Filtros de búsqueda

Lista de obras de Helen McShane

A New Vaccine for Tuberculosis: The Challenges of Development and Deployment

artículo científico publicado en 2009

A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults

artículo científico publicado en 2011

A Phase I, Open-Label Trial, Evaluating the Safety and Immunogenicity of Candidate Tuberculosis Vaccines AERAS-402 and MVA85A, Administered by Prime-Boost Regime in BCG-Vaccinated Healthy Adults

artículo científico publicado en 2015

A comparison of IFNgamma detection methods used in tuberculosis vaccine trials

artículo científico publicado en 2008

A first-in-human phase 1 trial to evaluate the safety and immunogenicity of the candidate tuberculosis vaccine MVA85A-IMX313, administered to BCG-vaccinated adults

artículo científico publicado en 2016

A human challenge model for Mycobacterium tuberculosis using Mycobacterium bovis bacille Calmette-Guerin

artículo científico publicado en 2012

A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans

artículo científico publicado en 2004

A multi-antigenic adenoviral-vectored vaccine improves BCG-induced protection of goats against pulmonary tuberculosis infection and prevents disease progression

artículo científico publicado en 2013

A mycobacterial growth inhibition assay (MGIA) for bovine TB vaccine development

artículo científico

A new TB vaccine, MVA85A, induces durable antigen-specific responses 14 months after vaccination in African infants ⬇️

artículo científico publicado el 27 de junio de 2012

A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis

artículo científico publicado en 2016

A phase IIa trial of the new tuberculosis vaccine, MVA85A, in HIV- and/or Mycobacterium tuberculosis-infected adults

artículo científico publicado en 2012

A review of clinical models for the evaluation of human TB vaccines

artículo científico publicado en 2016

Aerosol immunisation for TB: matching route of vaccination to route of infection

artículo científico publicado en 2015

Alternate aerosol and systemic immunisation with a recombinant viral vector for tuberculosis, MVA85A: A phase I randomised controlled trial

artículo científico publicado en 2019

Antibodies and tuberculosis

artículo científico publicado en 2016

Assay optimisation and technology transfer for multi-site immuno-monitoring in vaccine trials

artículo científico publicado en 2017

Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction

artículo científico publicado en 2016

Author Correction: The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays

scholarly article published in Scientific Reports

BCG: myths, realities, and the need for alternative vaccine strategies

artículo científico publicado en 2012

Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1.

artículo científico publicado en 2008

Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials

artículo científico publicado en 2005

Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials

artículo científico publicado en 2007

Boosting with poxviruses enhances Mycobacterium bovis BCG efficacy against tuberculosis in guinea pigs

artículo científico

CD8+ T cell-mediated suppression of intracellular Mycobacterium tuberculosis growth in activated human macrophages

artículo científico publicado en 2003

Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice

artículo científico publicado en 2013

Clinical Testing of Tuberculosis Vaccine Candidates

artículo científico publicado en 2016

Co-infection with HIV and TB: double trouble

artículo científico publicado en 2005

Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery

artículo científico publicado en 2012

Correction: MVA.85A Boosting of BCG and an Attenuated, Deficient Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

Correction: Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

article published in 2011

Correction: Safety and Immunogenicity of Boosting BCG Vaccinated Subjects with BCG: Comparison with Boosting with a New TB Vaccine, MVA85A.

artículo científico publicado en 2011

Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants

artículo científico publicado en 2016

Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies

artículo científico publicado en 2018

Current approaches toward identifying a correlate of immune protection from tuberculosis

artículo científico publicado en 2018

Delaying bacillus Calmette-Guérin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age.

artículo científico publicado en 2010

Determining the validity of hospital laboratory reference intervals for healthy young adults participating in early clinical trials of candidate vaccines

artículo científico publicado en 2013

Developing an improved vaccine against tuberculosis

artículo científico publicado en 2004

Development of a BCG challenge model for the testing of vaccine candidates against tuberculosis in cattle

artículo científico publicado en 2014

Development of a non-human primate BCG infection model for the evaluation of candidate tuberculosis vaccines

artículo científico publicado en 2017

Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis-Infected Individuals: Associations with Clinical Disease State and Effect of Treatment ⬇️

artículo científico publicado el 1 de noviembre de 2001

Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes

artículo científico publicado en 2015

Dose-finding study of the novel tuberculosis vaccine, MVA85A, in healthy BCG-vaccinated infants

artículo científico publicado en 2011

Dual neonate vaccine platform against HIV-1 and M. tuberculosis

artículo científico publicado en 2011

Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design

artículo científico publicado en 2006

Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults

artículo científico publicado en 2012

Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review

artículo científico publicado en 2016

Efficacy of follow-up and contact tracing of women who test positive for genital tract chlamydia trachomatis prior to pregnancy termination

artículo científico publicado en 2004

Elevated IgG Responses in Infants Are Associated With Reduced Prevalence of Infection

article

Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara

artículo científico publicado en 2003

Enhanced immunogenicity of CD4(+) t-cell responses and protective efficacy of a DNA-modified vaccinia virus Ankara prime-boost vaccination regimen for murine tuberculosis

artículo científico publicado en 2001

Enhancing the Biological Relevance of Machine Learning Classifiers for Reverse Vaccinology

artículo científico publicado en 2017

Evaluating the sensitivity of the bovine BCG challenge model using a prime boost Ad85A vaccine regimen

scientific article published on 20 November 2019

Evaluation of Xpert® MTB/RIF Assay in Induced Sputum and Gastric Lavage Samples from Young Children with Suspected Tuberculosis from the MVA85A TB Vaccine Trial

artículo científico publicado en 2015

Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate tuberculosis vaccine, MVA85A, alone and in combination

artículo científico publicado en 2013

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis

artículo científico

From AIDS to TB vaccines--A career in infectious diseases and translational vaccinology

artículo científico publicado en 2015

Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model

artículo científico publicado en 2014

Helen McShane and colleagues reply to Deborah Cohen

artículo científico publicado en 2018

Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function

scientific article published on 08 July 2013

Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo.

artículo científico publicado en 2014

Human Immunodeficiency Virus Infection Impairs Th1 and Th17 Mycobacterium tuberculosis-Specific T-Cell Responses

artículo científico publicado en 2018

Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate TB Subunit Vaccine

artículo científico publicado en 2018

Identification of antigens presented by MHC for vaccines against tuberculosis

artículo científico publicado en 2020

Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses

artículo científico publicado en 2011

Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis

artículo científico publicado en 2009

Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations

artículo científico publicado en 2007

Immunogenicity and protective efficacy of prime-boost regimens with recombinant (delta)ureC hly+ Mycobacterium bovis BCG and modified vaccinia virus ankara expressing M. tuberculosis antigen 85A against murine tuberculosis

artículo científico publicado en 2008

Immunogenicity of the Tuberculosis Vaccine MVA85A Is Reduced by Coadministration with EPI Vaccines in a Randomized Controlled Trial in Gambian Infants

artículo científico publicado en 2011

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations

artículo científico publicado en 2008

Impaired IFN-gamma-secreting capacity in mycobacterial antigen-specific CD4 T cells during chronic HIV-1 infection despite long-term HAART.

artículo científico publicado en 2006

In vitro mycobacterial growth inhibition assays: A tool for the assessment of protective immunity and evaluation of tuberculosis vaccine efficacy

artículo científico publicado en 2016

Incidental diagnosis in healthy clinical trial subjects

artículo científico publicado en 2012

Individual-level factors associated with variation in mycobacterial-specific immune response: Gender and previous BCG vaccination status

artículo científico publicado en 2015

Induction and maintenance of a phenotypically heterogeneous lung tissue-resident CD4 T cell population following BCG immunisation

scholarly article by Naomi C Bull et al published 5 September 2018 in Vaccine

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response

artículo científico publicado en 2014

Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG.

artículo científico publicado en 2013

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

artículo científico publicado en 2015

Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A

artículo científico publicado en 2010

Lessons from the first clinical trial of a non-licensed vaccine among Ugandan adolescents: a phase II field trial of the tuberculosis candidate vaccine, MVA85A

artículo científico publicado en 2018

Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG.

artículo científico publicado en 2013

MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques

artículo científico publicado en 2009

Markers of achievement for assessing and monitoring gender equity in a UK National Institute for Health Research Biomedical Research Centre: A two-factor model

artículo científico publicado en 2020

Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

artículo científico publicado en 2010

Mucosal delivery of tuberculosis vaccines: a review of current approaches and challenges

artículo científico publicado en 2019

Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice

artículo científico publicado en 2008

Mycobacterial growth inhibition in murine splenocytes as a surrogate for protection against Mycobacterium tuberculosis (M. tb).

artículo científico publicado en 2013

Mycobacterium tuberculosis PPD-induced immune biomarkers measurable in vitro following BCG vaccination of UK adolescents by multiplex bead array and intracellular cytokine staining.

artículo científico publicado en 2010

Need for more TB vaccine field sites.

artículo científico publicado en 2009

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation

scientific article published on 01 July 2019

Non-tuberculous mycobacteria have diverse effects on BCG efficacy against Mycobacterium tuberculosis.

artículo científico publicado en 2014

Optimising immunogenicity with viral vectors: mixing MVA and HAdV-5 expressing the mycobacterial antigen Ag85A in a single injection

artículo científico publicado en 2012

Optimization of a Human Bacille Calmette-Guérin Challenge Model: A Tool to Evaluate Antimycobacterial Immunity

artículo científico publicado en 2015

Phase I clinical trial safety of DNA- and modified virus Ankara-vectored human immunodeficiency virus type 1 (HIV-1) vaccines administered alone and in a prime-boost regime to healthy HIV-1-uninfected volunteers

artículo científico publicado en 2005

Preclinical development of an in vivo BCG challenge model for testing candidate TB vaccine efficacy

artículo científico publicado en 2011

Prime-boost immunisation strategies for tuberculosis

artículo científico publicado en 2005

Prime-boost immunization strategies for infectious diseases

artículo científico publicado en 2002

Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A

artículo científico publicado en 2014

Progress and challenges in TB vaccine development

artículo científico publicado en 2018

Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8(+)- and CD4(+)-T-cell epitopes from antigen 85A.

artículo científico publicado en 2002

Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy

scientific article published on 16 September 2013

Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans

artículo científico publicado en 2004

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin

artículo científico publicado en 2018

Replacing, reducing and refining the use of animals in tuberculosis vaccine research

artículo científico publicado en 2016

Risk of Disease After Isoniazid Preventive Therapy for Mycobacterium tuberculosis Exposure in Young HIV-uninfected Children

artículo científico publicado en 2015

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A.

artículo científico publicado en 2013

Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin (BCG) for Infants of HIV Infected Mothers: A Phase 2 Randomized Controlled Trial

artículo científico publicado en 2017

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

artículo científico publicado en 2013

Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial.

artículo científico publicado en 2014

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in Mycobacterium tuberculosis-infected individuals

artículo científico publicado en 2009

Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa

artículo científico publicado en 2008

Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: a phase I clinical trial.

artículo científico publicado en 2012

Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A

artículo científico publicado en 2009

Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa

artículo científico publicado en 2008

Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial

artículo científico publicado en 2015

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

artículo científico publicado en 2022

Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study.

artículo científico publicado en 2017

Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A

artículo científico publicado en 2014

Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis

artículo científico publicado en 2005

T-cell activation is an immune correlate of risk in BCG vaccinated infants

artículo científico publicado en 2016

TB vaccine development: where are we and why is it so difficult?

artículo científico publicado en 2014

TB vaccines in clinical development

artículo científico publicado en 2016

TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development

artículo científico publicado en 2017

Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A

artículo científico publicado en 2011

The <i>in vitro</i> direct mycobacterial growth inhibition assay (MGIA) for the early evaluation of TB vaccine candidates and assessment of protective immunity: a protocol for non-human primate cells

publication published on 30 March 2021

The Cross-species Mycobacterial Growth Inhibition Assay (MGIA) Project 2010-2014.

artículo científico

The Role of Clinical Symptoms in the Diagnosis of Intrathoracic Tuberculosis in Young Children

artículo científico publicado en 2015

The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women

artículo científico publicado en 2014

The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life

artículo científico publicado en 2014

The candidate TB vaccine, MVA85A, induces highly durable Th1 responses

artículo científico publicado en 2014

The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated adolescents: An open-label trial

artículo científico publicado en 2017

The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-γ producing cells ex vivo

artículo científico publicado en 2007

The human immune response to tuberculosis and its treatment: a view from the blood

artículo científico publicado en 2015

The next 10 years for tuberculosis vaccines: do we have the right plans in place?

artículo científico publicado en 2013

The tuberculin skin test (TST) is affected by recent BCG vaccination but not by exposure to non-tuberculosis mycobacteria (NTM) during early life

artículo científico publicado en 2010

Tuberculin skin testing and treatment modulates interferon-gamma release assay results for latent tuberculosis in migrants

artículo científico publicado en 2014

Tuberculosis vaccine promises sterilizing immunity

scientific article published on 11 October 2011

Tuberculosis vaccine trials – Authors' reply ⬇️

artículo científico publicado el 29 de junio de 2013

Tuberculosis vaccines in clinical trials

scientific article published on May 2011

Tuberculosis vaccines: beyond bacille Calmette-Guerin ⬇️

artículo científico publicado el 12 de octubre de 2011

Tuberculosis vaccines: current status and future prospects

artículo científico publicado en 2006

Tuberculosis vaccines: present and future

artículo científico publicado en 2008

Tuberculosis vaccines: progress and challenges

artículo científico publicado en 2011

Two doses of candidate TB vaccine MVA85A in antiretroviral therapy (ART) naïve subjects gives comparable immunogenicity to one dose in ART+ subjects

artículo científico publicado en 2013

Understanding BCG is the key to improving it.

artículo científico publicado en 2013

Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods

artículo científico publicado en 2017

Vaccination against tuberculosis: how can we better BCG?

artículo científico

Vaccine platform for prevention of tuberculosis and mother-to-child transmission of human immunodeficiency virus type 1 through breastfeeding

artículo científico publicado en 2007

Vaccine strategies against tuberculosis

artículo científico publicado en 2009

Viral Booster Vaccines Improve Mycobacterium bovis BCG-Induced Protection against Bovine Tuberculosis

scholarly article by H. Martin Vordermeier et al published 19 April 2011 in Infection and Immunity

Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis

artículo científico publicado en 2009

Why don't we have an effective tuberculosis vaccine yet?

artículo científico publicado en 2016

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda