Lista de obras - Andrew Hughes - Dominio Público Uruguay

A Pilot Study Assessing the Prognostic Value of CK18 and nDNA Biomarkers in Severe Sepsis Patients

A first-in-man phase I tolerability and pharmacokinetic study of the cyclin-dependent kinase-inhibitor AZD5438 in healthy male volunteers

artículo científico publicado en 2006

A phase I pharmacodynamic study of the effects of the cyclin-dependent kinase-inhibitor AZD5438 on cell cycle markers within the buccal mucosa, plucked scalp hairs and peripheral blood mononucleocytes of healthy male volunteers

article

A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker.

artículo científico publicado en 2011

Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry

artículo científico publicado en 2006

An investigation of components of variance and tachyphylaxis in a placebo-controlled intravenous tyramine study

artículo científico publicado en 2004

Analysis of Circulating Tumor Cells in Patients with Non-small Cell Lung Cancer Using Epithelial Marker-Dependent and -Independent Approaches

article

Analytical validation of BRAF mutation testing from circulating free DNA using the amplification refractory mutation testing system

artículo científico

Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development.

artículo científico publicado en 2005

Assessment of diurnal changes and confounding factors that affect circulating cell death biomarker levels: a short communication.

artículo científico publicado en 2013

Assessment of the reproducibility of intradermal administration of capsaicin as a model for inducing human pain

artículo científico publicado en 2002

Biomarker utility of circulating tumor cells in metastatic cutaneous melanoma

artículo científico publicado en 2012

Circulating tumor cells as a window on metastasis biology in lung cancer

artículo científico publicado en 2011

Considerations for powering a clinical proteomics study: Normal variability in the human plasma proteome

artículo científico publicado en 2009

Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study.

artículo científico publicado en 2009

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer

artículo científico

Diurnal variation in the quantitative EEG in healthy adult volunteers

artículo científico publicado en 2000

Effect of oral linezolid on the pressor response to intravenous tyramine

artículo científico publicado en 2004

Effects of Zolmitriptan (ZomigTM) on Central Serotonergic Neurotransmission as Assessed by Active Oddball Auditory Event-Related Potentials in Volunteers without Migraine

article

Effects of the antimigraine compound zolmitriptan ('Zomig') on psychomotor performance alone and in combination with diazepam in healthy volunteers

artículo científico publicado el 1 de septiembre de 1998

Electroencephalographic and psychomotor effects of chlorpromazine and risperidone relative to placebo in normal healthy volunteers

artículo científico publicado en 1999

Evaluation and Prognostic Significance of Circulating Tumor Cells in Patients With Non–Small-Cell Lung Cancer

article

Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy

scientific article published on 23 July 2009

Isolation and Extraction of Circulating Tumor DNA from Patients with Small Cell Lung Cancer

artículo científico publicado en 2008

Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects

artículo científico publicado en 2004

Multiplexed assays for detection of mutations in PIK3CA.

artículo científico publicado en 2008

Novel approaches in oncology at AstraZeneca

Oxytocin in the central nervous system and sexual behaviour in male rats.

artículo científico publicado en 1987

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

artículo científico publicado en 2008

Prevalence and heterogeneity of circulating tumour cells in metastatic cutaneous melanoma

scientific article

Quantification of skeletal metastases in castrate-resistant prostate cancer predicts progression-free and overall survival

artículo científico publicado en 2014

Quantitative multiplexed quantum dot immunohistochemistry.

artículo científico publicado en 2008

Serum biomarkers of apoptosis

Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence.

artículo científico publicado en 2005

Staged Risk Management of Candidate Drug Efficacy

The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans

artículo científico publicado en 2003

Lista de obras de Andrew Hughes

A Pilot Study Assessing the Prognostic Value of CK18 and nDNA Biomarkers in Severe Sepsis Patients

A first-in-man phase I tolerability and pharmacokinetic study of the cyclin-dependent kinase-inhibitor AZD5438 in healthy male volunteers

A phase I pharmacodynamic study of the effects of the cyclin-dependent kinase-inhibitor AZD5438 on cell cycle markers within the buccal mucosa, plucked scalp hairs and peripheral blood mononucleocytes of healthy male volunteers

A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker.

Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry

An investigation of components of variance and tachyphylaxis in a placebo-controlled intravenous tyramine study

Analysis of Circulating Tumor Cells in Patients with Non-small Cell Lung Cancer Using Epithelial Marker-Dependent and -Independent Approaches

Analytical validation of BRAF mutation testing from circulating free DNA using the amplification refractory mutation testing system

Assessing proliferation, cell-cycle arrest and apoptotic end points in human buccal punch biopsies for use as pharmacodynamic biomarkers in drug development.

Assessment of diurnal changes and confounding factors that affect circulating cell death biomarker levels: a short communication.

Assessment of the reproducibility of intradermal administration of capsaicin as a model for inducing human pain

Biomarker utility of circulating tumor cells in metastatic cutaneous melanoma

Circulating tumor cells as a window on metastasis biology in lung cancer

Considerations for powering a clinical proteomics study: Normal variability in the human plasma proteome

Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study.

Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer

Diurnal variation in the quantitative EEG in healthy adult volunteers

Effect of oral linezolid on the pressor response to intravenous tyramine

Effects of Zolmitriptan (ZomigTM) on Central Serotonergic Neurotransmission as Assessed by Active Oddball Auditory Event-Related Potentials in Volunteers without Migraine

Effects of the antimigraine compound zolmitriptan ('Zomig') on psychomotor performance alone and in combination with diazepam in healthy volunteers

Electroencephalographic and psychomotor effects of chlorpromazine and risperidone relative to placebo in normal healthy volunteers

Evaluation and Prognostic Significance of Circulating Tumor Cells in Patients With Non–Small-Cell Lung Cancer

Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy

Isolation and Extraction of Circulating Tumor DNA from Patients with Small Cell Lung Cancer

Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects

Multiplexed assays for detection of mutations in PIK3CA.

Novel approaches in oncology at AstraZeneca

Oxytocin in the central nervous system and sexual behaviour in male rats.

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

Prevalence and heterogeneity of circulating tumour cells in metastatic cutaneous melanoma

Quantification of skeletal metastases in castrate-resistant prostate cancer predicts progression-free and overall survival

Quantitative multiplexed quantum dot immunohistochemistry.

Serum biomarkers of apoptosis

Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence.

Staged Risk Management of Candidate Drug Efficacy

The prostaglandin E2 receptor-1 (EP-1) mediates acid-induced visceral pain hypersensitivity in humans