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Lista de obras de E. Dale Abel

A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.

artículo científico publicado en 2007

A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance.

artículo científico publicado en 2013

A new twist in the function of the cardiac lipid droplet ⬇️

artículo científico publicado el 7 de septiembre de 2011

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

artículo científico publicado en 2016

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance

artículo científico publicado en 2006

Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia

artículo científico publicado en 2012

Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice

artículo científico publicado en 2017

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

artículo científico publicado en 2001

Airway epithelial regeneration requires autophagy and glucose metabolism

scientific article published on 20 November 2019

An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart.

artículo científico publicado en 2010

An unliganded thyroid hormone receptor causes severe neurological dysfunction

artículo científico publicado en 2001

Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome ⬇️

artículo científico publicado en 2015

Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

artículo científico publicado en 2016

Captopril normalizes insulin signaling and insulin-regulated substrate metabolism in obese (ob/ob) mouse hearts.

artículo científico publicado en 2008

Cardiac PI3K-Akt impairs insulin-stimulated glucose uptake independent of mTORC1 and GLUT4 translocation.

artículo científico publicado en 2012

Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor

scientific article published on 01 March 2000

Cardiac hypertrophy caused by peroxisome proliferator- activated receptor-gamma agonist treatment occurs independently of changes in myocardial insulin signaling

artículo científico publicado en 2007

Cardiac metabolism in heart failure: implications beyond ATP production.

artículo científico publicado en 2013

Cardiac remodeling in obesity.

artículo científico publicado en 2008

Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice.

artículo científico publicado en 2011

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

artículo científico publicado en 2008

Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex

artículo científico publicado en 2012

Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo.

artículo científico publicado en 2015

Cerebellar neurons possess a vesicular compartment structurally and functionally similar to Glut4-storage vesicles from peripheral insulin-sensitive tissues.

artículo científico publicado en 2009

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

artículo científico publicado en 2020

Comparison of the Effects of High-Fat Diet on Energy Flux in Mice Using Two Multiplexed Metabolic Phenotyping Systems

artículo científico publicado en 2019

Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function.

artículo científico publicado en 2011

Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts

artículo científico publicado en 2018

Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density.

artículo científico publicado en 2005

Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

artículo científico publicado en 2009

Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

artículo científico publicado en 2009

Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

artículo científico publicado en 2019

Correction: Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training.

artículo científico publicado en 2012

Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

artículo científico publicado en 2017

Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice

artículo científico publicado en 2012

DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging

scientific article published on 01 August 2017

Deep sequence analysis of gene expression identifies osteopontin as a downstream effector of integrin-linked kinase (ILK) in cardiac-specific ILK knockout mice

artículo científico publicado en 2013

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.

artículo científico publicado en 2017

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.

artículo científico publicado en 2017

Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function.

artículo científico publicado en 2017

Deletion of GLUT1 in mouse lens epithelium leads to cataract formation.

artículo científico publicado en 2018

Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice

artículo científico publicado en 2015

Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

artículo científico publicado en 2018

Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.

artículo científico publicado en 2006

Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression.

artículo científico publicado en 2007

Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin

scientific journal article

Effective Metabolic Approaches for the Energy Starved Failing Heart: Bioenergetic Resiliency via Redundancy or Something Else?

scientific article published on 01 July 2018

Endonuclease G: the link between mitochondria and cardiac hypertrophy?

artículo científico publicado en 2012

Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases.

artículo científico publicado en 2009

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

artículo científico publicado en 2011

Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.

artículo científico publicado en 2014

Erratum: SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis.

artículo científico publicado en 2017

Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning

artículo científico publicado en 2016

Exercise training improves vascular mitochondrial function.

artículo científico publicado en 2016

Expression of slow skeletal TnI in adult mouse hearts confers metabolic protection to ischemia ⬇️

artículo científico publicado el 26 de mayo de 2011

Fasting-induced reductions in cardiovascular and metabolic variables occur sooner in obese versus lean mice.

artículo científico publicado en 2010

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

artículo científico publicado en 2021

GLUT1 deficiency in cardiomyocytes does not accelerate the transition from compensated hypertrophy to heart failure.

artículo científico publicado en 2014

Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart

artículo científico publicado en 2017

Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.

artículo científico publicado en 2012

Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes

artículo científico publicado en 2019

Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation.

artículo científico publicado en 2017

Glucose for the aging heart?

artículo científico publicado en 2007

Glucose metabolism induced by Bmp signaling is essential for murine skeletal development

artículo científico publicado en 2018

Glucose metabolism is linked to the inflammatory status of macrophages.

artículo científico publicado en 2012

Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.

artículo científico publicado en 2014

Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses.

artículo científico publicado en 2017

HSPB2 Is Dispensable for the Cardiac Hypertrophic Response but Reduces Mitochondrial Energetics following Pressure Overload In Mice ⬇️

artículo científico publicado el 1 de enero de 2012

Heart Failure in Type 2 Diabetes Mellitus

artículo científico publicado en 2019

Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis

scientific journal article

Hearts lacking caveolin-1 develop hypertrophy with normal cardiac substrate metabolism

artículo científico publicado en 2008

Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.

artículo científico publicado en 2004

Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.

artículo científico publicado en 2012

Increased glycolysis mediates Wnt7b-induced bone formation

scientific article published on 26 March 2019

Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction.

scientific article published on 19 September 2013

Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5

artículo científico publicado en 2012

Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. ⬇️

artículo científico publicado en 2016

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

artículo científico publicado en 2015

Insulin Signaling and Heart Failure.

artículo científico publicado en 2016

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.

scientific article published on 15 August 2016

Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts.

artículo científico publicado en 2014

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart.

artículo científico publicado en 2013

Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training.

artículo científico publicado en 2014

Insulin regulation of myocardial autophagy.

artículo científico publicado en 2014

Insulin resistance: metabolic mechanisms and consequences in the heart.

artículo científico publicado en 2012

Insulin signaling in heart muscle: lessons from genetically engineered mouse models.

artículo científico publicado en 2004

Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway

artículo científico publicado en 2013

Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms.

artículo científico publicado en 2013

Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4.

artículo científico publicado en 2017

Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis. ⬇️

artículo científico publicado en 2010

Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.

artículo científico publicado en 2008

Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload

artículo científico publicado en 2010

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.

artículo científico publicado en 2015

Lipids, lysosomes, and autophagy.

artículo científico publicado en 2016

Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide.

artículo científico publicado en 2013

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation

scientific article published on 30 April 2019

Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.

artículo científico publicado en 2010

Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction.

artículo científico publicado en 2006

MITOCHONDRIAL DYNAMICS AND METABOLIC REGULATION IN CARDIAC AND SKELETAL MUSCLE

artículo científico publicado en 2018

Maintaining PGC-1α expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function.

artículo científico publicado en 2014

Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats.

artículo científico publicado en 2009

Mechanisms of Lipotoxicity in the Cardiovascular System ⬇️

artículo científico publicado el 1 de diciembre de 2012

Mechanisms of leucocyte sodium influx in essential hypertension

artículo científico publicado en 1988

Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth

artículo científico publicado en 2013

Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements.

artículo científico publicado en 1998

Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload

artículo científico publicado en 2003

Mitochondria in the diabetic heart

artículo científico publicado en 2010

Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy

artículo científico publicado en 2016

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission.

artículo científico publicado en 2017

Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy ⬇️

artículo científico publicado el 21 de enero de 2011

Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

artículo científico publicado en 2007

Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations

artículo científico publicado en 2008

Mitochondrial pyruvate carriers are required for myocardial stress adaptation

artículo científico publicado en 2020

Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.

artículo científico publicado en 2006

Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells

scientific article published on 21 November 2018

Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo.

artículo científico publicado en 2011

Modulation of the cardiovascular system by leptin.

artículo científico

Molecular mechanisms of diabetic cardiomyopathy.

artículo científico publicado en 2014

Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action.

artículo científico publicado en 2005

Myeloid -Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1

artículo científico publicado en 2019

Myocardial insulin resistance and cardiac complications of diabetes.

artículo científico publicado en 2005

Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.

artículo científico publicado en 2015

NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes ⬇️

artículo científico publicado el 27 de enero de 2012

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

artículo científico publicado en 2016

Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation.

artículo científico publicado en 2017

Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.

artículo científico publicado en 2013

Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth.

artículo científico publicado en 2010

OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.

artículo científico publicado en 2017

Obesity Stresses Cardiac Mitochondria Even When You Are Young ⬇️

artículo científico publicado el 1 de febrero de 2011

Oxidative Phosphorylation Flexibility in the Liver of Mice Resistant to High-Fat Diet–Induced Hepatic Steatosis ⬇️

artículo científico publicado el 13 de julio de 2011

PAS kinase is required for normal cellular energy balance

scientific journal article

PGC-1 proteins and heart failure

artículo científico publicado en 2012

PGC-1β Deficiency Accelerates the Transition to Heart Failure in Pressure Overload Hypertrophy ⬇️

artículo científico publicado el 28 de julio de 2011

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation

article published in 2010

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation.

artículo científico publicado en 2010

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

artículo científico publicado en 2015

Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations

artículo científico publicado en 2015

Podocyte-specific GLUT4-deficient mice have fewer and larger podocytes and are protected from diabetic nephropathy.

artículo científico publicado en 2013

Prorenin independently causes hypertension and renal and cardiac fibrosis in cyp1a1-prorenin transgenic rats.

artículo científico publicado en 2018

Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation

artículo científico publicado en 2020

Receptor activator of nuclear factor-κB ligand is a novel inducer of myocardial inflammation ⬇️

artículo científico publicado el 1 de abril de 2012

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity.

artículo científico publicado en 2005

Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α

artículo científico publicado en 2013

Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes.

artículo científico publicado en 2004

Rodent models of diabetic cardiomyopathy.

artículo científico publicado en 2009

SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis

artículo científico publicado en 2017

SWELL1 regulates skeletal muscle cell size, intracellular signalling, adiposity and glucose metabolism

scientific article published on 15 September 2020

Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.

scientific article published on 24 January 2017

Solid Phase Synthesis of Mitochondrial Triphenylphosphonium-Vitamin E Metabolite Using a Lysine Linker for Reversal of Oxidative Stress ⬇️

artículo científico publicado el 14 de enero de 2013

Spotlight on metabolic remodelling in heart failure

artículo científico publicado en 2011

Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts

scientific journal article

Superoxide Dismutase 2 is dispensable for platelet function.

artículo científico publicado en 2017

Systematic Transmission Electron Microscopy‐Based Identification and 3D Reconstruction of Cellular Degradation Machinery

artículo científico publicado en 2023

Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.

artículo científico publicado en 2012

Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.

artículo científico publicado en 2004

Targeting myocardial substrate metabolism in heart failure: potential for new therapies

artículo científico publicado en 2012

The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization

scientific article published on 27 December 2013

The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis

artículo científico publicado en 2016

The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function

artículo científico publicado en 2014

The maximal downstroke of epicardial potentials as an index of electrical activity in mouse hearts

artículo científico publicado en 2011

The role of mPer2 clock gene in glucocorticoid and feeding rhythms.

artículo científico publicado en 2009

Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation

scientific article published on 22 September 2018

Time to Look Back and to Look Forward

artículo científico publicado en 2014

Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.

scientific article published on 19 June 2009

Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

artículo científico publicado en 2008

UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice.

artículo científico publicado en 2012

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

scientific article published on 01 August 2019

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