Lista de obras -

A dual small-molecule rheostat for precise control of protein concentration in Mammalian cells

artículo científico publicado en 2014

A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding

artículo científico publicado en 2008

An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells

artículo científico publicado en 2013

Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent

artículo científico publicado en 2009

Asking more from metabolic oligosaccharide engineering

Azide- and Alkyne-Bearing Metabolic Chemical Reporters of Glycosylation Show Structure-Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway

artículo científico publicado en 2018

Bioorthogonal Profiling of a Cancer Cell Proteome Identifies a Large Set of 3-Bromopyruvate Targets beyond Glycolysis

scholarly article by Narek Darabedian et al published 5 November 2018 in ACS Chemical Biology

Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification

artículo científico publicado en 2014

Chemical Methods for Encoding and Decoding of Posttranslational Modifications

artículo científico publicado en 2016

Chemical methods for the proteome-wide identification of posttranslationally modified proteins

artículo científico publicado en 2014

Chemical reporter for visualizing metabolic cross-talk between carbohydrate metabolism and protein modification

artículo científico publicado en 2014

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1 ⬇️

artículo científico publicado el 3 de mayo de 2011

Chemistry-enabled methods for the visualization of cell-surface glycoproteins in Metazoans

artículo científico

Chemoproteomics reveals Toll-like receptor fatty acylation.

artículo científico publicado en 2014

Chemoselective ligation applied to the synthesis of a biantennary N-linked glycoform of CD52.

artículo científico publicado en 2003

Click Chemistry in Proteomic Investigations

scientific article published on 13 February 2020

Comparison of <i>N</i>-Acetyl-Glucosamine to Other Monosaccharides Reveals Structural Differences for the Inhibition of α-Synuclein Aggregation

artículo científico publicado en 2021

Correction to “An Alkyne–Aspirin Chemical Reporter for the Detection of Aspirin-Dependent Protein Modification in Living Cells”

scientific article published on 28 March 2018

Covalent capture of phospho-dependent protein oligomerization by site-specific incorporation of a diazirine photo-cross-linker

artículo científico publicado en 2007

Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling

artículo científico publicado en 2004

Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe

artículo científico publicado en 2009

Extent of inhibition of α-synuclein aggregation in vitro by SUMOylation is conjugation site- and SUMO isoform-selective

artículo científico publicado en 2015

Formation of 1,1-alpha,alpha-glycosidic bonds by intramolecular aglycone delivery. A convergent synthesis of trehalose

artículo científico publicado en 2003

Homogeneous glycopeptides and glycoproteins for biological investigation.

artículo científico publicado en 2001

Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy

artículo científico publicado en 2014

Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis

scientific journal article

Identifying potentially O-GlcNAcylated proteins using metabolic labeling, bioorthogonal enrichment, and Western blotting

artículo científico publicado en 2019

Incorporation of unnatural sugars for the identification of glycoproteins

artículo científico publicado en 2013

Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress

artículo científico publicado en 2019

Investigating the Effects of O-GlcNAc Modifications in Parkinson's Disease Using Semisynthetic α-Synuclein

artículo científico publicado en 2020

MYPT1 O-GlcNAc modification regulates sphingosine-1-phosphate mediated contraction

scientific article published on 14 September 2020

Metabolic Chemical Reporters of Glycans Exhibit Cell-Type-Selective Metabolism and Glycoprotein Labeling

artículo científico publicado en 2017

Metabolic Labeling for the Visualization and Identification of Potentially O-GlcNAc-Modified Proteins

scientific article published on 01 June 2020

Methods for Studying Site-Specific O-GlcNAc Modifications: Successes, Limitations, and Important Future Goals

artículo científico publicado en 2021

N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation.

artículo científico publicado en 2012

O-Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins

artículo científico publicado en 2020

O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity

artículo científico publicado en 2019

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

artículo científico publicado en 2015

O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.

artículo científico publicado en 2017

O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation

artículo científico publicado en 2012

O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding.

artículo científico publicado en 2017

Optimization of Chemoenzymatic Mass Tagging by Strain-Promoted Cycloaddition (SPAAC) for the Determination of O-GlcNAc Stoichiometry by Western Blotting

artículo científico publicado en 2018

Precise Control of Protein Concentration in Living Cells ⬇️

artículo científico publicado el 2 de noviembre de 2010

Probing glycosyltransferase activities with the Staudinger ligation

artículo científico publicado en 2004

Revolutionizing Our Understanding of Amyloidogenic Proteins by Cryo-Electron Microscopy.

artículo científico publicado en 2018

Robust in-gel fluorescence detection of mucin-type O-linked glycosylation ⬇️

artículo científico publicado el 14 de abril de 2011

Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation ⬇️

artículo científico publicado el 14 de marzo de 2012

Simple and Efficient Preparation of O- and S-GlcNAcylated Amino Acids through InBr-Catalyzed Synthesis of β- N-Acetylglycosides from Commercially Available Reagents

artículo científico publicado en 2018

Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein.

artículo científico publicado en 2013

Small-Molecule Reprogramming of Cancer Metabolism ⬇️

artículo científico publicado el 21 de septiembre de 2012

Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt

artículo científico publicado en 2007

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

artículo científico publicado en 2009

Syntheses of 6-sulfo sialyl Lewis X glycans corresponding to the L-selectin ligand "sulfoadhesin"

artículo científico publicado en 2004

Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity.

artículo científico publicado en 2016

Synthesis of thioether-linked analogues of the 2,3-sialyl-TF and MECA-79 antigens: mucin-type glycopeptides associated with cancer and inflammation

artículo científico publicado en 2003

Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational Modifications

artículo científico publicado en 2015

Synthetic glycopeptides and glycoproteins as tools for biology.

artículo científico publicado en 2004

The Metabolic Chemical Reporter 6-Azido-6-deoxy-glucose Further Reveals the Substrate Promiscuity of O-GlcNAc Transferase and Catalyzes the Discovery of Intracellular Protein Modification by O-Glucose.

artículo científico publicado en 2018

The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.

artículo científico publicado en 2017

The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase.

artículo científico publicado en 2017

The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels

artículo científico publicado en 2017

Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

scientific article published on 03 June 2020

Translation of Microbiota Short-Chain Fatty Acid Mechanisms Affords Anti-infective Acyl-Salicylic Acid Derivatives

artículo científico publicado en 2020

Trehalose is required for growth of Mycobacterium smegmatis

artículo científico publicado en 2004

Ubiquitination Can Change the Structure of the α-Synuclein Amyloid Fiber in a Site Selective Fashion

artículo científico publicado en 2019

Using chemistry to investigate the molecular consequences of protein ubiquitylation

artículo científico

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease

artículo científico publicado en 2019

Lista de obras de

A dual small-molecule rheostat for precise control of protein concentration in Mammalian cells

A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding

An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells

Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent

Asking more from metabolic oligosaccharide engineering

Azide- and Alkyne-Bearing Metabolic Chemical Reporters of Glycosylation Show Structure-Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway

Bioorthogonal Profiling of a Cancer Cell Proteome Identifies a Large Set of 3-Bromopyruvate Targets beyond Glycolysis

Bioorthogonal Profiling of a Cancer Cell Proteome Identifies a Large Set of 3-Bromopyruvate Targets beyond Glycolysis

Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification

Chemical Methods for Encoding and Decoding of Posttranslational Modifications

Chemical methods for the proteome-wide identification of posttranslationally modified proteins

Chemical reporter for visualizing metabolic cross-talk between carbohydrate metabolism and protein modification

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1 ⬇️

Chemistry-enabled methods for the visualization of cell-surface glycoproteins in Metazoans

Chemoproteomics reveals Toll-like receptor fatty acylation.

Chemoselective ligation applied to the synthesis of a biantennary N-linked glycoform of CD52.

Click Chemistry in Proteomic Investigations

Comparison of <i>N</i>-Acetyl-Glucosamine to Other Monosaccharides Reveals Structural Differences for the Inhibition of α-Synuclein Aggregation

Correction to “An Alkyne–Aspirin Chemical Reporter for the Detection of Aspirin-Dependent Protein Modification in Living Cells”

Covalent capture of phospho-dependent protein oligomerization by site-specific incorporation of a diazirine photo-cross-linker

Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling

Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe

Extent of inhibition of α-synuclein aggregation in vitro by SUMOylation is conjugation site- and SUMO isoform-selective

Formation of 1,1-alpha,alpha-glycosidic bonds by intramolecular aglycone delivery. A convergent synthesis of trehalose

Homogeneous glycopeptides and glycoproteins for biological investigation.

Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy

Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis

Identifying potentially O-GlcNAcylated proteins using metabolic labeling, bioorthogonal enrichment, and Western blotting

Incorporation of unnatural sugars for the identification of glycoproteins

Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress

Investigating the Effects of O-GlcNAc Modifications in Parkinson's Disease Using Semisynthetic α-Synuclein

MYPT1 O-GlcNAc modification regulates sphingosine-1-phosphate mediated contraction

Metabolic Chemical Reporters of Glycans Exhibit Cell-Type-Selective Metabolism and Glycoprotein Labeling

Metabolic Labeling for the Visualization and Identification of Potentially O-GlcNAc-Modified Proteins

Methods for Studying Site-Specific O-GlcNAc Modifications: Successes, Limitations, and Important Future Goals

N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation.

O-Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins

O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.

O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation

O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding.

Optimization of Chemoenzymatic Mass Tagging by Strain-Promoted Cycloaddition (SPAAC) for the Determination of O-GlcNAc Stoichiometry by Western Blotting

Precise Control of Protein Concentration in Living Cells ⬇️

Probing glycosyltransferase activities with the Staudinger ligation

Revolutionizing Our Understanding of Amyloidogenic Proteins by Cryo-Electron Microscopy.

Robust in-gel fluorescence detection of mucin-type O-linked glycosylation ⬇️

Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation ⬇️

Simple and Efficient Preparation of O- and S-GlcNAcylated Amino Acids through InBr-Catalyzed Synthesis of β- N-Acetylglycosides from Commercially Available Reagents

Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein.

Small-Molecule Reprogramming of Cancer Metabolism ⬇️

Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

Syntheses of 6-sulfo sialyl Lewis X glycans corresponding to the L-selectin ligand "sulfoadhesin"

Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity.

Synthesis of thioether-linked analogues of the 2,3-sialyl-TF and MECA-79 antigens: mucin-type glycopeptides associated with cancer and inflammation

Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational Modifications

Synthetic glycopeptides and glycoproteins as tools for biology.

The Metabolic Chemical Reporter 6-Azido-6-deoxy-glucose Further Reveals the Substrate Promiscuity of O-GlcNAc Transferase and Catalyzes the Discovery of Intracellular Protein Modification by O-Glucose.

The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.

The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase.

The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels

Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

Translation of Microbiota Short-Chain Fatty Acid Mechanisms Affords Anti-infective Acyl-Salicylic Acid Derivatives

Trehalose is required for growth of Mycobacterium smegmatis

Ubiquitination Can Change the Structure of the α-Synuclein Amyloid Fiber in a Site Selective Fashion

Using chemistry to investigate the molecular consequences of protein ubiquitylation

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease