Lista de obras -

A crystallographic glimpse of a nucleotide triphosphate (AMPPNP) bound to a protein surface: external and internal AMPPNP molecules in crystalline N-acetyl-L-glutamate kinase.

artículo científico publicado en 2002

Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy

artículo científico publicado en 2020

Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD

artículo científico publicado en 2018

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the aspartate transcarbamoylase domain of human CAD.

artículo científico publicado en 2013

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD.

artículo científico publicado en 2012

Functional and structural deficiencies of Gemin5 variants associated with neurological disorders

artículo científico publicado en 2022

Gain-of-function mutations in DNMT3A in patients with paraganglioma

artículo científico publicado en 2018

Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

artículo científico publicado en 2021

Molecular physiology of phosphoryl group transfer from carbamoyl phosphate by a hyperthermophilic enzyme at low temperature.

artículo científico publicado en 2002

MuB gives a new twist to target DNA selection.

artículo científico publicado en 2013

MuB is an AAA+ ATPase that forms helical filaments to control target selection for DNA transposition ⬇️

artículo científico publicado el 17 de junio de 2013

N-Acetyl-L-glutamate kinase from Escherichia coli: cloning of the gene, purification and crystallization of the recombinant enzyme and preliminary X-ray analysis of the free and ligand-bound forms

article

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

artículo científico publicado en 2007

Site-directed mutagenesis of Escherichia coli acetylglutamate kinase and aspartokinase III probes the catalytic and substrate-binding mechanisms of these amino acid kinase family enzymes and allows three-dimensional modelling of aspartokinase.

artículo científico publicado en 2003

Site-directed mutagenesis of the regulatory domain of escherichia coli carbamoyl phosphate synthetase identifies crucial residues for allosteric regulation and for transduction of the regulatory signals 1 1Edited by A. R. Fersht

scholarly article by Vicente Fresquet et al published June 2000 in Journal of Molecular Biology

Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis

artículo científico publicado en 2017

Structural bases of feed-back control of arginine biosynthesis, revealed by the structures of two hexameric N-acetylglutamate kinases, from Thermotoga maritima and Pseudomonas aeruginosa

artículo científico publicado en 2005

Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALA

artículo científico publicado en 2016

Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair

artículo científico publicado en 2004

Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD

artículo científico publicado en 2014

Substrate binding and catalysis in carbamate kinase ascertained by crystallographic and site-directed mutagenesis studies: movements and significance of a unique globular subdomain of this key enzyme for fermentative ATP production in bacteria

artículo científico publicado en 2010

The 1.5 A resolution crystal structure of the carbamate kinase-like carbamoyl phosphate synthetase from the hyperthermophilic Archaeon pyrococcus furiosus, bound to ADP, confirms that this thermostable enzyme is a carbamate kinase, and provides [...]

artículo científico publicado en 2000

The Carbamoyl-phosphate Synthetase of Pyrococcus furiosus Is Enzymologically and Structurally a Carbamate Kinase

artículo científico publicado en 1999

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

artículo científico publicado en 2020

The N-terminal domain of MuB protein has striking structural similarity to DNA-binding domains and mediates MuB filament-filament interactions

artículo científico publicado en 2015

The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers

artículo científico publicado en 2011

Towards structural understanding of feedback control of arginine biosynthesis: cloning and expression of the gene for the arginine-inhibited N-acetyl-L-glutamate kinase from Pseudomonas aeruginosa, purification and crystallization of the recombinant

artículo científico publicado en 2002

Two crystal structures of Escherichia coli N-acetyl-L-glutamate kinase demonstrate the cycling between open and closed conformations

artículo científico publicado en 2010

Lista de obras de

A crystallographic glimpse of a nucleotide triphosphate (AMPPNP) bound to a protein surface: external and internal AMPPNP molecules in crystalline N-acetyl-L-glutamate kinase.

Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy

Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the aspartate transcarbamoylase domain of human CAD.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD.

Functional and structural deficiencies of Gemin5 variants associated with neurological disorders

Gain-of-function mutations in DNMT3A in patients with paraganglioma

Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

Molecular physiology of phosphoryl group transfer from carbamoyl phosphate by a hyperthermophilic enzyme at low temperature.

MuB gives a new twist to target DNA selection.

MuB is an AAA+ ATPase that forms helical filaments to control target selection for DNA transposition ⬇️

N-Acetyl-L-glutamate kinase from Escherichia coli: cloning of the gene, purification and crystallization of the recombinant enzyme and preliminary X-ray analysis of the free and ligand-bound forms

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

Site-directed mutagenesis of Escherichia coli acetylglutamate kinase and aspartokinase III probes the catalytic and substrate-binding mechanisms of these amino acid kinase family enzymes and allows three-dimensional modelling of aspartokinase.

Site-directed mutagenesis of the regulatory domain of escherichia coli carbamoyl phosphate synthetase identifies crucial residues for allosteric regulation and for transduction of the regulatory signals 1 1Edited by A. R. Fersht

Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis

Structural bases of feed-back control of arginine biosynthesis, revealed by the structures of two hexameric N-acetylglutamate kinases, from Thermotoga maritima and Pseudomonas aeruginosa

Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALA

Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair

Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD

Substrate binding and catalysis in carbamate kinase ascertained by crystallographic and site-directed mutagenesis studies: movements and significance of a unique globular subdomain of this key enzyme for fermentative ATP production in bacteria

The 1.5 A resolution crystal structure of the carbamate kinase-like carbamoyl phosphate synthetase from the hyperthermophilic Archaeon pyrococcus furiosus, bound to ADP, confirms that this thermostable enzyme is a carbamate kinase, and provides [...]

The Carbamoyl-phosphate Synthetase of Pyrococcus furiosus Is Enzymologically and Structurally a Carbamate Kinase

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

The N-terminal domain of MuB protein has striking structural similarity to DNA-binding domains and mediates MuB filament-filament interactions

The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers

Towards structural understanding of feedback control of arginine biosynthesis: cloning and expression of the gene for the arginine-inhibited N-acetyl-L-glutamate kinase from Pseudomonas aeruginosa, purification and crystallization of the recombinant

Two crystal structures of Escherichia coli N-acetyl-L-glutamate kinase demonstrate the cycling between open and closed conformations