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ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library

artículo científico publicado en 2017

Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells

artículo científico publicado en 2016

B Cell Receptor Activation Predominantly Regulates AKT-mTORC1/2 Substrates Functionally Related to RNA Processing

artículo científico publicado en 2016

Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells.

artículo científico publicado en 2013

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study

scientific article published on 27 September 2019

Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

scientific article published on 16 October 2019

Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7.

artículo científico publicado en 2016

Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).

artículo científico publicado en 2012

Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.

artículo científico publicado en 2013

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

artículo científico publicado en 2014

Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant.

artículo científico publicado en 2016

TEC family kinases in health and disease – loss‐of‐function of BTK and ITK and the gain‐of‐function fusions ITK–SYK and BTK–SYK ⬇️

artículo científico publicado el 18 de mayo de 2011

Terminating B cell receptor signaling.

artículo científico publicado en 2017

The kidney injury caused by the onset of acute graft-versus-host disease is associated with down-regulation of αKlotho

artículo científico publicado en 2019

Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression

artículo científico publicado en 2018

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