Lista de obras - Shaun Lott - Dominio Público Uruguay

3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity

artículo científico publicado en 2011

A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket

artículo científico publicado en 2015

A flexible and economical medium-throughput strategy for protein production and crystallization

artículo científico publicado en 2005

A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography

artículo científico publicado en 2015

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis

scientific journal article

A new Gateway vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis

artículo científico publicado en 2007

A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel

artículo científico publicado en 2002

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis

artículo científico publicado en 2014

Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.

artículo científico

Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2

scientific journal article

Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New Zealand

scientific article published on 03 September 2020

Combining cross-crystal averaging and MRSAD to phase a 4354-amino-acid structure

artículo científico publicado en 2016

Corrigendum: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis

artículo científico publicado en 2015

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

scientific article published on 26 April 2019

Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin

scientific journal article

Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis.

artículo científico publicado en 2014

Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas.

artículo científico publicado en 2017

Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation

artículo científico publicado en 2000

Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis

artículo científico publicado en 2005

Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis.

artículo científico publicado en 2004

Crystallization of a protein using dehydration without a precipitant.

artículo científico publicado en 2005

Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups

artículo científico publicado en 2017

Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: using structural genomics tools for a challenging target

artículo científico publicado en 2010

Expression and purification of high sulfur and high glycine-tyrosine keratin-associated proteins (KAPs) for biochemical and biophysical characterization

artículo científico publicado en 2018

High throughput crystallography of TB drug targets.

artículo científico publicado en 2007

Identification of extracellular siderophores and a related peptide from the endophytic fungus Epichloë festucae in culture and endophyte-infected Lolium perenne.

artículo científico publicado en 2011

Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis

artículo científico publicado en 2012

Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)

artículo científico publicado en 2010

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation

artículo científico publicado en 2010

Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis.

artículo científico publicado en 2009

Making the most of two crystals: structural analysis of a conserved hypothetical protein using native gel screening and SAD phasing.

artículo científico publicado en 2003

Membrane trafficking pathways regulating the epithelial sodium channel, ENaC

scientific article published on 28 October 2019

Mycobacterial MenJ: An Oxidoreductase Involved in Menaquinone Biosynthesis

artículo científico publicado en 2018

Prediction of the substrate for nonribosomal peptide synthetase (NRPS) adenylation domains by virtual screening

artículo científico publicado en 2015

Protein structure prediction and analysis as a tool for functional genomics

artículo científico publicado en 2003

Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (ketosteroid regulatory protein) from Mycobacterium tuberculosis

artículo científico publicado en 2014

Purification, crystallization and preliminary X-ray studies of MbtN (Rv1346) from Mycobacterium tuberculosis

artículo científico publicado en 2013

Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis

artículo científico publicado en 2014

Revealing the Inter-Module Interactions of Multi-Modular Nonribosomal Peptide Synthetases

artículo científico publicado en 2017

Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga

artículo científico publicado en 2012

Structural characterization of a PCP-R didomain from an archaeal nonribosomal peptide synthetase reveals novel interdomain interactions

artículo científico publicado en 2021

Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

artículo científico publicado en 2018

Structure and dynamics of human Nedd4-1 WW3 in complex with the αENaC PY motif

artículo científico publicado en 2013

Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex

artículo científico publicado en 2015

Structure of HisF, a histidine biosynthetic protein from Pyrobaculum aerophilum

artículo científico publicado en 2001

Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis

artículo científico publicado en 2010

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation

artículo científico publicado en 2014

Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site

artículo científico publicado en 2015

Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site.

artículo científico publicado en 2012

Synthesis of DOHNAA, aMycobacterium tuberculosisCholesterol CD Ring Catabolite and FadD3 Substrate

artículo científico publicado en 2015

Teneurin Structures Are Composed of Ancient Bacterial Protein Domains

artículo científico publicado en 2019

The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device

artículo científico publicado en 2013

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

artículo científico publicado en 2016

The TB Structural Genomics Consortium: a decade of progress

artículo científico publicado en 2011

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

artículo científico publicado en 2003

The TB structural genomics consortium: providing a structural foundation for drug discovery.

artículo científico publicado en 2002

The cloning, expression and crystallisation of a thermostable arginase.

artículo científico publicado en 1996

The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate

scientific journal article

The mechanism of fluorinated anthranilate-induced growth inhibition in Mycobacterium tuberculosis

artículo científico publicado en 2018

The potential impact of structural genomics on tuberculosis drug discovery

artículo científico publicado en 2006

The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis

artículo científico publicado en 2008

The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes

scientific journal article

The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase

scientific journal article

The structure of an ABC toxin particle determined by X-ray crystallography and single particle EM

artículo científico publicado en 2014

The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.

artículo científico publicado en 2006

The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition

artículo científico publicado en 2013

The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease

artículo científico publicado en 2020

Using secretion to solve a solubility problem: high-yield expression in Escherichia coli and purification of the bacterial glycoamidase PNGase F.

artículo científico publicado en 2002

Using structural genomics to understand Mycobacterium tuberculosis.

artículo científico publicado en 2004

Lista de obras de Shaun Lott

3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity

A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket

A flexible and economical medium-throughput strategy for protein production and crystallization

A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis

A new Gateway vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis

A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis

Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.

Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2

Collaborative networks enable the rapid establishment of serological assays for SARS-CoV-2 during nationwide lockdown in New Zealand

Combining cross-crystal averaging and MRSAD to phase a 4354-amino-acid structure

Corrigendum: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin

Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis.

Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas.

Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation

Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis

Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis.

Crystallization of a protein using dehydration without a precipitant.

Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups

Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: using structural genomics tools for a challenging target

Expression and purification of high sulfur and high glycine-tyrosine keratin-associated proteins (KAPs) for biochemical and biophysical characterization

High throughput crystallography of TB drug targets.

Identification of extracellular siderophores and a related peptide from the endophytic fungus Epichloë festucae in culture and endophyte-infected Lolium perenne.

Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis

Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation

Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis.

Making the most of two crystals: structural analysis of a conserved hypothetical protein using native gel screening and SAD phasing.

Membrane trafficking pathways regulating the epithelial sodium channel, ENaC

Mycobacterial MenJ: An Oxidoreductase Involved in Menaquinone Biosynthesis

Prediction of the substrate for nonribosomal peptide synthetase (NRPS) adenylation domains by virtual screening

Protein structure prediction and analysis as a tool for functional genomics

Purification, crystallization and preliminary X-ray crystallographic studies of KstR2 (ketosteroid regulatory protein) from Mycobacterium tuberculosis

Purification, crystallization and preliminary X-ray studies of MbtN (Rv1346) from Mycobacterium tuberculosis

Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis

Revealing the Inter-Module Interactions of Multi-Modular Nonribosomal Peptide Synthetases

Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga

Structural characterization of a PCP-R didomain from an archaeal nonribosomal peptide synthetase reveals novel interdomain interactions

Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

Structure and dynamics of human Nedd4-1 WW3 in complex with the αENaC PY motif

Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex

Structure of HisF, a histidine biosynthetic protein from Pyrobaculum aerophilum

Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation

Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site

Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site.

Synthesis of DOHNAA, aMycobacterium tuberculosisCholesterol CD Ring Catabolite and FadD3 Substrate

Teneurin Structures Are Composed of Ancient Bacterial Protein Domains

The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

The TB Structural Genomics Consortium: a decade of progress

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

The TB structural genomics consortium: providing a structural foundation for drug discovery.

The cloning, expression and crystallisation of a thermostable arginase.

The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate

The mechanism of fluorinated anthranilate-induced growth inhibition in Mycobacterium tuberculosis

The potential impact of structural genomics on tuberculosis drug discovery

The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis

The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes

The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase

The structure of an ABC toxin particle determined by X-ray crystallography and single particle EM

The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.

The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition

The tryptophan biosynthetic pathway is essential for Mycobacterium tuberculosis to cause disease

Using secretion to solve a solubility problem: high-yield expression in Escherichia coli and purification of the bacterial glycoamidase PNGase F.

Using structural genomics to understand Mycobacterium tuberculosis.