Lista de obras - Javier Hernandez-Losa - Dominio Público Uruguay

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation

artículo científico publicado en 2014

ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment

artículo científico publicado en 2017

Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

artículo científico

Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension.

artículo científico publicado en 2009

Brush border myosin Ia has tumor suppressor activity in the intestine.

artículo científico publicado en 2012

Brush border myosin Ia inactivation in gastric but not endometrial tumors.

artículo científico publicado en 2012

Cancer as an ecomolecular disease and a neoplastic consortium

artículo científico publicado en 2017

Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis.

artículo científico publicado en 2009

Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation.

artículo científico publicado en 2013

Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib

scientific article published on 20 August 2018

Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas

artículo científico publicado en 2012

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

artículo científico publicado en 2011

E1a is an exogenous in vivo tumour suppressor.

artículo científico publicado en 2017

Effect of low doses of actinomycin D on neuroblastoma cell lines

artículo científico publicado en 2016

Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy.

artículo científico publicado en 2013

Epithelial-mesenchymal transition markers and HER3 expression are predictors of elisidepsin treatment response in breast and pancreatic cancer cell lines

artículo científico publicado en 2013

ErbB3 expression predicts sensitivity to elisidepsin treatment: in vitro synergism with cisplatin, paclitaxel and gemcitabine in lung, breast and colon cancer cell lines ⬇️

artículo científico publicado el 3 de abril de 2012

ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor.

artículo científico publicado en 2013

Evaluation of the intraoperative human papillomavirus test as a marker of early cure at 12 months after electrosurgical excision procedure in women with cervical high-grade squamous intraepithelial lesion: a prospective cohort study

scientific article published on 25 September 2019

Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients

artículo científico publicado en 2018

Fluorescence in situ hybridization and immunohistochemistry as diagnostic methods for ALK positive non-small cell lung cancer patients

artículo científico publicado en 2013

Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine.

artículo científico publicado en 2015

Genetic Profiles of Squamous Cell Carcinomas Associated with Recessive Dystrophic Epidermolysis Bullosa Unveil NOTCH and TP53 Mutations and an Increased MYC Expression.

artículo científico publicado en 2017

Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations.

artículo científico publicado en 2016

Genetic profile of GNAQ-mutated blue melanocytic neoplasms reveals mutations in genes linked to genomic instability and the PI3K pathway.

artículo científico publicado en 2016

Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: Correlation with pathologic subtypes, p16INK4a expression, and prognosis ⬇️

artículo científico publicado el 3 de agosto de 2012

Identification of somatic gene mutations in penile squamous cell carcinoma.

artículo científico publicado en 2015

Identification of the novel mutation m.5658T>C in the mitochondrial tRNA(Asn) gene in a patient with myopathy, bilateral ptosis and ophthalmoparesis.

artículo científico publicado en 2013

Increased voltage-dependent K(+) channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness

artículo científico publicado en 2012

Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis

article

Integrating clinical, molecular, proteomic and histopathological data within the tissue context: tissunomics

scientific article published on 14 May 2019

JC virus and human colon carcinoma: an intriguing and inconclusive association.

artículo científico publicado en 2003

Lack of association of polyomavirus and herpesvirus types 6 and 7 in human lymphomas

artículo científico publicado en 2005

Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas

artículo científico publicado en 2013

Loss of the EPH receptor B6 contributes to colorectal cancer metastasis

artículo científico publicado en 2017

Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness

artículo científico publicado en 2015

Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth

artículo científico publicado en 2010

Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin.

artículo científico publicado en 2002

Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C.

artículo científico publicado en 2005

Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.

artículo científico publicado en 2012

Myo5b knockout mice as a model of microvillus inclusion disease.

artículo científico publicado en 2015

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.

artículo científico publicado en 2018

Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform Lungscape Project.

artículo científico publicado en 2014

RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas.

artículo científico publicado en 2015

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.

artículo científico publicado en 2014

RSK4 inhibition results in bypass of stress-induced and oncogene-induced senescence.

artículo científico publicado en 2011

Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors.

artículo científico publicado en 2009

Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

artículo científico publicado en 2005

Risk factors of high-grade anal intraepithelial neoplasia recurrence in HIV-infected MSM.

artículo científico publicado en 2017

S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

artículo científico publicado en 2008

Schwannomas, benign tumors with a senescent phenotype

artículo científico publicado en 2013

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation

Spiny hyperkeratosis (trichodysplasia spinulosa-like eruption): a cutaneous adverse effect of Hedgehog pathway inhibitors involving expression of p16

artículo científico publicado en 2016

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

artículo científico publicado en 2016

Targeting the voltage-dependent K(+) channels Kv1.3 and Kv1.5 as tumor biomarkers for cancer detection and prevention.

artículo científico

The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase.

artículo científico publicado en 2015

The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells.

artículo científico publicado en 2010

The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model.

artículo científico publicado en 2011

The patient has the diagnosis

scientific article published on 01 October 2010

The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

artículo científico publicado en 2009

The role of oncogenic HPV determination for diagnosis of high-grade anal intraepithelial neoplasia in HIV-infected MSM.

artículo científico publicado en 2017

The umbilical cord, preeclampsia and the VEGF family

scientific article published on 28 November 2018

The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer.

artículo científico publicado en 2013

Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients

artículo científico publicado en 2019

Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human fetus.

artículo científico publicado en 2010

c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy.

artículo científico publicado en 2008

mTOR signaling pathway in penile squamous cell carcinoma: pmTOR and peIF4E over expression correlate with aggressive tumor behavior.

artículo científico publicado en 2013

miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.

artículo científico publicado en 2013

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

artículo científico publicado en 2017

peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas.

scientific article published on 20 July 2016

Lista de obras de Javier Hernandez-Losa

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation

ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment

Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment.

Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension.

Brush border myosin Ia has tumor suppressor activity in the intestine.

Brush border myosin Ia inactivation in gastric but not endometrial tumors.

Cancer as an ecomolecular disease and a neoplastic consortium

Cell signaling in endometrial carcinoma: phosphorylated 4E-binding protein-1 expression in endometrial cancer correlates with aggressive tumors and prognosis.

Clinical response to a lapatinib-based therapy for a Li-Fraumeni syndrome patient with a novel HER2V659E mutation.

Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib

Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas

Down-regulation of spinophilin in lung tumours contributes to tumourigenesis

E1a is an exogenous in vivo tumour suppressor.

Effect of low doses of actinomycin D on neuroblastoma cell lines

Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy.

Epithelial-mesenchymal transition markers and HER3 expression are predictors of elisidepsin treatment response in breast and pancreatic cancer cell lines

ErbB3 expression predicts sensitivity to elisidepsin treatment: in vitro synergism with cisplatin, paclitaxel and gemcitabine in lung, breast and colon cancer cell lines ⬇️

ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor.

Evaluation of the intraoperative human papillomavirus test as a marker of early cure at 12 months after electrosurgical excision procedure in women with cervical high-grade squamous intraepithelial lesion: a prospective cohort study

Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients

Fluorescence in situ hybridization and immunohistochemistry as diagnostic methods for ALK positive non-small cell lung cancer patients

Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine.

Genetic Profiles of Squamous Cell Carcinomas Associated with Recessive Dystrophic Epidermolysis Bullosa Unveil NOTCH and TP53 Mutations and an Increased MYC Expression.

Genetic evolution of nevus of Ota reveals clonal heterogeneity acquiring BAP1 and TP53 mutations.

Genetic profile of GNAQ-mutated blue melanocytic neoplasms reveals mutations in genes linked to genomic instability and the PI3K pathway.

Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: Correlation with pathologic subtypes, p16INK4a expression, and prognosis ⬇️

Identification of somatic gene mutations in penile squamous cell carcinoma.

Identification of the novel mutation m.5658T>C in the mitochondrial tRNA(Asn) gene in a patient with myopathy, bilateral ptosis and ophthalmoparesis.

Increased voltage-dependent K(+) channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness

Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis

Integrating clinical, molecular, proteomic and histopathological data within the tissue context: tissunomics

JC virus and human colon carcinoma: an intriguing and inconclusive association.

Lack of association of polyomavirus and herpesvirus types 6 and 7 in human lymphomas

Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas

Loss of the EPH receptor B6 contributes to colorectal cancer metastasis

Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness

Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth

Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin.

Modulation of the p38 MAPK (mitogen-activated protein kinase) pathway through Bcr/Abl: implications in the cellular response to Ara-C.

Molecular profiling of patients with colorectal cancer and matched targeted therapy in phase I clinical trials.

Myo5b knockout mice as a model of microvillus inclusion disease.

Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.

Prevalence and clinical outcomes for patients with ALK-positive resected stage I to III adenocarcinoma: results from the European Thoracic Oncology Platform Lungscape Project.

RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas.

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.

RSK4 inhibition results in bypass of stress-induced and oncogene-induced senescence.

Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors.

Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

Risk factors of high-grade anal intraepithelial neoplasia recurrence in HIV-infected MSM.

S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.

Schwannomas, benign tumors with a senescent phenotype

Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation

Spiny hyperkeratosis (trichodysplasia spinulosa-like eruption): a cutaneous adverse effect of Hedgehog pathway inhibitors involving expression of p16

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

Targeting the voltage-dependent K(+) channels Kv1.3 and Kv1.5 as tumor biomarkers for cancer detection and prevention.

The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase.

The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells.

The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model.

The patient has the diagnosis

The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis.

The role of oncogenic HPV determination for diagnosis of high-grade anal intraepithelial neoplasia in HIV-infected MSM.

The umbilical cord, preeclampsia and the VEGF family

The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer.

Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients

Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human fetus.

c-Abl activates p38 MAPK independently of its tyrosine kinase activity: Implications in cisplatin-based therapy.

mTOR signaling pathway in penile squamous cell carcinoma: pmTOR and peIF4E over expression correlate with aggressive tumor behavior.

miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.

miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.

peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas.