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Lista de obras de José Manuel García Fernández

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties.

artículo científico publicado en 2010

6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase

artículo científico publicado en 2009

A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.

artículo científico publicado en 2013

Bicyclic derivatives of L-idonojirimycin as pharmacological chaperones for neuronopathic forms of Gaucher disease.

artículo científico publicado en 2013

Carbohydrate supramolecular chemistry: beyond the multivalent effect

scientific article published on 23 April 2020

Carbohydrate-Derived Spiroketals:  Stereoselective Synthesis of Di-d-fructose Dianhydrides via Intramolecular Aglycon Delivery

scientific article published on 01 March 2003

Carbohydrate-based receptors with multiple thiourea binding sites. Multipoint hydrogen bond recognition of dicarboxylates and monosaccharides.

artículo científico publicado en 2001

Carbon Dioxide as a Traceless Caramelization Promotor: Preparation of Prebiotic Difructose Dianhydrides (DFAs)-Enriched Caramels from d-Fructose.

artículo científico publicado en 2017

Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.

artículo científico publicado en 2002

Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery

artículo científico publicado en 2020

Conformationally-Locked N-Glycosides with Selective β-Glucosidase Inhibitory Activity: Identification of a New Non-Iminosugar-Type Pharmacological Chaperone for Gaucher Disease

artículo científico publicado en 2012

Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts

artículo científico publicado en 2016

Conformationally-locked N-glycosides: Exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease

artículo científico publicado en 2014

Cyclodextrin- and calixarene-based polycationic amphiphiles as gene delivery systems: a structure-activity relationship study

artículo científico publicado en 2015

Cyclodextrin-Based Functional Glyconanomaterials

scientific article published on 15 December 2020

Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis

artículo científico publicado en 2020

Cyclodextrin-based gene delivery systems.

artículo científico publicado en 2010

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate-protein interactions.

artículo científico

Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues

artículo científico publicado en 2011

Dependence of concanavalin A binding on anomeric configuration, linkage type, and ligand multiplicity for thiourea-bridged mannopyranosyl-beta-cyclodextrin conjugates.

artículo científico publicado en 2001

Di-D-fructose dianhydride-enriched caramels: effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats.

artículo científico publicado en 2010

Di-D-fructose dianhydride-enriched products by acid ion-exchange resin-promoted caramelization of D-fructose: chemical analyses.

artículo científico publicado en 2010

Difructose Dianhydrides (DFAs) and DFA-Enriched Products as Functional Foods

artículo científico publicado el 1 de enero de 2010

Dynamic self-assembly of polycationic clusters based on cyclodextrins for pH-sensitive DNA nanocondensation and delivery by component design.

artículo científico publicado en 2014

Effects of feed additives on ileal mucosa-associated microbiota composition of broiler chickens.

artículo científico publicado en 2015

Effects of inulin and di-D-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens

artículo científico publicado en 2013

Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity.

artículo científico publicado en 2010

Fluorinated Chaperone-β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease.

artículo científico publicado en 2017

Fullerene-sp2-iminosugar balls as multimodal ligands for lectins and glycosidases: a mechanistic hypothesis for the inhibitory multivalent effect.

artículo científico publicado en 2013

Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: ligands for concanavalin A.

artículo científico publicado en 2004

Generalized Anomeric Effect ingem-Diamines: Stereoselective Synthesis of α-N-Linked Disaccharide Mimics

artículo científico publicado en 2009

Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers.

artículo científico publicado en 2014

Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases.

artículo científico publicado en 2016

Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring

artículo científico publicado en 2009

Host-Guest-Mediated DNA Templation of Polycationic Supramolecules for Hierarchical Nanocondensation and the Delivery of Gene Material

artículo científico publicado en 2015

Influence of the configurational pattern of sp(2)-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties.

artículo científico publicado en 2016

Influence of the macroring size on the self-association thermodynamics of cyclodextrins with a double-linked naphthalene at the secondary face.

artículo científico publicado en 2013

Inhibition of type 1 fimbriae-mediated Escherichia coli adhesion and biofilm formation by trimeric cluster thiomannosides conjugated to diamond nanoparticles.

artículo científico publicado en 2015

Intramolecular Benzyl Protection Delivery:  A Practical Synthesis of DMDP and DGDP fromd-Fructose

scientific article published on 01 January 2006

Mannose-coated polydiacetylene (PDA)-based nanomicelles: synthesis, interaction with concanavalin A and application in the water solubilization and delivery of hydrophobic molecules

artículo científico publicado en 2019

Microwave-assisted synthesis of prebiotic di-D-fructose dianhydride-enriched caramels

artículo científico publicado en 2012

Molecular basis for beta-glucosidase inhibition by ring-modified calystegine analogues

artículo científico publicado en 2008

Molecular basis of 1-deoxygalactonojirimycin arylthiourea binding to human α-galactosidase a: pharmacological chaperoning efficacy on Fabry disease mutants

artículo científico publicado en 2014

Multimeric lactoside "click clusters" as tools to investigate the effect of linker length in specific interactions with peanut lectin, galectin-1, and -3.

artículo científico publicado en 2010

Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies.

artículo científico publicado en 2013

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

artículo científico publicado en 2019

Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds

artículo científico publicado en 2012

Novel Therapies for Orphan Diseases

scientific article published on 18 June 2019

One-pot regioselective synthesis of 2I,3I-O-(o-xylylene)-capped cyclomaltooligosaccharides: tailoring the topology and supramolecular properties of cyclodextrins

artículo científico publicado en 2007

One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides.

artículo científico publicado en 2002

Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease

artículo científico publicado en 2015

Pharmacological Chaperones for the Treatment of α-Mannosidosis

artículo científico publicado en 2019

Pharmacological chaperone therapy for Gaucher disease: a patent review.

artículo científico publicado en 2011

Plasmid-Templated Control of DNA-Cyclodextrin Nanoparticle Morphology Through Molecular Vector Design for Effective Gene Delivery

artículo científico publicado en 2018

Polycationic amphiphilic cyclodextrin-based nanoparticles for therapeutic gene delivery.

artículo científico publicado en 2011

Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition.

artículo científico publicado en 2016

Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters".

artículo científico publicado en 2009

Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

artículo científico publicado en 2018

Probing the Nature of the Cluster Effect Observed with Synthetic Multivalent Galactosides and Peanut Agglutinin Lectin

scientific article published on 21 November 2012

Promoting helicity in carbohydrate-containing foldamers through long-range hydrogen bonds

artículo científico publicado en 2006

Protonic and thermal activation of sucrose and the oligosaccharide composition of caramel

scientific article published on 01 April 1994

Protonic reactivity of sucrose in anhydrous hydrogen fluoride.

artículo científico publicado en 1994

Qualitative and quantitative evaluation of mono- and disaccharides in D-fructose, D-glucose and sucrose caramels by gas-liquid chromatography-mass spectrometry. Di-D-fructose dianhydrides as tracers of caramel authenticity.

artículo científico publicado en 1999

Rational design of cationic cyclooligosaccharides as efficient gene delivery systems

article

Rigid Spacer-Mediated Synthesis of Bis-Spiroketal Ring Systems:  Stereoselective Synthesis of Nonsymmetrical Spiro Disaccharides

artículo científico publicado en 2005

Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.

artículo científico publicado en 2012

Selective Antimicrobial and Antibiofilm Disrupting Properties of Functionalized Diamond Nanoparticles AgainstEscherichia coliandStaphylococcus aureus

Selective protonic activation of isomeric glycosylfructoses with pyridinium poly(hydrogen fluoride) and synthesis of spirodioxanyl oligosaccharides

artículo científico publicado el 31 de diciembre de 1992

Stereoselective Synthesis of 2-Acetamido-1,2-dideoxyallonojirimycin (DAJNAc), a New Potent Hexosaminidase Inhibitor

artículo científico publicado en 2013

Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis

scientific article published on 23 March 2020

Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors

artículo científico publicado en 2015

Structural basis of pharmacological chaperoning for human β-galactosidase.

artículo científico publicado en 2014

Structure and serological analysis of the Hafnia alvei 481-L O-specific polysaccharide containing phosphate in the backbone chain.

artículo científico publicado en 2006

Structure of the Hafnia alvei strain PCM 1188 O-specific polysaccharide

scientific article published on 01 November 1995

Sugar-modified foldamers as conformationally defined and biologically distinct glycopeptide mimics

artículo científico publicado en 2013

Synthesis and Biophysical Study of Disassembling Nanohybrid Bioconjugates with a Cubic Octasilsesquioxane Core

Synthesis and biological evaluation of guanidine-type iminosugars.

artículo científico publicado en 2008

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.

artículo científico publicado en 2010

Synthesis of Prebiotic Caramels Catalyzed by Ion-Exchange Resin Particles: Kinetic Model for the Formation of Di-d-fructose Dianhydrides.

artículo científico publicado en 2018

Synthesis of dispirodioxanyl pseudo-oligosaccharides by selective protonic activation of isomeric glycosylfructoses in anhydrous hydrogen fluoride

scientific article published on 01 January 1994

Synthesis of multibranched australine derivatives from reducing castanospermine analogues through the Amadori rearrangement of gem-diamine intermediates: selective inhibitors of β-glucosidase

artículo científico publicado en 2014

Synthesis of thiohydantoin-castanospermine glycomimetics as glycosidase inhibitors.

artículo científico publicado en 2009

Synthesis, conformational analysis and <i>in vivo</i> assays of an anti-cancer vaccine that features an unnatural antigen based on an sp<sup>2</sup>-iminosugar fragment

artículo científico publicado en 2020

Tailoring beta-cyclodextrin for DNA complexation and delivery by homogeneous functionalization at the secondary face.

artículo científico publicado en 2008

Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier.

artículo científico publicado en 2014

Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo.

artículo científico publicado en 2013

The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study

artículo científico publicado en 2017

The o-xylylene protecting group as an element of conformational control of remote stereochemistry in the synthesis of spiroketals

artículo científico publicado en 2006

Thermodynamics of the dimer formation of 2(I),3(I)-O-(o-xylylene)-per-O-Me-gamma-cyclodextrin: fluorescence, molecular mechanics and molecular dynamics.

artículo científico publicado en 2009

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids

scientific article published on 08 August 2019

Trehalose- and glucose-derived glycoamphiphiles: small-molecule and nanoparticle Toll-like receptor 4 (TLR4) modulators

artículo científico publicado en 2014

Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

artículo científico publicado en 2019

Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM1 gangliosidosis

artículo científico publicado en 2012

Unprecedented inhibition of glycosidase-catalyzed substrate hydrolysis by nanodiamond-grafted O-glycosides

scholarly article in RSC Advances, vol. 5 no. 122, 2015

Urea-, thiourea-, and guanidine-linked glycooligomers as phosphate binders in water.

artículo científico publicado en 2006

Xylylene Clips for the Topology-Guided Control of the Inclusion and Self-Assembling Properties of Cyclodextrins

artículo científico publicado en 2018

o-Xylylene protecting group in carbohydrate chemistry: application to the regioselective protection of a single vic-diol segment in cyclodextrins.

artículo científico publicado en 2013

pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases.

artículo científico publicado en 2015

β-Cyclodextrin-based polycationic amphiphilic "click" clusters: effect of structural modifications in their DNA complexing and delivery properties

artículo científico publicado el 6 de julio de 2011