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Lista de obras de Yu-Jun Zhao

AM-8553: A Novel MDM2 Inhibitor with a Promising Outlook for Potential Clinical Development ⬇️

artículo científico publicado el 24 de mayo de 2012

Allenamide as a bioisostere of acrylamide in the design and synthesis of targeted covalent inhibitors.

artículo científico publicado en 2017

Asymmetric Syntheses of 8‐Oxabicyclo[3,2,1]octanes: A Cationic Cascade Cyclization ⬇️

artículo científico publicado el 2 de julio de 2012

Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo

scientific article published on 07 April 2020

Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression.

artículo científico publicado en 2017

Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins

scientific article published on 21 August 2019

Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo.

artículo científico publicado en 2015

Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.

artículo científico publicado en 2012

Lewis Acid-Promoted Intermolecular Acetal-Initiated Cationic Polyene Cyclizations

artículo científico publicado en 2007

Lewis Acids Promoted 3 + 2 Cycloaddition of Oxaziridines and Cyclic Allylic Alcohols through Carbonyl Imine Intermediates

scientific article published on 25 March 2019

SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression

artículo científico publicado en 2014

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

artículo científico publicado en 2014

Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors

artículo científico publicado en 2015

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

scientific article published on 10 December 2019

Synthesis of 3‐Oxaterpenoids and Its Application in the Total Synthesis of (±)‐Moluccanic Acid Methyl Ester ⬇️

artículo científico publicado el 17 de septiembre de 2012

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.

artículo científico publicado en 2017

Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges.

artículo científico publicado en 2017

The making of I-BET762, a BET bromodomain inhibitor now in clinical development

artículo científico publicado en 2013

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