Lista de obras -

"Double hit" makes the difference.

artículo científico publicado en 2012

Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death

artículo científico publicado en 2009

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

artículo científico publicado en 2010

Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia

artículo científico publicado en 2020

Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.

artículo científico publicado en 2010

Editorial: Metformin: Beyond Diabetes

artículo científico publicado en 2019

Effect of maternal hyperglycemia on NaK ATPase activity in fetal rat kidney

scientific article published on 01 January 1993

Energy disruptors: rising stars in anticancer therapy?

artículo científico publicado en 2016

Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC

artículo científico publicado en 2020

Frequency and prognostic evaluation of 3p21-22 allelic losses in non-small-cell lung cancer

artículo científico publicado en 1995

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage

artículo científico publicado en 1998

Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1

artículo científico publicado en 1992

Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence

artículo científico publicado en 1993

Hypoxia decreases insulin signaling pathways in adipocytes

artículo científico publicado en 2008

Hypoxia protects against the cell death triggered by oxovanadium-galactomannan complexes in HepG2 cells

artículo científico publicado en 2019

Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients

artículo científico publicado en 2020

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.

artículo científico publicado en 2017

Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics

artículo científico publicado en 2020

Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.

artículo científico publicado en 2014

Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes

artículo científico publicado en 2010

Low carbohydrate diet prevents Mcl-1-mediated resistance to BH3-mimetics

artículo científico publicado en 2016

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.

artículo científico publicado en 2017

Metformin and cancer therapy.

artículo científico

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

artículo científico publicado en 2010

Metformin targets the GTPase Rac1 to inhibit prostate cancer cell migration.

artículo científico publicado en 2014

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

artículo científico publicado en 2011

Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells

artículo científico publicado en 2015

Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia

artículo científico

Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.

artículo científico publicado en 1998

New perspectives for metformin in cancer therapy

artículo científico publicado en 2013

PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness

artículo científico publicado en 2019

Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells

artículo científico publicado en 2012

Primary Cilium in Cancer Hallmarks ⬇️

artículo científico

Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells

artículo científico publicado en 2018

Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage.

artículo científico publicado en 2002

Role of MAPKs in development and differentiation: lessons from knockout mice.

artículo científico publicado en 2006

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

artículo científico publicado en 2012

Sirtuin 7: a new marker of aggressiveness in prostate cancer

artículo científico publicado en 2017

Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes

artículo científico publicado en 1994

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

artículo científico publicado en 2010

The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells.

artículo científico publicado en 1997

The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells

artículo científico publicado en 1999

The Lac repressor provides a reversible gene expression system in undifferentiated and differentiated embryonic stem cell.

artículo científico publicado en 2005

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

artículo científico publicado en 2008

The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

artículo científico publicado en 2010

The defective transforming phenotype of c-Jun Ala(63/73) is rescued by mutation of the C-terminal phosphorylation site.

artículo científico publicado en 2001

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

artículo científico publicado en 2017

The metabolic modulator PGC-1α in cancer

artículo científico publicado en 2019

The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.

artículo científico publicado en 2013

The role of MAPKs in adipocyte differentiation and obesity.

artículo científico publicado en 2005

UBTD1 is a mechano-regulator controlling cancer aggressiveness

scientific article published on 25 February 2019

[Implication of MAP kinases in obesity-induced inflammation and insulin resistance].

artículo científico publicado en 2014

[Obesity, diabetes and insulin resistance. Alterations of insulin signalling]

scientific article published on 01 January 2006

c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells.

artículo científico publicado en 2000

Lista de obras de

"Double hit" makes the difference.

Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death

Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans

Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia

Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity.

Editorial: Metformin: Beyond Diabetes

Effect of maternal hyperglycemia on NaK ATPase activity in fetal rat kidney

Energy disruptors: rising stars in anticancer therapy?

Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC

Frequency and prognostic evaluation of 3p21-22 allelic losses in non-small-cell lung cancer

Guidelines for the use and interpretation of assays for monitoring autophagy

Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage

Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1

Human pre-alpha-trypsin inhibitor-precursor heavy chain. cDNA and deduced amino-acid sequence

Hypoxia decreases insulin signaling pathways in adipocytes

Hypoxia protects against the cell death triggered by oxovanadium-galactomannan complexes in HepG2 cells

Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.

Identification of oncolytic vaccinia restriction factors in canine high-grade mammary tumor cells using single-cell transcriptomics

Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells.

Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes

Low carbohydrate diet prevents Mcl-1-mediated resistance to BH3-mimetics

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.

Metformin and cancer therapy.

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

Metformin targets the GTPase Rac1 to inhibit prostate cancer cell migration.

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells

Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia

Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.

New perspectives for metformin in cancer therapy

PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness

Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells

Primary Cilium in Cancer Hallmarks ⬇️

Protein N-glycosylation alteration and glycolysis inhibition both contribute to the antiproliferative action of 2-deoxyglucose in breast cancer cells

Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage.

Role of MAPKs in development and differentiation: lessons from knockout mice.

Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

Sirtuin 7: a new marker of aggressiveness in prostate cancer

Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells.

The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells

The Lac repressor provides a reversible gene expression system in undifferentiated and differentiated embryonic stem cell.

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

The defective transforming phenotype of c-Jun Ala(63/73) is rescued by mutation of the C-terminal phosphorylation site.

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

The metabolic modulator PGC-1α in cancer

The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.

The role of MAPKs in adipocyte differentiation and obesity.

UBTD1 is a mechano-regulator controlling cancer aggressiveness

[Implication of MAP kinases in obesity-induced inflammation and insulin resistance].

[Obesity, diabetes and insulin resistance. Alterations of insulin signalling]

c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells.