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A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity

artículo científico publicado en 2012

First evidence of intraclonal genetic exchange in trypanosomatids using two Leishmania infantum fluorescent transgenic clones

artículo científico publicado en 2014

Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect.

artículo científico publicado en 2013

Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB.

artículo científico publicado en 2013

Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis

artículo científico publicado en 2012

Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis

artículo científico publicado en 2015

Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase

scientific article published on 01 August 2011

Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB.

artículo científico publicado en 2015

Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis

artículo científico publicado en 2011

Synthesis of marine α-methoxylated fatty acid analogs that effectively inhibit the topoisomerase IB from Leishmania donovani with a mechanism different from that of camptothecin

scientific article published on 30 September 2013

Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

artículo científico publicado en 2014

Trypanosomatids see the light: recent advances in bioimaging research

artículo científico

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

artículo científico publicado en 2014

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