Lista de obras - Brent A Appleton - Dominio Público Uruguay

2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors

artículo científico publicado en 2014

A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients

artículo científico publicado en 2011

A specificity map for the PDZ domain family

artículo científico publicado en 2008

A structural portrait of the PDZ domain family

artículo científico publicado en 2014

Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families.

artículo científico publicado en 2006

Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44

artículo científico publicado en 2005

Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

artículo científico publicado en 2017

Design and synthesis of potent RSK inhibitors

scientific article published on 21 August 2018

Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity

artículo científico publicado en 2018

Discovery of Potent and Selective RSK Inhibitors as Biological Probes

artículo científico publicado en 2015

Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma

artículo científico publicado en 2015

Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design.

artículo científico publicado en 2016

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1

artículo científico publicado en 2014

Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.

artículo científico publicado en 2018

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.

artículo científico publicado en 2017

Inhibition of Wnt signaling by Dishevelled PDZ peptides

artículo científico publicado en 2009

Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes

scientific article published on 20 August 2018

Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers

artículo científico publicado en 2014

Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44

artículo científico publicado en 2004

Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit.

artículo científico publicado en 2004

Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3

artículo científico publicado en 2007

Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain

artículo científico publicado en 2007

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

artículo científico publicado en 2007

The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer.

artículo científico publicado en 2004

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

artículo científico publicado en 2009

Lista de obras de Brent A Appleton

2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors

A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients

A specificity map for the PDZ domain family

A structural portrait of the PDZ domain family

Convergent and divergent ligand specificity among PDZ domains of the LAP and zonula occludens (ZO) families.

Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44

Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

Design and synthesis of potent RSK inhibitors

Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity

Discovery of Potent and Selective RSK Inhibitors as Biological Probes

Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma

Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design.

Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1

Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria.

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.

Inhibition of Wnt signaling by Dishevelled PDZ peptides

Mathematical and Structural Characterization of Strong Nonadditive Structure-Activity Relationship Caused by Protein Conformational Changes

Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers

Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44

Specific residues in the connector loop of the human cytomegalovirus DNA polymerase accessory protein UL44 are crucial for interaction with the UL54 catalytic subunit.

Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3

Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain

Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer.

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site