Lista de obras - Jeff Idle - Dominio Público Uruguay

(2R,3S)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid Leukemia

artículo científico publicado en 2020

A Novel Anti-Hepatitis C Virus and Antiproliferative Agent Alters Metabolic Networks in HepG2 and Hep3B Cells

artículo científico publicado en 2017

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics

artículo científico publicado en 2011

A metabolomic perspective of melatonin metabolism in the mouse

artículo científico publicado en 2008

A polymorphic CfoI site in exon 6 of the human cytochrome P450 CYP2D6 gene detected by the polymerase chain reaction

article

A population and familial study of the defective alicyclic hydroxylation of debrisoquine among Egyptians

artículo científico publicado el 1 de enero de 1979

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

artículo científico publicado en 1997

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling

artículo científico publicado en 2011

An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution

scientific article published on 01 March 1995

Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice

artículo científico publicado en 2010

Benzoylglutamic acid, a metabolite of benzoic acid in Indian fruit bats

artículo científico publicado en 1975

Beta blockers and drug oxidation status

artículo científico publicado en 1982

CYP2D6 genotype and smoking behaviour in cigarette smokers ⬇️

artículo científico publicado el 1 de octubre de 1997

CYP2D6 polymorphism, tramadol pharmacokinetics and pupillary response.

artículo científico publicado en 2005

Combined thin-layer chromatography-photography-densitometry for the quantification of ifosfamide and its principal metabolites in urine, cerebrospinal fluid and plasma

artículo científico publicado el 13 de marzo de 1992

Combined thin-layer chromatography—photography—densitometry for the quantitation of cyclophosphamide and its four principal urinary metabolites ⬇️

artículo científico publicado el 13 de mayo de 1988

Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6

artículo científico publicado en 2006

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

artículo científico publicado en 2010

Comparison of continuous infusion and bolus administration of ifosfamide in children

scientific article published on 01 January 1995

Conjugation of foreign compounds in the elephant and hyaena

artículo científico publicado el 15 de diciembre de 1975

Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.

artículo científico publicado en 2003

Cytochrome P450dbl phenotypes in malignant and benign breast disease

artículo científico publicado en 1990

Deficient sulphoxidation status and D-penicillamine toxicity

artículo científico publicado en 1983

Differential expression of glutathione transferases by native and cultured human lymphocytes

artículo científico publicado en 1988

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

artículo científico publicado en 2005

Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver.

artículo científico publicado en 2014

Early glucose and methylene blue are effective against unripe ackee apple (Blighia sapida) poisoning in mice.

artículo científico publicado en 2004

Elevated serum cholesterol in drug-oxidation-deficient rats

scientific article published on 01 April 1982

Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics.

artículo científico publicado en 2009

Genetic impairment of phenformin metabolism

artículo científico publicado en 1980

Genetic variation of CYP2A6, smoking, and risk of cancer.

artículo científico publicado en 1999

Genetically determined defcts of oxidation at carbon centres of drugs

artículo científico publicado en 1978

Genetically determined impaired drug sulphoxidation

artículo científico publicado en 1981

Genetically determined variability in drug metabolism: dual slow acetylation and drug oxidation traits

artículo científico publicado en 1979

Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation.

scientific article published on September 2009

Hypotensive response to debrisoquine and hydroxylation phenotype

scientific article published on 01 March 1978

Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse.

artículo científico publicado en 2010

Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics

scientific article published on 01 June 1996

Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine

artículo científico publicado en 1979

Intrasubject variation in children of ifosfamide pharmacokinetics and metabolism during repeated administration

artículo científico publicado en 1996

LC-MS-based metabolomics in drug metabolism

artículo científico publicado en 2007

Lung cancer risk in relation to the CYP2C9 genetic polymorphism among Caucasians in Los Angeles County ⬇️

artículo científico publicado el 1 de octubre de 1997

Mass isotopomer-guided decluttering of metabolomic data to visualize endogenous biomarkers of drug toxicity

scientific article published on 20 September 2018

Metabolic oxidation of methaqualone in extensive and poor metabolisers of debrisoquine

artículo científico publicado en 1982

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

artículo científico publicado en 1984

Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice

artículo científico publicado en 2017

Metabolic profiling of praziquantel enantiomers.

artículo científico publicado en 2014

Metabolism of melatonin by human cytochromes p450.

artículo científico publicado en 2004

Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.

artículo científico publicado en 2017

Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.

artículo científico publicado en 2007

Metabolomic markers for intestinal ischemia in a mouse model.

artículo científico publicado en 2012

Metabolomics and its potential in drug development.

artículo científico publicado en 2012

Metabolomics reveals aging-associated attenuation of noninvasive radiation biomarkers in mice: potential role of polyamine catabolism and incoherent DNA damage-repair.

artículo científico publicado en 2013

Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus

artículo científico publicado en 2011

Metabolomics reveals that aldose reductase activity due to AKR1B10 is upregulated in hepatitis C virus infection.

artículo científico publicado en 2014

Metabolomics reveals the metabolic map of procainamide in humans and mice.

artículo científico publicado en 2012

Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

artículo científico publicado en 2013

Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

scientific journal article

Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer.

artículo científico publicado en 2014

Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics ⬇️

artículo científico publicado el 5 de septiembre de 2012

Painting the liver with lasers: the future of liver histology?

artículo científico publicado en 2013

Pharmacogenetic phenotyping and genotyping. Present status and future potential.

artículo científico publicado en 1994

Pharmacokinetics and metabolism of cyclophosphamide in paediatric patients

scientific article published on 01 January 1992

Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435T

scientific article published on 30 January 2007

Pharmacokinetics, metabolism and clinical effect of ifosfamide in breast cancer patients

scientific article published on 01 January 1995

Phenformin-induced lacticacidosis associated with impaired debrisoquine hydroxylation

scientific article published on 01 April 1981

Pinning down the polo-box domain.

artículo científico publicado en 2008

Polymorphic 4-hydroxylation of debrisoquine in chronic discoid psoriasis

artículo científico publicado en 1981

Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.

artículo científico publicado en 2004

Polymorphic sulphoxidation of S-carboxymethyl-L-cysteine in man

artículo científico publicado en 1982

Polymorphisms of Oxidation at Carbon Centers of Drugs and Their Clinical Significance ⬇️

artículo científico publicado el 1 de enero de 1979

Poor metabolisers of nicotine and CYP2D6 polymorphism

artículo científico publicado en 1994

Potential inhibition of alkylating agent metabolism by fluconazole

scientific article published on 01 December 1994

Potential role of CYP2D6 in the central nervous system ⬇️

artículo científico publicado el 25 de abril de 2013

Prediction of subclinical perhexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation.

artículo científico publicado en 1983

Protecting poor metabolizers, a group at high risk of adverse drug reactions

scientific article published on 01 June 1983

Racemates revisited: heterochiral assemblies and the example of DL-thalidomide.

artículo científico publicado en 2011

Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm.

artículo científico publicado en 2009

Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats

artículo científico publicado en 2011

Radiation metabolomics. 5. Identification of urinary biomarkers of ionizing radiation exposure in nonhuman primates by mass spectrometry-based metabolomics

artículo científico publicado en 2012

Reduced serum lipoprotein(a) levels in patients with primary biliary cirrhosis.

artículo científico publicado en 1994

Robust Regression Analysis of GCMS Data Reveals Differential Rewiring of Metabolic Networks in Hepatitis B and C Patients.

artículo científico publicado en 2017

Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance.

artículo científico publicado en 2007

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

article by Holthe M et al published 1 January 2003 in The Pharmacogenomics Journal

Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer ⬇️

artículo científico publicado el 1 de febrero de 1981

Spectral binding studies of the polymorphically metabolized drugs debrisoquine, sparteine and phenformin by cytochrome P-450 of normal and hydroxylation deficient rat strains

artículo científico publicado en 1982

Sulphoxidation of S-carboxymethyl-L-cysteine in the rhesus monkey (Macaca mulatta), cynomologus monkey (Macaca fascicularis), African green monkey (Cercopithecus aethiops) and the marmoset (Callithrix jacchus).

artículo científico publicado en 1986

Taurine Conjugates as Metabolites of Arylacetic Acids in the Ferret ⬇️

artículo científico publicado el 1 de abril de 1978

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

artículo científico publicado en 2006

The conjugation of benzoic acid and phenylacetic acid by the pipistrelle bat ⬇️

artículo científico publicado el 1 de enero de 1977

The conjugation of benzoic acid in the African bat, Epomops franqueti ⬇️

artículo científico publicado el 1 de enero de 1977

The contribution of genetically determined oxidation status to inter-individual variation in phenacetin disposition

artículo científico publicado en 1983

The effect of route of administration and fractionation of dose on the metabolism of ifosfamide

artículo científico publicado en 1990

The glycine deportation system and its pharmacological consequences.

artículo científico publicado en 2012

The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion

scientific article published on 01 January 1995

The metabolism of 14C-labelled trimethylamine and its N-oxide in man

artículo científico publicado en 1987

The metabolism of [14C]cimetidine in man

scientific article published on 01 May 1982

The metabolomic profile of gamma-irradiated human hepatoma and muscle cells reveals metabolic changes consistent with the Warburg effect.

artículo científico publicado en 2016

The metabolomic window into hepatobiliary disease ⬇️

artículo científico publicado el 25 de mayo de 2013

The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases

artículo científico publicado en 2006

The polymorphic 4-hydroxylation of debrisoquine in a Saudi arab population

artículo científico publicado en 1980

The production and composition of rat sebum is unaffected by 3 Gy gamma radiation

artículo científico publicado en 2010

The relative contribution of monoamine oxidase and cytochrome p450 isozymes to the metabolic deamination of the trace amine tryptamine.

artículo científico publicado en 2003

The role of individual human cytochromes P450 in drug metabolism and clinical response

artículo científico publicado el 1 de diciembre de 1992

Tissue metabolomics of hepatocellular carcinoma: tumor energy metabolism and the role of transcriptomic classification.

artículo científico publicado en 2013

Trimethylaminuria (fish-odour syndrome): an inborn error of oxidative metabolism

artículo científico publicado en 1987

Trimethylaminuria: the detection of carriers using a trimethylamine load test

scientific article published on 01 January 1989

UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation.

artículo científico publicado en 2008

UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model

artículo científico publicado en 2011

Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene

article

Unequivocal synthesis and characterisation of dopamine 3- and 4-O-sulphates

artículo científico publicado en 1982

Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6

scientific article published on 01 July 1998

Xenobiotic metabolomics: major impact on the metabolome

artículo científico

Lista de obras de Jeff Idle

(2R,3S)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid Leukemia

A Novel Anti-Hepatitis C Virus and Antiproliferative Agent Alters Metabolic Networks in HepG2 and Hep3B Cells

A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics

A metabolomic perspective of melatonin metabolism in the mouse

A polymorphic CfoI site in exon 6 of the human cytochrome P450 CYP2D6 gene detected by the polymerase chain reaction

A population and familial study of the defective alicyclic hydroxylation of debrisoquine among Egyptians

A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling

An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution

Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice

Benzoylglutamic acid, a metabolite of benzoic acid in Indian fruit bats

Beta blockers and drug oxidation status

CYP2D6 genotype and smoking behaviour in cigarette smokers ⬇️

CYP2D6 polymorphism, tramadol pharmacokinetics and pupillary response.

Combined thin-layer chromatography-photography-densitometry for the quantification of ifosfamide and its principal metabolites in urine, cerebrospinal fluid and plasma

Combined thin-layer chromatography—photography—densitometry for the quantitation of cyclophosphamide and its four principal urinary metabolites ⬇️

Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.

Comparison of continuous infusion and bolus administration of ifosfamide in children

Conjugation of foreign compounds in the elephant and hyaena

Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.

Cytochrome P450dbl phenotypes in malignant and benign breast disease

Deficient sulphoxidation status and D-penicillamine toxicity

Differential expression of glutathione transferases by native and cultured human lymphocytes

Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver.

Early glucose and methylene blue are effective against unripe ackee apple (Blighia sapida) poisoning in mice.

Elevated serum cholesterol in drug-oxidation-deficient rats

Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics.

Genetic impairment of phenformin metabolism

Genetic variation of CYP2A6, smoking, and risk of cancer.

Genetically determined defcts of oxidation at carbon centres of drugs

Genetically determined impaired drug sulphoxidation

Genetically determined variability in drug metabolism: dual slow acetylation and drug oxidation traits

Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation.

Hypotensive response to debrisoquine and hydroxylation phenotype

Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse.

Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics

Interindividual and interspecies variation in the metabolism of the hallucinogen 4-methoxyamphetamine

Intrasubject variation in children of ifosfamide pharmacokinetics and metabolism during repeated administration

LC-MS-based metabolomics in drug metabolism

Lung cancer risk in relation to the CYP2C9 genetic polymorphism among Caucasians in Los Angeles County ⬇️

Mass isotopomer-guided decluttering of metabolomic data to visualize endogenous biomarkers of drug toxicity

Metabolic oxidation of methaqualone in extensive and poor metabolisers of debrisoquine

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice

Metabolic profiling of praziquantel enantiomers.

Metabolism of melatonin by human cytochromes p450.

Metabolomic Analysis of Mice Exposed to Gamma Radiation Reveals a Systemic Understanding of Total-Body Exposure.

Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation.

Metabolomic markers for intestinal ischemia in a mouse model.

Metabolomics and its potential in drug development.

Metabolomics reveals aging-associated attenuation of noninvasive radiation biomarkers in mice: potential role of polyamine catabolism and incoherent DNA damage-repair.

Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus

Metabolomics reveals that aldose reductase activity due to AKR1B10 is upregulated in hepatitis C virus infection.

Metabolomics reveals the metabolic map of procainamide in humans and mice.

Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum.

Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer.

Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics ⬇️

Painting the liver with lasers: the future of liver histology?

Pharmacogenetic phenotyping and genotyping. Present status and future potential.

Pharmacokinetics and metabolism of cyclophosphamide in paediatric patients

Pharmacokinetics of tramadol is affected by MDR1 polymorphism C3435T

Pharmacokinetics, metabolism and clinical effect of ifosfamide in breast cancer patients

Phenformin-induced lacticacidosis associated with impaired debrisoquine hydroxylation

Pinning down the polo-box domain.

Polymorphic 4-hydroxylation of debrisoquine in chronic discoid psoriasis

Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.

Polymorphic sulphoxidation of S-carboxymethyl-L-cysteine in man

Polymorphisms of Oxidation at Carbon Centers of Drugs and Their Clinical Significance ⬇️

Poor metabolisers of nicotine and CYP2D6 polymorphism

Potential inhibition of alkylating agent metabolism by fluconazole

Potential role of CYP2D6 in the central nervous system ⬇️

Prediction of subclinical perhexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation.

Protecting poor metabolizers, a group at high risk of adverse drug reactions

Racemates revisited: heterochiral assemblies and the example of DL-thalidomide.

Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm.

Radiation metabolomics. 4. UPLC-ESI-QTOFMS-Based metabolomics for urinary biomarker discovery in gamma-irradiated rats