Lista de obras - Evy Lobbestael - Dominio Público Uruguay

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

artículo científico publicado en 2012

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

artículo científico publicado en 2015

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

artículo científico publicado en 2014

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

artículo científico publicado en 2020

Editorial: Protein Degradation Pathways in Parkinson's Disease and Neurodegeneration

artículo científico publicado en 2020

Editorial: The Role of Lipids in the Pathogenesis of Parkinson's Disease

scientific article published on 24 March 2020

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

artículo científico publicado en 2012

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

artículo científico publicado en 2013

Immunohistochemical detection of transgene expression in the brain using small epitope tags

artículo científico publicado en 2010

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

artículo científico publicado en 2014

Inflammatory bowel disease and Parkinson's disease: common pathophysiological links

scientific article published on 16 October 2020

Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization

scientific article published on 27 December 2018

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

artículo científico publicado en 2011

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

scientific article published on 08 June 2020

Kinases as targets for Parkinson's disease: from genetics to therapy

artículo científico publicado en 2011

LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo

scientific article published on 16 February 2021

LRRK2 Phosphorylation: Behind the Scenes

artículo científico publicado en 2018

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

artículo científico publicado en 2011

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

artículo científico publicado en 2015

Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration

artículo científico publicado en 2014

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

artículo científico publicado en 2012

Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation

artículo científico publicado en 2020

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

artículo científico publicado en 2017

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

artículo científico publicado en 2018

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity

artículo científico publicado en 2020

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation

artículo científico publicado en 2016

Phosphorylation of LRRK2: from kinase to substrate

artículo científico publicado en 2012

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

artículo científico publicado en 2009

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A

artículo científico publicado en 2018

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

scientific article published on 01 November 2019

Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking

artículo científico publicado en 2019

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

artículo científico publicado en 2014

Lista de obras de Evy Lobbestael

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

Editorial: Protein Degradation Pathways in Parkinson's Disease and Neurodegeneration

Editorial: The Role of Lipids in the Pathogenesis of Parkinson's Disease

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

Immunohistochemical detection of transgene expression in the brain using small epitope tags

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

Inflammatory bowel disease and Parkinson's disease: common pathophysiological links

Inhibition of LRRK2 or Casein Kinase 1 Results in LRRK2 Protein Destabilization

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions

Kinases as targets for Parkinson's disease: from genetics to therapy

LRRK2 Ablation Attenuates Αlpha-Synuclein-Induced Neuroinflammation Without Affecting Neurodegeneration or Neuropathology In Vivo

LRRK2 Phosphorylation: Behind the Scenes

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain

Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein.

Multiple-Hit Hypothesis in Parkinson's Disease: LRRK2 and Inflammation

PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2.

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

Pathogenic LRRK2 requires secondary factors to induce cellular toxicity

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation

Phosphorylation of LRRK2: from kinase to substrate

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease