Lista de obras - Vytas K Svedas - Dominio Público Uruguay

2,5-Diketopiperazines: A New Class of Poly(ADP-ribose)polymerase Inhibitors.

artículo científico publicado en 2018

A new method for spectrophotometric assay of activity of cross-linked penicillin acylase aggregates

scientific article published on 01 March 2006

Active site titration as a tool for the evaluation of immobilization procedures of penicillin acylase.

artículo científico publicado en 2002

Acyl group transfer by proteases forming acyl-enzyme intermediate: kinetic model analysis

artículo científico publicado en 1988

Acyl group transfer by proteases forming an acylenzyme intermediate: kinetic model analysis (including hydrolysis of acylenzyme- nucleophile complex)

artículo científico publicado en 1989

Bioinformatic analysis of alpha/beta-hydrolase fold enzymes reveals subfamily-specific positions responsible for discrimination of amidase and lipase activities ⬇️

artículo científico publicado el 4 de octubre de 2012

Bioinformatic analysis of protein families for identification of variable amino acid residues responsible for functional diversity.

artículo científico publicado en 2013

Bioinformatic analysis of the fold type I PLP-dependent enzymes reveals determinants of reaction specificity in l-threonine aldolase from Aeromonas jandaei.

artículo científico publicado en 2018

Chiral high-performance liquid chromatography analysis of alpha-amino acid mixtures using a novel SH reagent--N-R-mandelyl-L-cysteine and traditional enantiomeric thiols for precolumn derivatization.

artículo científico publicado en 2007

Comparative modeling of substrate binding in the S1' subsite of serine carboxypeptidases from yeast, wheat, and human

scientific article published on 01 November 1996

Computational design of a pH stable enzyme: understanding molecular mechanism of penicillin acylase's adaptation to alkaline conditions

artículo científico publicado en 2014

Continuous spectrophotometric assay of human lysosomal cathepsin A/protective protein in normal and galactosialidosis cells

scientific article published on 01 September 1995

Crystal structures of carboxypeptidase T complexes with transition-state analogs.

artículo científico publicado en 2017

Efficient enantiomeric analysis of primary amines and amino alcohols by high-performance liquid chromatography with precolumn derivatization using novel chiral SH-reagent N-(R)-mandelyl-(S)-cysteine

artículo científico publicado en 2005

Enantioselective penicillin acylase-catalyzed reactions. Factors governing substrate and stereospecificity of the enzyme

artículo científico publicado en 1996

Guidelines for reporting of biocatalytic reactions

artículo científico publicado en 2010

Highly efficient synthesis of ampicillin in an "aqueous solution-precipitate" system: repetitive addition of substrates in a semicontinuous process.

artículo científico publicado en 2001

Hydrophobicity of beta-lactam antibiotics. Explanation and prediction of their behaviour in various partitioning solvent systems and reversed-phase chromatography

artículo científico publicado en 1991

Influence of the immunization against heterologous alcohol dehydrogenase on liver alcohol dehydrogenase isozymes and alcohol abuse of rats

artículo científico publicado en 1993

Investigation of formate transport through the substrate channel of formate dehydrogenase by steered molecular dynamics simulations

article

Kinetic study of penicillin acylase from Alcaligenes faecalis

artículo científico publicado en 1997

Kinetics of ampicillin synthesis catalyzed by penicillin acylase from E. coli in homogeneous and heterogeneous systems. Quantitative characterization of nucleophile reactivity and mathematical modeling of the process.

artículo científico publicado en 2000

Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine

scientific article published on 20 March 2020

Molecular modeling of different substrate‐binding modes and their role in penicillin acylase catalysis ⬇️

artículo científico publicado el 22 de noviembre de 2012

Molecular modeling of formate dehydrogenase: the formation of the Michaelis complex

artículo científico publicado en 2012

Mustguseal: a Server for Multiple Structure-Guided Sequence Alignment of Protein Families.

artículo científico publicado en 2017

Neuraminidase A from Streptococcus pneumoniae has a modular organization of catalytic and lectin domains separated by a flexible linker

artículo científico publicado en 2018

Novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase: Covalent modification of NAD-binding site by aromatic thiols ⬇️

artículo científico publicado el 1 de diciembre de 2010

Penicillin acylase-catalyzed ampicillin synthesis using a pH gradient: a new approach to optimization.

artículo científico publicado en 2002

Preparation and properties of penicillin amidase immobilized in polyelectrolyte complexes

scientific article published on 01 August 1981

Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions.

artículo científico publicado en 2002

Quantum chemical studies of the catalytic mechanism of N-terminal nucleophile hydrolase

artículo científico publicado en 2007

Soluble-insoluble immobilized enzymes

scientific article published on 01 January 1982

Structural insights into the broad substrate specificity of carboxypeptidase T from Thermoactinomyces vulgaris

artículo científico publicado en 2015

Structure of the carboxypeptidase B complex with N-sulfamoyl-L-phenylalanine - a transition state analog of non-specific substrate.

artículo científico publicado en 2017

Study of nucleophile binding in the penicillin acylase active center. Kinetic analysis.

artículo científico publicado en 2003

Substrate specificity of penicillin amidase from E. coli

scientific article published on 01 December 1980

The interaction of amino acids with ophthaldialdehyde: a kinetic study and spectrophotometric assay of the reaction product

artículo científico publicado en 1980

The mechanism of the alpha-chymotrypsin and trypsin-catalyzed hydrolysis of amides. Evidence for the participation of the active serine in the amidase activity of trypsin

artículo científico publicado en 1973

The visualCMAT: A web-server to select and interpret correlated mutations/co-evolving residues in protein families

artículo científico publicado en 2017

Thermodynamic and kinetic stability of penicillin acylase from Escherichia coli.

artículo científico publicado en 2008

Totally enzymatic synthesis of peptides. Penicillin acylase-catalyzed protection and deprotection of amino groups as important building blocks of this strategy

artículo científico publicado en 1998

Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.

artículo científico publicado en 2016

Zebra: a web server for bioinformatic analysis of diverse protein families.

artículo científico publicado en 2013

pocketZebra: a web-server for automated selection and classification of subfamily-specific binding sites by bioinformatic analysis of diverse protein families.

artículo científico publicado en 2014

Lista de obras de Vytas K Svedas

2,5-Diketopiperazines: A New Class of Poly(ADP-ribose)polymerase Inhibitors.

A new method for spectrophotometric assay of activity of cross-linked penicillin acylase aggregates

Active site titration as a tool for the evaluation of immobilization procedures of penicillin acylase.

Acyl group transfer by proteases forming acyl-enzyme intermediate: kinetic model analysis

Acyl group transfer by proteases forming an acylenzyme intermediate: kinetic model analysis (including hydrolysis of acylenzyme- nucleophile complex)

Bioinformatic analysis of alpha/beta-hydrolase fold enzymes reveals subfamily-specific positions responsible for discrimination of amidase and lipase activities ⬇️

Bioinformatic analysis of protein families for identification of variable amino acid residues responsible for functional diversity.

Bioinformatic analysis of the fold type I PLP-dependent enzymes reveals determinants of reaction specificity in l-threonine aldolase from Aeromonas jandaei.

Chiral high-performance liquid chromatography analysis of alpha-amino acid mixtures using a novel SH reagent--N-R-mandelyl-L-cysteine and traditional enantiomeric thiols for precolumn derivatization.

Comparative modeling of substrate binding in the S1' subsite of serine carboxypeptidases from yeast, wheat, and human

Computational design of a pH stable enzyme: understanding molecular mechanism of penicillin acylase's adaptation to alkaline conditions

Continuous spectrophotometric assay of human lysosomal cathepsin A/protective protein in normal and galactosialidosis cells

Crystal structures of carboxypeptidase T complexes with transition-state analogs.

Efficient enantiomeric analysis of primary amines and amino alcohols by high-performance liquid chromatography with precolumn derivatization using novel chiral SH-reagent N-(R)-mandelyl-(S)-cysteine

Enantioselective penicillin acylase-catalyzed reactions. Factors governing substrate and stereospecificity of the enzyme

Guidelines for reporting of biocatalytic reactions

Highly efficient synthesis of ampicillin in an "aqueous solution-precipitate" system: repetitive addition of substrates in a semicontinuous process.

Hydrophobicity of beta-lactam antibiotics. Explanation and prediction of their behaviour in various partitioning solvent systems and reversed-phase chromatography

Influence of the immunization against heterologous alcohol dehydrogenase on liver alcohol dehydrogenase isozymes and alcohol abuse of rats

Investigation of formate transport through the substrate channel of formate dehydrogenase by steered molecular dynamics simulations

Kinetic study of penicillin acylase from Alcaligenes faecalis

Kinetics of ampicillin synthesis catalyzed by penicillin acylase from E. coli in homogeneous and heterogeneous systems. Quantitative characterization of nucleophile reactivity and mathematical modeling of the process.

Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine

Molecular modeling of different substrate‐binding modes and their role in penicillin acylase catalysis ⬇️

Molecular modeling of formate dehydrogenase: the formation of the Michaelis complex

Mustguseal: a Server for Multiple Structure-Guided Sequence Alignment of Protein Families.

Neuraminidase A from Streptococcus pneumoniae has a modular organization of catalytic and lectin domains separated by a flexible linker

Novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase: Covalent modification of NAD-binding site by aromatic thiols ⬇️

Penicillin acylase-catalyzed ampicillin synthesis using a pH gradient: a new approach to optimization.

Preparation and properties of penicillin amidase immobilized in polyelectrolyte complexes

Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions.

Quantum chemical studies of the catalytic mechanism of N-terminal nucleophile hydrolase

Soluble-insoluble immobilized enzymes

Structural insights into the broad substrate specificity of carboxypeptidase T from Thermoactinomyces vulgaris

Structure of the carboxypeptidase B complex with N-sulfamoyl-L-phenylalanine - a transition state analog of non-specific substrate.

Study of nucleophile binding in the penicillin acylase active center. Kinetic analysis.

Substrate specificity of penicillin amidase from E. coli

The interaction of amino acids with ophthaldialdehyde: a kinetic study and spectrophotometric assay of the reaction product

The mechanism of the alpha-chymotrypsin and trypsin-catalyzed hydrolysis of amides. Evidence for the participation of the active serine in the amidase activity of trypsin

The visualCMAT: A web-server to select and interpret correlated mutations/co-evolving residues in protein families

Thermodynamic and kinetic stability of penicillin acylase from Escherichia coli.

Totally enzymatic synthesis of peptides. Penicillin acylase-catalyzed protection and deprotection of amino groups as important building blocks of this strategy

Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.

Zebra: a web server for bioinformatic analysis of diverse protein families.

pocketZebra: a web-server for automated selection and classification of subfamily-specific binding sites by bioinformatic analysis of diverse protein families.