Lista de obras - Dolores Gonzalez-Pacanowska

2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.

artículo científico publicado en 2012

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

artículo científico publicado en 2003

3-Hydroxy-3-methyl-glutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: subcellular localization and kinetic properties

artículo científico publicado en 1998

A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in <i>Trypanosoma brucei</i>

artículo científico publicado en 2021

A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments

scientific article published on 01 July 1996

A novel calcium-dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major.

artículo científico publicado en 2004

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

scientific article published on 01 July 2006

Amplification of the H locus in Leishmania infantum.

artículo científico publicado en 1994

Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.

artículo científico publicado en 2011

Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli

artículo científico publicado en 1999

Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.

artículo científico publicado en 2003

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

artículo científico publicado en 2016

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei ⬇️

artículo científico publicado el 14 de octubre de 2013

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei

artículo científico publicado en 2016

Changes in chick liver and brain mevalonate kinase, mevalonate-5-phosphate kinase and mevalonate-5-pyrophosphate decarboxylase during development

artículo científico publicado en 1984

Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

artículo científico publicado en 2000

Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.

artículo científico publicado en 2002

Cholesterol synthesis and esterification in isolated enterocytes: regulation by cholesterol and cholestyramine feeding

scientific article published on 01 June 1993

Cloning and expression of the dihydrofolate reductase-thymidylate synthase gene from Trypanosoma cruzi

artículo científico publicado en 1994

Co-existence of circular and multiple linear amplicons in methotrexate-resistantLeishmania ⬇️

artículo científico publicado el 11 de agosto de 1995

Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major

artículo científico publicado en 2007

Crystallization and preliminary X-ray diffraction of Trypanosoma cruzi dUTPase

scientific article published on 01 February 1999

DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools

scientific article published on 03 August 2019

Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme.

artículo científico publicado en 2008

Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.

artículo científico publicado en 2008

Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.

artículo científico publicado en 2005

Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase

artículo científico publicado en 2011

Differential response of chick liver and brain membranes to short ethanol treatment.

artículo científico publicado en 1986

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

artículo científico publicado en 2016

Distribution of 3-hydroxy-3-methylglutaryl-CoA reductase in isolated villus and crypt cells of chick duodenum, jejunum and ileum

artículo científico publicado en 1989

Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase

artículo científico publicado en 2007

Embryonic development of mevalonate metabolism by sterol and nonsterol pathways in chick brain and liver

artículo científico publicado en 1986

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

artículo científico publicado en 2012

Evaluation of azasterols as anti-parasitics.

artículo científico publicado en 2006

Evolution of 3-hydroxy-3-methylglutaryl-CoA reductase and microsomal membrane fluidity throughout chick embryo development

artículo científico publicado en 1985

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

artículo científico publicado en 2010

Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

artículo científico publicado en 2015

Expression and characterization of the Trypanosoma cruzi dihydrofolate reductase domain

artículo científico publicado en 1996

Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.

artículo científico publicado en 2006

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

artículo científico publicado en 2014

Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.

artículo científico publicado en 2009

In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives

artículo científico publicado en 2014

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

artículo científico publicado en 2012

Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei.

artículo científico publicado en 2017

Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.

artículo científico publicado en 2008

Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.

artículo científico publicado en 2013

Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.

artículo científico publicado en 2011

Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase.

artículo científico publicado en 2008

Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives

artículo científico publicado en 2007

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

artículo científico publicado en 2002

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

artículo científico publicado en 2009

MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii

artículo científico publicado en 2014

Mevalonate 5-pyrophosphate decarboxylase in isolated villus and crypt cells of chick intestine

artículo científico publicado en 1988

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

artículo científico publicado en 2014

New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.

artículo científico publicado en 2006

New crystal forms of Trypanosoma cruzi dUTPase

artículo científico publicado en 2001

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei

artículo científico

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

artículo científico publicado en 2004

Novel inhibitors of Leishmanial dihydrofolate reductase.

artículo científico publicado en 2001

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

artículo científico publicado en 2001

On the catalytic mechanism of dimeric dUTPases

artículo científico publicado en 2013

Opening Opportunities for New Drugs Against Neglected Diseases

artículo científico publicado en 2008

Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.

artículo científico publicado en 2005

Overview of the role of kinetoplastid surface carbohydrates in infection and host cell invasion: prospects for therapeutic intervention

artículo científico publicado en 2019

Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives

artículo científico publicado en 2007

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.

artículo científico publicado en 2010

Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids.

artículo científico publicado en 2000

Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.

artículo científico publicado en 2005

Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.

artículo científico publicado en 2012

Quantitative role of different embryonic tissues in mevalonate metabolism by sterol and nonsterol pathways. Relationship with enzyme activities of cholesterogenesis

artículo científico publicado en 1986

Quinuclidine derivatives as potential antiparasitics

artículo científico publicado en 2007

Regulation of mevalonate 5-pyrophosphate decarboxylase in HeLa cells. Inhibition of enzymatic protein synthesis by serum lipoproteins

scientific article published on 01 July 1997

Relationship between changes in free cholesterol and pyrophosphomevalonate decarboxylase activity during myelination

artículo científico publicado en 1983

Role of mevalonate-5-pyrophosphate decarboxylase in the regulation of chick intestinal cholesterogenesis

artículo científico publicado en 1985

SQ109, a new drug lead for Chagas disease

artículo científico publicado en 2015

Squalene synthase as a target for Chagas disease therapeutics

artículo científico publicado en 2014

Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major

artículo científico publicado en 2015

Structural and thermodynamic basis of the inhibition ofLeishmania majorfarnesyl diphosphate synthase by nitrogen-containing bisphosphonates

artículo científico publicado en 2014

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

artículo científico publicado en 2010

Structures of adenosine kinase from Trypanosoma brucei brucei

artículo científico publicado en 2014

Studies on the diurnal rhythm of mevalonate metabolism by sterol and nonsterol pathways and of mevalonate-activating enzymes

artículo científico publicado en 1985

Surface Glycans: A Therapeutic Opportunity for Kinetoplastid Diseases.

artículo científico publicado en 2017

Surface Glycans: A Therapeutic Opportunity for Kinetoplastid Diseases: (Trends in Parasitology 2017).

artículo científico publicado en 2017

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

artículo científico publicado en 2012

Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase

artículo científico publicado en 2002

Synthesis of sterols by chick brain and liver during embryonic development.

artículo científico publicado en 1985

The Crystal Structure of the Leishmania major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, dUMP, and Deoxyuridine ⬇️

artículo científico publicado en 2011

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

scientific journal article

The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold

artículo científico publicado en 2004

The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases

artículo científico publicado en 2004

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

artículo científico publicado en 1999

Thermodynamic analysis of the binding of 5-fluoro-2'-deoxyuridine 5'-monophosphate to thymidylate synthase over a range of temperatures

artículo científico publicado en 1995

Thermodynamic characterization of the binding of dCMP to the Asn229Asp mutant of thymidylate synthase

scientific article published on 01 June 1997

Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents ⬇️

artículo científico publicado el 29 de octubre de 2011

Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity

artículo científico publicado en 2013

Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.

artículo científico publicado en 2004

Trypanosomal dUTPases as potential targets for drug design.

artículo científico publicado en 2001

Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.

artículo científico publicado en 2012

Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity

scientific article published on 03 December 2019

β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

artículo científico publicado en 2011

Lista de obras de Dolores Gonzalez-Pacanowska

2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

3-Hydroxy-3-methyl-glutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: subcellular localization and kinetic properties

A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in <i>Trypanosoma brucei</i>

A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments

A novel calcium-dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major.

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

Amplification of the H locus in Leishmania infantum.

Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.

Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli

Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei ⬇️

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei

Changes in chick liver and brain mevalonate kinase, mevalonate-5-phosphate kinase and mevalonate-5-pyrophosphate decarboxylase during development

Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.

Cholesterol synthesis and esterification in isolated enterocytes: regulation by cholesterol and cholestyramine feeding

Cloning and expression of the dihydrofolate reductase-thymidylate synthase gene from Trypanosoma cruzi

Co-existence of circular and multiple linear amplicons in methotrexate-resistantLeishmania ⬇️

Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major

Crystallization and preliminary X-ray diffraction of Trypanosoma cruzi dUTPase

DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools

Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme.

Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.

Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.

Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase

Differential response of chick liver and brain membranes to short ethanol treatment.

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

Distribution of 3-hydroxy-3-methylglutaryl-CoA reductase in isolated villus and crypt cells of chick duodenum, jejunum and ileum

Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase

Embryonic development of mevalonate metabolism by sterol and nonsterol pathways in chick brain and liver

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

Evaluation of azasterols as anti-parasitics.

Evolution of 3-hydroxy-3-methylglutaryl-CoA reductase and microsomal membrane fluidity throughout chick embryo development

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

Expression and characterization of the Trypanosoma cruzi dihydrofolate reductase domain

Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.

In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei.

Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.

Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.

Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.

Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase.

Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii

Mevalonate 5-pyrophosphate decarboxylase in isolated villus and crypt cells of chick intestine

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.

New crystal forms of Trypanosoma cruzi dUTPase

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

Novel inhibitors of Leishmanial dihydrofolate reductase.

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

On the catalytic mechanism of dimeric dUTPases

Opening Opportunities for New Drugs Against Neglected Diseases

Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.

Overview of the role of kinetoplastid surface carbohydrates in infection and host cell invasion: prospects for therapeutic intervention

Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.

Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids.

Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.

Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.

Quantitative role of different embryonic tissues in mevalonate metabolism by sterol and nonsterol pathways. Relationship with enzyme activities of cholesterogenesis

Quinuclidine derivatives as potential antiparasitics

Regulation of mevalonate 5-pyrophosphate decarboxylase in HeLa cells. Inhibition of enzymatic protein synthesis by serum lipoproteins

Relationship between changes in free cholesterol and pyrophosphomevalonate decarboxylase activity during myelination

Role of mevalonate-5-pyrophosphate decarboxylase in the regulation of chick intestinal cholesterogenesis

SQ109, a new drug lead for Chagas disease

Squalene synthase as a target for Chagas disease therapeutics

Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major

Structural and thermodynamic basis of the inhibition ofLeishmania majorfarnesyl diphosphate synthase by nitrogen-containing bisphosphonates

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase