Lista de obras - Christopher J Squire - Dominio Público Uruguay

2-Ethylthio-9-methyl-1,4-dihydroacridine-1,4-dione and 9-methyl-2-(4-tolylthio)-1,4-dihydroacridine-1,4-dione

artículo científico publicado en 1999

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

artículo científico publicado en 2017

Activation domain-dependent degradation of somatic Wee1 kinase

artículo científico publicado en 2009

Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in α-isopropylmalate synthase from Mycobacterium tuberculosis

artículo científico publicado en 2013

Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin

artículo científico publicado en 2014

Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed

artículo científico publicado en 2015

Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B.

artículo científico publicado en 2017

Chemical synthesis of γ-secretase activating protein using pseudoglutamines as ligation sites

artículo científico publicado en 2015

Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) fromMycobacterium tuberculosis ⬇️

artículo científico publicado el 30 de septiembre de 2011

Complexes of DNA with minor groove binders: crystallographic studies ⬇️

1998 doctoral thesis by Christopher John Squire at University of Auckland

Crystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3

artículo científico publicado en 2012

Crystal and NMR Structures of a Peptidomimetic β-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides

artículo científico publicado en 2017

Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding

artículo científico publicado en 2008

Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis

artículo científico publicado en 2004

Defining the potassium binding region in an apple terpene synthase

artículo científico publicado en 2009

Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).

artículo científico publicado en 2013

Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis

artículo científico publicado en 2016

Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability

artículo científico publicado en 2017

Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system

artículo científico publicado en 2007

Harnessing ester bond chemistry for protein ligation.

artículo científico publicado en 2017

High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon

artículo científico publicado en 2007

In vitro studies with methylproamine: a potent new radioprotector

artículo científico publicado en 2004

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance

artículo científico publicado en 2018

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes.

artículo científico publicado en 2016

Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2

artículo científico publicado en 1997

Poxviral ankyrin proteins

artículo científico publicado en 2015

Preparation of truncated orf virus entry fusion complex proteins by chemical synthesis

artículo científico publicado en 2014

Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily

artículo científico publicado en 2016

Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate binding

artículo científico publicado en 2012

Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria

artículo científico publicado en 2015

Structure and function of GlmU fromMycobacterium tuberculosis

artículo científico publicado en 2009

Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation

artículo científico publicado en 2005

Structure of AKR1C3 with 3-phenoxybenzoic acid bound

artículo científico publicado en 2012

Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).

artículo científico publicado en 2006

Structure of the first parallel DNA quadruplex-drug complex

artículo científico publicado en 2003

Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery

artículo científico publicado en 2009

Structures of the dimerization domains of the Escherichia coli disulfide-bond isomerase enzymes DsbC and DsbG

artículo científico publicado en 2007

Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases

artículo científico publicado en 2008

Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases

artículo científico publicado en 2008

TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure

artículo científico publicado en 2019

The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition

artículo científico publicado en 2015

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster

artículo científico publicado en 2019

The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages

artículo científico publicado en 2012

Total Chemical Synthesis of an Orf Virus Protein, ORFV002, an Inhibitor of the Master Gene Regulator NF-κB.

artículo científico publicado en 2014

Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

artículo científico publicado en 2003

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

artículo científico publicado en 2021

Lista de obras de Christopher J Squire

2-Ethylthio-9-methyl-1,4-dihydroacridine-1,4-dione and 9-methyl-2-(4-tolylthio)-1,4-dihydroacridine-1,4-dione

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

Activation domain-dependent degradation of somatic Wee1 kinase

Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in α-isopropylmalate synthase from Mycobacterium tuberculosis

Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin

Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed

Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B.

Chemical synthesis of γ-secretase activating protein using pseudoglutamines as ligation sites

Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) fromMycobacterium tuberculosis ⬇️

Complexes of DNA with minor groove binders: crystallographic studies ⬇️

Crystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3

Crystal and NMR Structures of a Peptidomimetic β-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides

Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding

Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis

Defining the potassium binding region in an apple terpene synthase

Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).

Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis

Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability

Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system

Harnessing ester bond chemistry for protein ligation.

High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon

In vitro studies with methylproamine: a potent new radioprotector

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes.

Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2

Poxviral ankyrin proteins

Preparation of truncated orf virus entry fusion complex proteins by chemical synthesis

Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily

Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate binding

Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria

Structure and function of GlmU fromMycobacterium tuberculosis

Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation

Structure of AKR1C3 with 3-phenoxybenzoic acid bound

Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).

Structure of the first parallel DNA quadruplex-drug complex

Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery

Structures of the dimerization domains of the Escherichia coli disulfide-bond isomerase enzymes DsbC and DsbG

Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases

Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases

TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure

The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster

The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages

Total Chemical Synthesis of an Orf Virus Protein, ORFV002, an Inhibitor of the Master Gene Regulator NF-κB.

Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs