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Lista de obras de Stephen H. Leppla

A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins

artículo científico publicado en 2011

A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague ⬇️

artículo científico publicado en 2018

A Bivalent Anthrax-Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis

artículo científico publicado en 2017

A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection

artículo científico publicado en 2016

A New Minimal Replicon of Bacillus anthracis Plasmid pXO1.

artículo científico publicado en 2009

A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo

artículo científico publicado en 1989

A dominant-negative therapy for anthrax

artículo científico publicado en 2001

A heterodimer of a VHH (variable domains of camelid heavy chain-only) antibody that inhibits anthrax toxin cell binding linked to a VHH antibody that blocks oligomer formation is highly protective in an anthrax spore challenge model

artículo científico publicado en 2015

A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome

artículo científico publicado en 2018

A new minimal replicon of Bacillus anthracis plasmid pXO1.

artículo científico publicado en 2009

A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen ⬇️

artículo científico publicado el 1 de agosto de 1997

A spontaneous translational fusion of Bacillus cereus PlcR and PapR activates transcription of PlcR-dependent genes in Bacillus anthracis via binding with a specific palindromic sequence

scientific article published on October 2004

A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types

artículo científico publicado en 2006

A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts

artículo científico publicado en 2004

Accidental selection and intentional restoration of sporulation-deficient Bacillus anthracis mutants

artículo científico publicado en 2010

Activation of the latent PlcR regulon in Bacillus anthracis ⬇️

artículo científico publicado el 5 de agosto de 2010

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

artículo científico publicado en 2016

Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells

artículo científico publicado en 1989

Alanine-scanning mutations in domain 4 of anthrax toxin protective antigen reveal residues important for binding to the cellular receptor and to a neutralizing monoclonal antibody

artículo científico publicado en 2003

An anthrax toxin variant with an improved activity in tumor targeting

artículo científico publicado en 2015

An antibody-based microarray assay for small RNA detection

artículo científico publicado en 2006

Anthrax LFn-PA Hybrid Antigens: Biochemistry, Immunogenicity, and Protection Against Lethal Ames Spore Challenge in Rabbits

artículo científico publicado en 2009

Anthrax Lethal Factor

book chapter of Handbook of Proteolytic Enzymes

Anthrax Pathogenesis

artículo científico

Anthrax Toxin

Anthrax Toxin Protective Antigen Variants That Selectively Utilize either the CMG2 or TEM8 Receptors for Cellular Uptake and Tumor Targeting

artículo científico publicado en 2016

Anthrax Toxins

Anthrax and the inflammasome

artículo científico publicado en 2011

Anthrax edema factor toxicity is strongly mediated by the N-end rule

artículo científico publicado en 2013

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport

artículo científico publicado en 2017

Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model

artículo científico publicado en 2011

Anthrax edema toxin impairs clearance in mice

artículo científico publicado en 2011

Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin

artículo científico publicado en 2007

Anthrax fusion protein therapy of cancer

artículo científico publicado en 2002

Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support

artículo científico publicado en 2017

Anthrax lethal and edema toxins in anthrax pathogenesis

artículo científico publicado en 2014

Anthrax lethal factor

Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome

artículo científico publicado en 2012

Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages

artículo científico publicado en 2012

Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality

artículo científico publicado en 2020

Anthrax lethal factor represses glucocorticoid and progesterone receptor activity

artículo científico publicado en 2003

Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages

scientific journal article

Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice

artículo científico publicado en 2006

Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome

artículo científico publicado en 2007

Anthrax protective antigen cleavage and clearance from the blood of mice and rats

artículo científico publicado en 2007

Anthrax target in macrophages unveiled

scientific article published on 01 February 2006

Anthrax toxin components stimulate chemotaxis of human polymorphonuclear neutrophils

artículo científico publicado en 1985

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells ⬇️

artículo científico publicado el 1 de mayo de 1982

Anthrax toxin fusion proteins for intracellular delivery of macromolecules

artículo científico publicado en 1999

Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

scientific journal article

Anthrax toxin mechanisms of receptor binding and internalization

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin ⬇️

artículo científico publicado el 1 de noviembre de 1992

Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice

artículo científico publicado en 2010

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

artículo científico publicado en 2003

Anthrax toxin uptake by primary immune cells as determined with a lethal factor-beta-lactamase fusion protein

artículo científico publicado en 2009

Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage

artículo científico publicado en 2007

Anthrax toxin-mediated delivery of the Pseudomonas exotoxin A enzymatic domain to the cytosol of tumor cells via cleavable ubiquitin fusions

artículo científico publicado en 2013

Anthrax toxin-neutralizing antibody reconfigures the protective antigen heptamer into a supercomplex

artículo científico publicado en 2010

Anthrax toxin: structures, functions and tumour targeting

artículo científico publicado en 2003

Anthrax toxins induce shock in rats by depressed cardiac ventricular function

artículo científico publicado en 2007

Anti-tumor activity of anthrax toxin variants that form a functional translocation pore by intermolecular complementation ⬇️

artículo científico publicado en 2017

Antibodies specific for nucleic acids and applications in genomic detection and clinical diagnostics

artículo científico

Antibodies to anthrax toxin in humans and guinea pigs and their relevance to protective immunity ⬇️

artículo científico publicado en 1988

Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy

artículo científico publicado en 2010

Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy

artículo científico publicado en 2011

Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain

artículo científico publicado en 2012

Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase

artículo científico publicado en 2002

Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes

scientific article published on 13 December 2013

Association of diphtheria toxin with Vero cells. Demonstration of a receptor ⬇️

artículo científico publicado en 1978

Auranofin protects against anthrax lethal toxin-induced activation of the Nlrp1b inflammasome

artículo científico publicado en 2010

B. anthracis Lethal Toxin but not Edema Toxin, Increases Pulmonary Artery Pressure and Permeability in Isolated Perfused Rat Lungs

artículo científico publicado en 2019

BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin

artículo científico publicado en 2005

Bacillus anthracis Capsular Conjugates Elicit Chimpanzee Polyclonal Antibodies That Protect Mice from Pulmonary Anthrax

artículo científico publicado en 2015

Bacillus anthracis Edema Toxin Inhibits Hypoxic Pulmonary Vasoconstrictionvia Edema Factor and cAMP Mediated Mechanisms in Isolated Perfused Rat Lungs

scientific article published on 16 October 2020

Bacillus anthracis Virulence Regulator AtxA Binds Specifically to the pagA Promoter Region

artículo científico publicado en 2019

Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells

artículo científico publicado el 1 de enero de 1984

Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model

scientific article published on 03 January 2007

Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens

artículo científico publicado en 2006

Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice

artículo científico publicado en 2005

Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice

artículo científico publicado en 2003

Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice

article

Bacillus anthracis toxins

chapter article published in academic textbook

Bacillus anthracis toxins ⬇️

academic chapter published in The Comprehensive Sourcebook of Bacterial Protein Toxins, 4th edition

Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome ⬇️

artículo científico publicado en 2020

Bacterial Exotoxins and the Inflammasome

artículo científico publicado en 2015

Bacteriophage T4 capsid: a unique platform for efficient surface assembly of macromolecular complexes

scholarly article by Qin Li et al published 20 October 2006 in Journal of Molecular Biology

Bismaleimide cross‐linked anthrax toxin forms functional octamers with high specificity in tumor targeting

artículo científico publicado en 2019

Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design

artículo científico publicado en 2005

Broad expression analysis of human ANTXR1/TEM8 transcripts reveals differential expression and novel splizce variants

artículo científico publicado en 2012

CA-074Me protection against anthrax lethal toxin

artículo científico publicado en 2009

Calcium is required for the expression of anthrax lethal toxin activity in the macrophagelike cell line J774A.1.

artículo científico publicado en 1989

Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis

artículo científico publicado en 2012

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

artículo científico publicado en 2009

Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization

artículo científico publicado en 2002

Cellular and systemic effects of anthrax lethal toxin and edema toxin

artículo científico publicado en 2009

Characterization of a Chinese hamster ovary cell mutant having a mutation in elongation factor-2.

artículo científico publicado en 2010

Characterization of lethal factor binding and cell receptor binding domains of protective antigen of Bacillus anthracis using monoclonal antibodies

scientific article published on 01 March 1996

Characterization of macrophage sensitivity and resistance to anthrax lethal toxin

artículo científico publicado en 1993

Characterization of the NLRP1 inflammasome response in bovine species

artículo científico publicado en 2019

Characterization of the interaction between anthrax toxin and its cellular receptors

artículo científico publicado en 2007

Characterization of the subunit structure of the ribonucleic acid genome of influenza virus ⬇️

artículo científico publicado en 1971

Cisplatin inhibition of anthrax lethal toxin

artículo científico publicado en 2006

Cloning and characterization of a gene whose product is a trans-activator of anthrax toxin synthesis

artículo científico publicado en 1993

Cloning of the protective antigen gene of Bacillus anthracis

artículo científico publicado en 1983

Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.

artículo científico publicado en 1999

Clostridium septicum alpha-toxin is proteolytically activated by furin ⬇️

artículo científico publicado el 1 de octubre de 1997

Codon-optimized fluorescent proteins designed for expression in low-GC gram-positive bacteria

scientific article published on 30 January 2009

Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities

artículo científico publicado en 2014

Comparison of the 3' termini of discrete segments of the double-stranded ribonucleic acid genomes of cytoplasmic polyhedrosis virus, wound tumor virus, and reovirus

artículo científico publicado en 1972

Contributions of edema factor and protective antigen to the induction of protective immunity by Bacillus anthracis edema toxin as an intranasal adjuvant

artículo científico publicado en 2010

Correction: Broad Expression Analysis of Human ANTXR1/TEM8 Transcripts Reveals Differential Expression and Novel Splizce Variants

Correlation between lethal toxin-neutralizing antibody titers and protection from intranasal challenge with Bacillus anthracis Ames strain spores in mice after transcutaneous immunization with recombinant anthrax protective antigen

artículo científico publicado en 2006

Cross-inhibition between furin and lethal factor inhibitors

artículo científico publicado en 2004

Crystal structure of a complex between anthrax toxin and its host cell receptor

artículo científico publicado en 2004

Crystal structure of the anthrax lethal factor

artículo científico publicado en 2001

Crystal structure of the anthrax toxin protective antigen

artículo científico publicado en 1997

Crystallization of the protective antigen protein of Bacillus anthracis

artículo científico publicado en 1985

Crystallographic studies of the anthrax lethal toxin

artículo científico publicado en 1999

Cytolethal distending toxin B as a cell-killing component of tumor-targeted anthrax toxin fusion proteins ⬇️

artículo científico publicado en 2014

Cytotoxic effects of a chimeric protein consisting of tetanus toxin light chain and anthrax toxin lethal factor in non-neuronal cells

artículo científico publicado en 1994

Cytotoxicity of anthrax lethal toxin to human acute myeloid leukemia cells is nonapoptotic and dependent on extracellular signal-regulated kinase 1/2 activity

artículo científico publicado en 2013

Cytotoxicity of the matrix metalloproteinase-activated anthrax lethal toxin is dependent on gelatinase expression and B-RAF status in human melanoma cells

artículo científico publicado en 2008

Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice

artículo científico publicado en 2011

Delivery of Antigens to the MHC Class I Pathway Using Bacterial Toxins ⬇️

artículo científico publicado el 1 de mayo de 1997

Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles

artículo científico publicado en 2009

Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays

artículo científico publicado en 2006

Development of an improved vaccine for anthrax

artículo científico publicado en 2002

Development of an improved vaccine for anthrax

article published in 2002

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

artículo científico publicado en 2012

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells. ⬇️

artículo científico publicado en 2004

Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin

artículo científico publicado en 2009

Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development

artículo científico publicado en 2006

Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii

artículo científico publicado en 2014

Effect of Late Endosomal Dobmp Lipid and Traditional Model Lipids of Electrophysiology on the Anthrax Toxin Channel Activity

artículo científico publicado en 2019

Effect of ammonium chloride on receptor-mediated uptake of diphtheria toxin by Vero cells

artículo científico publicado en 1981

Effect of late endosomal DOBMP lipid and traditional model lipids of electrophysiology on the anthrax toxin channel activity

scientific article published in Biochimica et Biophysica Acta in November 2018

Effect of over expressing protective antigen on global gene transcription in Bacillus anthracis BH500 ⬇️

artículo científico publicado en 2018

Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen

artículo científico publicado en 2003

Effects of anthrax toxin components on human neutrophils

artículo científico publicado en 1985

Effects of lectins on the interaction of diphtheria toxin with mammalian cells ⬇️

artículo científico publicado el 1 de junio de 1979

Efficient neutralization of anthrax toxin by chimpanzee monoclonal antibodies against protective antigen

artículo científico publicado en 2006

Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin

artículo científico publicado en 2011

Endocrine perturbation increases susceptibility of mice to anthrax lethal toxin

artículo científico publicado en 2005

Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors

artículo científico publicado en 2013

Evaluation of Pseudomonas aeruginosa toxin A in experimental rat burn wound sepsis ⬇️

artículo científico publicado el 1 de septiembre de 1979

Evidence for pseudomonas exotoxin A receptors on plasma membrane of toxin-sensitive lm fibroblasts.

artículo científico publicado en 1984

Exploring the Nature of Cationic Blocker Recognition by the Anthrax Toxin Channel

artículo científico publicado en 2019

Expression of Bacillus anthracis protective antigen in transgenic chloroplasts of tobacco, a non-food/feed crop

artículo científico publicado en 2004

Fluid support worsens outcome and negates the benefit of protective antigen-directed monoclonal antibody in a lethal toxin-infused rat Bacillus anthracis shock model.

artículo científico publicado en 2007

Frontline Science: Anthrax lethal toxin-induced, NLRP1-mediated IL-1β release is a neutrophil and PAD4-dependent event

scientific article published on 18 May 2020

Functional characterization of protease-treated Bacillus anthracis protective antigen ⬇️

artículo científico publicado el 25 de agosto de 1992

Functional mapping of anthrax toxin lethal factor by in-frame insertion mutagenesis.

artículo científico publicado en 1991

Furin is important but not essential for the proteolytic maturation of gp160 of HIV-1 ⬇️

artículo científico publicado en 1995

Furin regulates both the activation of Pseudomonas exotoxin A and the Quantity of the toxin receptor expressed on target cells

artículo científico publicado en 1996

Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells

artículo científico publicado en 1992

Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells

artículo científico publicado en 1994

Genome engineering in Bacillus anthracis using Cre recombinase

artículo científico publicado en 2006

Genome engineering in Bacillus anthracis using tyrosine site-specific recombinases.

artículo científico publicado en 2017

Heat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin

artículo científico publicado en 2008

Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis

artículo científico publicado en 2015

Hfqs in Bacillus anthracis: Role of protein sequence variation in the structure and function of proteins in the Hfq family ⬇️

artículo científico publicado en 2015

Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin

artículo científico publicado en 2013

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen ⬇️

artículo científico

Identification of a receptor-binding region within domain 4 of the protective antigen component of anthrax toxin

artículo científico publicado en 1999

Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2

artículo científico publicado en 2004

Identification of three noncontiguous regions on Bacillus anthracis plasmid pXO1 that are important for its maintenance ⬇️

artículo científico publicado en 2014

Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry

artículo científico publicado en 2021

Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins

artículo científico publicado en 2009

Imaging specific cell-surface proteolytic activity in single living cells.

artículo científico publicado en 2006

Immunization studies with attenuated strains of Bacillus anthracis

artículo científico publicado en 1986

Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin.

artículo científico publicado en 1984

Immunotoxin therapy of hematologic malignancies

artículo científico publicado en 2003

Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin

artículo científico publicado en 2003

In vitro binding of anthrax protective antigen on bacteriophage T4 capsid surface through Hoc-capsid interactions: a strategy for efficient display of large full-length proteins

artículo científico publicado en 2005

In vitro processing of anthrax toxin protective antigen by recombinant PC1 (SPC3) and bovine intermediate lobe secretory vesicle membranes

artículo científico publicado en 1995

In vivo characterization of an Hfq protein encoded by the Bacillus anthracis virulence plasmid pXO1 ⬇️

artículo científico publicado en 2017

In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin

artículo científico publicado en 2008

Induction of hepatitis C virus-specific cytotoxic T lymphocytes in mice by immunization with dendritic cells treated with an anthrax toxin fusion protein

artículo científico publicado en 2001

Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii

artículo científico publicado en 2014

Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment

artículo científico publicado en 2010

Inhibition of diphtheria toxin degradation and cytotoxic action by chloroquine

artículo científico publicado en 1980

Inhibition of protein synthesis by Shiga toxin

artículo científico publicado en 1980

Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma

artículo científico publicado en 2010

Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin

artículo científico publicado en 1988

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas

artículo científico publicado en 2020

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells

artículo científico publicado en 2020

Interactions of high-affinity cationic blockers with the translocation pores of B. anthracis, C. botulinum, and C. perfringens binary toxins

artículo científico publicado en 2012

Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin

artículo científico publicado en 2005

Internalization and processing of Bacillus anthracis lethal toxin by toxin-sensitive and -resistant cells

artículo científico publicado en 1989

Internalization of a Bacillus anthracis protective antigen-c-Myc fusion protein mediated by cell surface anti-c-Myc antibodies.

artículo científico publicado en 1998

Key tissue targets responsible for anthrax-toxin-induced lethality

artículo científico publicado en 2013

Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway ⬇️

artículo científico publicado en 2008

Large-scale purification and characterization of the exotoxin of Pseudomonas aeruginosa ⬇️

artículo científico publicado el 1 de octubre de 1976

Large-scale structural changes accompany binding of lethal factor to anthrax protective antigen: a cryo-electron microscopic study

artículo científico publicado en 2004

Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis

artículo científico publicado en 2004

Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells ⬇️

artículo científico publicado en 2018

Lethal and edema toxins of anthrax induce distinct hemodynamic dysfunction

scientific article published on 01 May 2007

Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats

artículo científico publicado en 2004

Lipoprotein biosynthesis by prolipoprotein diacylglyceryl transferase is required for efficient spore germination and full virulence of Bacillus anthracis

artículo científico publicado en 2011

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

artículo científico publicado en 2007

Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis

artículo científico publicado en 2009

Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

artículo científico publicado en 2004

Methylation-dependent DNA restriction in Bacillus anthracis

artículo científico publicado en 2011

Molecular cloning and expression in Escherichia coli of the lethal factor gene of Bacillus anthracis

scientific article published on 01 January 1986

Mouse monoclonal antibodies to anthrax edema factor protect against infection

artículo científico publicado en 2011

Mouse susceptibility to anthrax lethal toxin is influenced by genetic factors in addition to those controlling macrophage sensitivity

artículo científico publicado en 2004

Multicomponent anthrax toxin display and delivery using bacteriophage T4.

artículo científico publicado en 2006

Mutation in the platelet-derived growth factor receptor alpha inhibits adeno-associated virus type 5 transduction

artículo científico publicado en 2012

MyD88-dependent signaling protects against anthrax lethal toxin-induced impairment of intestinal barrier function

artículo científico publicado en 2010

Nitric oxide production contributes to Bacillus anthracis edema toxin-associated arterial hypotension and lethality: ex vivo and in vivo studies in the rat.

artículo científico publicado en 2016

Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats

artículo científico publicado en 2009

Novel Protein Targeted Therapy of Metastatic Melanoma ⬇️

artículo científico publicado el 1 de enero de 2003

Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody

artículo científico publicado en 2009

Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase

scientific journal article

Occurrence, recognition, and reversion of spontaneous, sporulation-deficient Bacillus anthracis mutants that arise during laboratory culture

artículo científico publicado en 2012

Oligomerization of anthrax toxin protective antigen and binding of lethal factor during endocytic uptake into mammalian cells

artículo científico publicado en 1999

Optimized production and purification of Bacillus anthracis lethal factor

scientific article published on 01 April 2000

Oxidized ATP protection against anthrax lethal toxin

artículo científico publicado en 2006

PapR peptide maturation: role of the NprB protease in Bacillus cereus 569 PlcR/PapR global gene regulation

scientific article published on 12 January 2009

Pathophysiology of anthrax

artículo científico publicado en 2009

Peptide toxins directed at the matrix dissolution systems of cancer cells

artículo científico publicado en 2002

Phase 1 study of a recombinant mutant protective antigen of Bacillus anthracis

artículo científico publicado en 2011

Phosphatidylcholine-Specific Phospholipase C and Sphingomyelinase Activities in Bacteria of theBacillus cereusGroup ⬇️

artículo científico publicado el 1 de noviembre de 2003

Phospho-MEK1/2 and uPAR Expression Determine Sensitivity of AML Blasts to a Urokinase-Activated Anthrax Lethal Toxin (PrAgU2/LF). ⬇️

artículo científico publicado en 2015

Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal toxin challenge

artículo científico publicado en 2005

Poly(gamma-D-glutamic acid) protein conjugates induce IgG antibodies in mice to the capsule of Bacillus anthracis: a potential addition to the anthrax vaccine

artículo científico publicado en 2003

Potent antitumor activity of a urokinase-activated engineered anthrax toxin

artículo científico publicado en 2003

Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: implications for broad anti-tumor efficacy

scientific article published on 18 January 2008

Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding

artículo científico publicado en 2009

Pre- and postexposure protection against virulent anthrax infection in mice by humanized monoclonal antibodies to Bacillus anthracis capsule ⬇️

artículo científico publicado el 27 de diciembre de 2010

Pre-labelling versus direct labelling of anthrax proteins for imaging of matrix metalloproteinases activity using DOTA-GA

artículo científico publicado en 2019

Production and Characterization of Monoclonal Antibodies against the Lethal Factor Component of Bacillus anthracis Toxin

scientific publication

Production and Purification of Anthrax Toxin ⬇️

artículo científico publicado en 1986

Production and characterization of monoclonal antibodies against the lethal factor component of Bacillus anthracis lethal toxin

artículo científico publicado en 1990

Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin.

artículo científico publicado en 1988

Production and purification of anthrax toxin

artículo científico publicado en 1988

Production, recovery and immunogenicity of the protective antigen from a recombinant strain of Bacillus anthracis

artículo científico publicado en 2002

Proteasome activity is required for anthrax lethal toxin to kill macrophages

artículo científico publicado en 1999

Protection against anthrax lethal toxin challenge by genetic immunization with a plasmid encoding the lethal factor protein

artículo científico publicado en 2001

Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo

artículo científico publicado en 2004

Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity

artículo científico publicado en 2002

Protection against anthrax toxin by vaccination with a DNA plasmid encoding anthrax protective antigen

artículo científico publicado en 1999

Protection against experimental Pseudomonas aeruginosa infection in mice by active immunization with exotoxin A toxoids.

artículo científico publicado en 1981

Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases

artículo científico publicado en 1995

Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases

artículo científico publicado en 1994

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

artículo científico publicado en 1998

Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein

artículo científico publicado en 1995

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

artículo científico publicado en 2009

Quickening the pace of anthrax research: three advances point towards possible therapies

artículo científico publicado en 2002

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

artículo científico publicado en 2012

Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines

artículo científico publicado en 2015

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis

artículo científico publicado en 2006

Receptor-mediated internalization and degradation of diphtheria toxin by monkey kidney cells ⬇️

artículo científico publicado el 25 de noviembre de 1979

Recombinant anthrax toxin receptor-Fc fusion proteins produced in plants protect rabbits against inhalational anthrax

artículo científico publicado en 2010

Recombinant expression and purification of a tumor-targeted toxin in Bacillus anthracis

artículo científico publicado en 2012

Reductive methylation and mutation of an anthrax toxin fusion protein modulates its stability and cytotoxicity

artículo científico publicado en 2014

Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides

artículo científico publicado en 1993

Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins

scientific journal article

Role of Exotoxin and Protease as Possible Virulence Factors in Experimental Infections with Pseudomonas aeruginosa ⬇️

artículo científico publicado el 1 de marzo de 1978

Role of N-terminal amino acids in the potency of anthrax lethal factor

artículo científico publicado en 2008

Saccharides cross-reactive with Bacillus anthracis spore glycoprotein as an anthrax vaccine component

artículo científico publicado en 2008

Selection of Pseudomonas exotoxin-resistant cells with altered expression of alpha 2MR/LRP

scientific article published on 01 September 1994

Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells

artículo científico publicado en 2007

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation

artículo científico publicado en 2010

Separation of three exotoxic factors of Bacillus anthracis by sequential immunosorbent chromatography

artículo científico publicado en 1988

Sequence and analysis of the DNA encoding protective antigen of Bacillus anthracis

artículo científico publicado en 1988

Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors

artículo científico publicado en 2020

Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.

artículo científico publicado en 2017

Small molecule inhibitors of Bacillus anthracis protective antigen proteolytic activation and oligomerization

artículo científico publicado en 2012

Small molecule inhibitors of anthrax edema factor

artículo científico publicado en 2017

Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection

scientific article published on 17 June 2013

Solid tumor therapy by selectively targeting stromal endothelial cells

artículo científico publicado en 2016

Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'

artículo científico publicado en 2008

Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome

artículo científico publicado en 2016

Structural basis of R-loop recognition by the S9.6 monoclonal antibody

artículo científico publicado en 2022

Structure-function analysis of Bacillus anthracis edema factor by using monoclonal antibodies

scientific article published on 01 March 1994

Study of immunization against anthrax with the purified recombinant protective antigen of Bacillus anthracis

artículo científico publicado en 1998

Sublethal doses of Bacillus anthracis lethal toxin inhibit inflammation with lipopolysaccharide and Escherichia coli challenge but have opposite effects on survival

artículo científico publicado en 2006

Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism

artículo científico publicado en 2015

Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways

artículo científico publicado en 2001

Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1

artículo científico publicado en 2010

Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice

artículo científico publicado en 2007

Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice ⬇️

artículo científico publicado en 2006

Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion protein ⬇️

artículo científico publicado el 28 de octubre de 1997

Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin

artículo científico publicado en 2001

Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion.

artículo científico publicado en 2016

Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden

artículo científico publicado en 2015

The Bacillus cereus Hbl and Nhe tripartite enterotoxin components assemble sequentially on the surface of target cells and are not interchangeable

artículo científico publicado en 2013

The Exotoxin of P. aeruginosa: A Proenzyme Having an Unusual Mode of Activation ⬇️

artículo científico publicado en 1977

The IntXO-PSL Recombination System Is a Key Component of the Second Maintenance System for Bacillus anthracis Plasmid pXO1

artículo científico publicado en 2016

The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin

artículo científico publicado en 2006

The Pore-forming Toxin Proaerolysin Is Activated by Furin ⬇️

artículo científico publicado en 1998

The carboxyl-terminal end of protective antigen is required for receptor binding and anthrax toxin activity.

artículo científico publicado en 1991

The chymotrypsin-sensitive site, FFD315, in anthrax toxin protective antigen is required for translocation of lethal factor

scientific article published on 01 November 1994

The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes

artículo científico publicado en 2015

The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin ⬇️

artículo científico publicado en 2008

The exotoxin of P. Aeruginosa: A proenzyme having an unusual mode of activation ⬇️

artículo científico publicado el 30 de marzo de 1978

The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS).

artículo científico publicado en 2009

The receptors that mediate the direct lethality of anthrax toxin

artículo científico publicado en 2012

The roles of anthrax toxin in pathogenesis

artículo científico publicado en 2004

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

artículo científico publicado en 2004

The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6.

artículo científico publicado en 2013

Transcriptional analysis of the three Nlrp1 paralogs in mice

artículo científico publicado en 2013

Transcriptional regulation of the protective antigen gene of Bacillus anthracis

artículo científico publicado en 1989

Transcriptome analysis identifies Bacillus anthracis genes that respond to CO2 through an AtxA-dependent mechanism

artículo científico publicado en 2014

Tumor Imaging Using Radiolabeled Matrix Metalloproteinase-Activated Anthrax Proteins

scientific article published on 06 April 2019

Tumor Targeting and Drug Delivery by Anthrax Toxin

artículo científico publicado en 2016

Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin ⬇️

artículo científico publicado en 2000

Tumor therapy with a urokinase plasminogen activator-activated anthrax lethal toxin alone and in combination with paclitaxel

artículo científico publicado en 2012

Unveiling the novel dual specificity protein kinases in Bacillus anthracis: identification of the first prokaryotic dual specificity tyrosine phosphorylation-regulated kinase (DYRK)-like kinase

artículo científico publicado en 2012

Virus deals anthrax a killer blow

artículo científico publicado en 2002

Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax

artículo científico publicado en 2019

[116b] Borohydride reduction of periodate-oxidized chain ends

[13] Purification and characterization of adenylyl cyclase from Bacillus anthracis

scientific article published on 01 January 1991

clpC operon regulates cell architecture and sporulation in Bacillus anthracis.

artículo científico publicado en 2014

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