Lista de obras - Alexander Leitner - Dominio Público Uruguay

A mass spectrometry-based hybrid method for structural modeling of protein complexes

artículo científico

A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

scientific article published on 27 January 2020

A review of the role of chemical modification methods in contemporary mass spectrometry-based proteomics research

artículo científico publicado en 2017

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

artículo científico publicado en 2008

An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor

scientific article published on 26 July 2018

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies

artículo científico publicado en 2015

Applications of chemical tagging approaches in combination with 2DE and mass spectrometry

artículo científico publicado en 2009

Architecture and conformational switch mechanism of the ryanodine receptor

artículo científico publicado en 2015

Architecture and functional dynamics of the pentafunctional AROM complex

artículo científico publicado en 2020

Architecture of the large subunit of the mammalian mitochondrial ribosome

artículo científico publicado en 2014

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

artículo científico publicado en 2014

Chemical tagging strategies for mass spectrometry-based phospho-proteomics

artículo científico publicado en 2009

Chemistry meets proteomics: the use of chemical tagging reactions for MS-based proteomics

artículo científico publicado en 2006

Combining Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein-RNA Complexes

scientific article published on 01 July 2019

Comparative study on the use of ortho-phthalaldehyde, naphthalene-2,3-dicarboxaldehyde and anthracene-2,3-dicarboxaldehyde reagents for alpha-amino acids followed by the enantiomer separation of the formed isoindolin-1-one derivatives using quinine-

artículo científico publicado en 2005

Comparison of toad venoms from different Bufo species by HPLC and LC-DAD-MS/MS.

artículo científico publicado en 2010

Conformational control and DNA-binding mechanism of the metazoan origin recognition complex

article published in the Proceedings of the National Academy of Sciences of the United States of America

Conserved peptide fragmentation as a benchmarking tool for mass spectrometers and a discriminating feature for targeted proteomics

artículo científico publicado en 2014

Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling

artículo científico publicado en 2016

Cross-link guided molecular modeling with ROSETTA

artículo científico publicado en 2013

Cross-linking and other structural proteomics techniques: how chemistry is enabling mass spectrometry applications in structural biology

scientific article published on 26 April 2016

Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines

artículo científico publicado en 2015

CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation

scientific article published on 02 September 2019

Current chemical tagging strategies for proteome analysis by mass spectrometry

artículo científico publicado en 2004

Derivatisation of arginine residues with malondialdehyde for the analysis of peptides and protein digests by LC-ESI-MS/MS

artículo científico publicado en 2006

Development of an indole-based chemically cleavable linker concept for immobilizing bait compounds for protein pull-down experiments.

artículo científico publicado en 2011

Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF

artículo científico publicado en 2022

Enrichment Strategies in Phosphoproteomics

artículo científico

Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac.

artículo científico publicado en 2004

Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes

scientific article published on 13 September 2018

Expanding the Cross-Link Coverage of a Carboxyl-Group Specific Chemical Cross-Linking Strategy for Structural Proteomics Applications

artículo científico publicado en 2021

Expanding the chemical cross-linking toolbox by the use of multiple proteases and enrichment by size exclusion chromatography

artículo científico publicado en 2012

False discovery rate estimation for cross-linked peptides identified by mass spectrometry

artículo científico publicado en 2012

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

artículo científico publicado en 2019

Functional probing of arginine residues in proteins using mass spectrometry and an arginine-specific covalent tagging concept

artículo científico publicado en 2005

Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

artículo científico publicado en 2016

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

artículo científico publicado en 2020

Identification of marker proteins for the adulteration of meat products with soybean proteins by multidimensional liquid chromatography-tandem mass spectrometry

artículo científico publicado en 2006

Improving fragmentation of poorly fragmenting peptides and phosphopeptides during collision-induced dissociation by malondialdehyde modification of arginine residues

artículo científico publicado en 2007

Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation

artículo científico publicado en 2016

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

article published in the Proceedings of the National Academy of Sciences of the United States of America

Insights into chemoselectivity principles in metal oxide affinity chromatography using tailored nanocast metal oxide microspheres and mass spectrometry-based phosphoproteomics

artículo científico publicado en 2017

Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility

artículo científico publicado en 2023

Integrative structural investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding

artículo científico publicado en 2018

Interaction of 2-oxoglutarate dehydrogenase OdhA with its inhibitor OdhI in Corynebacterium glutamicum: Mutants and a model

artículo científico publicado en 2014

Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline

artículo científico publicado en 2013

Malondialdehyde tagging improves the analysis of arginine oligomers and arginine-containing dendrimers by HPLC-MS.

artículo científico publicado en 2008

Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing

artículo científico publicado en 2016

Mass spectrometry supported determination of protein complex structure

artículo científico publicado en 2013

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.

artículo científico publicado en 2017

Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery

artículo científico publicado en 2019

Molecular Architecture of Yeast Chromatin Assembly Factor 1.

artículo científico publicado en 2016

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

artículo científico publicado en 2015

Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.

artículo científico publicado en 2017

Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2

scientific article published in Nature Communications

Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns

artículo científico publicado en 2021

Optimizing the performance of tin dioxide microspheres for phosphopeptide enrichment

artículo científico publicado en 2009

Photooxidation Generates Biologically Active Phospholipids That Induce Heme Oxygenase-1 in Skin Cells

scientific article published in Journal of Biological Chemistry

Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics

artículo científico publicado en 2010

Probing of arginine residues in peptides and proteins using selective tagging and electrospray ionization mass spectrometry

artículo científico publicado en 2003

Probing the phosphoproteome of HeLa cells using nanocast metal oxide microspheres for phosphopeptide enrichment

artículo científico publicado en 2010

Proteomic identification of a marker signature for MAPKi resistance in melanoma

scientific article published on 26 June 2019

Puf6 primes 60S pre-ribosome nuclear export at low temperature

artículo científico publicado en 2021

Quantitative high-performance liquid chromatography-tandem mass spectrometry impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing L-alanyl-L-glutamine

artículo científico publicado en 2012

Reaction of the indole group with malondialdehyde: application for the derivatization of tryptophan residues in peptides

artículo científico publicado en 2007

Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome

artículo científico publicado en 2015

Selective enrichment of tryptophan-containing peptides from protein digests employing a reversible derivatization with malondialdehyde and solid-phase capture on hydrazide beads

artículo científico publicado en 2007

Silica-based monolithic columns with mixed-mode reversed-phase/weak anion-exchange selectivity principle for high-performance liquid chromatography

artículo científico publicado en 2006

SnapShot: mass spectrometry for protein and proteome analyses

artículo científico publicado en 2013

Solid-phase capture and release of arginine peptides by selective tagging and boronate affinity chromatography.

artículo científico publicado en 2005

Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry

artículo científico publicado en 2012

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

artículo científico publicado en 2016

Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel

artículo científico publicado en 2023

Structural modeling of protein-RNA complexes using crosslinking of segmentally isotope-labeled RNA and MS/MS

artículo científico publicado en 2017

Structure of a human cap-dependent 48S translation pre-initiation complex

artículo científico publicado en 2018

Synthesis, in vitro progesterone receptors affinity of gadolinium containing mifepristone conjugates and estimation of binding sites in human breast cancer cells

artículo científico publicado en 2010

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

scientific article published on 04 April 2019

The complete structure of the large subunit of the mammalian mitochondrial ribosome

artículo científico publicado en 2014

The human GID complex engages two independent modules for substrate recruitment

artículo científico publicado en 2021

The molecular architecture of the eukaryotic chaperonin TRiC/CCT

artículo científico publicado en 2012

The mzIdentML data standard version 1.2, supporting advances in proteome informatics.

artículo científico publicado en 2017

The structure and symmetry of radial spoke protein complex in Chlamydomonas flagella

artículo científico publicado en 2020

Tools for analyzing the phosphoproteome and other phosphorylated biomolecules: a review

artículo científico publicado en 2011

Use of the arginine-specific butanedione/phenylboronic acid tag for analysis of peptides and protein digests using matrix-assisted laser desorption/ionization mass spectrometry

artículo científico publicado en 2007

Visual documentation of the stability of intravenous solutions of omeprazole (Losec) and pantoprazole (Pantoloc)

artículo científico publicado en 2002

xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry

artículo científico publicado en 2015

Lista de obras de Alexander Leitner

A mass spectrometry-based hybrid method for structural modeling of protein complexes

A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

A review of the role of chemical modification methods in contemporary mass spectrometry-based proteomics research

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response

An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies

Applications of chemical tagging approaches in combination with 2DE and mass spectrometry

Architecture and conformational switch mechanism of the ryanodine receptor

Architecture and functional dynamics of the pentafunctional AROM complex

Architecture of the large subunit of the mammalian mitochondrial ribosome

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

Chemical tagging strategies for mass spectrometry-based phospho-proteomics

Chemistry meets proteomics: the use of chemical tagging reactions for MS-based proteomics

Combining Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) Spectroscopy for Integrative Structural Biology of Protein-RNA Complexes

Comparative study on the use of ortho-phthalaldehyde, naphthalene-2,3-dicarboxaldehyde and anthracene-2,3-dicarboxaldehyde reagents for alpha-amino acids followed by the enantiomer separation of the formed isoindolin-1-one derivatives using quinine-

Comparison of toad venoms from different Bufo species by HPLC and LC-DAD-MS/MS.

Conformational control and DNA-binding mechanism of the metazoan origin recognition complex

Conserved peptide fragmentation as a benchmarking tool for mass spectrometers and a discriminating feature for targeted proteomics

Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling

Cross-link guided molecular modeling with ROSETTA

Cross-linking and other structural proteomics techniques: how chemistry is enabling mass spectrometry applications in structural biology

Crosslinking and Mass Spectrometry: An Integrated Technology to Understand the Structure and Function of Molecular Machines

CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation

Current chemical tagging strategies for proteome analysis by mass spectrometry

Derivatisation of arginine residues with malondialdehyde for the analysis of peptides and protein digests by LC-ESI-MS/MS

Development of an indole-based chemically cleavable linker concept for immobilizing bait compounds for protein pull-down experiments.

Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF

Enrichment Strategies in Phosphoproteomics

Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac.

Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes

Expanding the Cross-Link Coverage of a Carboxyl-Group Specific Chemical Cross-Linking Strategy for Structural Proteomics Applications

Expanding the chemical cross-linking toolbox by the use of multiple proteases and enrichment by size exclusion chromatography

False discovery rate estimation for cross-linked peptides identified by mass spectrometry

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study

Functional probing of arginine residues in proteins using mass spectrometry and an arginine-specific covalent tagging concept

Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module

Identification of marker proteins for the adulteration of meat products with soybean proteins by multidimensional liquid chromatography-tandem mass spectrometry

Improving fragmentation of poorly fragmenting peptides and phosphopeptides during collision-induced dissociation by malondialdehyde modification of arginine residues

Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

Insights into chemoselectivity principles in metal oxide affinity chromatography using tailored nanocast metal oxide microspheres and mass spectrometry-based phosphoproteomics

Integrative solution structure of PTBP1-IRES complex reveals strong compaction and ordering with residual conformational flexibility

Integrative structural investigation on the architecture of human Importin4_histone H3/H4_Asf1a complex and its histone H3 tail binding

Interaction of 2-oxoglutarate dehydrogenase OdhA with its inhibitor OdhI in Corynebacterium glutamicum: Mutants and a model

Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline

Malondialdehyde tagging improves the analysis of arginine oligomers and arginine-containing dendrimers by HPLC-MS.

Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing

Mass spectrometry supported determination of protein complex structure

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.

Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery

Molecular Architecture of Yeast Chromatin Assembly Factor 1.

Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2.

Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.

Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2

Native mass spectrometry analyses of chaperonin complex TRiC/CCT reveal subunit N-terminal processing and re-association patterns

Optimizing the performance of tin dioxide microspheres for phosphopeptide enrichment

Photooxidation Generates Biologically Active Phospholipids That Induce Heme Oxygenase-1 in Skin Cells

Probing native protein structures by chemical cross-linking, mass spectrometry, and bioinformatics

Probing of arginine residues in peptides and proteins using selective tagging and electrospray ionization mass spectrometry

Probing the phosphoproteome of HeLa cells using nanocast metal oxide microspheres for phosphopeptide enrichment

Proteomic identification of a marker signature for MAPKi resistance in melanoma

Puf6 primes 60S pre-ribosome nuclear export at low temperature

Quantitative high-performance liquid chromatography-tandem mass spectrometry impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing L-alanyl-L-glutamine

Reaction of the indole group with malondialdehyde: application for the derivatization of tryptophan residues in peptides

Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome

Selective enrichment of tryptophan-containing peptides from protein digests employing a reversible derivatization with malondialdehyde and solid-phase capture on hydrazide beads

Silica-based monolithic columns with mixed-mode reversed-phase/weak anion-exchange selectivity principle for high-performance liquid chromatography

SnapShot: mass spectrometry for protein and proteome analyses

Solid-phase capture and release of arginine peptides by selective tagging and boronate affinity chromatography.

Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry

Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel

Structural modeling of protein-RNA complexes using crosslinking of segmentally isotope-labeled RNA and MS/MS

Structure of a human cap-dependent 48S translation pre-initiation complex

Synthesis, in vitro progesterone receptors affinity of gadolinium containing mifepristone conjugates and estimation of binding sites in human breast cancer cells

The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

The complete structure of the large subunit of the mammalian mitochondrial ribosome

The human GID complex engages two independent modules for substrate recruitment