Lista de obras - Bruno Linclau - Dominio Público Uruguay

3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation

artículo científico publicado en 2019

6'-derivatised alpha-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice

artículo científico publicado en 2008

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

scientific article published on 30 January 2019

A Study of Intramolecular Hydrogen Bonding in Levoglucosan Derivatives

artículo científico publicado en 2017

A computational study of vicinal fluorination in 2,3-difluorobutane: implications for conformational control in alkane chains

scientific article published on 21 November 2014

A linear synthesis of gemcitabine.

artículo científico publicado en 2015

A novel stereoselective one-pot conversion of alcohols into alkyl halides mediated by N,N'-diisopropylcarbodiimide.

artículo científico publicado en 2003

A novel, versatile D-->BCD steroid construction strategy, illustrated by the enantioselective total synthesis of estrone.

artículo científico publicado en 2010

A practical synthesis of a high-loading solid-supported IBX amide for the oxidation of alcohols.

artículo científico publicado en 2005

An enantioselective desymmetrisation approach to C9-substituted trans-hydrindene rings based on a diastereotopic group-selective intramolecular Diels-Alder reaction

scientific article published on 05 October 2006

An unexpected and significantly lower hydrogen-bond-donating capacity of fluorohydrins compared to nonfluorinated alcohols.

artículo científico publicado en 2012

Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates

artículo científico publicado en 2020

Conformational influence of fluorinated building blocks on the physical properties of polyesters

Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer-Moest Reaction under Flow Conditions

scientific article published on 07 November 2019

Design of fluorinated 5-HT(4)R antagonists: influence of the basicity and lipophilicity toward the 5-HT(4)R binding affinities

artículo científico publicado en 2013

Development of a Solid Phase Array Assay for the Screening of Galactose Oxidase Activity and for Fast Identification of Inhibitors.

artículo científico publicado en 2017

Dietary Phytosterols Protective Against Peptic Ulceration

artículo científico publicado en 2011

Divergent synthetic approach to 6''-modified α-GalCer analogues ⬇️

artículo científico publicado en 2011

Effects of sugar functional groups, hydrophobicity, and fluorination on carbohydrate-DNA stacking interactions in water.

artículo científico publicado en 2014

Efficient desymmetrization of "pseudo"-C2-symmetric substrates: illustration in the synthesis of a disubstituted butenolide from arabitol.

artículo científico publicado en 2003

Enantioselective Synthesis of Dideoxy-tetrafluorinated Hexoses

artículo científico publicado en 2016

Enantioselective synthesis and selective monofunctionalization of (4R,6R)-4,6- dihydroxy-2,8-dioxabicyclo[3.3.0]octane

artículo científico publicado en 2006

Enantioselective synthesis of tetrafluorinated glucose and galactose

artículo científico publicado en 2008

Enzymatic glycosylation involving fluorinated carbohydrates

scientific article published on 22 April 2020

Exploring anomeric glycosylation of phosphoric acid: Optimisation and scope for non-native substrates

artículo científico publicado en 2019

Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

artículo científico publicado en 2020

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase

artículo científico publicado en 2011

Influence of Alcohol β-Fluorination on Hydrogen-Bond Acidity of Conformationally Flexible Substrates

artículo científico publicado en 2016

Influence of Fluorination on the Conformational Properties and Hydrogen-Bond Acidity of Benzyl Alcohol Derivatives.

artículo científico publicado en 2015

Intramolecular OH⋅⋅⋅Fluorine Hydrogen Bonding in Saturated, Acyclic Fluorohydrins: The γ-Fluoropropanol Motif.

artículo científico publicado en 2015

Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands

artículo científico publicado en 2021

Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method.

artículo científico publicado en 2015

Isolation and characterisation of an unexpected byproduct in the regioselective butane diacetal protection of α-methyl galactopyranoside.

artículo científico publicado en 2017

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups

artículo científico publicado en 2020

Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas

artículo científico publicado en 2002

Minimising conformational bias in fluoroprolines through vicinal difluorination.

artículo científico publicado en 2018

Molecular Insights into DC-SIGN Binding to Self-Antigens: The Interaction with the Blood Group A/B Antigens

scientific article published on 08 July 2019

Plant cell wall imaging by metabolic click-mediated labelling of rhamnogalacturonan II using azido 3-deoxy-D-manno-oct-2-ulosonic acid.

artículo científico publicado en 2016

Polymer-supported O-methylisourea: a new reagent for the O-methylation of carboxylic acids

artículo científico publicado en 2002

Polymer-supported o-benzyl and o-allylisoureas: convenient preparation and use in ester synthesis from carboxylic acids

scientific article published on 01 March 2003

Ready synthetic access to enantiopure allylic α(F)-branched fluoroalkenes

artículo científico publicado en 2013

Reducing the lipophilicity of perfluoroalkyl groups by CF2-F/CF2-Me or CF3/CH3 exchange

artículo científico publicado en 2018

Short synthesis of enantiopure C2-symmetric 1,2:4,5-diepoxypentane and "pseudo"-C2-symmetric 3-azido-1,2:4,5-diepoxypentane from arabitol.

artículo científico publicado en 2003

Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs

artículo científico publicado en 2021

Stereoarrays with an all-carbon quaternary center: diastereoselective desymmetrization of prochiral malonaldehydes

artículo científico publicado en 2011

Stereocontrol by quaternary centres: a stereoselective synthesis of (-)-luminacin D.

artículo científico publicado en 2014

Stereoselectivity of the Honda–Reformatsky Reaction in Reactions with Ethyl Bromodifluoroacetate with α-Oxygenated Sulfinylimines

artículo científico publicado en 2014

Structural basis of ligand binding to UDP-galactopyranose mutase from Mycobacterium tuberculosis using substrate and tetrafluorinated substrate analogues

artículo científico publicado en 2015

Synthesis and Conformational Properties of 3,4-Difluoro-l-prolines

scientific article published on 27 February 2019

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

artículo científico publicado en 2008

Synthesis and crystallographic analysis of meso-2,3-difluoro-1,4-butanediol and meso-1,4-dibenzyloxy-2,3-difluorobutane.

artículo científico publicado en 2010

Synthesis and evaluation of amino-modified alpha-GalCer analogues

artículo científico publicado en 2010

Synthesis and in vitro evaluation of alpha-GalCer epimers

artículo científico publicado en 2008

Synthesis of 2,3,4-Trideoxy-2,3,4-trifluoroglucose

scientific article published on 28 March 2019

Synthesis of vicinal dideoxy-difluorinated galactoses

scientific article published on 01 May 2019

Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs

artículo científico publicado en 2020

Tetrafluorination of sugars as strategy for enhancing protein-carbohydrate affinity: application to UDP-Galp mutase inhibition.

artículo científico publicado en 2013

The conformation of tetrafluorinated methyl galactoside anomers: crystallographic and NMR studies

artículo científico publicado en 2011

The development of a short route to the API ropinirole hydrochloride.

artículo científico publicado en 2015

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.

artículo científico publicado en 2009

The synthesis of gemcitabine

artículo científico publicado en 2014

The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers

artículo científico publicado en 2017

Total Synthesis of (-)-Luminacin D

artículo científico publicado en 2016

Total Synthesis of (±)-Paroxetine by Diastereoconvergent Cobalt-Catalysed Arylation

artículo científico publicado en 2014

Transmembrane Exchange of Fluorosugars: Characterization of Red Cell GLUT1 Kinetics Using F NMR

artículo científico publicado en 2018

Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates

scientific article published on 25 June 2019

α-Fluoro-o-cresols: The Key Role of Intramolecular Hydrogen Bonding in Conformational Preference and Hydrogen-Bond Acidity

artículo científico publicado en 2016

Lista de obras de Bruno Linclau

3,4-Dideoxy-3,3,4,4-tetrafluoro- and 4-OH epimeric 3-deoxy-3,3-difluoro-α-GalCer analogues: Synthesis and biological evaluation on human iNKT cells stimulation

6'-derivatised alpha-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

A Study of Intramolecular Hydrogen Bonding in Levoglucosan Derivatives

A computational study of vicinal fluorination in 2,3-difluorobutane: implications for conformational control in alkane chains

A linear synthesis of gemcitabine.

A novel stereoselective one-pot conversion of alcohols into alkyl halides mediated by N,N'-diisopropylcarbodiimide.

A novel, versatile D-->BCD steroid construction strategy, illustrated by the enantioselective total synthesis of estrone.

A practical synthesis of a high-loading solid-supported IBX amide for the oxidation of alcohols.

An enantioselective desymmetrisation approach to C9-substituted trans-hydrindene rings based on a diastereotopic group-selective intramolecular Diels-Alder reaction

An unexpected and significantly lower hydrogen-bond-donating capacity of fluorohydrins compared to nonfluorinated alcohols.

Chemoenzymatic synthesis of 3-deoxy-3-fluoro-l-fucose and its enzymatic incorporation into glycoconjugates

Conformational influence of fluorinated building blocks on the physical properties of polyesters

Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer-Moest Reaction under Flow Conditions

Design of fluorinated 5-HT(4)R antagonists: influence of the basicity and lipophilicity toward the 5-HT(4)R binding affinities

Development of a Solid Phase Array Assay for the Screening of Galactose Oxidase Activity and for Fast Identification of Inhibitors.

Dietary Phytosterols Protective Against Peptic Ulceration

Divergent synthetic approach to 6''-modified α-GalCer analogues ⬇️

Effects of sugar functional groups, hydrophobicity, and fluorination on carbohydrate-DNA stacking interactions in water.

Efficient desymmetrization of "pseudo"-C2-symmetric substrates: illustration in the synthesis of a disubstituted butenolide from arabitol.

Enantioselective Synthesis of Dideoxy-tetrafluorinated Hexoses

Enantioselective synthesis and selective monofunctionalization of (4R,6R)-4,6- dihydroxy-2,8-dioxabicyclo[3.3.0]octane

Enantioselective synthesis of tetrafluorinated glucose and galactose

Enzymatic glycosylation involving fluorinated carbohydrates

Exploring anomeric glycosylation of phosphoric acid: Optimisation and scope for non-native substrates

Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives

Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase

Influence of Alcohol β-Fluorination on Hydrogen-Bond Acidity of Conformationally Flexible Substrates

Influence of Fluorination on the Conformational Properties and Hydrogen-Bond Acidity of Benzyl Alcohol Derivatives.

Intramolecular OH⋅⋅⋅Fluorine Hydrogen Bonding in Saturated, Acyclic Fluorohydrins: The γ-Fluoropropanol Motif.

Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands

Investigating the Influence of (Deoxy)fluorination on the Lipophilicity of Non-UV-Active Fluorinated Alkanols and Carbohydrates by a New log P Determination Method.

Isolation and characterisation of an unexpected byproduct in the regioselective butane diacetal protection of α-methyl galactopyranoside.

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups

Microwave-accelerated O-alkylation of carboxylic acids with O-alkylisoureas

Minimising conformational bias in fluoroprolines through vicinal difluorination.

Molecular Insights into DC-SIGN Binding to Self-Antigens: The Interaction with the Blood Group A/B Antigens

Plant cell wall imaging by metabolic click-mediated labelling of rhamnogalacturonan II using azido 3-deoxy-D-manno-oct-2-ulosonic acid.

Polymer-supported O-methylisourea: a new reagent for the O-methylation of carboxylic acids

Polymer-supported o-benzyl and o-allylisoureas: convenient preparation and use in ester synthesis from carboxylic acids

Ready synthetic access to enantiopure allylic α(F)-branched fluoroalkenes

Reducing the lipophilicity of perfluoroalkyl groups by CF2-F/CF2-Me or CF3/CH3 exchange

Short synthesis of enantiopure C2-symmetric 1,2:4,5-diepoxypentane and "pseudo"-C2-symmetric 3-azido-1,2:4,5-diepoxypentane from arabitol.

Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs

Stereoarrays with an all-carbon quaternary center: diastereoselective desymmetrization of prochiral malonaldehydes

Stereocontrol by quaternary centres: a stereoselective synthesis of (-)-luminacin D.

Stereoselectivity of the Honda–Reformatsky Reaction in Reactions with Ethyl Bromodifluoroacetate with α-Oxygenated Sulfinylimines

Structural basis of ligand binding to UDP-galactopyranose mutase from Mycobacterium tuberculosis using substrate and tetrafluorinated substrate analogues

Synthesis and Conformational Properties of 3,4-Difluoro-l-prolines

Synthesis and In Vivo Evaluation of 4-Deoxy-4,4-difluoro-KRN7000

Synthesis and crystallographic analysis of meso-2,3-difluoro-1,4-butanediol and meso-1,4-dibenzyloxy-2,3-difluorobutane.

Synthesis and evaluation of amino-modified alpha-GalCer analogues

Synthesis and in vitro evaluation of alpha-GalCer epimers

Synthesis of 2,3,4-Trideoxy-2,3,4-trifluoroglucose

Synthesis of vicinal dideoxy-difluorinated galactoses

Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs

Tetrafluorination of sugars as strategy for enhancing protein-carbohydrate affinity: application to UDP-Galp mutase inhibition.

The conformation of tetrafluorinated methyl galactoside anomers: crystallographic and NMR studies

The development of a short route to the API ropinirole hydrochloride.

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.

The synthesis of gemcitabine

The synthesis of the 2,3-difluorobutan-1,4-diol diastereomers

Total Synthesis of (-)-Luminacin D

Total Synthesis of (±)-Paroxetine by Diastereoconvergent Cobalt-Catalysed Arylation

Transmembrane Exchange of Fluorosugars: Characterization of Red Cell GLUT1 Kinetics Using F NMR

Unraveling Sugar Binding Modes to DC-SIGN by Employing Fluorinated Carbohydrates

α-Fluoro-o-cresols: The Key Role of Intramolecular Hydrogen Bonding in Conformational Preference and Hydrogen-Bond Acidity