Lista de obras - Donatella Tondi - Dominio Público Uruguay

Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?

artículo científico publicado en 2020

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases.

artículo científico publicado en 2017

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth

artículo científico publicado en 2018

Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations

scientific article published on 01 October 1996

Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases

artículo científico publicado en 2008

Decoding the Structural Basis For Carbapenem Hydrolysis By Class A β-lactamases: Fishing For A Pharmacophore

artículo científico publicado en 2015

First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase

scientific article published on 02 January 2019

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine

artículo científico publicado en 2005

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling

artículo científico publicado en 1998

Naphthalimido derivatives as antifolate thymidylate synthase inhibitors

Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy

artículo científico publicado en 2007

Phenylboronic Acid Derivatives as Validated Leads Active in Clinical Strains Overexpressing KPC-2: A Step against Bacterial Resistance.

artículo científico publicado en 2018

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition

artículo científico publicado en 1999

Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase

artículo científico publicado en 2001

Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase1,21Escherichia coli thymidylate synthase numbering is used unless otherwise noted.2PDB coordinates have been deposited with the RCSB wi

article published in 2001

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

artículo científico publicado en 2011

SOS response in bacteria: Inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein

artículo científico publicado en 2017

Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors

artículo científico publicado en 2010

Structure-Based Virtual Screening for the Discovery of Novel Inhibitors of New Delhi Metallo-β-lactamase-1.

artículo científico publicado en 2017

Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase

artículo científico publicado en 2001

Structure-based design of inhibitors specific for bacterial thymidylate synthase

artículo científico publicado en 1999

Structure-based discovery and in-parallel optimization of novelcompetitive inhibitors of thymidylate synthase

scientific article published on 01 May 1999

Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture

artículo científico publicado en 2005

Structure-based studies on species-specific inhibition of thymidylate synthase

artículo científico publicado en 2002

Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

artículo científico publicado en 2014

Targeting the Class A Carbapenemase GES-5 via Virtual Screening

artículo científico publicado en 2020

Ten Years with New Delhi Metallo-β-lactamase-1 (NDM-1): From Structural Insights to Inhibitor Design

scientific article published on 28 November 2018

The inhibition of extended spectrum β-lactamases: hits and leads

artículo científico publicado en 2014

Thymidylate synthase structure, function and implication in drug discovery.

artículo científico publicado en 2005

X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid β-Lactamase Inhibitors

scientific article published on 27 March 2019

ortho-Halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity

artículo científico publicado en 2003

Lista de obras de Donatella Tondi

Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases.

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth

Conformational analysis of phthalein derivatives acting as thymidylate synthase inhibitors by means of 1H NMR and quantum chemical calculations

Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases

Decoding the Structural Basis For Carbapenem Hydrolysis By Class A β-lactamases: Fishing For A Pharmacophore

First virtual screening and experimental validation of inhibitors targeting GES-5 carbapenemase

Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine

Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling

Naphthalimido derivatives as antifolate thymidylate synthase inhibitors

Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy

Phenylboronic Acid Derivatives as Validated Leads Active in Clinical Strains Overexpressing KPC-2: A Step against Bacterial Resistance.

Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition

Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase

Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase1,21Escherichia coli thymidylate synthase numbering is used unless otherwise noted.2PDB coordinates have been deposited with the RCSB wi

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

SOS response in bacteria: Inhibitory activity of lichen secondary metabolites against Escherichia coli RecA protein

Structural study of phenyl boronic acid derivatives as AmpC β-lactamase inhibitors

Structure-Based Virtual Screening for the Discovery of Novel Inhibitors of New Delhi Metallo-β-lactamase-1.

Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase

Structure-based design of inhibitors specific for bacterial thymidylate synthase

Structure-based discovery and in-parallel optimization of novelcompetitive inhibitors of thymidylate synthase

Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture

Structure-based studies on species-specific inhibition of thymidylate synthase

Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

Targeting the Class A Carbapenemase GES-5 via Virtual Screening

Ten Years with New Delhi Metallo-β-lactamase-1 (NDM-1): From Structural Insights to Inhibitor Design

The inhibition of extended spectrum β-lactamases: hits and leads

Thymidylate synthase structure, function and implication in drug discovery.

X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid β-Lactamase Inhibitors

ortho-Halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity