Lista de obras - Mark Prichard - Dominio Público Uruguay

(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.

artículo científico publicado en 2009

A microtiter virus yield reduction assay for the evaluation of antiviral compounds against human cytomegalovirus and herpes simplex virus.

artículo científico publicado en 1990

A novel potential therapy for HSV.

artículo científico publicado en 2014

A possible pitfall in acyclovir prophylaxis for recurrent herpetic keratitis?

artículo científico publicado en 2013

A standardized approach to the evaluation of antivirals against DNA viruses: Orthopox-, adeno-, and herpesviruses

scientific article published on 01 October 2018

A standardized approach to the evaluation of antivirals against DNA viruses: Polyomaviruses and lymphotropic herpesviruses

artículo científico publicado en 2018

Analysis of Mutations in the Gene Encoding Cytomegalovirus DNA Polymerase in a Phase 2 Clinical Trial of Brincidofovir Prophylaxis.

artículo científico publicado en 2016

Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses ⬇️

artículo científico publicado el 16 de septiembre de 2010

Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters

artículo científico publicado en 2006

Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses.

artículo científico publicado en 2009

Benzimidazole Analogs Inhibit Human Herpesvirus 6 ⬇️

artículo científico publicado el 7 de febrero de 2011

Brincidofovir treatment of acyclovir-resistant disseminated varicella zoster virus infection in an immunocompromised host.

artículo científico publicado en 2016

CMX001 Potentiates the Efficacy of Acyclovir in Herpes Simplex Virus Infections ⬇️

artículo científico publicado el 25 de julio de 2011

Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir

scientific article published on 21 January 2009

Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance.

artículo científico publicado en 2014

Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.

artículo científico publicado en 2011

Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibility

artículo científico publicado en 2014

Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs

artículo científico publicado en 2008

Efficacy of ganciclovir in combination with zidovudine against cytomegalovirus in vitro and in vivo. Freitas, V.R., Fraser-Smith, E.B., Chiu, S., Michelson, S. and Schatzman, R.C. (1993) Antiviral Res. 21, 301-315

scientific article published on 01 August 1994

Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis.

artículo científico publicado en 2017

Evaluation of AD472, a live attenuated recombinant herpes simplex virus type 2 vaccine in guinea pigs.

artículo científico publicado en 2005

Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine

artículo científico publicado en 2008

Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.

artículo científico publicado en 2009

Helicase-primase as a target of new therapies for herpes simplex virus infections.

artículo científico publicado en 2014

Host immune system gene targeting by a viral miRNA

artículo científico publicado en 2007

Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis

artículo científico publicado en 2005

Human cytomegalovirus UL97 kinase alters the accumulation of CDK1 ⬇️

artículo científico publicado el 2 de mayo de 2012

Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions.

artículo científico publicado en 2013

Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia

artículo científico publicado en 2010

Human cytomegalovirus gene expression in long-term infected glioma stem cells.

artículo científico publicado en 2014

Human cytomegalovirus plasmid-based amplicon vector system for gene therapy

artículo científico publicado en 2005

Human herpesvirus 6 U69 kinase phosphorylates the methylenecyclopropane nucleosides cyclopropavir, MBX 2168, and MBX 1616 to their monophosphates.

artículo científico publicado en 2013

Identification of protein-protein interaction inhibitors targeting vaccinia virus processivity factor for development of antiviral agents.

artículo científico publicado en 2011

In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication

artículo científico publicado en 2005

In vitro and in vivo enhancement of ddI activity against Rauscher murine leukemia virus by ribavirin.

artículo científico publicado en 1995

Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.

artículo científico publicado en 2008

L-valine ester of cyclopropavir: a new antiviral prodrug.

artículo científico publicado en 2009

New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion

artículo científico publicado en 2013

New therapies for human cytomegalovirus infections

article

Orthopoxvirus targets for the development of antiviral therapies

artículo científico publicado en 2005

Orthopoxvirus targets for the development of new antiviral agents.

artículo científico publicado en 2012

Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza

artículo científico publicado en 2012

Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.

artículo científico publicado en 2009

Pre-clinical Assessment of C134, a Chimeric Oncolytic Herpes Simplex Virus, in Mice and Non-human Primates.

scientific article published on March 2017

Progress in the development of new therapies for herpesvirus infections ⬇️

artículo científico publicado el 1 de diciembre de 2011

Reassessing the organization of the UL42-UL43 region of the human cytomegalovirus strain AD169 genome.

artículo científico publicado en 1997

Reduction of the in vitro activity of A77003, an inhibitor of human immunodeficiency virus protease, by human serum alpha 1 acid glycoprotein.

artículo científico publicado en 1995

Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.

artículo científico publicado en 2014

Simultaneous titration and phenotypic antiviral drug susceptibility testing for herpes simplex virus 1 and 2.

artículo científico publicado en 2014

Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.

artículo científico publicado en 2016

Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.

artículo científico publicado en 2013

Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues

artículo científico publicado en 2006

Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.

artículo científico publicado en 2012

Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus).

artículo científico publicado en 2005

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides ⬇️

artículo científico publicado el 15 de junio de 2012

Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication

artículo científico publicado en 2011

TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.

artículo científico publicado en 2015

The development of new therapies for human herpesvirus 6.

artículo científico publicado en 2014

The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and ε-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli.

artículo científico publicado en 2012

The search for new therapies for human cytomegalovirus infections.

artículo científico publicado en 2010

Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro

artículo científico publicado en 2010

USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.

artículo científico publicado en 2018

Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

artículo científico publicado en 2008

Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease

Valganciclovir for symptomatic congenital cytomegalovirus disease

artículo científico publicado en 2015

Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus

artículo científico publicado en 2009

Xenotransplantation panel for the detection of infectious agents in pigs

scholarly article by Caroll B Hartline et al published July 2018 in Xenotransplantation

Lista de obras de Mark Prichard

(Z)- and (E)-2-(1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine. Synthesis of all stereoisomers, absolute configuration, and antiviral activity.

A microtiter virus yield reduction assay for the evaluation of antiviral compounds against human cytomegalovirus and herpes simplex virus.

A novel potential therapy for HSV.

A possible pitfall in acyclovir prophylaxis for recurrent herpetic keratitis?

A standardized approach to the evaluation of antivirals against DNA viruses: Orthopox-, adeno-, and herpesviruses

A standardized approach to the evaluation of antivirals against DNA viruses: Polyomaviruses and lymphotropic herpesviruses

Analysis of Mutations in the Gene Encoding Cytomegalovirus DNA Polymerase in a Phase 2 Clinical Trial of Brincidofovir Prophylaxis.

Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses ⬇️

Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters

Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses.

Benzimidazole Analogs Inhibit Human Herpesvirus 6 ⬇️

Brincidofovir treatment of acyclovir-resistant disseminated varicella zoster virus infection in an immunocompromised host.

CMX001 Potentiates the Efficacy of Acyclovir in Herpes Simplex Virus Infections ⬇️

Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir

Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance.

Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase.

Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibility

Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein D on genital HSV-2 infections of guinea pigs

Efficacy of ganciclovir in combination with zidovudine against cytomegalovirus in vitro and in vivo. Freitas, V.R., Fraser-Smith, E.B., Chiu, S., Michelson, S. and Schatzman, R.C. (1993) Antiviral Res. 21, 301-315

Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis.

Evaluation of AD472, a live attenuated recombinant herpes simplex virus type 2 vaccine in guinea pigs.

Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine

Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.

Helicase-primase as a target of new therapies for herpes simplex virus infections.

Host immune system gene targeting by a viral miRNA

Human cytomegalovirus UL97 Kinase is required for the normal intranuclear distribution of pp65 and virion morphogenesis

Human cytomegalovirus UL97 kinase alters the accumulation of CDK1 ⬇️

Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions.

Human cytomegalovirus UL97 kinase prevents the deposition of mutant protein aggregates in cellular models of Huntington's disease and ataxia

Human cytomegalovirus gene expression in long-term infected glioma stem cells.

Human cytomegalovirus plasmid-based amplicon vector system for gene therapy

Human herpesvirus 6 U69 kinase phosphorylates the methylenecyclopropane nucleosides cyclopropavir, MBX 2168, and MBX 1616 to their monophosphates.

Identification of protein-protein interaction inhibitors targeting vaccinia virus processivity factor for development of antiviral agents.

In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication

In vitro and in vivo enhancement of ddI activity against Rauscher murine leukemia virus by ribavirin.

Inhibition of herpesvirus replication by hexadecyloxypropyl esters of purine- and pyrimidine-based phosphonomethoxyethyl nucleoside phosphonates.

L-valine ester of cyclopropavir: a new antiviral prodrug.

New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion

New therapies for human cytomegalovirus infections

Orthopoxvirus targets for the development of antiviral therapies

Orthopoxvirus targets for the development of new antiviral agents.

Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza

Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.

Pre-clinical Assessment of C134, a Chimeric Oncolytic Herpes Simplex Virus, in Mice and Non-human Primates.

Progress in the development of new therapies for herpesvirus infections ⬇️

Reassessing the organization of the UL42-UL43 region of the human cytomegalovirus strain AD169 genome.

Reduction of the in vitro activity of A77003, an inhibitor of human immunodeficiency virus protease, by human serum alpha 1 acid glycoprotein.

Retinazone inhibits certain blood-borne human viruses including Ebola virus Zaire.

Simultaneous titration and phenotypic antiviral drug susceptibility testing for herpes simplex virus 1 and 2.

Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.

Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.

Synthesis and antiviral activities of new acyclic and "double-headed" nucleoside analogues

Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.

Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus).

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides ⬇️

Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication

TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.

The development of new therapies for human herpesvirus 6.

The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and ε-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli.

The search for new therapies for human cytomegalovirus infections.

Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro

USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.

Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease

Valganciclovir for symptomatic congenital cytomegalovirus disease

Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus

Xenotransplantation panel for the detection of infectious agents in pigs