Lista de obras - Alessandro Sacchetti - Dominio Público Uruguay

A new spirocyclic proline-based lactam as efficient type II′ β-turn inducing peptidomimetic

A new three dimensional biomimetic hydrogel to deliver factors secreted by human mesenchymal stem cells in spinal cord injury.

artículo científico publicado en 2015

Addition of TMSCN to chiral ketimines derived from isatin. Synthesis of an oxindole-based peptidomimetic and a bioactive spirohydantoin ⬇️

artículo científico publicado el 17 de junio de 2011

An efficient enantioselective approach to cyclic beta-amino acid derivatives via olefin metathesis reactions

artículo científico publicado en 2006

Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives.

artículo científico publicado en 2014

Biotechnological Development of a Practical Synthesis of Ethyl (S)-2-Ethoxy-3-(p-methoxyphenyl)propanoate (EEHP): Over 100-Fold Productivity Increase from Yeast Whole Cells to Recombinant Isolated Enzymes

article

Cascade Coupling of Ene Reductases with Alcohol Dehydrogenases: Enantioselective Reduction of Prochiral Unsaturated Aldehydes

artículo científico publicado en 2012

Combinatorial solid-phase synthesis of 6-hydroxy-1,2,3,4-tetrahydro-beta-carbolines from l-5-hydroxytryptophan.

artículo científico publicado en 2005

Combined structural and theoretical investigation on differently substituted bispidine ligands: predicting the properties of their corresponding coordination polymers

artículo científico publicado en 2020

Comparison between two different click strategies to synthesize fluorescent nanogels for therapeutic applications

Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues

artículo científico publicado en 2015

Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

scientific article published on 26 August 2020

Design of polymer-based antimicrobial hydrogels through physico-chemical transition

artículo científico publicado en 2019

Design, synthesis, and conformational analysis of 3-cyclo-butylcarbamoyl hydantoins as novel hydrogen bond driven universal peptidomimetics.

artículo científico publicado en 2017

Ecdysteroid Derivatives that Reverse P-Glycoprotein-Mediated Drug Resistance

artículo científico publicado en 2020

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels

artículo científico publicado en 2014

Effects of primary amine-based coatings on microglia internalization of nanogels

scientific article published on 17 October 2019

Ester coupling of ibuprofen in hydrogel matrix: A facile one-step strategy for controlled anti-inflammatory drug release

scientific article published on 11 November 2019

Evaluation of RGD functionalization in hybrid hydrogels as 3D neural stem cell culture systems.

artículo científico publicado en 2018

Grignard addition to imines derived from isatine: a method for the asymmetric synthesis of quaternary 3-aminooxindoles.

artículo científico publicado en 2009

Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation

artículo científico publicado en 2014

Highly Dynamic and Tunable Behavior of 1D Coordination Polymers based on the Bispidine Ligand

artículo científico publicado en 2018

Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels

scientific article published on 10 September 2020

Microwave-assisted synthesis of TEMPO-labeled hydrogels traceable with MRI.

artículo científico publicado en 2018

Microwave-assisted, solid-phase synthesis of a chiral 1,2,3,4-tetrahydro-quinoline library.

artículo científico publicado en 2006

Modulation of electrostatic interactions to improve controlled drug delivery from nanogels.

artículo científico publicado en 2016

Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides

artículo científico publicado en 2019

Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library

artículo científico publicado en 2015

Olefin metathesis based approach to diversely functionalized pyrrolizidines and indolizidines; total synthesis of (+)-monomorine.

artículo científico publicado en 2009

Organocatalytic Asymmetric Biginelli-like Reaction Involving Isatin.

artículo científico publicado en 2016

Organocatalytic vinylogous Mannich reaction of trimethylsiloxyfuran with isatin-derived benzhydryl-ketimines.

artículo científico publicado en 2016

Phe-Ala-based diazaspirocyclic lactam as nucleator of type II' β-turn

artículo científico publicado en 2011

Preparation and Luminescence Thermochromism of Tetranuclear Copper(I)–Pyridine–Iodide Clusters

Productivity enhancement of CC bioreductions by coupling the in situ substrate feeding product removal technology with isolated enzymes

artículo científico publicado en 2012

Pyrroloisoquinoline-based tetrapeptide analogues mimicking reverse-turn secondary structures

artículo científico publicado en 2007

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

artículo científico publicado en 2013

Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel in Spinal Cord Injury

artículo científico publicado en 2019

Selective Protein Conjugation of Poly(glycerol monomethacrylate) and Poly(polyethylene glycol methacrylate) with Tunable Topology via Reductive Amination with Multifunctional ATRP Initiators for Activity Preservation

artículo científico publicado en 2022

Spectroscopic, Structural, and Computational Characterization of Three Bispidinone Derivatives, as Ligands for Enantioselective Metal Catalyzed Reactions

artículo científico publicado en 2016

Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

artículo científico publicado en 2019

Structural and biological exploration of phe(3)-phe(4)-modified endomorphin-2 peptidomimetics

artículo científico publicado en 2013

Substrate scope and synthetic applications of the enantioselective reduction of α-alkyl-β-arylenones mediated by Old Yellow Enzymes.

artículo científico publicado en 2013

Substrate-engineering approach to the stereoselective chemo-multienzymatic cascade synthesis of Nicotiana tabacum lactone

artículo científico publicado en 2015

Synthesis and Antimicrobial Evaluation of Novel Chiral 2-Amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Derivatives

artículo científico publicado en 2019

Synthesis of Robalzotan, Ebalzotan, and Rotigotine Precursors via the Stereoselective Multienzymatic Cascade Reduction of α,β-Unsaturated Aldehydes

artículo científico publicado en 2013

Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues

scholarly article by Giordano Lesma et al published 4 November 2012 in Molecular Diversity

Tetrahydro-β-carboline-based spirocyclic lactam as type II' β-turn: application to the synthesis and biological evaluation of somatostatine mimetics.

artículo científico publicado en 2013

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

artículo científico publicado en 2016

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure.

artículo científico publicado en 2013

Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.

artículo científico publicado en 2006

Total enantioselective synthesis of (-)-cytisine

scientific article published on 01 February 2004

Tunable drug delivery using chemoselective functionalization of hydrogels.

artículo científico publicado en 2016

Ugi 4-CR/Pictet-Spengler reaction as a short route to tryptophan-derived peptidomimetics

scientific article published on 16 October 2012

trans-6-Aminocyclohept-3-enols, a new designed polyfunctionalized chiral building block for the asymmetric synthesis of 2-substituted-4-hydroxypiperidines

artículo científico publicado en 2002

Lista de obras de Alessandro Sacchetti

A new spirocyclic proline-based lactam as efficient type II′ β-turn inducing peptidomimetic

A new three dimensional biomimetic hydrogel to deliver factors secreted by human mesenchymal stem cells in spinal cord injury.

Addition of TMSCN to chiral ketimines derived from isatin. Synthesis of an oxindole-based peptidomimetic and a bioactive spirohydantoin ⬇️

An efficient enantioselective approach to cyclic beta-amino acid derivatives via olefin metathesis reactions

Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives.

Biotechnological Development of a Practical Synthesis of Ethyl (S)-2-Ethoxy-3-(p-methoxyphenyl)propanoate (EEHP): Over 100-Fold Productivity Increase from Yeast Whole Cells to Recombinant Isolated Enzymes

Cascade Coupling of Ene Reductases with Alcohol Dehydrogenases: Enantioselective Reduction of Prochiral Unsaturated Aldehydes

Combinatorial solid-phase synthesis of 6-hydroxy-1,2,3,4-tetrahydro-beta-carbolines from l-5-hydroxytryptophan.

Combined structural and theoretical investigation on differently substituted bispidine ligands: predicting the properties of their corresponding coordination polymers

Comparison between two different click strategies to synthesize fluorescent nanogels for therapeutic applications

Complementary isonitrile-based multicomponent reactions for the synthesis of diversified cytotoxic hemiasterlin analogues

Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

Design of polymer-based antimicrobial hydrogels through physico-chemical transition

Design, synthesis, and conformational analysis of 3-cyclo-butylcarbamoyl hydantoins as novel hydrogen bond driven universal peptidomimetics.

Ecdysteroid Derivatives that Reverse P-Glycoprotein-Mediated Drug Resistance

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels

Effects of primary amine-based coatings on microglia internalization of nanogels

Ester coupling of ibuprofen in hydrogel matrix: A facile one-step strategy for controlled anti-inflammatory drug release

Evaluation of RGD functionalization in hybrid hydrogels as 3D neural stem cell culture systems.

Grignard addition to imines derived from isatine: a method for the asymmetric synthesis of quaternary 3-aminooxindoles.

Hemiasterlin analogues incorporating an aromatic, and heterocyclic type C-terminus: design, synthesis and biological evaluation

Highly Dynamic and Tunable Behavior of 1D Coordination Polymers based on the Bispidine Ligand

Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels

Microwave-assisted synthesis of TEMPO-labeled hydrogels traceable with MRI.

Microwave-assisted, solid-phase synthesis of a chiral 1,2,3,4-tetrahydro-quinoline library.

Modulation of electrostatic interactions to improve controlled drug delivery from nanogels.

Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides

Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library

Olefin metathesis based approach to diversely functionalized pyrrolizidines and indolizidines; total synthesis of (+)-monomorine.

Organocatalytic Asymmetric Biginelli-like Reaction Involving Isatin.

Organocatalytic vinylogous Mannich reaction of trimethylsiloxyfuran with isatin-derived benzhydryl-ketimines.

Phe-Ala-based diazaspirocyclic lactam as nucleator of type II' β-turn

Preparation and Luminescence Thermochromism of Tetranuclear Copper(I)–Pyridine–Iodide Clusters

Productivity enhancement of CC bioreductions by coupling the in situ substrate feeding product removal technology with isolated enzymes

Pyrroloisoquinoline-based tetrapeptide analogues mimicking reverse-turn secondary structures

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured Gel in Spinal Cord Injury

Selective Protein Conjugation of Poly(glycerol monomethacrylate) and Poly(polyethylene glycol methacrylate) with Tunable Topology via Reductive Amination with Multifunctional ATRP Initiators for Activity Preservation

Spectroscopic, Structural, and Computational Characterization of Three Bispidinone Derivatives, as Ligands for Enantioselective Metal Catalyzed Reactions

Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Structural and biological exploration of phe(3)-phe(4)-modified endomorphin-2 peptidomimetics

Substrate scope and synthetic applications of the enantioselective reduction of α-alkyl-β-arylenones mediated by Old Yellow Enzymes.

Substrate-engineering approach to the stereoselective chemo-multienzymatic cascade synthesis of Nicotiana tabacum lactone

Synthesis and Antimicrobial Evaluation of Novel Chiral 2-Amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Derivatives

Synthesis of Robalzotan, Ebalzotan, and Rotigotine Precursors via the Stereoselective Multienzymatic Cascade Reduction of α,β-Unsaturated Aldehydes

Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues

Tetrahydro-β-carboline-based spirocyclic lactam as type II' β-turn: application to the synthesis and biological evaluation of somatostatine mimetics.

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure.

Thiocolchicine-podophyllotoxin conjugates: dynamic libraries based on disulfide exchange reaction.

Total enantioselective synthesis of (-)-cytisine

Tunable drug delivery using chemoselective functionalization of hydrogels.

Ugi 4-CR/Pictet-Spengler reaction as a short route to tryptophan-derived peptidomimetics

trans-6-Aminocyclohept-3-enols, a new designed polyfunctionalized chiral building block for the asymmetric synthesis of 2-substituted-4-hydroxypiperidines