Lista de obras - Christophe Rochais - Dominio Público Uruguay

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

scientific article published on 16 May 2019

3D-QSAR and docking studies of selective GSK-3beta inhibitors. Comparison with a thieno[2,3-b]pyrrolizinone derivative, a new potential lead for GSK-3beta ligands.

artículo científico publicado en 2005

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential

artículo científico publicado en 2019

A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth

artículo científico publicado en 2019

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment.

artículo científico publicado en 2017

Carbazole derivatives: a promising scenario for breast cancer treatment.

artículo científico

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances

artículo científico publicado en 2015

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease

artículo científico publicado en 2016

Disproportionality analysis in VigiBase® as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

scientific article published on 03 December 2020

Donecopride, a Swiss army knife with potential against Alzheimer's disease

scientific article published on 27 December 2019

Drug repositioning: a brief overview

artículo científico publicado en 2020

Facing the complexity of Alzheimer's disease

scientific article published on 21 November 2019

First Synthesis of Racemic <i>Trans</i> Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease

artículo científico publicado en 2020

Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity.

artículo científico publicado en 2009

Indenopyrazole oxime ethers: synthesis and β1-adrenergic blocking activity

artículo científico publicado en 2015

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease

artículo científico publicado en 2019

Intramolecular cyclisation of β-aryl-β-amino acids in the design of novel heterocyclic systems with therapeutic interest: an unfailing source of diversity.

artículo científico publicado en 2010

Matrix Metalloproteinases as New Targets in Alzheimer's Disease: Opportunities and Challenges

scientific article published on 27 May 2020

Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment.

artículo científico

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment.

artículo científico publicado en 2016

Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

artículo científico publicado en 2019

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride

artículo científico publicado en 2015

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

artículo científico publicado en 2018

Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease Treatment

artículo científico publicado en 2020

Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT<sub>6</sub> receptor antagonist with therapeutic interest in Alzheimer's disease

scientific article published on 03 December 2020

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease

artículo científico publicado en 2020

Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review

scientific article published on 16 September 2019

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

artículo científico publicado en 2012

Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents

artículo científico publicado en 2006

Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors.

artículo científico publicado en 2004

Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography.

artículo científico publicado en 2016

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors

artículo científico publicado en 2008

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

artículo científico publicado en 2012

Therapeutic Potential of 5-HT6 Receptor Agonists.

artículo científico

Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)

artículo científico publicado en 2020

Tripentones: a promising series of potent anti-cancer agents

artículo científico publicado en 2009

Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library

artículo científico publicado en 2010

hERG toxicity assessment: Useful guidelines for drug design

scientific article published on 03 April 2020

Lista de obras de Christophe Rochais

26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie

3D-QSAR and docking studies of selective GSK-3beta inhibitors. Comparison with a thieno[2,3-b]pyrrolizinone derivative, a new potential lead for GSK-3beta ligands.

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential

A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment.

Carbazole derivatives: a promising scenario for breast cancer treatment.

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease

Disproportionality analysis in VigiBase® as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease

Donecopride, a Swiss army knife with potential against Alzheimer's disease

Drug repositioning: a brief overview

Facing the complexity of Alzheimer's disease

First Synthesis of Racemic <i>Trans</i> Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer's Disease

Hydrogenative desulphurization of thienopyrrolizinones: an easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity.

Indenopyrazole oxime ethers: synthesis and β1-adrenergic blocking activity

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease

Intramolecular cyclisation of β-aryl-β-amino acids in the design of novel heterocyclic systems with therapeutic interest: an unfailing source of diversity.

Matrix Metalloproteinases as New Targets in Alzheimer's Disease: Opportunities and Challenges

Modulating 5-HT4 and 5-HT6 receptors in Alzheimer's disease treatment.

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment.

Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride

Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase

Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer's Disease Treatment

Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT<sub>6</sub> receptor antagonist with therapeutic interest in Alzheimer's disease

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer's disease

Structure-activity relationships of serotonin 5-HT7 receptors ligands: A review

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

Synthesis and biological evaluation of novel pyrrolopyrrolizinones as anticancer agents

Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors.

Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography.

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors

Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect

Therapeutic Potential of 5-HT6 Receptor Agonists.

Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)

Tripentones: a promising series of potent anti-cancer agents

Virtual screening discovery of new acetylcholinesterase inhibitors issued from CERMN chemical library

hERG toxicity assessment: Useful guidelines for drug design