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Lista de obras de Tim Friede

A Bayesian time-to-event pharmacokinetic model for phase I dose-escalation trials with multiple schedules

artículo científico publicado en 2020

A Comparison of Methods for Adaptive Treatment Selection

article published in 2008

A comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints

artículo científico publicado en 2015

A comparison of subgroup identification methods in clinical drug development: Simulation study and regulatory considerations

artículo científico publicado en 2019

A conditional error function approach for adaptive enrichment designs with continuous endpoints

scientific article published on 07 May 2019

A conditional error function approach for subgroup selection in adaptive clinical trials

artículo científico publicado en 2012

A design-by-treatment interaction model for network meta-analysis and meta-regression with integrated nested Laplace approximations.

artículo científico publicado en 2017

A group-sequential design for clinical trials with treatment selection

article by Nigel Stallard & Tim Friede published 20 December 2008 in Statistics in Medicine

A note on testing for intervention effects on binary responses.

artículo científico publicado en 2006

A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis

scientific article published on 26 August 2010

A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial).

artículo científico publicado en 2017

A studentized permutation test for three-arm trials in the 'gold standard' design ⬇️

artículo científico publicado en 2016

A systematic review identifies shortcomings in the reporting of crossover trials in chronic painful conditions

artículo científico

Adaptive designs for confirmatory clinical trials with subgroup selection.

artículo científico

Adaptive seamless clinical trials using early outcomes for treatment or subgroup selection: Methods, simulation model and their implementation in R

artículo científico publicado en 2020

Adaptive trial designs in diagnostic accuracy research

scientific article published on 27 November 2019

Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα.

artículo científico publicado en 2013

Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome

artículo científico publicado en 2016

An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection

An Unconditional Test for Change Point Detection in Binary Sequences with Applications to Clinical Registries.

artículo científico publicado en 2016

Anticholinergics for urinary symptoms in multiple sclerosis

artículo científico publicado en 2015

Anticholinergics for urinary symptoms in multiple sclerosis

artículo científico publicado en 2009

Assess, compare and enhance the status of Persons with Multiple Sclerosis (MS) in Europe: a European Register for MS.

artículo científico

Assessment of statistical significance and clinical relevance

artículo científico publicado en 2012

Authors’ response: on the role of data, statistics and decisions in a pandemic

artículo científico publicado en 2022

Automated electronic reminders to facilitate primary cardiovascular disease prevention: randomised controlled trial

artículo científico publicado en 2010

Back schools for the treatment of chronic low back pain: possibility of benefit but no convincing evidence after 47 years of research-systematic review and meta-analysis

scientific article published on June 2016

Baseline CSF/Serum-Ratio of Apolipoprotein E and Rate of Differential Decline in Alzheimer's Disease

artículo científico publicado en 2015

Biometrical Journal and Reproducible Research

artículo científico publicado en 2009

Bladder symptoms in multiple sclerosis: a review of pathophysiology and management

artículo científico publicado en 2010

Blinded and unblinded internal pilot study designs for clinical trials with count data

artículo científico publicado en 2013

Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials

artículo científico publicado en 2020

Blinded sample size re-estimation for recurrent event data with time trends

artículo científico publicado en 2013

Blinded sample size re-estimation in three-arm trials with 'gold standard' design.

artículo científico publicado en 2017

Blinded sample size recalculation for clinical trials with normal data and baseline adjusted analysis

artículo científico publicado en 2011

Blinded sample size reestimation for negative binomial regression with baseline adjustment

artículo científico publicado en 2020

Blinded sample size reestimation in event-driven clinical trials: Methods and an application in multiple sclerosis

scientific article published on 16 January 2019

Blinded sample size reestimation with count data: methods and applications in multiple sclerosis

artículo científico publicado en 2010

Blinded sample size reestimation with negative binomial counts in superiority and non-inferiority trials

artículo científico publicado el 5 de agosto de 2010

Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations.

artículo científico publicado en 2016

CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease.

artículo científico publicado en 2014

Calcineurin inhibitor sparing with mycophenolate mofetil in liver transplantion: a systematic review of randomized controlled trials.

artículo científico

Causal inference methods for small non-randomized studies: Methods and an application in COVID-19

artículo científico publicado en 2020

Cerebrospinal fluid apolipoprotein E concentration and progression of Alzheimer's disease.

artículo científico publicado en 2015

Changing EDSS Progression in Placebo Cohorts in Relapsing MS: A Systematic Review and Meta-Regression

artículo científico publicado en 2015

Clinical Trials in Oncology

Clinical presentation of pediatric multiple sclerosis before puberty.

artículo científico publicado en 2013

Clinical trials with nested subgroups: Analysis, sample size determination and internal pilot studies.

artículo científico publicado en 2017

Considerations on what constitutes a 'qualified statistician' in regulatory guidelines

artículo científico publicado en 2011

Contribution to the discussion of “When should meta-analysis avoid making hidden normality assumptions?” A Bayesian perspective

artículo científico publicado en 2018

Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework

artículo científico publicado en 2017

Correction

scholarly article published in Statistics in Medicine

Correction: study protocol: improving patient choice in treating Low back pain (IMPACT - LBP): a randomised controlled trial of a decision support package for use in physical therapy.

artículo científico publicado en 2013

Correction: ‘A conditional error function approach for subgroup selection in adaptive clinical trials’

Cross cultural evaluation of the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) --a mixed methods study

artículo científico publicado en 2013

Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data

artículo científico publicado en 2014

Decreasing longitudinal use of glucocorticosteroids in multiple sclerosis

artículo científico publicado en 2018

Design and analysis of three-arm trials with negative binomially distributed endpoints.

artículo científico publicado en 2015

Design and development of a decision support package for low back pain.

artículo científico publicado en 2014

Design and semiparametric analysis of non-inferiority trials with active and placebo control for censored time-to-event data

artículo científico publicado en 2013

Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: an application in multiple sclerosis

artículo científico publicado en 2011

Development and external validation of prediction models to predict implantable cardioverter-defibrillator efficacy in primary prevention of sudden cardiac death

artículo científico publicado en 2021

Development of oral immunomodulatory agents in the management of multiple sclerosis

artículo científico publicado en 2011

Differences in the Reponses to Apheresis Therapy of Patients With 3 Histopathologically Classified Immunopathological Patterns of Multiple Sclerosis

artículo científico publicado en 2018

Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy

article

Discrete Approximation of a Mixture Distribution via Restricted Divergence ⬇️

Do we consent to rules of consent and confidentiality?

artículo científico publicado en 2017

Dose-finding methods for Phase I clinical trials using pharmacokinetics in small populations

artículo científico publicado en 2017

Doxycycline in early CJD: a double-blinded randomised phase II and observational study.

artículo científico publicado en 2016

Dynamically borrowing strength from another study through shrinkage estimation

scientific article published on 01 March 2019

EFSPI/PSI working group on data sharing: accessing and working with pharmaceutical clinical trial patient level datasets - a primer for academic researchers

artículo científico publicado en 2016

Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy

artículo científico publicado en 2011

Economic Analysis of a Telemedicine Intervention to Improve Glycemic Control in Patients with Diabetes Mellitus

article

Educating orally anticoagulated patients in drug safety: a cluster-randomized study in general practice

artículo científico publicado en 2014

Effect and Feasibility of Controlled Rewarming After Moderate Hypothermia in Stroke Patients With Malignant Infarction of the Middle Cerebral Artery

artículo científico publicado en 2001

Effect of the left internal mammary artery to the left anterior descending artery on mortality and morbidity after combined coronary and valve operations.

artículo científico publicado en 2005

Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis.

artículo científico publicado en 2014

Evaluation of dysphagia by novel real-time MRI.

artículo científico publicado en 2016

Evidence synthesis for count distributions based on heterogeneous and incomplete aggregated data.

artículo científico publicado en 2015

Exact change point detection with improved power in small-sample binomial sequences

artículo científico publicado en 2020

Explaining temporal trends in annualised relapse rates in placebo groups of randomised controlled trials in relapsing multiple sclerosis: systematic review and meta-regression.

artículo científico

Exploring changes in treatment effects across design stages in adaptive trials.

artículo científico

Factors Influencing the Frequency of Airway Infections in Underage Refugees: A Retrospective, Cross Sectional Study

scientific article published on 18 September 2020

Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial

artículo científico publicado en 2020

First international meeting of early career investigators: Current opportunities, challenges and horizon in critical care nutrition research

artículo científico publicado en 2020

Flexible selection of a single treatment incorporating short-term endpoint information in a phase II/III clinical trial

artículo científico publicado en 2015

Gender Differences in Appropriate Shocks and Mortality among Patients with Primary Prophylactic Implantable Cardioverter-Defibrillators: Systematic Review and Meta-Analysis

artículo científico publicado en 2016

Group sequential designs for negative binomial outcomes

scientific article published on 17 May 2018

Group sequential designs with robust semiparametric recurrent event models

artículo científico publicado en 2018

Guest Editors' Introduction

artículo científico publicado en 2014

Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few studies ⬇️

artículo científico publicado en 2015

Impact of COVID-19 outbreak on regional STEMI care in Germany

scientific article published on 16 July 2020

Impact of community neonatal services: a multicentre survey.

artículo científico publicado en 2002

Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial.

artículo científico publicado en 2018

Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology

artículo científico

Independent academic Data Monitoring Committees for clinical trials in cardiovascular and cardiometabolic diseases

artículo científico publicado en 2017

Insights into permanent pacemaker implantation following TAVR in a real-world cohort

scientific article published in PLoS ONE

Interleukin-2 receptor antagonists for pediatric liver transplant recipients: a systematic review and meta-analysis of controlled studies.

artículo científico

Intervention effects in observational survival studies with an application in total hip replacements.

artículo científico publicado en 2003

Is there a role for statistics in artificial intelligence?

artículo científico publicado en 2021

Memorandum "Open Metadata". Open Access to Documentation Forms and Item Catalogs in Healthcare

artículo científico publicado en 2015

Meta-analysis of few small studies in orphan diseases ⬇️

artículo científico publicado en 2016

Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases.

artículo científico publicado en 2016

Methods for evidence synthesis in the case of very few studies

article

Methods for identification and confirmation of targeted subgroups in clinical trials: A systematic review

artículo científico publicado en 2016

Modeling the recovery from depressive illness by an exponential model with mixed effects.

artículo científico publicado en 2000

Modelling and sample size reestimation for longitudinal count data with incomplete follow up.

artículo científico publicado en 2017

Monitoring of 30 marker candidates in early Parkinson disease as progression markers

artículo científico publicado en 2016

Multifocal ERG with confocal scanning laser ophthalmoscope. Comparison with monitor simulation

artículo científico publicado en 2002

Multiple sclerosis registries in Europe – results of a systematic survey

artículo científico publicado en 2014

On estimands and the analysis of adverse events in the presence of varying follow-up times within the benefit assessment of therapies

artículo científico publicado en 2018

On weakly informative prior distributions for the heterogeneity parameter in Bayesian random‐effects meta‐analysis

artículo científico publicado en 2021

Optimal choice of the number of treatments to be included in a clinical trial

artículo científico publicado en 2009

Over three decades study populations in progressive multiple sclerosis have become older and more disabled, but have lower on-trial progression rates: A systematic review and meta-analysis of 43 randomised placebo-controlled trials

scientific article published on 24 August 2018

Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale-29.

artículo científico publicado en 2017

Patients characteristics influencing the longitudinal utilization of steroids in multiple sclerosis--an observational study

artículo científico

Peripheral Nerve Dysfunction in Middle-Aged Subjects Born with Thalidomide Embryopathy

artículo científico publicado en 2016

Perspectives on the Use of Adaptive Designs in Clinical Trials. Part II. Panel Discussion

artículo científico publicado en 2010

Pharmacological Approaches to the Management of Secondary Progressive Multiple Sclerosis

artículo científico publicado en 2017

Pilot of "Families for Health": community-based family intervention for obesity

artículo científico publicado en 2008

Plasma prion protein concentration and progression of Alzheimer disease

artículo científico publicado en 2014

Point and Interval Estimators of the Target Dose in Clinical Dose-Finding Studies with Active Control.

artículo científico publicado en 2014

Practice nursed-based, individual and video-assisted patient education in oral anticoagulation--protocol of a cluster-randomized controlled trial

artículo científico publicado en 2011

Precise variant interpretation, phenotype ascertainment and genotype-phenotype correlation of children in the EARLY PRO-TECT Alport trial

artículo científico publicado en 2020

Predicting menstrual bleeding patterns with levonorgestrel-releasing intrauterine systems

scientific article published on 03 December 2020

Predictors of mortality and ICD shock therapy in primary prophylactic ICD patients-A systematic review and meta-analysis

artículo científico publicado en 2017

Primum non nocere: shared informed decision making in low back pain--a pilot cluster randomised trial

artículo científico publicado en 2014

Pro-active call center treatment support (PACCTS) to improve glucose control in type 2 diabetes: a randomized controlled trial

artículo científico publicado en 2005

Quantitative approaches underpinning decision making

scientific article published on 28 July 2019

Random-effects meta-analysis of few studies involving rare events

artículo científico publicado en 2019

Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis.

artículo científico publicado en 2018

Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis

artículo científico publicado en 2005

Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation

article

Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype

artículo científico publicado en 2011

Reclassifying Acute Respiratory Distress Syndrome.

artículo científico publicado en 2018

Reducing antibiotic use for uncomplicated urinary tract infection in general practice by treatment with uva-ursi (REGATTA) - a double-blind, randomized, controlled comparative effectiveness trial.

artículo científico publicado en 2018

Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies with an Application to Multiple Sclerosis

article

Regression to the mean and predictors of MRI disease activity in RRMS placebo cohorts--is there a place for baseline-to-treatment studies in MS?

artículo científico publicado en 2015

Repeating noninvasive risk stratification improves prediction of outcome in ICD patients

artículo científico publicado en 2020

Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes. ⬇️

artículo científico publicado en 2011

Reporting and interpretation of subgroup analyses in heart failure randomized controlled trials

artículo científico publicado en 2020

Results of medial patellofemoral ligament reconstruction compared with trochleoplasty plus individual extensor apparatus balancing in patellar instability caused by severe trochlear dysplasia: a systematic review and meta-analysis

artículo científico publicado en 2016

Robustness of methods for blinded sample size re-estimation with overdispersed count data.

artículo científico publicado en 2013

Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker

artículo científico publicado en 2018

Safety relevant knowledge of orally anticoagulated patients without self-monitoring: a baseline survey in primary care.

artículo científico publicado en 2014

Sample size re-estimation for clinical trials with longitudinal negative binomial counts including time trends

artículo científico publicado en 2018

Sample size re-estimation incorporating prior information on a nuisance parameter

artículo científico publicado en 2017

Sample size reassessment in non-inferiority trials. Internal pilot study designs with ANCOVA.

artículo científico publicado en 2010

Sample size recalculation in multicenter randomized controlled clinical trials based on noncomparative data

artículo científico publicado en 2020

Scientific Versus Experiential Evidence: Discourse Analysis of the Chronic Cerebrospinal Venous Insufficiency Debate in a Multiple Sclerosis Forum

artículo científico publicado en 2015

Semi-parametric analysis of overdispersed count and metric data with varying follow-up times: Asymptotic theory and small sample approximations

artículo científico publicado en 2018

Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis

artículo científico publicado en 2016

Sex differences in outcomes of primary prevention implantable cardioverter defibrillator therapy: combined registry data from eleven European countries.

artículo científico publicado en 2017

Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial

artículo científico publicado en 2020

Software tools for implementing simulation studies in adaptive seamless designs: introducing R package ASD.

artículo científico publicado en 2011

Sources of information and behavioral patterns in online health forums: observational study

artículo científico publicado en 2014

Spline-based procedures for dose-finding studies with active control.

artículo científico publicado en 2014

Strategies to reduce antibiotic use in women with uncomplicated urinary tract infection in primary care: protocol of a systematic review and meta-analysis including individual patient data

artículo científico publicado en 2020

Study protocol: improving patient choice in treating low back pain (IMPACT-LBP): a randomised controlled trial of a decision support package for use in physical therapy

artículo científico publicado en 2011

Survival analysis for AdVerse events with VarYing follow-up times (SAVVY): Rationale and statistical concept of a meta-analytic study

artículo científico publicado en 2020

Symptomatology and symptomatic treatment in multiple sclerosis: Results from a nationwide MS registry

artículo científico publicado en 2018

Systematic review of randomized controlled trials of clinical prediction rules for physical therapy in low back pain.

artículo científico publicado en 2013

Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis.

artículo científico publicado en 2011

Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions

artículo científico publicado en 2016

T-wave loop area from a pre-implant 12-lead ECG is associated with appropriate ICD shocks

artículo científico publicado en 2017

Telephone peer-delivered intervention for diabetes motivation and support: the telecare exploratory RCT.

artículo científico publicado en 2008

The impact of smoking cessation on multiple sclerosis disease progression

scientific article published on 01 May 2022

Therapeutic Apheresis in Pediatric Patients with Acute CNS Inflammatory Demyelinating Disease

artículo científico publicado en 2013

Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: a systematic review and meta-analysis.

artículo científico

Toward evidence-based diagnosis of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform

artículo científico publicado en 2017

Treatment for fatigue in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND)

artículo científico publicado en 2014

Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease

artículo científico publicado en 2018

Trends in annualized relapse rates in relapsing-remitting multiple sclerosis and consequences for clinical trial design.

artículo científico publicado en 2011

Trochleoplasty versus MPFL-Reconstruction in Severe Trochlear Dysplasia. A Systematic Review and Meta-Analysis.

artículo científico publicado en 2016

Using phase II data for the analysis of phase III studies: An application in rare diseases. ⬇️

artículo científico publicado en 2017

Validation and Reliability of the Neuropathic Pain Scale (NPS) in Multiple Sclerosis

scientific article published on 01 July 2007

Warwick-Edinburgh Mental Well-being Scale (WEMWBS): validated for teenage school students in England and Scotland. A mixed methods assessment

artículo científico publicado en 2011

Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis

artículo científico publicado en 2014

dfpk: An R-package for Bayesian dose-finding designs using pharmacokinetics (PK) for phase I clinical trials.

artículo científico publicado en 2018

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