Lista de obras - Andrés Francesch - Dominio Público Uruguay

Aplicyanins A–F, new cytotoxic bromoindole derivatives from the marine tunicate Aplidium cyaneum

Cytotoxic staurosporines from the marine ascidian Cystodytes solitus

artículo científico publicado en 2008

Dearomatizing anionic cyclization of phosphonamides. A route to phosphonic acid derivatives with antitumor properties.

artículo científico publicado en 2008

Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem.

artículo científico publicado en 2009

Diazonamides C–E, new cytotoxic metabolites from the ascidian Diazona sp

Double dearomatization of bis(diphenylphosphinamides) through anionic cyclization. A facile route of accessing multifunctional systems with antitumor properties

artículo científico publicado en 2007

Enzyme-labile protecting groups for the synthesis of natural products: solid-phase synthesis of thiocoraline.

artículo científico publicado en 2013

Fourier transform infrared spectroscopy indicates a major conformational rearrangement in the activation of rhodopsin.

artículo científico publicado en 1995

Halogenated helianane derivatives from the sponge Spirastrella hartmani

artículo científico publicado en 2005

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

artículo científico publicado en 2009

Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds

artículo científico publicado en 2013

Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives.

artículo científico publicado en 2009

Lignopurines: a new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation.

artículo científico publicado en 2012

MI130004, a novel antibody-drug conjugate combining trastuzumab with a molecule of marine origin, shows outstanding in vivo activity against HER2 expressing tumors.

artículo científico publicado en 2018

Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin

artículo científico publicado en 2018

Njaoamines A–F, new cytotoxic polycyclic alkaloids from the haplosclerid sponge Reniera sp

Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.

artículo científico publicado en 2011

Plumisclerin A, a diterpene with a new skeleton from the soft coral Plumigorgia terminosclera

artículo científico publicado en 2010

Smallest peptoids with antiproliferative activity on human neoplastic cells.

artículo científico publicado en 2007

Solid-phase synthesis of oxathiocoraline by a key intermolecular disulfide dimer.

artículo científico publicado en 2007

Stellatolides, a new cyclodepsipeptide family from the sponge Ecionemia acervus: isolation, solid-phase total synthesis, and full structural assignment of stellatolide A.

artículo científico publicado en 2014

Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis

artículo científico publicado en 2010

Structure-activity relationship of kahalalide F synthetic analogues

artículo científico publicado en 2008

Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.

artículo científico publicado en 2012

Synthesis of Retinals Fluorinated at Odd-Numbered Side-Chain Positions and of the Corresponding Fluorobacteriorhodopsins

scientific article published on 01 January 1997

Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B

artículo científico publicado en 2000

Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives.

artículo científico publicado en 2012

Tanjungides A and B: new antitumoral bromoindole derived compounds from Diazona cf formosa. isolation and total synthesis

artículo científico publicado en 2014

The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo

artículo científico publicado en 2015

The potent anticancer compound ecteinascidin-743 (ET-743) as its 2-propanol disolvate.

artículo científico publicado en 2003

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.

artículo científico publicado en 2004

Total synthesis and antiproliferative activity screening of (+/-)-aplicyanins A, B and E and related analogues.

artículo científico publicado en 2009

Total synthesis of natural myriaporones

artículo científico publicado en 2004

Lista de obras de Andrés Francesch

Aplicyanins A–F, new cytotoxic bromoindole derivatives from the marine tunicate Aplidium cyaneum

Cytotoxic staurosporines from the marine ascidian Cystodytes solitus

Dearomatizing anionic cyclization of phosphonamides. A route to phosphonic acid derivatives with antitumor properties.

Development of Yondelis (trabectedin, ET-743). A semisynthetic process solves the supply problem.

Diazonamides C–E, new cytotoxic metabolites from the ascidian Diazona sp

Double dearomatization of bis(diphenylphosphinamides) through anionic cyclization. A facile route of accessing multifunctional systems with antitumor properties

Enzyme-labile protecting groups for the synthesis of natural products: solid-phase synthesis of thiocoraline.

Fourier transform infrared spectroscopy indicates a major conformational rearrangement in the activation of rhodopsin.

Halogenated helianane derivatives from the sponge Spirastrella hartmani

In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.

Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds

Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives.

Lignopurines: a new family of hybrids between cyclolignans and purines. Synthesis and biological evaluation.

MI130004, a novel antibody-drug conjugate combining trastuzumab with a molecule of marine origin, shows outstanding in vivo activity against HER2 expressing tumors.

Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of 14C-plitidepsin

Njaoamines A–F, new cytotoxic polycyclic alkaloids from the haplosclerid sponge Reniera sp

Optically active 1,3,4,4-tetrasubstituted β-lactams: synthesis and evaluation as tumor cell growth inhibitors.

Plumisclerin A, a diterpene with a new skeleton from the soft coral Plumigorgia terminosclera

Smallest peptoids with antiproliferative activity on human neoplastic cells.

Solid-phase synthesis of oxathiocoraline by a key intermolecular disulfide dimer.

Stellatolides, a new cyclodepsipeptide family from the sponge Ecionemia acervus: isolation, solid-phase total synthesis, and full structural assignment of stellatolide A.

Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis

Structure-activity relationship of kahalalide F synthetic analogues

Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.

Synthesis of Retinals Fluorinated at Odd-Numbered Side-Chain Positions and of the Corresponding Fluorobacteriorhodopsins

Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B

Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives.

Tanjungides A and B: new antitumoral bromoindole derived compounds from Diazona cf formosa. isolation and total synthesis

The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo

The potent anticancer compound ecteinascidin-743 (ET-743) as its 2-propanol disolvate.

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.

Total synthesis and antiproliferative activity screening of (+/-)-aplicyanins A, B and E and related analogues.

Total synthesis of natural myriaporones