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A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models ⬇️

artículo científico publicado el 31 de agosto de 2012

An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury

artículo científico publicado en 2012

Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug

artículo científico publicado en 2014

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

artículo científico publicado en 2012

Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts

artículo científico publicado en 2013

Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABAA receptor antagonist NP260.

artículo científico publicado en 2014

Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide: gene expression profiles correlate with treatment efficacy and an established clinical endpoint

artículo científico publicado en 2005

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

artículo científico publicado en 2009

Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel

scientific article published on 06 May 2009

Replication and narrowing of gene expression quantitative trait loci using inbred mice

artículo científico publicado en 2009

Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity

artículo científico publicado en 2008

The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers.

artículo científico publicado en 2012

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