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A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome activity resulting in microcephaly, psychomotor retardation, and epilepsy

artículo científico publicado en 2019

A rapid method for the isolation of metabolically active mitochondria from rat neurons and astrocytes in primary culture

artículo científico publicado el 1 de marzo de 1998

A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons.

artículo científico publicado en 2001

APC/C-Cdh1 coordinates neurogenesis and cortical size during development

artículo científico publicado en 2013

APC/CCdh1-Rock2 pathway controls dendritic integrity and memory

artículo científico publicado en 2017

Amyloid-ß promotes neurotoxicity by Cdk5-induced p53 stabilization

artículo científico publicado en 2018

Antioxidant and bioenergetic coupling between neurons and astrocytes.

artículo científico

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.

artículo científico publicado en 2015

Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid.

artículo científico publicado en 2009

Brain energy metabolism in glutamate-receptor activation and excitotoxicity: role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway.

artículo científico

Cdh1/Hct1-APC is essential for the survival of postmitotic neurons.

artículo científico publicado en 2005

Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

scientific journal article

Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.

artículo científico publicado en 2015

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes.

artículo científico publicado en 2016

D-Glucose prevents glutathione oxidation and mitochondrial damage after glutamate receptor stimulation in rat cortical primary neurons

artículo científico publicado en 2000

DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1.

artículo científico publicado en 2015

E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation

artículo científico publicado en 2009

Effect of ethanol consumption on adult rat liver mitochondrial populations analyzed by flow cytometry

scientific article published on 01 October 1995

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration

artículo científico publicado en 2012

Expression of glucose transporter GLUT3 by endotoxin in cultured rat astrocytes: the role of nitric oxide.

artículo científico publicado en 2001

Genetic determinants of neuronal vulnerability to apoptosis.

artículo científico publicado en 2012

Glutamate excitoxicity is the key molecular mechanism which is influenced by body temperature during the acute phase of brain stroke

artículo científico publicado en 2012

Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion.

artículo científico publicado en 1998

Hippocampal neurons require a large pool of glutathione to sustain dendrite integrity and cognitive function

artículo científico publicado en 2018

Hypothyroidism prevents postnatal changes in rat liver mitochondrial populations defined by rhodamine-123 staining

scientific article published on 01 October 1995

Increased mitochondrial respiration maintains the mitochondrial membrane potential and promotes survival of cerebellar neurons in an endogenous model of glutamate receptor activation.

artículo científico publicado en 2005

Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway

scientific journal article

Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase

scientific journal article

Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system.

artículo científico publicado en 1997

Isolation and characterization of tightly coupled mitochondria from neurons and astrocytes in primary culture.

artículo científico publicado en 1997

Ketogenesis from lactate in rat liver during the perinatal period

scientific article published on 01 April 1992

Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide.

artículo científico publicado en 2007

Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications.

artículo científico publicado en 2009

Mitochondrial Complex I Activity is Conditioned by Supercomplex I-III2-IV Assembly in Brain Cells: Relevance for Parkinson's Disease.

artículo científico publicado en 2017

Mitochondrial respiratory chain and free radical generation in stroke.

artículo científico publicado en 2005

Modulation of astroglial energy metabolism by nitric oxide.

artículo científico publicado en 2006

Neovascularization and functional recovery after intracerebral hemorrhage is conditioned by the Tp53 Arg72Pro single-nucleotide polymorphism

artículo científico publicado en 2016

Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons.

artículo científico publicado en 2007

Nitric oxide mediates brain mitochondrial damage during perinatal anoxia.

artículo científico publicado en 1998

Nitric oxide mediates brain mitochondrial maturation immediately after birth.

artículo científico publicado en 1999

Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway.

artículo científico publicado en 2003

Nuclear WRAP53 promotes neuronal survival and functional recovery after stroke

artículo científico publicado en 2020

PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1.

artículo científico publicado en 2014

Peroxynitrite anion stimulates arginine release from cultured rat astrocytes

scientific article published on 01 October 1999

Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection

scientific journal article

Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress

scientific journal article

Postnatal changes in rhodamine-123 stained mitochondrial populations are sensitive to protein synthesis inhibitors but mimicked in vitro by ATP

artículo científico publicado en 1994

Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria

scientific article published on 01 January 1994

Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain

scientific article published on 01 January 1995

Provoking neuroprotection by peroxynitrite.

artículo científico publicado en 2004

Regulation of APC/C-Cdh1 and Its Function in Neuronal Survival

artículo científico publicado el 27 de julio de 2012

Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival

artículo científico publicado en 2015

Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia

artículo científico publicado en 2014

Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation

artículo científico publicado en 2008

Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

scientific article published on 12 August 2019

The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia.

artículo científico publicado en 2018

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.

artículo científico publicado en 2009

The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke.

artículo científico publicado en 2011

The pentose-phosphate pathway in neuronal survival against nitrosative stress.

artículo científico publicado en 2010

Thyroid hormones regulate the onset of osmotic activity of rat liver mitochondria after birth

scientific article published on 01 February 1997