Lista de obras - Herman A Schreuder - Dominio Público Uruguay

5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor

artículo científico publicado en 2013

A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles

artículo científico publicado en 2015

A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist

artículo científico publicado en 1997

A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.

artículo científico publicado en 2018

Analysis of the active site of the flavoprotein p-hydroxybenzoate hydroxylase and some ideas with respect to its reaction mechanism

artículo científico publicado en 1990

Chitinase and beta-1,3-glucanase in the lutoid-body fraction of Hevea latex

artículo científico publicado en 1996

Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases

artículo científico publicado en 2014

Crystal structure of p-hydroxybenzoate hydroxylase complexed with its reaction product 3,4-dihydroxybenzoate

artículo científico publicado en 1988

Crystal structure of p-hydroxybenzoate hydroxylase reconstituted with the modified FAD present in alcohol oxidase from methylotrophic yeasts: evidence for an arabinoflavin.

artículo científico publicado en 1994

Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes

artículo científico publicado en 1989

Crystal structure of the reduced form of p-hydroxybenzoate hydroxylase refined at 2.3 A resolution

scientific article published on 01 October 1992

Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton [...]

artículo científico publicado en 1994

Crystallization and preliminary X-ray analysis of human antithrombin III

scientific article published on 01 January 1993

Crystallization and preliminary crystallographic analysis of antistasin, a leech-derived inhibitor of blood coagulation factor Xa

scientific article published on 01 June 1993

Crystals of soluble interleukin-1 receptor complexed with its natural antagonist reveal a 1:1 receptor-ligand complex

scientific article published on 01 October 1995

Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa

scientific article published on 01 December 2004

Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa

artículo científico publicado en 2002

Design, synthesis, and structure-activity relationship of a new class of amidinophenylurea-based factor VIIa inhibitors.

artículo científico publicado en 2003

Determination of beta-galactosidase activity in the intestinal tract of mice by ion-exchange high-performance liquid chromatography using epsilon-N-1-(1-deoxylactulosyl)-L-lysine as substrate

artículo científico publicado en 1983

Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations

artículo científico publicado en 2018

Evidence for C-Cl/C-Br...pi interactions as an important contribution to protein-ligand binding affinity.

artículo científico publicado en 2009

Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents.

artículo científico publicado en 2004

Fragment deconstruction of small, potent factor Xa inhibitors: exploring the superadditivity energetics of fragment linking in protein-ligand complexes

artículo científico publicado en 2012

Identification of a novel conserved sequence motif in flavoprotein hydroxylases with a putative dual function in FAD/NAD(P)H binding ⬇️

artículo científico publicado el 1 de noviembre de 1997

Inhibition of CatA: an emerging strategy for the treatment of heart failure.

artículo científico publicado en 2013

Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones

artículo científico publicado en 1998

Interdomain binding of NADPH in p-Hydroxybenzoate Hydroxylase as Suggested by Kinetic, Crystallographic and Modeling Studies of Histidine 162 and Arginine 269 Variants ⬇️

artículo científico publicado el 14 de agosto de 1998

Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) ⬇️

artículo científico publicado en 2016

Lys42 and Ser42 variants of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens reveal that Arg42 is essential for NADPH binding