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Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways

artículo científico publicado en 2007

Contributions of the RNA-binding and linker domains and RNA structure to the specificity and affinity of the nucleolin RBD12/NRE interaction.

artículo científico publicado en 2004

DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction.

artículo científico publicado en 2016

Flap Endonuclease 1 Mutations A159V and E160D Cause Genomic Instability by Slowing Reaction on Double-Flap Substrates

scientific article published on 05 December 2018

Functional regulation of FEN1 nuclease and its link to cancer

artículo científico publicado el 6 de octubre de 2010

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

artículo científico publicado en 2011

Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases

article

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

artículo científico publicado en 2005

Observation of unpaired substrate DNA in the flap endonuclease-1 active site.

artículo científico publicado en 2013

Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing

artículo científico publicado en 2013

Solution nuclear magnetic resonance probing of cation binding sites on nucleic acids.

artículo científico publicado en 2001

Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target.

artículo científico publicado en 2004

Solution structures of stem-loop RNAs that bind to the two N-terminal RNA-binding domains of nucleolin

artículo científico publicado en 2003

The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis

artículo científico publicado en 2009

The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome

artículo científico publicado en 2011

The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.

artículo científico publicado en 2006

The wonders of flap endonucleases: structure, function, mechanism and regulation.

artículo científico publicado en 2012

Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases

artículo científico publicado en 2012