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Lista de obras de Wolf-Dietrich Hardt

'Blooming' in the gut: how dysbiosis might contribute to pathogen evolution

artículo científico publicado en 2013

A Burkholderia pseudomallei type III secreted protein, BopE, facilitates bacterial invasion of epithelial cells and exhibits guanine nucleotide exchange factor activity ⬇️

artículo científico publicado en 2003

A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion

artículo científico publicado en 2016

A mouse model for S. typhimurium-induced enterocolitis

artículo científico publicado en 2005

A novel phage element of Salmonella enterica serovar Enteritidis P125109 contributes to accelerated type III secretion system 2-dependent early inflammation kinetics in a mouse colitis model

artículo científico publicado en 2012

A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants

artículo científico publicado en 2021

A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria.

artículo científico publicado en 1997

A simple screen to identify promoters conferring high levels of phenotypic noise

artículo científico publicado en 2008

A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage.

artículo científico publicado en 1998

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

artículo científico publicado en 2019

Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation

artículo científico publicado en 2010

Accelerated type III secretion system 2-dependent enteropathogenesis by a Salmonella enterica serovar enteritidis PT4/6 strain

artículo científico publicado en 2009

Amino acids of the bacterial toxin SopE involved in G nucleotide exchange on Cdc42.

artículo científico publicado en 2003

An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection

artículo científico publicado en 2016

An externally modulated, noise-driven switch for the regulation of SPI1 in Salmonella enterica serovar Typhimurium.

artículo científico publicado en 2010

Antibiotic treatment selects for cooperative virulence of Salmonella typhimurium

artículo científico publicado en 2014

Antibiotics: Homed to the hideout

artículo científico publicado en 2015

Antimicrobial resistance: Survival by reversible resistance.

artículo científico publicado en 2016

Autophagy Proteins Promote Repair of Endosomal Membranes Damaged by the Salmonella Type Three Secretion System 1.

artículo científico publicado en 2015

Bacterial colitis increases susceptibility to oral prion disease

artículo científico publicado en 2009

Bacteriophage-encoded type III effectors in Salmonella enterica subspecies 1 serovar Typhimurium

artículo científico publicado en 2005

Barcoded Consortium Infections Resolve Cell Type-Dependent Salmonella enterica Serovar Typhimurium Entry Mechanisms

artículo científico publicado en 2019

Bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake

artículo científico publicado en 2011

Basic Processes in Salmonella-Host Interactions: Within-Host Evolution and the Transmission of the Virulent Genotype.

artículo científico publicado en 2017

Bistable expression of virulence genes in salmonella leads to the formation of an antibiotic-tolerant subpopulation

artículo científico publicado en 2014

CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis.

artículo científico publicado en 2015

CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis

Caspase-1 Has Both Proinflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1 and IL-18

artículo científico publicado en 2012

Caspase-1 activation via Rho GTPases: a common theme in mucosal infections?

artículo científico publicado en 2010

Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment

artículo científico publicado en 2014

Characterization of SprA, an AraC-like transcriptional regulator encoded within the Salmonella typhimurium pathogenicity island 1.

artículo científico publicado en 1999

Characterization of effector proteins translocated via the SPI1 type III secretion system of Salmonella typhimurium

artículo científico publicado en 2002

Cholera toxin-B (ctxB) antigen expressing Salmonella Typhimurium polyvalent vaccine exerts protective immune response against Vibrio cholerae infection

artículo científico publicado en 2015

Chronic Salmonella enterica serovar Typhimurium-induced colitis and cholangitis in streptomycin-pretreated Nramp1+/+ mice

artículo científico publicado en 2006

Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria

artículo científico publicado en 2009

Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin

artículo científico publicado en 2005

Consequences of Epithelial Inflammasome Activation by Bacterial Pathogens

artículo científico publicado en 2017

Contribution of structural elements to Thermus thermophilus ribonuclease P RNA function ⬇️

artículo científico publicado el 17 de octubre de 1994

Correction: Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis

artículo científico publicado en 2015

Dangerous liaisons between a microbe and the prion protein

artículo científico publicado en 2003

Definitions and guidelines for research on antibiotic persistence

scientific article published on 01 July 2019

Deletion of invH gene in Salmonella enterica serovar Typhimurium limits the secretion of Sip effector proteins

artículo científico publicado en 2012

Elucidating Host-Microbe Interactions in vivo by Studying Population Dynamics Using Neutral Genetic Tags

scientific article published on 15 September 2020

Enchained growth and cluster dislocation: a possible mechanism for microbiota homeostasis

Enhanced CellClassifier: a multi-class classification tool for microscopy images

artículo científico publicado en 2010

Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa

artículo científico publicado en 2014

Epitope-Tagged Autotransporters as Single-Cell Reporters for Gene Expression by a Salmonella Typhimurium wbaP Mutant

artículo científico publicado en 2016

Erratum to: gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens

artículo científico publicado en 2015

Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice

artículo científico publicado en 2019

Evolution of bacterial virulence

artículo científico publicado en 2017

Evolutionary causes and consequences of bacterial antibiotic persistence

artículo científico publicado en 2020

Experimental approaches to phenotypic diversity in infection

artículo científico

Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice

artículo científico publicado en 2004

Gel retardation analysis ofE.coliM1 RNA-tRNA complexes ⬇️

artículo científico publicado el 25 de julio de 1993

Genomic, Proteomic and Phenotypic Heterogeneity in HeLa Cells across Laboratories: Implications for Reproducibility of Research Results

Germ-free and microbiota-associated mice yield small intestinal epithelial organoids with equivalent and robust transcriptome/proteome expression phenotypes

scientific article published on 18 February 2020

Granulocytes impose a tight bottleneck upon the gut luminal pathogen population during Salmonella typhimurium colitis

artículo científico publicado en 2014

Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition

article

Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae

artículo científico publicado en 2012

Hierarchical effector protein transport by the Salmonella Typhimurium SPI-1 type III secretion system

artículo científico publicado en 2008

High-avidity IgA protects the intestine by enchaining growing bacteria

artículo científico publicado en 2017

IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection

artículo científico publicado en 2016

IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium

artículo científico publicado en 2010

Impact of Salmonella Typhimurium DT104 virulence factors invC and sseD on the onset, clinical course, colonization patterns and immune response of porcine salmonellosis.

artículo científico publicado en 2007

In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin

artículo científico publicado en 2010

Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract

artículo científico publicado en 2015

Infected Cell in Trouble: Bystander Cells Ring the Bell ⬇️

artículo científico publicado el 24 de noviembre de 2010

Inflammasomes of the intestinal epithelium

artículo científico

Inflammation boosts bacteriophage transfer between Salmonella spp.

artículo científico publicado en 2017

Inflammatory bactericidal lectin RegIIIβ: Friend or Foe for the host?

artículo científico publicado en 2017

Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism

scientific article published on July 2009

Intestinal lamina propria dendritic cell subsets have different origin and functions.

artículo científico publicado en 2009

InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium

artículo científico publicado en 2004

Journal club

scientific article published on 01 June 2009

Lack of mismatch correction facilitates genome evolution in mycobacteria

artículo científico publicado en 2004

Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria

artículo científico publicado en 2010

Live attenuated S. Typhimurium vaccine with improved safety in immuno-compromised mice

artículo científico publicado en 2012

Low-oxygen tensions found in Salmonella-infected gut tissue boost Salmonella replication in macrophages by impairing antimicrobial activity and augmenting Salmonella virulence

artículo científico publicado en 2015

Lymph node colonization dynamics after oral Salmonella Typhimurium infection in mice

artículo científico publicado en 2013

Mechanisms controlling pathogen colonization of the gut.

artículo científico publicado en 2010

Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis

artículo científico publicado en 2008

Microbiota stability in healthy individuals after single-dose lactulose challenge - a randomized controlled study

Microbiota stability in healthy individuals after single-dose lactulose challenge-A randomized controlled study

scientific article published in PLoS ONE

Microbiota-derived hydrogen fuels Salmonella typhimurium invasion of the gut ecosystem

artículo científico publicado en 2013

Molecular dissection of Salmonella-induced membrane ruffling versus invasion

artículo científico publicado en 2009

Motility allows S. Typhimurium to benefit from the mucosal defence

artículo científico publicado en 2008

Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract.

artículo científico publicado en 2019

Multi-omic measurements of heterogeneity in HeLa cells across laboratories

artículo científico publicado en 2019

Myeloperoxidase targets oxidative host attacks to Salmonella and prevents collateral tissue damage

artículo científico publicado en 2017

NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium

artículo científico publicado en 2013

Near surface swimming of Salmonella Typhimurium explains target-site selection and cooperative invasion

artículo científico publicado en 2012

O-antigen-negative Salmonella enterica serovar Typhimurium is attenuated in intestinal colonization but elicits colitis in streptomycin-treated mice

artículo científico publicado en 2009

Occurrence of sopE gene and its phenotypic expression among different serovars of Salmonella enterica isolated from man and animals.

artículo científico publicado en 2005

Outer membrane permeabilization is an essential step in the killing of gram-negative bacteria by the lectin RegIIIβ.

artículo científico publicado en 2013

PEGylation of bacteriophages increases blood circulation time and reduces T-helper type 1 immune response

artículo científico publicado en 2008

Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness

artículo científico publicado en 2017

Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.

artículo científico publicado en 2012

Phage mediated horizontal transfer of the sopE1 gene increases enteropathogenicity of Salmonella enterica serotype Typhimurium for calves

artículo científico publicado en 2002

Phages and the evolution of bacterial pathogens: from genomic rearrangements to lysogenic conversion

artículo científico publicado en 2004

Pilot study to evaluate microarray hybridization as a tool for Salmonella enterica serovar Typhimurium strain differentiation.

artículo científico publicado en 2005

Plasmid- and strain-specific factors drive variation in ESBL-plasmid spread in vitro and in vivo

scientific article published on 04 November 2020

Population Dynamics Analysis of Ciprofloxacin-Persistent S. Typhimurium Cells in a Mouse Model for Salmonella Diarrhea

artículo científico publicado en 2016

Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host

artículo científico publicado en 2003

Prevalence and polymorphism of genes encoding translocated effector proteins among clinical isolates of Salmonella enterica.

artículo científico publicado en 2000

Protection against murine listeriosis by oral vaccination with recombinant Salmonella expressing hybrid Yersinia type III proteins.

artículo científico publicado en 2001

Quantitative insights into actin rearrangements and bacterial target site selection from Salmonella Typhimurium infection of micropatterned cells

artículo científico publicado en 2013

RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42 ⬇️

artículo científico publicado en 2011

Real-time imaging of type III secretion: Salmonella SipA injection into host cells

artículo científico publicado en 2005

Role of the D arm and the anticodon arm in tRNA recognition by eubacterial and eukaryotic RNase P enzymes ⬇️

artículo científico publicado el 7 de diciembre de 1993

Role of the Salmonella pathogenicity island 1 (SPI-1) protein InvB in type III secretion of SopE and SopE2, two Salmonella effector proteins encoded outside of SPI-1.

artículo científico publicado en 2003

Role of the Salmonella pathogenicity island 1 effector proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica subspecies 1 serovar Typhimurium colitis in streptomycin-pretreated mice

artículo científico publicado en 2004

Roles of spvB and spvC in S. Typhimurium colitis via the alternative pathway

artículo científico publicado en 2010

Rp-phosphorothioate modifications in RNase P RNA that interfere with tRNA binding.

artículo científico publicado en 1995

S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells.

artículo científico publicado en 1998

Salmonella Pathogenicity Island 4 encodes a giant non-fimbrial adhesin and the cognate type 1 secretion system

artículo científico publicado en 2007

Salmonella Typhimurium Diarrhea Reveals Basic Principles of Enteropathogen Infection and Disease-Promoted DNA Exchange

artículo científico publicado en 2017

Salmonella Typhimurium strain ATCC14028 requires H2-hydrogenases for growth in the gut, but not at systemic sites

artículo científico publicado en 2014

Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems

scientific journal article

Salmonella enterica serovar Typhimurium binds to HeLa cells via Fim-mediated reversible adhesion and irreversible type three secretion system 1-mediated docking

artículo científico publicado en 2010

Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota

artículo científico publicado en 2007

Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes

artículo científico publicado en 2012

Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells

artículo científico publicado en 2010

Salmonella pathogenicity island 2-mediated overexpression of chimeric SspH2 proteins for simultaneous induction of antigen-specific CD4 and CD8 T cells

artículo científico publicado en 2005

Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut

artículo científico publicado en 2019

Salmonella transiently reside in luminal neutrophils in the inflamed gut

artículo científico publicado en 2012

Salmonella type III secretion effectors: pulling the host cell's strings

artículo científico publicado en 2006

Salmonella typhimurium diarrhea: switching the mucosal epithelium from homeostasis to defense

artículo científico publicado en 2011

Salmonella typhimurium discreet-invasion of the murine gut absorptive epithelium

scientific article published on 04 May 2020

Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island.

artículo científico publicado en 1999

Salmonella-induced mucosal lectin RegIIIβ kills competing gut microbiota

scientific journal article

Self-destructive cooperation mediated by phenotypic noise.

artículo científico publicado en 2008

Simultaneous analysis of large-scale RNAi screens for pathogen entry

artículo científico publicado en 2014

Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection

artículo científico publicado en 2020

Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens

artículo científico publicado en 2014

Stability of gene rankings from RNAi screens

artículo científico publicado en 2012

Stabilization of cooperative virulence by the expression of an avirulent phenotype.

artículo científico publicado en 2013

Stromal IFN-γR-signaling modulates goblet cell function during Salmonella Typhimurium infection

artículo científico publicado en 2011

Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.

artículo científico publicado en 2002

Subpopulation-specific metabolic pathway usage in mixed cultures as revealed by reporter protein-based 13C analysis

artículo científico publicado en 2011

TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa

artículo científico publicado en 2010

The Bactericidal Lectin RegIIIβ Prolongs Gut Colonization and Enteropathy in the Streptomycin Mouse Model for Salmonella Diarrhea

artículo científico publicado en 2017

The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium.

artículo científico publicado en 2016

The Interplay between Salmonella enterica Serovar Typhimurium and the Intestinal Mucosa during Oral Infection

artículo científico publicado en 2019

The Major RNA-Binding Protein ProQ Impacts Virulence Gene Expression in Salmonella enterica Serovar Typhimurium

article

The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation

artículo científico publicado en 2009

The Salmonella enterica serotype typhimurium effector proteins SipA, SopA, SopB, SopD, and SopE2 act in concert to induce diarrhea in calves.

artículo científico publicado en 2002

The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms.

artículo científico publicado en 2005

The Salmonella Typhimurium effector protein SopE transiently localizes to the early SCV and contributes to intracellular replication

artículo científico publicado en 2014

The SopEPhi phage integrates into the ssrA gene of Salmonella enterica serovar Typhimurium A36 and is closely related to the Fels-2 prophage

artículo científico publicado en 2003

The bactericidal activity of the C-type lectin RegIIIβ against Gram-negative bacteria involves binding to lipid A.

artículo científico publicado en 2012

The chaperone binding domain of SopE inhibits transport via flagellar and SPI-1 TTSS in the absence of InvB.

artículo científico publicado en 2006

The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1

artículo científico publicado en 2011

The microbiota mediates pathogen clearance from the gut lumen after non-typhoidal Salmonella diarrhea

artículo científico publicado en 2010

The role of microbiota in infectious disease

artículo científico publicado en 2008

The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen's virulence factors, and the host's mucosal immune response

artículo científico

Transfer of the Salmonella type III effector sopE between unrelated phage families.

artículo científico publicado en 2001

Triggered phagocytosis by Salmonella: bacterial molecular mimicry of RhoGTPase activation/deactivation.

artículo científico publicado en 2005

Two newly identified SipA domains (F1, F2) steer effector protein localization and contribute to Salmonella host cell manipulation

artículo científico publicado en 2007

Virulence of broad- and narrow-host-range Salmonella enterica serovars in the streptomycin-pretreated mouse model

artículo científico publicado en 2006

gespeR: a statistical model for deconvoluting off-target-confounded RNA interference screens

artículo científico publicado en 2015

miR-802 regulates Paneth cell function and enterocyte differentiation in the mouse small intestine

artículo científico publicado en 2021

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