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A functional genetic screen defines the AKT-induced senescence signaling network

scientific article published on 08 July 2019

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

scientific article published on 26 May 2020

Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.

artículo científico publicado en 2008

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

artículo científico publicado en 2016

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

artículo científico publicado en 2012

Cystathionine β-Synthase in Physiology and Cancer.

artículo científico publicado en 2018

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

artículo científico publicado en 2015

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

artículo científico publicado en 2016

Integrins in cell migration.

artículo científico publicado en 2007

Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin

artículo científico publicado en 2013

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.

artículo científico publicado en 2014

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

artículo científico publicado en 2012

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

scientific article published on 22 August 2019

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

scientific article published on 18 September 2020

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

scientific article published on 11 November 2020

Unraveling the enigma: progress towards understanding the coronin family of actin regulators.

artículo científico publicado en 2011

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.

artículo científico publicado en 2015