Lista de obras - Christina L.L. Chai - Dominio Público Uruguay

3-Deazaneplanocin A and neplanocin A analogues and their effects on apoptotic cell death.

artículo científico publicado en 2014

A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites

artículo científico publicado en 2005

A fast and straightforward route towards the synthesis of the lissoclimide class of anti-tumour agents

article

A fluorescence-displacement assay using molecularly imprinted polymers for the visual, rapid, and sensitive detection of the algal metabolites, geosmin and 2-methylisoborneol

artículo científico publicado en 2019

A one step method for the functional and property modification of DOPA based nanocoatings

artículo científico publicado en 2017

A synthetic approach to chrysophaentin F

scientific article published on 01 April 2019

An efficient synthesis of an exo-enone analogue of LL-Z1640-2 and evaluation of its protein kinase inhibitory activities

artículo científico publicado en 2015

Atmospheric pressure aminocarbonylation of aryl iodides using palladium nanoparticles supported on MOF-5.

artículo científico publicado en 2012

Bidentate inhibitors of protein tyrosine phosphatases.

artículo científico

CLEVER: pipeline for designing in silico chemical libraries.

artículo científico publicado en 2008

Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling

artículo científico publicado en 2014

Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis.

artículo científico

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

artículo científico publicado en 2000

Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids

artículo científico publicado en 2011

Controlled polymerization and self-assembly of a supramolecular star polymer with a guanosine quadruplex core

scientific article published on 27 May 2009

Copper-catalyzed oxidative amidation of aldehydes with amine salts: synthesis of primary, secondary, and tertiary amides

artículo científico publicado en 2012

Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core

artículo científico publicado en 2014

Diallyl tartrate as a multifunctional monomer for bio-polymer synthesis.

artículo científico publicado en 2010

Direct Evidence for the Critical Role of 5,6-Dihydroxyindole in Polydopamine Deposition and Aggregation

scientific article published on 04 April 2019

Efficient formal synthesis of oseltamivir phosphate (Tamiflu) with inexpensive D-ribose as the starting material.

artículo científico publicado en 2010

Euplectin and coneuplectin, new naphthopyrones from the lichen Flavoparmelia euplecta.

artículo científico publicado en 2000

Evidence for gliotoxin-glutathione conjugate adducts.

artículo científico publicado en 2001

Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.

artículo científico publicado en 2011

Friedel-Crafts acylation and metalation strategies in the synthesis of calothrixins A and B.

artículo científico publicado en 2003

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)

artículo científico publicado en 2015

Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2<i>H</i>-Chromenes

artículo científico publicado en 2020

Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N-Desbutyl Dronedarone.

artículo científico publicado en 2015

Inactivation of rabbit muscle creatine kinase by reversible formation of an internal disulfide bond induced by the fungal toxin gliotoxin

scientific article published on 01 August 2000

Influencing the Fate of Cardiac and Neural Stem Cell Differentiation Using Small Molecule Inhibitors of ALK5

artículo científico publicado en 2018

Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins.

artículo científico publicado en 2002

Metabolism-Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development.

artículo científico publicado en 2015

Mimics of pramanicin derived from pyroglutamic acid and their antibacterial activity.

artículo científico publicado en 2017

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease

artículo científico publicado en 2016

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease

artículo científico publicado en 2015

One size does not fit all: Challenging some dogmas and taboos in drug discovery.

artículo científico publicado en 2015

One-Pot UV-Triggered o-Nitrobenzyl Dopamine Polymerization and Coating for Surface Antibacterial Application.

artículo científico publicado en 2016

Organic polymer composites as robust, non-covalent supports of metal salts

artículo científico publicado en 2009

Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones

artículo científico publicado en 2015

PolyPEGA with predetermined molecular weights from enzyme-mediated radical polymerization in water.

artículo científico publicado en 2011

Polypharmacology of andrographolide: beyond one molecule one target

artículo científico publicado en 2020

Promoting GAINs (Give Attention to Limitations in Assays) over PAINs Alerts: no PAINS, more GAINs

artículo científico publicado en 2022

Scope of direct arylation of fluorinated aromatics with aryl sulfonates

artículo científico publicado en 2012

Searching for "environmentally-benign" antifouling biocides

artículo científico publicado en 2014

Self-supported chiral titanium cluster (SCTC) as a robust catalyst for the asymmetric cyanation of imines under batch and continuous flow at room temperature

scientific article published on 21 March 2012

Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1.

artículo científico publicado en 2010

Structure-activity delineation of quinones related to the biologically active Calothrixin B

artículo científico publicado en 2006

Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity.

artículo científico publicado en 2014

Synthesis of mimics of pramanicin from pyroglutamic acid and their antibacterial activity.

artículo científico publicado en 2015

Synthesis of neplanocin A and its 3'-epimer via an intramolecular Baylis-Hillman reaction.

artículo científico publicado en 2014

Synthesis, electrochemistry, and bioactivity of the cyanobacterial calothrixins and related quinones.

artículo científico publicado en 2004

Systematic Evaluation of the Metabolism and Toxicity of Thiazolidinone and Imidazolidinone Heterocycles.

artículo científico publicado en 2015

The Chemistry of Bioinspired Catechol(amine)-Based Coatings

scientific article published on 29 May 2019

The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent

artículo científico publicado en 2019

The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases

artículo científico publicado en 2016

Total synthesis of (+/-)-cordypyridones A and B and related epimers

artículo científico publicado en 2009

Transparent, flexible and highly conductive ion gels from ionic liquid compatible cyclic carbonate network.

artículo científico publicado en 2010

Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS.

artículo científico publicado en 2016

Lista de obras de Christina L.L. Chai

3-Deazaneplanocin A and neplanocin A analogues and their effects on apoptotic cell death.

A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites

A fast and straightforward route towards the synthesis of the lissoclimide class of anti-tumour agents

A fluorescence-displacement assay using molecularly imprinted polymers for the visual, rapid, and sensitive detection of the algal metabolites, geosmin and 2-methylisoborneol

A one step method for the functional and property modification of DOPA based nanocoatings

A synthetic approach to chrysophaentin F

An efficient synthesis of an exo-enone analogue of LL-Z1640-2 and evaluation of its protein kinase inhibitory activities

Atmospheric pressure aminocarbonylation of aryl iodides using palladium nanoparticles supported on MOF-5.

Bidentate inhibitors of protein tyrosine phosphatases.

CLEVER: pipeline for designing in silico chemical libraries.

Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling

Clinical utility of neuroprotective agents in neurodegenerative diseases: current status of drug development for Alzheimer's, Parkinson's and Huntington's diseases, and amyotrophic lateral sclerosis.

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

Control of chemoselectivity in Dieckmann ring closures leading to tetramic acids

Controlled polymerization and self-assembly of a supramolecular star polymer with a guanosine quadruplex core

Copper-catalyzed oxidative amidation of aldehydes with amine salts: synthesis of primary, secondary, and tertiary amides

Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core

Diallyl tartrate as a multifunctional monomer for bio-polymer synthesis.

Direct Evidence for the Critical Role of 5,6-Dihydroxyindole in Polydopamine Deposition and Aggregation

Efficient formal synthesis of oseltamivir phosphate (Tamiflu) with inexpensive D-ribose as the starting material.

Euplectin and coneuplectin, new naphthopyrones from the lichen Flavoparmelia euplecta.

Evidence for gliotoxin-glutathione conjugate adducts.

Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.

Friedel-Crafts acylation and metalation strategies in the synthesis of calothrixins A and B.

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)

Gold(I)-Catalyzed Intramolecular Hydroarylation of Phenol-Derived Propiolates and Certain Related Ethers as a Route to Selectively Functionalized Coumarins and 2<i>H</i>-Chromenes

Inactivation of Human Cytochrome P450 3A4 and 3A5 by Dronedarone and N-Desbutyl Dronedarone.

Inactivation of rabbit muscle creatine kinase by reversible formation of an internal disulfide bond induced by the fungal toxin gliotoxin

Influencing the Fate of Cardiac and Neural Stem Cell Differentiation Using Small Molecule Inhibitors of ALK5

Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins.

Metabolism-Activated Multitargeting (MAMUT): An Innovative Multitargeting Approach to Drug Design and Development.

Mimics of pramanicin derived from pyroglutamic acid and their antibacterial activity.

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease

Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease

One size does not fit all: Challenging some dogmas and taboos in drug discovery.

One-Pot UV-Triggered o-Nitrobenzyl Dopamine Polymerization and Coating for Surface Antibacterial Application.

Organic polymer composites as robust, non-covalent supports of metal salts

Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones

PolyPEGA with predetermined molecular weights from enzyme-mediated radical polymerization in water.

Polypharmacology of andrographolide: beyond one molecule one target

Promoting GAINs (Give Attention to Limitations in Assays) over PAINs Alerts: no PAINS, more GAINs

Scope of direct arylation of fluorinated aromatics with aryl sulfonates

Searching for "environmentally-benign" antifouling biocides

Self-supported chiral titanium cluster (SCTC) as a robust catalyst for the asymmetric cyanation of imines under batch and continuous flow at room temperature

Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1.

Structure-activity delineation of quinones related to the biologically active Calothrixin B

Synthesis of 3-acyltetramates by side chain manipulation and their antibacterial activity.

Synthesis of mimics of pramanicin from pyroglutamic acid and their antibacterial activity.

Synthesis of neplanocin A and its 3'-epimer via an intramolecular Baylis-Hillman reaction.

Synthesis, electrochemistry, and bioactivity of the cyanobacterial calothrixins and related quinones.

Systematic Evaluation of the Metabolism and Toxicity of Thiazolidinone and Imidazolidinone Heterocycles.

The Chemistry of Bioinspired Catechol(amine)-Based Coatings

The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent

The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases

Total synthesis of (+/-)-cordypyridones A and B and related epimers

Transparent, flexible and highly conductive ion gels from ionic liquid compatible cyclic carbonate network.

Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS.