Lista de obras - Barbara Wiśniowska - Dominio Público Uruguay

Am I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity.

artículo científico publicado en 2016

An Open-Access Dataset of Thorough QT Studies Results

artículo científico publicado en 2020

BDTcomparator: a program for comparing binary classifiers.

artículo científico publicado en 2011

Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development

artículo científico publicado en 2019

Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry

scientific article published on 18 December 2020

Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

artículo científico publicado en 2009

Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges

artículo científico publicado en 2014

Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating

artículo científico publicado en 2022

Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models

artículo científico publicado en 2017

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

artículo científico publicado en 2016

Drug-physiology interaction and its influence on the QT prolongation-mechanistic modeling study

scientific article published on 15 March 2018

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates

artículo científico publicado en 2015

Enhanced QSAR models for drug-triggered inhibition of the main cardiac ion currents

artículo científico publicado en 2015

Evaluation of patients’ adherence to statins in Poland ⬇️

artículo científico publicado el 24 de noviembre de 2010

Evolutionary Algorithms in Modeling Aerodynamic Properties of Spray-Dried Microparticulate Systems

artículo científico publicado en 2020

From Heuristic to Mathematical Modeling of Drugs Dissolution Profiles: Application of Artificial Neural Networks and Genetic Programming

artículo científico publicado en 2015

From probiotics to psychobiotics - the gut-brain axis in psychiatric disorders

artículo científico publicado en 2020

How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology - model-based case study

artículo científico publicado en 2021

How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction

artículo científico publicado en 2015

Humans Vary, So Cardiac Models Should Account for That Too!

artículo científico publicado en 2017

In vitro-in vivo extrapolation of drug-induced proarrhythmia predictions at the population level.

artículo científico

Magnetic Core-Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma-Material Characterization, Theoretical Analysis and Pharmacokinetics

artículo científico publicado en 2021

Prediction of the hERG potassium channel inhibition potential with use of artificial neural networks

artículo científico publicado en 2011

Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.

artículo científico publicado en 2012

Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools

artículo científico publicado en 2018

Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.

artículo científico publicado en 2017

Slow delayed rectifying potassium current (IKs ) - analysis of the in vitro inhibition data and predictive model development.

artículo científico publicado en 2012

The Role of Interaction Model in Simulation of Drug Interactions and QT Prolongation

artículo científico publicado en 2016

Thorough QT (TQT) studies: concordance with torsadogenesis and an evolving cardiac safety testing paradigm

artículo científico publicado en 2017

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

artículo científico publicado en 2016

Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin.

artículo científico publicado en 2018

Tox-database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition

artículo científico publicado en 2012

Virtual Clinical Trial Toward Polytherapy Safety Assessment: Combination of Physiologically Based Pharmacokinetic/Pharmacodynamic-Based Modeling and Simulation Approach With Drug-Drug Interactions Involving Terfenadine as an Example

artículo científico publicado en 2016

Virtual Thorough QT (TQT) Trial-Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine

scientific article published on 11 July 2018

Virtual population generator for human cardiomyocytes parameters: in silico drug cardiotoxicity assessment.

artículo científico publicado en 2012

hERG in vitro interchange factors--development and verification

artículo científico publicado en 2009

Lista de obras de Barbara Wiśniowska

Am I or am I not proarrhythmic? Comparison of various classifications of drug TdP propensity.

An Open-Access Dataset of Thorough QT Studies Results

BDTcomparator: a program for comparing binary classifiers.

Better prediction of the local concentration-effect relationship: the role of physiologically based pharmacokinetics and quantitative systems pharmacology and toxicology in the evolution of model-informed drug discovery and development

Characterization of In Vitro and In Vivo Metabolism of Antazoline Using Liquid Chromatography-Tandem Mass Spectrometry

Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges

Development and Performance Verification of the PBPK Model for Antazoline and Its Metabolite and Its Utilization for Pharmacological Hypotheses Formulating

Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models

Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials

Drug-physiology interaction and its influence on the QT prolongation-mechanistic modeling study

Early Drug Discovery Prediction of Proarrhythmia Potential and Its Covariates

Enhanced QSAR models for drug-triggered inhibition of the main cardiac ion currents

Evaluation of patients’ adherence to statins in Poland ⬇️

Evolutionary Algorithms in Modeling Aerodynamic Properties of Spray-Dried Microparticulate Systems

From Heuristic to Mathematical Modeling of Drugs Dissolution Profiles: Application of Artificial Neural Networks and Genetic Programming

From probiotics to psychobiotics - the gut-brain axis in psychiatric disorders

How circadian variability of the heart rate and plasma electrolytes concentration influence the cardiac electrophysiology - model-based case study

How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction

Humans Vary, So Cardiac Models Should Account for That Too!

In vitro-in vivo extrapolation of drug-induced proarrhythmia predictions at the population level.

Magnetic Core-Shell Molecularly Imprinted Nano-Conjugates for Extraction of Antazoline and Hydroxyantazoline from Human Plasma-Material Characterization, Theoretical Analysis and Pharmacokinetics

Prediction of the hERG potassium channel inhibition potential with use of artificial neural networks

Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.

Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools

Real Patient and its Virtual Twin: Application of Quantitative Systems Toxicology Modelling in the Cardiac Safety Assessment of Citalopram.

Slow delayed rectifying potassium current (IKs ) - analysis of the in vitro inhibition data and predictive model development.

The Role of Interaction Model in Simulation of Drug Interactions and QT Prolongation

Thorough QT (TQT) studies: concordance with torsadogenesis and an evolving cardiac safety testing paradigm

Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations

Towards Bridging Translational Gap in Cardiotoxicity Prediction: an Application of Progressive Cardiac Risk Assessment Strategy in TdP Risk Assessment of Moxifloxacin.

Tox-database.net: a curated resource for data describing chemical triggered in vitro cardiac ion channels inhibition

Virtual Clinical Trial Toward Polytherapy Safety Assessment: Combination of Physiologically Based Pharmacokinetic/Pharmacodynamic-Based Modeling and Simulation Approach With Drug-Drug Interactions Involving Terfenadine as an Example

Virtual Thorough QT (TQT) Trial-Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine

Virtual population generator for human cardiomyocytes parameters: in silico drug cardiotoxicity assessment.

hERG in vitro interchange factors--development and verification