N-10 substituted pyrrolo[2,3-a]carbazole derivatives.

New N-1,N-10-bridged pyrrolo[2,3-a]carbazole-3-carbaldehydes: synthesis and biological activities

New potent and selective inhibitor of Pim-1/3 protein kinases sensitizes human colon carcinoma cells to doxorubicin

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion

Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety

Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.

Semi-synthesis, topoisomerase I and kinases inhibitory properties, and antiproliferative activities of new rebeccamycin derivatives.

Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens

Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.

Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent

Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle

Syntheses, biochemical and biological evaluation of staurosporine analogues from the microbial metabolite rebeccamycin

Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells

Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives.

Synthesis and biological activities of 4-substituted pyrrolo[2,3-a]carbazole Pim kinase inhibitors.

Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

Synthesis and biological activities of isogranulatimide analogues.

Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.

Synthesis and biological activities of new di- and trimeric quinoline derivatives.

Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators

Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives.

Synthesis and biological activity of pyrazole analogues of the staurosporine aglycon K252c.

Synthesis and biological evaluation of diversely substituted indolin-2-ones

Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions

Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework

Synthesis and in vitro antiproliferative activities of quinoline derivatives.

Synthesis and molecular modeling study of new trimeric quinoline derivatives

Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives

Synthesis of pyrazolo[4,3-a]phenanthridines, a new scaffold for Pim kinase inhibition

Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.

Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.

Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone.

Synthesis, kinase inhibitory potencies and in vitro antiproliferative activity of isoindigo and 7'-azaisoindigo derivatives substituted by Sonogashira cross-coupling.

Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors

Synthesis, mode of action, and biological activities of rebeccamycin bromo derivatives

Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives.

Use of copper(I) catalyzed azide alkyne cycloaddition (CuAAC) for the preparation of conjugated pyrrolo[2,3-a]carbazole Pim kinase inhibitors.