Lista de obras - Tatiana G Kutateladze - Dominio Público Uruguay

A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.

artículo científico publicado en 2017

A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response

scientific journal article

A histone reader becomes the readout.

artículo científico publicado en 2018

A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity

artículo científico publicado en 2020

ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.

artículo científico publicado en 2016

Accessibility of the histone H3 tail in the nucleosome for binding of paired readers.

artículo científico publicado en 2017

An acetyl-methyl switch drives a conformational change in p53.

artículo científico publicado en 2015

An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3.

artículo científico publicado en 2015

Architecture of PRC2 Holo Complexes

scientific article published on 03 May 2018

Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response

artículo científico publicado en 2015

Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility

artículo científico publicado en 2013

Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications

artículo científico publicado en 2009

Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation

artículo científico publicado en 2014

Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain.

artículo científico publicado en 2011

Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation

artículo científico publicado en 2015

Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression ⬇️

artículo científico publicado el 3 de enero de 2012

Characterization of histone acylations links chromatin modifications with metabolism

artículo científico publicado en 2017

Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate

artículo científico publicado en 2006

Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive

artículo científico publicado en 2016

Combinatorial profiling of chromatin binding modules reveals multisite discrimination

artículo científico publicado en 2010

Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation

artículo científico publicado en 2011

Covalent Modifications of Histone H3K9 Promote Binding of CHD3.

artículo científico publicado en 2017

Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.

artículo científico publicado en 2013

Dido3 PHD Modulates Cell Differentiation and Division

artículo científico publicado en 2013

Diet and the epigenome

artículo científico publicado en 2018

Diverse functions of PHD fingers of the MLL/KMT2 subfamily

artículo científico publicado en 2014

Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

artículo científico publicado en 2017

E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair

scientific article published on 30 October 2019

Emerging methodologies to investigate lipid-protein interactions

artículo científico publicado en 2012

Epigenetic countermarks in mitotic chromosome condensation

artículo científico publicado en 2017

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.

artículo científico publicado en 2013

Exploring epigenetics with chemical tools

artículo científico publicado en 2020

Focus on Epigenetics

artículo científico publicado en 2016

G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.

artículo científico publicado en 2016

HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.

artículo científico publicado en 2009

Handpicking epigenetic marks with PHD fingers.

artículo científico publicado en 2011

Histone H3 Dual Ubiquitylation Mediates Maintenance DNA Methylation

artículo científico publicado en 2017

Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

scientific article published on 17 October 2019

Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.

artículo científico publicado en 2012

Histone deacetylation: IP4 is an epigenetic coregulator.

artículo científico publicado en 2012

Histone modifications for chromatin dynamics and cellular plasticity

artículo científico publicado en 2017

ING family of tumor suppressors.

artículo científico publicado en 2009

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

artículo científico publicado en 2006

Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphate.

artículo científico publicado en 2006

Inhibition of histone binding by supramolecular hosts

artículo científico publicado en 2014

Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2

scientific article published on 09 October 2020

Insights into newly discovered marks and readers of epigenetic information

scientific article published on August 2016

Limits to Catalysis by Ribonuclease A. ⬇️

artículo científico publicado en 1995

MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes

artículo científico publicado en 2012

MORC3 Forms Nuclear Condensates through Phase Separation

artículo científico publicado en 2019

Mechanism for autoinhibition and activation of the MORC3 ATPase

artículo científico publicado en 2019

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

artículo científico publicado en 2012

Mechanistic insight into the regulation of SQSTM1/p62

scientific article published on 22 January 2019

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

artículo científico publicado en 2020

Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes.

artículo científico publicado en 2007

Membrane insertion of the FYVE domain is modulated by pH

artículo científico publicado en 2009

Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications.

artículo científico publicado en 2011

Methyl fingerprinting of the nucleosome reveals the molecular mechanism of high-mobility group nucleosomal-2 (HMGN2) association

artículo científico publicado en 2011

Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain

artículo científico publicado en 2011

Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes

artículo científico publicado en 2015

Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2

artículo científico publicado en 2006

Molecular mechanism of membrane docking by the Vam7p PX domain

artículo científico publicado en 2006

Molecular mechanism of the MORC4 ATPase activation

artículo científico publicado en 2020

Molecular structure analyses suggest strategies to therapeutically target SARS-CoV-2

artículo científico publicado en 2020

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.

artículo científico publicado en 2016

NMR assignments and histone specificity of the ING2 PHD finger

artículo científico publicado en 2009

Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity

artículo científico publicado en 2021

O-GlcNAcylation of MLL5β is essential for MLL5β-AP-1 transcription complex assembly at the HPV16/18-long control region.

artículo científico publicado en 2015

PHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility

artículo científico publicado en 2017

PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.

scientific article published on October 2016

Perceiving the epigenetic landscape through histone readers.

artículo científico publicado en 2012

Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

article

Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain.

artículo científico publicado en 2006

Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain

scientific article published on March 2006

Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.

artículo científico publicado en 2001

Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9

artículo científico publicado en 2011

Preparation, Biochemical Analysis, and Structure Determination of Methyllysine Readers.

artículo científico publicado en 2016

Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.

artículo científico publicado en 2007

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

artículo científico publicado en 2007

Recognition of Histone H3K14 Acylation by MORF.

artículo científico publicado en 2017

Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers

artículo científico publicado en 2018

Regulation of Methyllysine Readers through Phosphorylation

artículo científico publicado en 2016

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

scientific article published on 24 May 2019

Sequence-specific 1H, 13C, and 15N resonance assignments of GRP1 PH domain.

artículo científico publicado en 2008

Sequence-specific 1H, 15N and 13C resonance assignments of the EEA1 FYVE domain

artículo científico publicado en 2000

SnapShot: Histone readers.

artículo científico publicado en 2011

Structural Insight into Recognition of Methylated Histone H3K4 by Set3

artículo científico publicado en 2016

Structural Insight into p53 Recognition by the 53BP1 Tandem Tudor Domain

artículo científico publicado en 2010

Structural insights into histone demethylation by JMJD2 family members.

artículo científico publicado en 2006

Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain

artículo científico publicado en 2018

Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1

artículo científico publicado en 2015

Switching 53BP1 on and off via Tudors

scientific article published on 01 August 2018

Synthesis and molecular recognition of phosphatidylinositol-3-methylenephosphate.

artículo científico publicado en 2006

Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin

artículo científico publicado en 2012

Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch

artículo científico publicado en 2005

The DIX domain targets dishevelled to actin stress fibres and vesicular membranes

artículo científico publicado en 2002

The NuRD architecture ⬇️

artículo científico publicado el 23 de enero de 2013

The PHD finger of Spp1 mediates histone modification cross-talk

scientific article published on 28 August 2019

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin.

artículo científico publicado en 2017

The Taf14 YEATS domain is a reader of histone crotonylation

artículo científico publicado en 2016

The ZZ domain as a new epigenetic reader and a degradation signal sensor

artículo científico publicado en 2019

The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3.

artículo científico publicado en 2018

The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation

scientific article published in Nature Communications

The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation

artículo científico publicado en 2016

The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers

artículo científico publicado en 2014

The structural basis of urea-induced protein unfolding in β-catenin

artículo científico publicado en 2014

Towards understanding methyllysine readout.

artículo científico publicado en 2014

YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.

artículo científico publicado en 2017

ZZ-dependent regulation of p62/SQSTM1 in autophagy

scientific article published in Nature Communications

pH-dependent binding of the Epsin ENTH domain and the AP180 ANTH domain to PI(4,5)P2-containing bilayers.

artículo científico publicado en 2007

Lista de obras de Tatiana G Kutateladze

A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.

A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response

A histone reader becomes the readout.

A triple action CDK4/6-PI3K-BET inhibitor with augmented cancer cell cytotoxicity

ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.

Accessibility of the histone H3 tail in the nucleosome for binding of paired readers.

An acetyl-methyl switch drives a conformational change in p53.

An aromatic cage is required but not sufficient for binding of Tudor domains of the Polycomblike protein family to H3K36me3.

Architecture of PRC2 Holo Complexes

Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response

Binding of PHF1 Tudor to H3K36me3 enhances nucleosome accessibility

Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications

Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation

Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain.

Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation

Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression ⬇️

Characterization of histone acylations links chromatin modifications with metabolism

Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate

Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive

Combinatorial profiling of chromatin binding modules reveals multisite discrimination

Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation

Covalent Modifications of Histone H3K9 Promote Binding of CHD3.

Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.

Dido3 PHD Modulates Cell Differentiation and Division

Diet and the epigenome

Diverse functions of PHD fingers of the MLL/KMT2 subfamily

Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair

Emerging methodologies to investigate lipid-protein interactions

Epigenetic countermarks in mitotic chromosome condensation

Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.

Exploring epigenetics with chemical tools

Focus on Epigenetics

G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.

HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.

Handpicking epigenetic marks with PHD fingers.

Histone H3 Dual Ubiquitylation Mediates Maintenance DNA Methylation

Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation

Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.

Histone deacetylation: IP4 is an epigenetic coregulator.

Histone modifications for chromatin dynamics and cellular plasticity

ING family of tumor suppressors.

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

Increased mobility in the membrane targeting PX domain induced by phosphatidylinositol 3-phosphate.

Inhibition of histone binding by supramolecular hosts

Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2

Insights into newly discovered marks and readers of epigenetic information

Limits to Catalysis by Ribonuclease A. ⬇️

MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes

MORC3 Forms Nuclear Condensates through Phase Separation

Mechanism for autoinhibition and activation of the MORC3 ATPase

Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.

Mechanistic insight into the regulation of SQSTM1/p62

Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes.

Membrane insertion of the FYVE domain is modulated by pH

Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications.

Methyl fingerprinting of the nucleosome reveals the molecular mechanism of high-mobility group nucleosomal-2 (HMGN2) association

Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain

Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes

Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2

Molecular mechanism of membrane docking by the Vam7p PX domain

Molecular mechanism of the MORC4 ATPase activation

Molecular structure analyses suggest strategies to therapeutically target SARS-CoV-2

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.

NMR assignments and histone specificity of the ING2 PHD finger

Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity

O-GlcNAcylation of MLL5β is essential for MLL5β-AP-1 transcription complex assembly at the HPV16/18-long control region.

PHF1 Tudor and N-terminal domains synergistically target partially unwrapped nucleosomes to increase DNA accessibility

PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.

Perceiving the epigenetic landscape through histone readers.

Phosphatidylinositol 3-Phosphate Recognition by the FYVE Domain

Phosphatidylinositol 3-phosphate recognition and membrane docking by the FYVE domain.

Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domain

Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.

Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9

Preparation, Biochemical Analysis, and Structure Determination of Methyllysine Readers.

Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination