Lista de obras - Miguel F Segura - Dominio Público Uruguay

A High-Throughput Screening Identifies MicroRNA Inhibitors That Influence Neuronal Maintenance and/or Response to Oxidative Stress

scientific article published on 20 June 2019

ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures

scientific article published on 17 October 2019

Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer

artículo científico publicado en 2020

BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs

artículo científico publicado en 2008

BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy

artículo científico publicado en 2013

BRG1/SMARCA4 is essential for neuroblastoma cell viability through modulation of cell death and survival pathways

artículo científico publicado en 2016

CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models

scientific article published on 16 July 2020

Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis.

artículo científico publicado en 2017

FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis.

artículo científico publicado en 2013

Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system

artículo científico publicado en 2016

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma

artículo científico publicado en 2019

Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma.

artículo científico publicado en 2017

Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo

artículo científico publicado en 2013

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma

artículo científico publicado en 2015

Identification of metastasis-suppressive microRNAs in primary melanoma

artículo científico publicado en 2015

Interplay Between ncRNAs and Cellular Communication: A Proposal for Understanding Cell-Specific Signaling Pathways

scientific article published on 02 April 2019

Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions.

artículo científico publicado en 2017

Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment

artículo científico publicado en 2007

Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands.

artículo científico publicado en 2017

Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer

artículo científico publicado en 2019

MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness

artículo científico publicado en 2014

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer

artículo científico publicado en 2017

Methodological advances in the discovery of novel neuroblastoma therapeutics

artículo científico publicado en 2021

MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma.

artículo científico publicado en 2012

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

scientific article published on 20 December 2016

MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells.

artículo científico publicado en 2017

MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells.

artículo científico publicado en 2012

MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes

artículo científico publicado en 2016

MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways

scientific article published on 05 July 2019

Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f

artículo científico publicado en 2014

Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase.

artículo científico publicado en 2003

Nuevas estrategias terapéuticas para el neuroblastoma basadas en el uso de microRNAs

artículo científico publicado en 2015

Optimization of rhabdomyosarcoma disseminated disease assessment by flow cytometry

artículo científico publicado en 2014

Patient-derived xenografts for childhood solid tumors: a valuable tool to test new drugs and personalize treatments.

artículo científico publicado en 2016

Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.

artículo científico publicado en 2006

Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation

artículo científico publicado en 2006

SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L

artículo científico publicado en 2020

SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.

artículo científico publicado en 2015

TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas.

artículo científico publicado en 2015

Targeting of epigenetic regulators in neuroblastoma.

artículo científico publicado en 2018

The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome

publication published on 26 May 2021

The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells

scientific article published on 13 May 2020

The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis

scientific article published on 17 September 2020

The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling

artículo científico publicado en 2004

The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins

artículo científico publicado en 2010

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8 ⬇️

artículo científico publicado el 23 de diciembre de 2010

The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis.

artículo científico publicado en 2007

The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma

artículo científico publicado en 2011

miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.

artículo científico publicado en 2011

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

artículo científico publicado en 2017

microRNAs as pharmacological targets in cancer.

artículo científico publicado en 2013

Lista de obras de Miguel F Segura

A High-Throughput Screening Identifies MicroRNA Inhibitors That Influence Neuronal Maintenance and/or Response to Oxidative Stress

ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures

Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer

BCL-XL regulates TNF-alpha-mediated cell death independently of NF-kappaB, FLIP and IAPs

BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy

BRG1/SMARCA4 is essential for neuroblastoma cell viability through modulation of cell death and survival pathways

CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models

Combined miRNA profiling and proteomics demonstrates that different miRNAs target a common set of proteins to promote colorectal cancer metastasis.

FAIM-L is an IAP-binding protein that inhibits XIAP ubiquitinylation and protects from Fas-induced apoptosis.

Fas apoptosis inhibitory molecules: more than death-receptor antagonists in the nervous system

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma

Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma.

Hedgehog pathway blockade inhibits melanoma cell growth in vitro and in vivo

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma

Identification of metastasis-suppressive microRNAs in primary melanoma

Interplay Between ncRNAs and Cellular Communication: A Proposal for Understanding Cell-Specific Signaling Pathways

Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions.

Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment

Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands.

Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer

MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness

Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer

Methodological advances in the discovery of novel neuroblastoma therapeutics

MiR-182 overexpression in tumourigenesis of high-grade serous ovarian carcinoma.

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells.

MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells.

MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes

MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways

Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f

Mu-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via phosphatidylinositol 3-kinase.

Nuevas estrategias terapéuticas para el neuroblastoma basadas en el uso de microRNAs

Optimization of rhabdomyosarcoma disseminated disease assessment by flow cytometry

Patient-derived xenografts for childhood solid tumors: a valuable tool to test new drugs and personalize treatments.

Reactive oxygen species and p38 mitogen-activated protein kinase activate Bax to induce mitochondrial cytochrome c release and apoptosis in response to malonate.

Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation

SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L

SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.

TNFα sensitizes neuroblastoma cells to FasL-, cisplatin- and etoposide-induced cell death by NF-κB-mediated expression of Fas.

Targeting of epigenetic regulators in neuroblastoma.

The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome

The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells

The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis

The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling

The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8 ⬇️

The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis.

The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma

miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

microRNAs as pharmacological targets in cancer.