Lista de obras - Robert C Tuckey - Dominio Público Uruguay

1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis

artículo científico publicado en 2017

20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes

artículo científico publicado en 2009

20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

artículo científico publicado en 2010

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

artículo científico publicado en 2008

20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo

artículo científico publicado en 2013

A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia.

artículo científico publicado en 2015

Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin

artículo científico publicado en 2017

Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D3 levels in male mice

artículo científico publicado en 2012

An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.

artículo científico publicado en 2006

Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation

artículo científico publicado en 2015

Association among Vitamin D, Retinoic Acid-Related Orphan Receptors, and Vitamin D Hydroxyderivatives in Ovarian Cancer

artículo científico publicado en 2020

Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes

artículo científico publicado en 2016

CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds.

artículo científico publicado en 2014

CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.

artículo científico publicado en 2014

CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites.

artículo científico publicado en 2018

Catalytic properties of 25-hydroxyvitamin D3 3-epimerase in rat and human liver microsomes

artículo científico publicado en 2019

Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

artículo científico publicado en 2017

Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives.

artículo científico publicado en 2015

Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity.

artículo científico publicado en 2010

Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts

artículo científico publicado en 2015

Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength

artículo científico publicado en 2012

Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis

artículo científico publicado en 2017

Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity

artículo científico publicado en 2014

Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation

artículo científico publicado en 2011

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes ⬇️

artículo científico publicado el 2 de agosto de 2012

Design, synthesis, and biological action of 20R-hydroxyvitamin D3.

artículo científico publicado en 2012

Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey

artículo científico publicado en 2020

Detection of Serotonin, Melatonin, and Their Metabolites in Honey

artículo científico publicado en 2021

Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.

artículo científico publicado en 2015

Differential and Overlapping Effects of 20,23(OH)₂D3 and 1,25(OH)₂D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)₂D3

article

Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture.

artículo científico publicado en 2015

Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode

artículo científico publicado en 2003

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.

artículo científico publicado en 2016

Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462.

artículo científico publicado en 1998

Expression of human CYP27B1 in Escherichia coli and characterization in phospholipid vesicles.

artículo científico publicado en 2012

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives.

artículo científico publicado en 2011

Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.

artículo científico publicado en 2011

Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4.

artículo científico publicado en 2016

Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.

artículo científico publicado en 2013

Hydroxylumisterols, Photoproducts of Pre-Vitamin D3, Protect Human Keratinocytes against UVB-Induced Damage

artículo científico publicado en 2020

In vivo evidence for a novel pathway of vitamin D 3 metabolism initiated by P450scc and modified by CYP27B1 ⬇️

artículo científico publicado el 8 de junio de 2012

In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.

artículo científico publicado en 2013

Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.

artículo científico publicado en 2018

Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway

artículo científico publicado en 2014

Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin.

artículo científico publicado en 2008

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

artículo científico publicado en 2014

Membrane-Mediated Protein-Protein Interactions of Cholesterol Side-Chain Cleavage Cytochrome P450 with its Associated Electron Transport Proteins

artículo científico publicado en 2016

Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1

artículo científico publicado en 2015

Metabolism of 20-hydroxyvitamin D3 by mouse liver microsomes

artículo científico publicado en 2014

Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1).

artículo científico publicado en 2008

Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria.

artículo científico publicado en 2004

Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

artículo científico publicado en 2017

Novel activities of CYP11A1 and their potential physiological significance.

artículo científico publicado en 2014

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.

artículo científico publicado en 2015

Novel vitamin D photoproducts and their precursors in the skin.

scientific article published on January 2013

On the role of classical and novel forms of vitamin D in melanoma progression and management

artículo científico publicado en 2017

On the role of skin in the regulation of local and systemic steroidogenic activities.

artículo científico publicado en 2015

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

artículo científico publicado en 2008

Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase

artículo científico publicado en 2002

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

artículo científico publicado en 2010

Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3.

artículo científico publicado en 2017

Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity

artículo científico publicado en 2010

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.

artículo científico publicado en 2014

Role of CYP27A1 in progesterone metabolism in vitro and in vivo

artículo científico publicado en 2009

Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin

scientific journal article

Side-chain specificities of human and bovine cytochromes P-450scc

artículo científico publicado en 1993

Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer.

artículo científico publicado en 2016

The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane

artículo científico publicado en 2003

The concentration of adrenodoxin reductase limits cytochrome p450scc activity in the human placenta

artículo científico publicado en 1999

The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism.

artículo científico publicado en 2005

The effect of glycerol on cytochrome P450scc (CYP11A1) spin state, activity, and hydration

artículo científico publicado en 2002

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.

artículo científico publicado en 2013

The serum vitamin D metabolome: What we know and what is still to discover

artículo científico publicado en 2018

Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).

artículo científico publicado en 2002

Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity.

artículo científico publicado en 2011

Vitamin D and its low calcemic analogs modulate the anticancer properties of cisplatin and dacarbazine in the human melanoma A375 cell line

artículo científico publicado en 2019

Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

artículo científico publicado en 2021

Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes

artículo científico publicado en 2016

Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.

artículo científico publicado en 2017

Lista de obras de Robert C Tuckey

1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis

20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes

20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo

A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia.

Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin

Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D3 levels in male mice

An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.

Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation

Association among Vitamin D, Retinoic Acid-Related Orphan Receptors, and Vitamin D Hydroxyderivatives in Ovarian Cancer

Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes

CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds.

CYP24A1 expression inversely correlates with melanoma progression: clinic-pathological studies.

CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites.

Catalytic properties of 25-hydroxyvitamin D3 3-epimerase in rat and human liver microsomes

Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives.

Chemical synthesis of 20S-hydroxyvitamin D3, which shows antiproliferative activity.

Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts

Correlation between secosteroid-induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength

Cutaneous Glucocorticoidogenesis and Cortisol Signaling Are Defective in Psoriasis

Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity

Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes ⬇️

Design, synthesis, and biological action of 20R-hydroxyvitamin D3.

Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey

Detection of Serotonin, Melatonin, and Their Metabolites in Honey

Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.

Differential and Overlapping Effects of 20,23(OH)₂D3 and 1,25(OH)₂D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)₂D3

Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture.

Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.

Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462.

Expression of human CYP27B1 in Escherichia coli and characterization in phospholipid vesicles.

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives.

Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.

Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4.

Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.

Hydroxylumisterols, Photoproducts of Pre-Vitamin D3, Protect Human Keratinocytes against UVB-Induced Damage

In vivo evidence for a novel pathway of vitamin D 3 metabolism initiated by P450scc and modified by CYP27B1 ⬇️

In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland.

Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.

Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway

Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin.

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

Membrane-Mediated Protein-Protein Interactions of Cholesterol Side-Chain Cleavage Cytochrome P450 with its Associated Electron Transport Proteins

Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1

Metabolism of 20-hydroxyvitamin D3 by mouse liver microsomes

Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1).

Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria.

Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

Novel activities of CYP11A1 and their potential physiological significance.

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.

Novel vitamin D photoproducts and their precursors in the skin.

On the role of classical and novel forms of vitamin D in melanoma progression and management

On the role of skin in the regulation of local and systemic steroidogenic activities.

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3.

Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.

Role of CYP27A1 in progesterone metabolism in vitro and in vivo

Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin

Side-chain specificities of human and bovine cytochromes P-450scc

Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer.

The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane

The concentration of adrenodoxin reductase limits cytochrome p450scc activity in the human placenta

The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism.

The effect of glycerol on cytochrome P450scc (CYP11A1) spin state, activity, and hydration

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions.

The serum vitamin D metabolome: What we know and what is still to discover

Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).

Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity.

Vitamin D and its low calcemic analogs modulate the anticancer properties of cisplatin and dacarbazine in the human melanoma A375 cell line

Vitamin D and lumisterol derivatives can act on liver X receptors (LXRs)

Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes

Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.