Lista de obras - Vicente Alfaro - Dominio Público Uruguay

A Phase II multicenter, open-label, clinical and pharmokinetic trial of PM00104 in patients with advanced Ewing Family of Tumors

artículo científico publicado en 2013

A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin.

artículo científico publicado en 2012

A physical-chemical analysis of the acid-base response to chronic obstructive pulmonary disease

artículo científico publicado en 1996

A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas

artículo científico publicado en 2012

Abbreviated clinical study reports with investigational medicinal products for human use: current guidelines and recommendations.

artículo científico publicado en 2007

Acid-base analysis during experimental anemia in rats

scientific article published on 01 October 2000

Acid-base disturbance during hemorrhage in rats: significant role of strong inorganic ions.

artículo científico publicado en 1999

Acute mild hypothermia in awake unrestrained rats induces a mixed acid-base disorder

scientific article published on 01 June 1996

Age-stratified analysis of I-PSS and QoL values in spanish patients with symptoms potentially related to BPH.

artículo científico publicado en 2000

Blood acid-base changes during acute experimental inflammation in rats

scientific article published on 01 March 1996

Blood sampled in rats from right ventricle may not always be truly representative of a mixed venous sample

artículo científico publicado en 1996

CO2 in static mesenteric venous blood during intestinal ischemia and ischemic preconditioning in rats ⬇️

artículo científico publicado el 1 de noviembre de 2001

Complete and Sustained Objective Response per RECIST to Irvalec (PM02734) in Undifferentiated Large Cell Esophageal Adenocarcinoma: A Case Report and a Review of the Literature ⬇️

artículo científico publicado el 5 de julio de 2012

Components of the blood acid-base disturbance that accompanies urethane anaesthesia in rats during normothermia and hypothermia ⬇️

artículo científico publicado el 1 de julio de 1997

Differential effects of hypothermia upon blood acid-base state and blood gases in sodium pentobarbital and urethane anaesthetised rats

artículo científico publicado el 1 de julio de 1992

Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure-response analysis

artículo científico publicado en 2020

Erythrocyte osmotic resistance during acute hypothermia in awake unrestrained rats

artículo científico publicado en 1993

Evaluation of plitidepsin in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofibrosis: results of preclinical studies and a phase II clinical trial

artículo científico publicado en 2015

Exogenous adenosine enhances caspase-3 activity in warm renal ischaemia.

artículo científico publicado en 2003

Extracellular pH affects inflammatory cell production of superoxide and nitric oxide.

artículo científico publicado en 2002

Factors influencing acid-base status during acute severe hypothermia in unanesthetized rats.

artículo científico publicado en 1995

Factors influencing the acid-base changes in the air-pouch exudate following carrageenan induced inflammation in rats

artículo científico publicado en 1996

First-in-human, phase I study of elisidepsin (PM02734) administered as a 30-min or as a 3-hour intravenous infusion every three weeks in patients with advanced solid tumors

artículo científico publicado en 2015

First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours

artículo científico publicado en 2012

Gefitinib: current status in the treatment of non-small cell lung cancer.

artículo científico publicado en 2004

Glutamate-related excitotoxicity neuroprotection with memantine, an uncompetitive antagonist of NMDA-glutamate receptor, in Alzheimer's disease and vascular dementia

artículo científico publicado en 2006

Good Publication Practice guidelines for clinical trials?

scientific article published on 01 July 2003

Higher antitumor activity of trabectedin in germline BRCA2 carriers with advanced breast cancer as compared to BRCA1 carriers: A subset analysis of a dedicated phase II trial

artículo científico publicado en 2017

Improvement in exercise tolerance and spirometric values in stable chronic obstructive pulmonary disease patients after an individualized outpatient rehabilitation programme

scientific article published on 01 September 1996

Intestinal ischemic preconditioning: less xanthine accumulation relates with less apoptosis.

artículo científico publicado en 2004

Lipocalin-2-induced renal regeneration depends on cytokines

scientific article published on 24 September 2008

Long-term domiciliary treatment with nasal intermittent positive-pressure ventilation plus supplemental oxygen in COPD with severe hypercapnia

scientific article published on 01 January 1997

Mapping the literature: role of trabectedin as a new chemotherapy option in advanced pretreated soft tissue sarcoma

artículo científico publicado en 2009

Modification of glyceraldehyde-3-phosphate dehydrogenase in response to nitric oxide in intestinal preconditioning

artículo científico publicado en 1999

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy

scientific article published on 21 September 2018

Multiple inert gas elimination technique for determining ventilation/perfusion distributions in rat during normoxia, hypoxia and hyperoxia

artículo científico publicado en 2001

NO and NOS isoforms in the development of apoptosis in renal ischemia/reperfusion

article

Nucleotides modulate renal ischaemia-reperfusion injury by different effects on nitric oxide and superoxide.

artículo científico publicado en 2003

Phase I and pharmacokinetic study of trabectedin 3-hour infusion every three weeks in patients with advanced cancer and alteration of hepatic function

artículo científico publicado en 2011

Phase I and pharmacokinetic study of trabectedin as a 1- or 3-hour infusion weekly in patients with advanced solid malignancies.

artículo científico publicado en 2009

Phase I clinical and pharmacokinetic study of trabectedin and cisplatin given every three weeks in patients with advanced solid tumors

scientific article published on 07 March 2013

Phase I dose-escalation study of plitidepsin in combination with sorafenib or gemcitabine in patients with refractory solid tumors or lymphomas

artículo científico publicado en 2016

Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors

artículo científico publicado en 2012

Phase I study of carboplatin in combination with PM00104 (Zalypsis®) in patients with advanced solid tumors

artículo científico publicado en 2014

Phase II Study of Trabectedin in Pretreated Patients with Advanced Colorectal Cancer

scientific article published on 01 May 2007

Phase II clinical trial of PM00104 (Zalypsis(®)) in urothelial carcinoma patients progressing after first-line platinum-based regimen

artículo científico publicado en 2014

Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma

artículo científico publicado en 2011

Plitidepsin has a safe cardiac profile: a comprehensive analysis.

artículo científico publicado en 2011

Randomised phase III trial of trabectedin versus doxorubicin-based chemotherapy as first-line therapy in translocation-related sarcomas

artículo científico

Role of changes in tissular nucleotides on the development of apoptosis during ischemia/reperfusion in rat small bowel.

artículo científico publicado en 2002

Role of histamine and platelet-activating factor in allergic rhinitis.

artículo científico publicado en 2004

SID: a well-defined abbreviation?

scientific article published on 01 December 1999

Specification of laboratory animal use in scientific articles: current low detail in the journals' instructions for authors and some proposals.

artículo científico publicado en 2005

Spisulosine (ES-285) given as a weekly three-hour intravenous infusion: results of a phase I dose-escalating study in patients with advanced solid malignancies

artículo científico publicado en 2011

Trabectedin has a low cardiac risk profile: a comprehensive cardiac safety analysis ⬇️

artículo científico publicado el 18 de marzo de 2011

Trabectedin in patients with advanced non-small-cell lung cancer (NSCLC) with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum

artículo científico publicado en 2011

Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer: outcomes in the partially platinum-sensitive (platinum-free interval 6-12 months) subpopulation of OVA-301 phase III randomized trial

artículo científico publicado en 2010

Trabectedin plus pegylated liposomal doxorubicin in the treatment of patients with partially platinum-sensitive ovarian cancer: current evidence and future perspectives

artículo científico publicado en 2011

Trabectedin plus pegylated liposomal doxorubicin: retrospective analysis in heavily pretreated platinum-sensitive ovarian cancer ⬇️

artículo científico publicado en 2015

[Clinical trial registration: new ICMJE requirement]

scientific article published on 01 April 2005

[Clinical trials, good publication practice and legal regulations]

artículo científico publicado en 2004

[Encore abstracts in medical/scientific meetings]

artículo científico publicado en 2014

[New proposals for improving the publication of clinical trials]

scientific article published on 01 November 2004

Lista de obras de Vicente Alfaro

A Phase II multicenter, open-label, clinical and pharmokinetic trial of PM00104 in patients with advanced Ewing Family of Tumors

A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin.

A physical-chemical analysis of the acid-base response to chronic obstructive pulmonary disease

A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas

Abbreviated clinical study reports with investigational medicinal products for human use: current guidelines and recommendations.

Acid-base analysis during experimental anemia in rats

Acid-base disturbance during hemorrhage in rats: significant role of strong inorganic ions.

Acute mild hypothermia in awake unrestrained rats induces a mixed acid-base disorder

Age-stratified analysis of I-PSS and QoL values in spanish patients with symptoms potentially related to BPH.

Blood acid-base changes during acute experimental inflammation in rats

Blood sampled in rats from right ventricle may not always be truly representative of a mixed venous sample

CO2 in static mesenteric venous blood during intestinal ischemia and ischemic preconditioning in rats ⬇️

Complete and Sustained Objective Response per RECIST to Irvalec (PM02734) in Undifferentiated Large Cell Esophageal Adenocarcinoma: A Case Report and a Review of the Literature ⬇️

Components of the blood acid-base disturbance that accompanies urethane anaesthesia in rats during normothermia and hypothermia ⬇️

Differential effects of hypothermia upon blood acid-base state and blood gases in sodium pentobarbital and urethane anaesthetised rats

Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure-response analysis

Erythrocyte osmotic resistance during acute hypothermia in awake unrestrained rats

Evaluation of plitidepsin in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofibrosis: results of preclinical studies and a phase II clinical trial

Exogenous adenosine enhances caspase-3 activity in warm renal ischaemia.

Extracellular pH affects inflammatory cell production of superoxide and nitric oxide.

Factors influencing acid-base status during acute severe hypothermia in unanesthetized rats.

Factors influencing the acid-base changes in the air-pouch exudate following carrageenan induced inflammation in rats

First-in-human, phase I study of elisidepsin (PM02734) administered as a 30-min or as a 3-hour intravenous infusion every three weeks in patients with advanced solid tumors

First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours

Gefitinib: current status in the treatment of non-small cell lung cancer.

Glutamate-related excitotoxicity neuroprotection with memantine, an uncompetitive antagonist of NMDA-glutamate receptor, in Alzheimer's disease and vascular dementia

Good Publication Practice guidelines for clinical trials?

Higher antitumor activity of trabectedin in germline BRCA2 carriers with advanced breast cancer as compared to BRCA1 carriers: A subset analysis of a dedicated phase II trial

Improvement in exercise tolerance and spirometric values in stable chronic obstructive pulmonary disease patients after an individualized outpatient rehabilitation programme

Intestinal ischemic preconditioning: less xanthine accumulation relates with less apoptosis.

Lipocalin-2-induced renal regeneration depends on cytokines

Long-term domiciliary treatment with nasal intermittent positive-pressure ventilation plus supplemental oxygen in COPD with severe hypercapnia

Mapping the literature: role of trabectedin as a new chemotherapy option in advanced pretreated soft tissue sarcoma

Modification of glyceraldehyde-3-phosphate dehydrogenase in response to nitric oxide in intestinal preconditioning

Multicenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy

Multiple inert gas elimination technique for determining ventilation/perfusion distributions in rat during normoxia, hypoxia and hyperoxia

NO and NOS isoforms in the development of apoptosis in renal ischemia/reperfusion

Nucleotides modulate renal ischaemia-reperfusion injury by different effects on nitric oxide and superoxide.

Phase I and pharmacokinetic study of trabectedin 3-hour infusion every three weeks in patients with advanced cancer and alteration of hepatic function

Phase I and pharmacokinetic study of trabectedin as a 1- or 3-hour infusion weekly in patients with advanced solid malignancies.

Phase I clinical and pharmacokinetic study of trabectedin and cisplatin given every three weeks in patients with advanced solid tumors

Phase I dose-escalation study of plitidepsin in combination with sorafenib or gemcitabine in patients with refractory solid tumors or lymphomas

Phase I study of PM00104 (Zalypsis®) administered as a 1-hour weekly infusion resting every fourth week in patients with advanced solid tumors

Phase I study of carboplatin in combination with PM00104 (Zalypsis®) in patients with advanced solid tumors

Phase II Study of Trabectedin in Pretreated Patients with Advanced Colorectal Cancer

Phase II clinical trial of PM00104 (Zalypsis(®)) in urothelial carcinoma patients progressing after first-line platinum-based regimen

Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma

Plitidepsin has a safe cardiac profile: a comprehensive analysis.

Randomised phase III trial of trabectedin versus doxorubicin-based chemotherapy as first-line therapy in translocation-related sarcomas

Role of changes in tissular nucleotides on the development of apoptosis during ischemia/reperfusion in rat small bowel.

Role of histamine and platelet-activating factor in allergic rhinitis.

SID: a well-defined abbreviation?

Specification of laboratory animal use in scientific articles: current low detail in the journals' instructions for authors and some proposals.

Spisulosine (ES-285) given as a weekly three-hour intravenous infusion: results of a phase I dose-escalating study in patients with advanced solid malignancies

Trabectedin has a low cardiac risk profile: a comprehensive cardiac safety analysis ⬇️

Trabectedin in patients with advanced non-small-cell lung cancer (NSCLC) with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum

Trabectedin plus pegylated liposomal doxorubicin in relapsed ovarian cancer: outcomes in the partially platinum-sensitive (platinum-free interval 6-12 months) subpopulation of OVA-301 phase III randomized trial

Trabectedin plus pegylated liposomal doxorubicin in the treatment of patients with partially platinum-sensitive ovarian cancer: current evidence and future perspectives

Trabectedin plus pegylated liposomal doxorubicin: retrospective analysis in heavily pretreated platinum-sensitive ovarian cancer ⬇️

[Clinical trial registration: new ICMJE requirement]

[Clinical trials, good publication practice and legal regulations]

[Encore abstracts in medical/scientific meetings]

[New proposals for improving the publication of clinical trials]