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Lista de obras de C. Oliver Kappe

5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques.

artículo científico publicado en 2007

A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)Phenyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling

artículo científico publicado en 2012

A continuous-flow protocol for light-induced benzylic fluorinations

artículo científico publicado en 2014

A critical assessment of the specific role of microwave irradiation in the synthesis of ZnO micro- and nanostructured materials

scientific article published on 27 March 2012

A high-throughput platform for low-volume high-temperature/pressure sealed vessel solvent extractions

scientific article published on 17 September 2011

A novel pathway for the thermolysis of N-nitrosoanthranilates using flash vacuum pyrolysis leading to 7-aminophthalides

artículo científico publicado en 2020

A scalable procedure for light-induced benzylic brominations in continuous flow

artículo científico publicado en 2013

A sequential Ugi multicomponent/Cu-catalyzed azide-alkyne cycloaddition approach for the continuous flow generation of cyclic peptoids.

artículo científico publicado en 2015

A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitorAtazanavir

artículo científico publicado en 2013

A two-step continuous-flow synthesis of N-(2-aminoethyl)acylamides through ring-opening/hydrogenation of oxazolines

artículo científico publicado en 2011

A unified mechanistic view on the Morita-Baylis-Hillman reaction: computational and experimental investigations.

artículo científico publicado en 2010

Activation and deactivation of a chemical transformation by an electromagnetic field: evidence for specific microwave effects in the formation of Grignard reagents

artículo científico publicado en 2011

Amphiphilic polymers based on higher alkylene oxides Synthesis and characterization by different chromatographic techniques.

artículo científico publicado en 2008

An algorithm for the deconvolution of mass spectroscopic patterns in isotope labeling studies. Evaluation for the hydrogen-deuterium exchange reaction in ketones.

artículo científico publicado en 2007

An evaluation of microwave-assisted derivatization procedures using hyphenated mass spectrometric techniques.

artículo científico publicado en 2009

An experimental and computational assessment of acid-catalyzed azide-nitrile cycloadditions

artículo científico publicado en 2012

An investigation of wall effects in microwave-assisted ring-closing metathesis and cyclotrimerization reactions.

artículo científico publicado en 2010

Anthropogenic reaction parameters--the missing link between chemical intuition and the available chemical space.

artículo científico publicado en 2014

Automated library generation using sequential microwave-assisted chemistry. Application toward the Biginelli multicomponent condensation.

artículo científico publicado en 2001

Batch- and Continuous-Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines-A Concise Synthesis of Noroxymorphone.

artículo científico publicado en 2016

Bis(diethylamino)(pentafluorophenyl)phosphane – a Push–Pull Phosphane Available for Coordination.

artículo científico publicado en 2011

Can electromagnetic fields influence the structure and enzymatic digest of proteins? A critical evaluation of microwave-assisted proteomics protocols.

artículo científico publicado en 2012

Catalyst Free Oxytrifluoromethylation of Alkenes via Paired Electrolysis in Organic-Aqueous Media

artículo científico publicado en 2018

Cathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex

scientific article published on 12 September 2019

Chiral Chlorohydrins from the Biocatalyzed Reduction of Chloroketones: Chiral Building Blocks for Antiretroviral Drugs

Click chemistry under non-classical reaction conditions.

scientific article published on 27 July 2009

Combinatorial synthesis of functionalized 1,3-thiazine libraries using a combined polymer-supported reagent/catch-and-release strategy.

artículo científico publicado en 2004

Combined batch and continuous flow procedure to the chemo-enzymatic synthesis of biaryl moiety of Odanacatib

Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals: A Fast and Scalable Protocol for Trifluoromethylation.

artículo científico publicado en 2016

Continuous Flow Synthesis of Terminal Epoxides from Ketones Using in Situ Generated Bromomethyl Lithium

scientific article published on 03 December 2019

Continuous flow generation and reactions of anhydrous diazomethane using a Teflon AF-2400 tube-in-tube reactor.

artículo científico publicado en 2013

Continuous flow organic synthesis under high-temperature/pressure conditions.

scientific article published on June 2010

Continuous flow ozonolysis in a laboratory scale reactor

artículo científico publicado en 2011

Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing the gap towards a fully continuous synthesis of antimalarial drugs

scientific article published on 05 February 2015

Continuous flow synthesis of arylhydrazines via nickel/photoredox coupling of tert-butyl carbazate with aryl halides

artículo científico publicado en 2020

Continuous flow synthesis of α-halo ketones: essential building blocks of antiretroviral agents.

artículo científico publicado en 2014

Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysis

artículo científico publicado en 2014

Continuous multistep synthesis of 2-(azidomethyl)oxazoles.

artículo científico publicado en 2018

Continuous-Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex

artículo científico publicado en 2020

Continuous-Flow Electrophilic Amination of Arenes and Schmidt Reaction of Carboxylic Acids Utilizing the Superacidic Trimethylsilyl Azide/Triflic Acid Reagent System.

artículo científico publicado en 2016

Continuous-Flow Pd-Catalyzed Carbonylation of Aryl Chlorides with Carbon Monoxide at Elevated Temperature and Pressure

scientific article published on 15 January 2019

Continuous-Flow Synthesis of ZIF-8 Biocomposites with Tunable Particle Size

artículo científico publicado en 2020

Continuous-flow Synthesis of Aryl Aldehydes by Pd-catalyzed Formylation of Aryl Bromides Using Carbon Monoxide and Hydrogen

scientific article published on 13 November 2018

Continuous-flow synthesis of CdSe quantum dots: a size-tunable and scalable approach.

artículo científico publicado en 2013

Continuous-flow synthesis of adipic acid from cyclohexene using hydrogen peroxide in high-temperature explosive regimes

artículo científico publicado en 2013

Continuous-flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients.

artículo científico

Controlled microwave heating in modern organic synthesis.

artículo científico publicado en 2004

Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

artículo científico publicado en 2009

Copper-catalyzed C-C coupling of thiol esters and boronic acids under aerobic conditions

artículo científico publicado en 2008

Copper-catalyzed formation of C-O bonds by direct α-C-H bond activation of ethers using stoichiometric amounts of peroxide in batch and continuous-flow formats

artículo científico publicado en 2012

Correction to: The Use of Molecular Oxygen for Liquid Phase Aerobic Oxidations in Continuous Flow

scientific article published on 07 February 2019

Design and Performance Validation of a Conductively Heated Sealed-Vessel Reactor for Organic Synthesis

artículo científico publicado en 2016

Design and construction of an open source-based photometer and its applications in flow chemistry

artículo científico publicado en 2018

Design and evaluation of improved magnetic stir bars for single-mode microwave reactors

artículo científico publicado en 2013

Diazo Strategy for the Synthesis of Pyridazines: Pivotal Impact of the Configuration of the Diazo Precursor on the Process.

artículo científico publicado en 2015

Direct arylation of benzene with aryl bromides using high-temperature/high-pressure process windows: expanding the scope of C-H activation chemistry

artículo científico publicado en 2012

Direct preparation of nitriles from carboxylic acids in continuous flow

artículo científico publicado en 2013

Direct solid-phase synthesis of the beta-amyloid (1-42) peptide using controlled microwave heating.

artículo científico publicado en 2010

Diversity-oriented synthesis of dibenzoazocines and dibenzoazepines via a microwave-assisted intramolecular A(3)-coupling reaction

scientific article published on 01 June 2010

Effect of configuration of 2-vinyldiazocarbonyl compounds on their reactivity: experimental and computational study

artículo científico publicado en 2014

Electrochemical N-Demethylation of 14-Hydroxy Morphinans: Sustainable Access to Opioid Antagonists

scientific article published on 13 August 2020

Electromagnetic simulations of microwave heating experiments using reaction vessels made out of silicon carbide

artículo científico publicado en 2010

Enantioseparation of racemic 4-aryl-3,4-dihydro-2(1H)-pyrimidones on chiral stationary phases based on 3,5-dimethylanilides of N-(4-alkylamino-3,5-dinitro)benzoyl L-alpha-amino acids.

artículo científico publicado en 2003

Flash flow pyrolysis: mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment

artículo científico publicado en 2012

Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies

artículo científico publicado en 2016

HCN on Tap: On-Demand Continuous Production of Anhydrous HCN for Organic Synthesis

artículo científico publicado en 2019

Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors.

artículo científico publicado en 2011

Heterogeneous hydrogenation reactions using a continuous flow high pressure device.

artículo científico publicado en 2005

Heterogeneous versus homogeneous palladium catalysts for ligandless mizoroki-heck reactions: a comparison of batch/microwave and continuous-flow processing.

artículo científico publicado en 2009

High-speed microwave-assisted synthesis of the trifluoromethylpyrazol-derived canonical transient receptor potential (TRPC) channel inhibitor Pyr3.

artículo científico publicado en 2009

High-throughput experimentation platform: parallel microwave chemistry in HPLC/GC vials

artículo científico publicado en 2009

How to measure reaction temperature in microwave-heated transformations.

artículo científico

Hydrazine-mediated reduction of nitro and azide functionalities catalyzed by highly active and reusable magnetic iron oxide nanocrystals.

artículo científico publicado en 2013

Iminopropadienethiones, Ar=N=C=C=C=S

artículo científico publicado en 2001

Immobilized iron oxide nanoparticles as stable and reusable catalysts for hydrazine-mediated nitro reductions in continuous flow.

artículo científico publicado en 2014

In situ generated iron oxide nanocrystals as efficient and selective catalysts for the reduction of nitroarenes using a continuous flow method

Integration of Bromine and Cyanogen Bromide Generators for the Continuous-Flow Synthesis of Cyclic Guanidines.

artículo científico publicado en 2017

Investigating the existence of nonthermal/specific microwave effects using silicon carbide heating elements as power modulators

artículo científico publicado en 2008

Investigation of the Formation of CuInS2Nanoparticles by the Oleylamine Route: Comparison of Microwave-Assisted and Conventional Syntheses

artículo científico publicado en 2011

Lab-scale production of anhydrous diazomethane using membrane separation technology.

artículo científico publicado en 2017

Laboratory-Scale Membrane Reactor for the Generation of Anhydrous Diazomethane.

artículo científico publicado en 2016

Light-Induced C-H Arylation of (Hetero)arenes by In Situ Generated Diazo Anhydrides

scientific article published on 03 August 2015

Mechanistic Insights into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions using Continuous Flow Conditions

scholarly article by Michael Fuchs et al published 15 February 2010 in Advanced Synthesis & Catalysis

Mechanistic insights on azide-nitrile cycloadditions: on the dialkyltin oxide-trimethylsilyl azide route and a new Vilsmeier-Haack-type organocatalyst

artículo científico publicado en 2011

Microwave chemistry in silicon carbide reaction vials: separating thermal from nonthermal effects

artículo científico publicado en 2009

Microwave effects in organic synthesis: myth or reality?

artículo científico publicado en 2012

Microwave-assisted Negishi and Kumada cross-coupling reactions of aryl chlorides

scientific article published on 30 January 2004

Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides

scientific article published on 13 July 2011

Microwave-assisted asymmetric organocatalysis. A probe for nonthermal microwave effects and the concept of simultaneous cooling

scientific article published on 01 February 2007

Microwave-assisted cross-coupling and hydrogenation chemistry by using heterogeneous transition-metal catalysts: an evaluation of the role of selective catalyst heating

artículo científico publicado en 2009

Microwave-assisted forced degradation using high-throughput microtiter platforms

artículo científico publicado en 2011

Microwave-assisted high-throughput acid hydrolysis in silicon carbide microtiter platforms--a rapid and low volume sample preparation technique for total amino acid analysis in proteins and peptides

artículo científico publicado en 2010

Microwave-assisted ring-closing metathesis revisited. On the question of the nonthermal microwave effect

scientific article published on 01 November 2003

Microwave-assisted solution- and solid-phase synthesis of 2-amino-4-arylpyrimidine derivatives

artículo científico publicado en 2007

Microwave-assisted synthesis in water as solvent.

artículo científico publicado en 2007

Microwave-assisted synthesis involving immobilized catalysts.

artículo científico publicado en 2004

Microwave-assisted synthesis of CdSe quantum dots: can the electromagnetic field influence the formation and quality of the resulting nanocrystals?

artículo científico publicado en 2012

Microwave-assisted synthesis of colloidal inorganic nanocrystals.

artículo científico publicado en 2011

Microwave-assisted three-component synthesis of 7-aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxamides and their selective reduction.

artículo científico publicado en 2006

Microwave-enhanced and metal-catalyzed functionalizations of the 4-aryl-dihydropyrimidone template.

artículo científico publicado en 2005

Multigram-scale flow synthesis of the chiral key intermediate of (-)-paroxetine enabled by solvent-free heterogeneous organocatalysis

scientific article published on 18 October 2019

Nonthermal microwave effects revisited: on the importance of internal temperature monitoring and agitation in microwave chemistry.

artículo científico publicado en 2007

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways

artículo científico publicado en 2012

On the energy efficiency of microwave-assisted organic reactions.

artículo científico publicado en 2008

On the importance of simultaneous infrared/fiber-optic temperature monitoring in the microwave-assisted synthesis of ionic liquids.

artículo científico publicado en 2009

On the mechanism of the Dakin-West reaction

artículo científico publicado en 2012

One-pot, multicomponent route to pyrazoloquinolizinones

scientific article published on 27 March 2007

Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

artículo científico publicado en 2020

Palladium(0)-catalyzed, copper(I)-mediated coupling of boronic acids with cyclic thioamides. selective carbon-carbon bond formation for the functionalization of heterocycles

scientific article published on 11 May 2007

Palladium(0)-catalyzed, copper(i)-mediated coupling of cyclic thioamides with alkenylboronic acids, organostannanes, and siloxanes.

artículo científico publicado en 2009

Palladium-catalyzed direct arylation of heteroaromatic compounds: improved conditions utilizing controlled microwave heating

artículo científico publicado en 2011

Parallel microwave chemistry in silicon carbide reactor platforms: an in-depth investigation into heating characteristics

scientific article published on 23 June 2009

Parallel microwave synthesis of 2-styrylquinazolin-4(3H)-ones in a high-throughput platform using HPLC/GC vials as reaction vessels.

artículo científico publicado en 2009

Parallel synthesis of an amide library based on the 6,8-dioxa-3-azabicyclo[3.2.1]octane scaffold by direct aminolysis of methyl esters.

artículo científico publicado en 2007

Rapid formation of triarylphosphines by microwave-assisted transition metal-catalyzed C-p cross-coupling reactions

artículo científico publicado en 2002

Rapid nickel-catalyzed Suzuki-Miyaura cross-couplings of aryl carbamates and sulfamates utilizing microwave heating.

artículo científico publicado en 2011

Rapid preparation of the mitotic kinesin Eg5 inhibitor monastrol using controlled microwave-assisted synthesis

artículo científico publicado en 2007

Rapid solid-phase peptide synthesis using thermal and controlled microwave irradiation

scientific article published on 01 October 2006

Rapid solid-phase synthesis of a calmodulin-binding peptide using controlled microwave irradiation

artículo científico publicado en 2007

Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog.

artículo científico publicado en 2000

Shifting chemical equilibria in flow--efficient decarbonylation driven by annular flow regimes.

artículo científico publicado en 2014

Silicon carbide passive heating elements in microwave-assisted organic synthesis

scientific article published on 01 June 2006

Simulating microwave chemistry in a resistance-heated autoclave made of semiconducting silicon carbide ceramic.

artículo científico publicado en 2013

Singlet-oxygen oxidation of 5-hydroxymethylfurfural in continuous flow.

artículo científico publicado en 2014

Sintered Silicon Carbide: A New Ceramic Vessel Material for Microwave Chemistry in Single‐Mode Reactors ⬇️

artículo científico publicado el 25 de octubre de 2010

Solid-phase synthesis of difficult peptide sequences at elevated temperatures: a critical comparison of microwave and conventional heating technologies

artículo científico publicado en 2008

Stereoconservative Negishi arylation and alkynylation as an efficient approach to enantiopure 2,2'-diarylated 1,1'-binaphthyls

artículo científico publicado en 2004

Structure-activity relationships and molecular docking of novel dihydropyrimidine-based mitotic Eg5 inhibitors.

artículo científico publicado en 2010

Symmetrical bisquinolones via metal-catalyzed cross-coupling and homocoupling reactions.

artículo científico publicado en 2006

Synthesis of 5-substituted 1H-tetrazoles from nitriles and hydrazoic acid by using a safe and scalable high-temperature microreactor approach.

artículo científico publicado en 2010

Synthesis of bisquinolone-based mono- and diphosphine ligands of the Aza-BINAP type.

artículo científico publicado en 2008

TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.

artículo científico publicado en 2015

Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut

artículo científico publicado en 2020

The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow

artículo científico publicado en 2020

The Liebeskind-Srogl C-C cross-coupling reaction.

artículo científico publicado en 2009

The Use of Molecular Oxygen for Liquid Phase Aerobic Oxidations in Continuous Flow

artículo científico publicado en 2018

The Use of Molecular Oxygen in Pharmaceutical Manufacturing: Is Flow the Way to Go?

artículo científico publicado en 2016

The application of "click chemistry" for the decoration of 2(1H)-pyrazinone scaffold: generation of templates.

artículo científico publicado en 2005

The effect of pressure on microwave-enhanced Diels-Alder reactions. A case study

artículo científico publicado en 2003

The impact of microwave synthesis on drug discovery.

artículo científico publicado en 2006

The microwave-to-flow paradigm: translating high-temperature batch microwave chemistry to scalable continuous-flow processes

scientific article published on 20 September 2011

Towards a Scalable Synthesis of 2-Oxabicyclo[2.2.0]hex-5-en-3-one Using Flow Photochemistry

artículo científico publicado en 2019

Traceless solid-phase synthesis of bicyclic dihydropyrimidones using multidirectional cyclization cleavage.

artículo científico publicado en 2002

Tunable carbon-carbon and carbon-sulfur cross-coupling of boronic acids with 3,4-dihydropyrimidine-2-thiones

artículo científico publicado en 2004

Understanding microwave heating effects in single mode type cavities—theory and experiment

article

Unraveling the mysteries of microwave chemistry using silicon carbide reactor technology.

artículo científico

Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor.

artículo científico publicado en 2011

Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids

Visible Light-Promoted Beckmann Rearrangements: Separating Sequential Photochemical and Thermal Phenomena in a Continuous Flow Reactor

scientific article published on 08 March 2019

Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate

artículo científico publicado en 2019

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