Lista de obras - Christine Pirker - Dominio Público Uruguay

A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression

artículo científico publicado en 2011

Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression

artículo científico publicado en 2016

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation

artículo científico publicado en 2012

Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins.

artículo científico publicado en 2018

Anticancer metal drugs and immunogenic cell death.

artículo científico publicado en 2016

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis

artículo científico publicado en 2018

CD44 drives aggressiveness and chemoresistance of a metastatic human osteosarcoma xenograft model

artículo científico publicado en 2017

Chronic arsenic trioxide exposure leads to enhanced aggressiveness via Met oncogene addiction in cancer cells

artículo científico publicado en 2016

Cytogenetic and comparative genomic hybridization findings in four cases of breast cancer after neoadjuvant chemotherapy.

artículo científico publicado en 2003

DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies

artículo científico publicado en 2011

DR-01NOVEL PEDIATRIC EPENDYMOMA MODELS SHOW HIGH CHEMOTHERAPY-RESISTANCE AND HYPERACTIVATION OF ABC-TRANSPORTERS.

artículo científico publicado en 2014

Dynamics of CRISPR/Cas9-mediated genomic editing of the AXL locus in hepatocellular carcinoma cells.

artículo científico publicado en 2017

Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma.

artículo científico publicado en 2017

EGFR is not a major driver for osteosarcoma cell growth in vitro but contributes to starvation and chemotherapy resistance.

artículo científico publicado en 2015

Epigenetic down-regulation of integrin α7 increases migratory potential and confers poor prognosis in malignant pleural mesothelioma.

artículo científico publicado en 2015

FGF2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a MAPKinase/MMP1 signal.

artículo científico publicado en 2018

FGF5 is expressed in melanoma and enhances malignancy in vitro and in vivo.

artículo científico publicado en 2017

Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma.

artículo científico publicado en 2014

Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.

artículo científico publicado en 2014

Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition

artículo científico publicado en 2011

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

artículo científico publicado en 2012

Intrathoracic solitary fibrous tumor - an international multicenter study on clinical outcome and novel circulating biomarkers

artículo científico publicado en 2017

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer.

artículo científico publicado en 2017

Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance

artículo científico publicado en 2017

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

artículo científico publicado en 2016

MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases

artículo científico publicado en 2014

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis

artículo científico publicado en 2013

Malignant predominantly minigemistocytic glioma in two infants: a distinctive glioma variant?

scientific article published on 01 April 2007

Metal Drugs and the Anticancer Immune Response

artículo científico publicado en 2018

Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).

artículo científico publicado en 2007

Multiple chromosomal abnormalities in human liver (pre)neoplasia

artículo científico publicado en 2004

New 5-Aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting.

artículo científico publicado en 2013

New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis

artículo científico publicado en 2008

Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo

scientific article published on 03 May 2018

Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma.

artículo científico publicado en 2016

Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities

artículo científico publicado en 2011

Overexpression of the human major vault protein in astrocytic brain tumor cells

artículo científico publicado en 2001

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis

artículo científico publicado en 2015

Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients.

artículo científico publicado en 2016

Response of experimental malignant melanoma models to the pan-Aurora kinase inhibitor VE-465.

artículo científico publicado en 2010

SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors

artículo científico publicado en 2004

Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations.

artículo científico publicado en 2015

Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis.

artículo científico publicado en 2017

Seven novel and stable translocations associated with oncogenic gene expression in malignant melanoma.

artículo científico publicado en 2005

Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells

artículo científico publicado en 2009

Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle

artículo científico publicado en 2019

Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines

artículo científico publicado en 2009

Synergistic effects of erlotinib and everolimus on bronchial carcinoids and large-cell neuroendocrine carcinomas with activated EGFR/AKT/mTOR pathway

artículo científico publicado en 2012

TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma

artículo científico publicado en 2018

Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: effect of ectopic hTERT.

artículo científico publicado en 2006

The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals

artículo científico publicado en 2006

The metastatic microenvironment: Claudin-1 suppresses the malignant phenotype of melanoma brain metastasis.

artículo científico publicado en 2014

Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro

artículo científico publicado en 2016

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

artículo científico publicado en 2015

Vemurafenib resistance signature by proteome analysis offers new strategies and rational therapeutic concepts.

artículo científico publicado en 2015

Whole genome amplification for CGH analysis: Linker-adapter PCR as the method of choice for difficult and limited samples

artículo científico publicado en 2004

[11C]Erlotinib PET cannot detect acquired erlotinib resistance in NSCLC tumor xenografts in mice.

artículo científico publicado en 2017

Lista de obras de Christine Pirker

A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression

Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation

Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins.

Anticancer metal drugs and immunogenic cell death.

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis

CD44 drives aggressiveness and chemoresistance of a metastatic human osteosarcoma xenograft model

Chronic arsenic trioxide exposure leads to enhanced aggressiveness via Met oncogene addiction in cancer cells

Cytogenetic and comparative genomic hybridization findings in four cases of breast cancer after neoadjuvant chemotherapy.

DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies

DR-01NOVEL PEDIATRIC EPENDYMOMA MODELS SHOW HIGH CHEMOTHERAPY-RESISTANCE AND HYPERACTIVATION OF ABC-TRANSPORTERS.

Dynamics of CRISPR/Cas9-mediated genomic editing of the AXL locus in hepatocellular carcinoma cells.

Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma.

EGFR is not a major driver for osteosarcoma cell growth in vitro but contributes to starvation and chemotherapy resistance.

Epigenetic down-regulation of integrin α7 increases migratory potential and confers poor prognosis in malignant pleural mesothelioma.

FGF2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a MAPKinase/MMP1 signal.

FGF5 is expressed in melanoma and enhances malignancy in vitro and in vivo.

Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma.

Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.

Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

Intrathoracic solitary fibrous tumor - an international multicenter study on clinical outcome and novel circulating biomarkers

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer.

Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis

Malignant predominantly minigemistocytic glioma in two infants: a distinctive glioma variant?

Metal Drugs and the Anticancer Immune Response

Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).

Multiple chromosomal abnormalities in human liver (pre)neoplasia

New 5-Aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting.

New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis

Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo

Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma.

Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities

Overexpression of the human major vault protein in astrocytic brain tumor cells

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis

Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients.

Response of experimental malignant melanoma models to the pan-Aurora kinase inhibitor VE-465.

SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors

Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations.

Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis.

Seven novel and stable translocations associated with oncogenic gene expression in malignant melanoma.

Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells

Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle

Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines

Synergistic effects of erlotinib and everolimus on bronchial carcinoids and large-cell neuroendocrine carcinomas with activated EGFR/AKT/mTOR pathway

TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma

Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: effect of ectopic hTERT.

The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals

The metastatic microenvironment: Claudin-1 suppresses the malignant phenotype of melanoma brain metastasis.

Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

Vemurafenib resistance signature by proteome analysis offers new strategies and rational therapeutic concepts.

Whole genome amplification for CGH analysis: Linker-adapter PCR as the method of choice for difficult and limited samples

[11C]Erlotinib PET cannot detect acquired erlotinib resistance in NSCLC tumor xenografts in mice.