Lista de obras - Juan Carlos Zuniga-Pflucker

A 2020 View of Thymus Stromal Cells in T Cell Development

artículo científico publicado en 2021

A Notch ligand, Delta-like 1 functions as an adhesion molecule for mast cells.

artículo científico publicado en 2010

A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells.

artículo científico publicado en 2011

A key role for IL-7R in the generation of microenvironments required for thymic dendritic cells.

artículo científico publicado en 2017

A monoclonal antibody against the extracellular domain of mouse and human epithelial V-like antigen 1 reveals a restricted expression pattern among CD4- CD8- thymocytes.

artículo científico publicado en 2014

A survival guide to early T cell development

artículo científico publicado en 2006

Adapting in vitro embryonic stem cell differentiation to the study of locus control regions

artículo científico publicado en 2014

An in vitro model of innate lymphoid cell function and differentiation.

artículo científico publicado en 2014

An overview of the intrathymic intricacies of T cell development

artículo científico publicado en 2014

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

artículo científico publicado en 2008

Branching out to gain control: how the pre-TCR is linked to multiple functions

artículo científico publicado en 2000

CD8+ T cells are kept in tune by modulating IL-7 responsiveness

artículo científico publicado en 2007

Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch

artículo científico publicado en 2013

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.

artículo científico publicado en 2009

Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection

artículo científico publicado en 2020

Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.

artículo científico publicado en 2012

Complete TCR-α gene locus control region activity in T cells derived in vitro from embryonic stem cells

artículo científico publicado en 2013

Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

artículo científico publicado en 2007

Dedicated mTEC progenitors stay true, even into adulthood

artículo científico publicado en 2014

Derivation of T cells in vitro from mouse embryonic stem cells

artículo científico publicado en 2014

Determining γδ versus αß T cell development.

artículo científico publicado en 2010

Development of lymphoid lineages from embryonic stem cells in vitro

artículo científico publicado en 2003

Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.

artículo científico publicado en 2006

Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.

artículo científico publicado en 2010

Directed differentiation of embryonic stem cells to the T-lymphocyte lineage.

artículo científico publicado en 2013

Dynamics of human prothymocytes and xenogeneic thymopoiesis in hematopoietic stem cell-engrafted nonobese diabetic-SCID/IL-2rγnull mice.

artículo científico publicado en 2012

EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay

artículo científico publicado en 2017

Early hematopoietic lineage restrictions directed by Ikaros.

scientific article published on 05 March 2006

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

artículo científico publicado en 2001

Expression and function of CD105 during the onset of hematopoiesis from Flk1(+) precursors.

artículo científico publicado en 2001

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.

artículo científico publicado en 1999

FOXN1 (GFP/w) reporter hESCs enable identification of integrin-β4, HLA-DR, and EpCAM as markers of human PSC-derived FOXN1(+) thymic epithelial progenitors.

artículo científico publicado en 2014

Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.

artículo científico publicado en 1999

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells

artículo científico publicado en 2013

Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?

artículo científico

Generation and function of progenitor T cells from StemRegenin-1-expanded CD34+ human hematopoietic progenitor cells

artículo científico publicado en 2019

Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells

scientific article published on 01 December 2018

Generation of pro-T cells in vitro: potential for immune reconstitution.

artículo científico publicado en 2007

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins.

artículo científico publicado en 2018

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

artículo científico publicado en 2012

Hematopoiesis: from start to immune reconstitution potential

artículo científico publicado en 2015

Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages

scientific article published on 01 June 2004

Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature.

artículo científico publicado en 2011

Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture

artículo científico publicado en 2013

Identification of a Novel Developmental Stage Marking Lineage Commitment of Progenitor Thymocytes ⬇️

artículo científico publicado el 21 de julio de 1997

Identification of upstream cis-acting regulatory elements controlling lineage-specific expression of the mouse NK cell activation receptor, NKR-P1C.

artículo científico publicado en 2003

In vitro generation of T lymphocytes from embryonic stem cell–derived prehematopoietic progenitors ⬇️

artículo científico publicado el 8 de mayo de 2003

In vitro-generated MART-1-specific CD8 T cells display a broader T-cell receptor repertoire than ex vivo naïve and tumor-infiltrating lymphocytes

scientific article published on 15 February 2019

Induction of T Cell Development In Vitro by Delta-Like (Dll)-Expressing Stromal Cells.

artículo científico publicado en 2016

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

artículo científico publicado en 2002

Induction of T-cell development by Delta-like 4-expressing fibroblasts.

artículo científico publicado en 2013

Integration of T-cell receptor, Notch and cytokine signals programs mouse γδ T-cell effector differentiation

scientific article published on 28 June 2018

Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury

artículo científico publicado en 2014

Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

artículo científico publicado en 2004

Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency.

artículo científico publicado en 2013

Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates

artículo científico publicado en 2014

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

artículo científico publicado en 2012

Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12

scientific article published on 26 August 2019

Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors

artículo científico publicado en 2013

On becoming a T cell, a convergence of factors kick it up a Notch along the way.

artículo científico publicado en 2011

Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes

artículo científico publicado en 2001

Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression

scientific article published on 01 January 1995

Peroxisome Proliferator-Activated Receptor-δ Supports the Metabolic Requirements of Cell Growth in TCRβ-Selected Thymocytes and Peripheral CD4+ T Cells

artículo científico publicado en 2018

Positive selection of T cells, an in vitro view.

artículo científico publicado en 2010

Primary Immune Deficiency Treatment Consortium (PIDTC) report

artículo científico publicado en 2013

RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors

scientific article published on 21 October 2019

Regulation of thymocyte development from immature progenitors.

artículo científico publicado en 1996

Regulation of thymocyte differentiation: pre-TCR signals and beta-selection

artículo científico publicado en 2002

Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation

artículo científico publicado en 2006

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

artículo científico publicado en 2004

Synergy between T cell Receptor and Fas (CD95/APO-1) signaling in mouse thymocyte death

scientific article published on 01 April 1996

T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures.

artículo científico publicado en 2012

T-cell development, doing it in a dish.

artículo científico publicado en 2006

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

scientific journal article

The BTG/TOB family protein TIS21 regulates stage-specific proliferation of developing thymocytes.

artículo científico publicado en 2005

The OP9-DL1 system: generation of T-lymphocytes from embryonic or hematopoietic stem cells in vitro.

artículo científico publicado en 2009

The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification

artículo científico publicado en 2014

The ion channel TRPM7 is required for B cell lymphopoiesis.

artículo científico publicado en 2018

The original intrathymic progenitor from which T cells originate.

artículo científico publicado en 2009

The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development.

artículo científico publicado en 2013

The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation.

artículo científico publicado en 2005

The role of nuclear factor-kappaB essential modulator (NEMO) in B cell development and survival.

artículo científico publicado en 2003

The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.

artículo científico publicado en 2001

Thymic selection of the T-cell repertoire.

artículo científico publicado en 1988

Transcriptional control of IL-2 and IL-4 in T cells of young and old mice

artículo científico publicado en 1995

When three negatives made a positive influence in defining four early steps in T cell development.

artículo científico publicado en 2012

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

artículo científico publicado en 1996

Lista de obras de Juan Carlos Zuniga-Pflucker

A 2020 View of Thymus Stromal Cells in T Cell Development

A Notch ligand, Delta-like 1 functions as an adhesion molecule for mast cells.

A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells.

A key role for IL-7R in the generation of microenvironments required for thymic dendritic cells.

A monoclonal antibody against the extracellular domain of mouse and human epithelial V-like antigen 1 reveals a restricted expression pattern among CD4- CD8- thymocytes.

A survival guide to early T cell development

Adapting in vitro embryonic stem cell differentiation to the study of locus control regions

An in vitro model of innate lymphoid cell function and differentiation.

An overview of the intrathymic intricacies of T cell development

Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.

Branching out to gain control: how the pre-TCR is linked to multiple functions

CD8+ T cells are kept in tune by modulating IL-7 responsiveness

Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells.

Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection

Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.

Complete TCR-α gene locus control region activity in T cells derived in vitro from embryonic stem cells

Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

Dedicated mTEC progenitors stay true, even into adulthood

Derivation of T cells in vitro from mouse embryonic stem cells

Determining γδ versus αß T cell development.

Development of lymphoid lineages from embryonic stem cells in vitro

Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.

Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.

Directed differentiation of embryonic stem cells to the T-lymphocyte lineage.

Dynamics of human prothymocytes and xenogeneic thymopoiesis in hematopoietic stem cell-engrafted nonobese diabetic-SCID/IL-2rγnull mice.

EXTL3 mutations cause skeletal dysplasia, immune deficiency, and developmental delay

Early hematopoietic lineage restrictions directed by Ikaros.

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

Expression and function of CD105 during the onset of hematopoiesis from Flk1(+) precursors.

Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.

FOXN1 (GFP/w) reporter hESCs enable identification of integrin-β4, HLA-DR, and EpCAM as markers of human PSC-derived FOXN1(+) thymic epithelial progenitors.

Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells

Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?

Generation and function of progenitor T cells from StemRegenin-1-expanded CD34+ human hematopoietic progenitor cells

Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells

Generation of pro-T cells in vitro: potential for immune reconstitution.

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins.

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

Hematopoiesis: from start to immune reconstitution potential

Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages

Human CD8 T cells generated in vitro from hematopoietic stem cells are functionally mature.

Human proT-cells generated in vitro facilitate hematopoietic stem cell-derived T-lymphopoiesis in vivo and restore thymic architecture

Identification of a Novel Developmental Stage Marking Lineage Commitment of Progenitor Thymocytes ⬇️

Identification of upstream cis-acting regulatory elements controlling lineage-specific expression of the mouse NK cell activation receptor, NKR-P1C.

In vitro generation of T lymphocytes from embryonic stem cell–derived prehematopoietic progenitors ⬇️

In vitro-generated MART-1-specific CD8 T cells display a broader T-cell receptor repertoire than ex vivo naïve and tumor-infiltrating lymphocytes

Induction of T Cell Development In Vitro by Delta-Like (Dll)-Expressing Stromal Cells.

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

Induction of T-cell development by Delta-like 4-expressing fibroblasts.

Integration of T-cell receptor, Notch and cytokine signals programs mouse γδ T-cell effector differentiation

Leukocyte infiltration and activation of the NLRP3 inflammasome in white adipose tissue following thermal injury

Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency.

Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12

Notch signals are required for in vitro but not in vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors

On becoming a T cell, a convergence of factors kick it up a Notch along the way.

Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes

Parameters controlling the programmed death of mature mouse T lymphocytes in high-dose suppression

Peroxisome Proliferator-Activated Receptor-δ Supports the Metabolic Requirements of Cell Growth in TCRβ-Selected Thymocytes and Peripheral CD4+ T Cells

Positive selection of T cells, an in vitro view.

Primary Immune Deficiency Treatment Consortium (PIDTC) report

RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors

Regulation of thymocyte development from immature progenitors.

Regulation of thymocyte differentiation: pre-TCR signals and beta-selection

Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death

Synergy between T cell Receptor and Fas (CD95/APO-1) signaling in mouse thymocyte death

T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures.

T-cell development, doing it in a dish.

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

The BTG/TOB family protein TIS21 regulates stage-specific proliferation of developing thymocytes.

The OP9-DL1 system: generation of T-lymphocytes from embryonic or hematopoietic stem cells in vitro.

The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification

The ion channel TRPM7 is required for B cell lymphopoiesis.

The original intrathymic progenitor from which T cells originate.