Lista de obras - Manuela Zaccolo - Dominio Público Uruguay

A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes

artículo científico publicado en 2006

A genetically encoded, fluorescent indicator for cyclic AMP in living cells

scientific article published on 01 January 2000

A novel approach combining real-time imaging and the patch-clamp technique to calibrate FRET-based reporters for cAMP in their cellular microenvironment

artículo científico publicado en 2015

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

artículo científico publicado en 2011

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum

scientific journal article

Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling

artículo científico publicado en 2017

Adenoviral transduction of FRET-based biosensors for cAMP in primary adult mouse cardiomyocytes

artículo científico publicado en 2015

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization from Acidic Stores in Pancreatic α-Cells

artículo científico publicado en 2018

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

artículo científico publicado en 2014

Analysis of compartmentalized cAMP: a method to compare signals from differently targeted FRET reporters.

artículo científico publicado el 1 de enero de 2014

Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor.

artículo científico publicado en 2005

Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1.

artículo científico publicado en 2008

Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions

artículo científico publicado en 2016

Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog

artículo científico publicado en 2008

CAMP and Ca2+ interplay: a matter of oscillation patterns

artículo científico publicado en 2003

CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity

artículo científico publicado en 2012

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

artículo científico publicado en 2015

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts.

artículo científico publicado en 2018

Cell entry and cAMP imaging of anthrax edema toxin

artículo científico publicado en 2006

Compartmentalisation of cAMP and Ca(2+) signals

artículo científico publicado en 2002

Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling

artículo científico publicado en 2006

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway

artículo científico publicado en 2005

Components of the mitochondrial cAMP signalosome

artículo científico publicado en 2017

Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons

artículo científico publicado en 2016

Correctors of mutant CFTR enhance subcortical cAMP-PKA signaling through modulating ezrin phosphorylation and cytoskeleton organization

artículo científico publicado en 2016

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

scientific journal article

Defining a cellular map of cAMP nanodomains

scientific article published on 28 February 2020

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

artículo científico publicado en 2004

Developmentally acquired PKA localisation in mouse oocytes and embryos

artículo científico publicado en 2008

Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes

artículo científico publicado en 2002

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

artículo científico publicado en 2011

EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1.

artículo científico publicado en 2016

Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons

artículo científico publicado en 2015

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

artículo científico publicado en 2017

FRET-ting about RhoA signalling in heart and vasculature: a new tool in our cardiovascular toolbox

artículo científico publicado en 2018

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

artículo científico publicado en 2004

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

artículo científico publicado en 2015

Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation

artículo científico publicado en 2003

Imaging cAMP nanodomains in the heart

artículo científico publicado en 2019

Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades

artículo científico publicado en 2006

Imaging the cAMP-dependent signal transduction pathway.

artículo científico publicado en 2005

Improvement of a FRET-based indicator for cAMP by linker design and stabilization of donor-acceptor interaction

artículo científico publicado en 2005

Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling

artículo científico publicado en 2013

Local termination of 3'-5'-cyclic adenosine monophosphate signals: the role of A kinase anchoring protein-tethered phosphodiesterases

artículo científico publicado en 2011

Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors

artículo científico publicado en 2011

Missense mutations in desmocollin-2 N-terminus, associated with arrhythmogenic right ventricular cardiomyopathy, affect intracellular localization of desmocollin-2 in vitro

artículo científico publicado en 2007

Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity

artículo científico publicado en 2016

Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit

scientific article published on 14 April 2005

Multi-Compartment, Early Disruption of cGMP and cAMP Signalling in Cardiac Myocytes from the mdx Model of Duchenne Muscular Dystrophy

scientific article published on 25 September 2020

Mutations in the insulin-like factor 3 receptor are associated with osteoporosis

artículo científico publicado en 2008

Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.

artículo científico publicado en 2010

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling

artículo científico publicado en 2006

Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases

artículo científico publicado en 2009

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

artículo científico publicado en 2017

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

artículo científico publicado en 2006

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome

artículo científico publicado en 2012

PKA microdomain organisation and cAMP handling in healthy and dystrophic muscle in vivo

artículo científico publicado en 2009

Participation of myosin Va and Pka type I in the regeneration of neuromuscular junctions

artículo científico publicado en 2012

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy

artículo científico publicado en 2020

Phosphodiesterases and compartmentalized cAMP signalling in the heart

artículo científico publicado en 2006

Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system

artículo científico publicado en 2011

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides

artículo científico publicado en 2014

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

artículo científico publicado en 2015

Photon moment analysis in cells in the presence of photo-bleaching

artículo científico publicado en 2005

Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain

artículo científico publicado en 2011

Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines

artículo científico publicado en 2005

Protein kinase A type I and type II define distinct intracellular signaling compartments

artículo científico publicado en 2008

Rapsyn mediates subsynaptic anchoring of PKA type I and stabilisation of acetylcholine receptor in vivo.

artículo científico publicado en 2012

Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells

artículo científico publicado en 2006

Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop

artículo científico publicado en 2010

Regulation of the inflammatory response of vascular endothelial cells by EPAC1.

artículo científico

Response to Wagner et al.: phosphodiesterase-2-anti-adrenergic friend or hypertrophic foe in heart disease?

artículo científico publicado en 2016

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling

artículo científico publicado en 2006

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling

article by Manuela Zaccolo et al published 1 August 2006 in Biochemical Society Transactions

Small-molecule FRET probes for protein kinase activity monitoring in living cells

artículo científico publicado en 2010

Space and time-resolved gene expression experiments on cultured mammalian cells by a single-cell electroporation microarray

artículo científico publicado en 2008

Spatial control of cAMP signalling in health and disease ⬇️

artículo científico publicado el 13 de octubre de 2011

Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia

artículo científico publicado en 2007

Subcellular Organization of the cAMP Signaling Pathway

artículo científico publicado en 2021

Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes

artículo científico publicado en 2015

TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling

artículo científico publicado en 2004

Targeting FRET-Based Reporters for cAMP and PKA Activity Using AKAP79

artículo científico publicado en 2018

Termination of cAMP signals by Ca2+ and G(alpha)i via extracellular Ca2+ sensors: a link to intracellular Ca2+ oscillations

artículo científico publicado en 2005

The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations

artículo científico publicado en 2010

Transgenic fruit-flies expressing a FRET-based sensor for in vivo imaging of cAMP dynamics

artículo científico publicado en 2007

Unitary permeability of gap junction channels to second messengers measured by FRET microscopy

artículo científico publicado en 2007

Use of chimeric fluorescent proteins and fluorescence resonance energy transfer to monitor cellular responses

artículo científico publicado en 2004

cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology

artículo científico publicado en 2007

cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxin

artículo científico publicado en 2008

cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies

artículo científico publicado en 2009

cAMP signaling in subcellular compartments

artículo científico

cAMP: From Long-Range Second Messenger to Nanodomain Signalling

artículo científico publicado en 2017

cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

artículo científico publicado en 2011

cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism

artículo científico publicado en 2004

cGMP-cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function.

artículo científico publicado en 2012

Lista de obras de Manuela Zaccolo

A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes

A genetically encoded, fluorescent indicator for cyclic AMP in living cells

A novel approach combining real-time imaging and the patch-clamp technique to calibrate FRET-based reporters for cAMP in their cellular microenvironment

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum

Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling

Adenoviral transduction of FRET-based biosensors for cAMP in primary adult mouse cardiomyocytes

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization from Acidic Stores in Pancreatic α-Cells

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

Analysis of compartmentalized cAMP: a method to compare signals from differently targeted FRET reporters.

Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor.

Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1.

Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions

Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog

CAMP and Ca2+ interplay: a matter of oscillation patterns

CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in β2AR-cAMP Responsiveness in Murine Hearts.

Cell entry and cAMP imaging of anthrax edema toxin

Compartmentalisation of cAMP and Ca(2+) signals

Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway

Components of the mitochondrial cAMP signalosome

Control of βAR- and N-methyl-D-aspartate (NMDA) Receptor-Dependent cAMP Dynamics in Hippocampal Neurons

Correctors of mutant CFTR enhance subcortical cAMP-PKA signaling through modulating ezrin phosphorylation and cytoskeleton organization

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

Defining a cellular map of cAMP nanodomains

Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

Developmentally acquired PKA localisation in mouse oocytes and embryos

Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

EPAC1 activation by cAMP stabilizes CFTR at the membrane by promoting its interaction with NHERF1.

Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

FRET-ting about RhoA signalling in heart and vasculature: a new tool in our cardiovascular toolbox

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation

Imaging cAMP nanodomains in the heart

Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades

Imaging the cAMP-dependent signal transduction pathway.

Improvement of a FRET-based indicator for cAMP by linker design and stabilization of donor-acceptor interaction

Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling

Local termination of 3'-5'-cyclic adenosine monophosphate signals: the role of A kinase anchoring protein-tethered phosphodiesterases

Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors

Missense mutations in desmocollin-2 N-terminus, associated with arrhythmogenic right ventricular cardiomyopathy, affect intracellular localization of desmocollin-2 in vitro

Modulation of Compartmentalised Cyclic Nucleotide Signalling via Local Inhibition of Phosphodiesterase Activity

Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit

Multi-Compartment, Early Disruption of cGMP and cAMP Signalling in Cardiac Myocytes from the mdx Model of Duchenne Muscular Dystrophy

Mutations in the insulin-like factor 3 receptor are associated with osteoporosis

Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling

Odorant receptors at the growth cone are coupled to localized cAMP and Ca2+ increases

PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome

PKA microdomain organisation and cAMP handling in healthy and dystrophic muscle in vivo

Participation of myosin Va and Pka type I in the regeneration of neuromuscular junctions

Phosphodiesterase 2A2 regulates mitochondria clearance through Parkin-dependent mitophagy

Phosphodiesterases and compartmentalized cAMP signalling in the heart

Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

Photon moment analysis in cells in the presence of photo-bleaching

Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain

Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines

Protein kinase A type I and type II define distinct intracellular signaling compartments

Rapsyn mediates subsynaptic anchoring of PKA type I and stabilisation of acetylcholine receptor in vivo.

Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells

Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop

Regulation of the inflammatory response of vascular endothelial cells by EPAC1.

Response to Wagner et al.: phosphodiesterase-2-anti-adrenergic friend or hypertrophic foe in heart disease?

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling

Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling

Small-molecule FRET probes for protein kinase activity monitoring in living cells

Space and time-resolved gene expression experiments on cultured mammalian cells by a single-cell electroporation microarray

Spatial control of cAMP signalling in health and disease ⬇️

Spatiotemporal coupling of cAMP transporter to CFTR chloride channel function in the gut epithelia

Subcellular Organization of the cAMP Signaling Pathway