Lista de obras - Pascale Gaussem - Dominio Público Uruguay

0130 : Endoglin is a new partner involved in platelet – endothelium interactions: role in microvessel stability?

0260 : Endoglin in adhesion between endothelial and mural cells

0304 : Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells

280: Circulating endothelial cell levels decrease after vasodilator therapy and are a biomarker of deterioration in pediatric pulmonary hypertension

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis

artículo científico publicado en 2003

A monoclonal antibody recognizing the activation domain of protein C in its calcium-free conformation

scientific article published on 01 July 1998

Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects.

artículo científico publicado en 2003

Amino acids 225-235** of the protein C serine-protease domain are important for the interaction with the thrombin-thrombomodulin complex

scientific article published on 01 June 1995

An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN.

artículo científico publicado en 2002

Angiogenic potential of BM MSCs derived from patients with critical leg ischemia

artículo científico publicado en 2011

Antiplaquettaires et transfusion

artículo científico publicado en 2017

Arterial and venous thrombosis is associated with different angiogenic cytokine patterns in patients with antiphospholipid syndrome

artículo científico publicado en 2010

Assessment of platelet function in man

artículo científico publicado en 2006

Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban

artículo científico publicado en 2015

Biphasic myosin II light chain activation during clot retraction

artículo científico publicado en 2013

Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis-related characteristicsin vitro: a rebuttal

artículo científico publicado en 2009

Bone marrow-derived mononuclear cell therapy induces distal angiogenesis after local injection in critical leg ischemia

artículo científico publicado en 2008

Bone morphogenetic proteins 2 and 4 are selectively expressed by late outgrowth endothelial progenitor cells and promote neoangiogenesis.

artículo científico publicado en 2008

Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential

article

Caractérisation des progéniteurs endothéliaux et stratégies d'expansionin vitro

article

Cerebral haemorrhagic risk in children with sickle-cell disease.

artículo científico publicado en 2014

Circulating Endothelial Cells

Circulating endothelial cells in refractory pulmonary hypertension in children: markers of treatment efficacy and clinical worsening

artículo científico publicado en 2013

Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy

artículo científico publicado en 2006

Comparison of Endothelial Biomarkers According to Reversibility of Pulmonary Hypertension Secondary to Congenital Heart Disease

article published in 2010

Cooperation between human fibrocytes and endothelial colony-forming cells increases angiogenesis via the CXCR4 pathway.

artículo científico publicado en 2014

Correction: Circulating Endothelial Cells in Refractory Pulmonary Hypertension in Children: Markers of Treatment Efficacy and Clinical Worsening.

artículo científico publicado en 2014

Current and Novel Antiplatelet Therapies for the Treatment of Cardiovascular Diseases ⬇️

artículo científico publicado en 2021

Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects

artículo científico publicado en 2006

Delivery management in a woman with thrombocytopenia of the May-Hegglin anomaly type.

artículo científico publicado en 2001

Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status.

artículo científico publicado en 2007

Distinct patterns of circulating endothelial cells in pulmonary hypertension

artículo científico publicado en 2010

Dose-effect relationship for several coagulation markers during administration of the direct thrombin inhibitor S 18326 in healthy subjects

artículo científico publicado en 2002

Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia

Effect of clopidogrel on circulating biomarkers of angiogenesis and endothelial activation

Effect of rivaroxaban and dabigatran on platelet functions: in vitro study

artículo científico publicado en 2019

Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers

artículo científico publicado en 2013

Egfl7 Represses the Vasculogenic Potential of Human Endothelial Progenitor Cells

artículo científico publicado en 2017

Elevated plasma fibrin D-dimer as a risk factor for vascular dementia: the Three-City cohort study

artículo científico publicado en 2009

Endogenous oestradiol as a positive correlate of plasma fibrinogen among older postmenopausal women: a population-based study (the Three-City cohort study).

artículo científico publicado en 2012

Endoglin regulates mural cell adhesion in the circulatory system

artículo científico publicado en 2015

Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis

artículo científico publicado en 2017

Endothelial progenitor cells are selectively mobilised immediately after coronary artery bypass grafting or valve surgery

Endothelial progenitor cells: characterization, in vitro expansion, and prospects for autologous cell therapy.

artículo científico publicado en 2007

Epinephrine restores platelet functions inhibited by ticagrelor: A mechanistic approach

artículo científico publicado en 2019

Erratum to "Thrombin generation test: A reliable tool to evaluate the pharmacodynamics of vitamin K antagonist rodenticides in rats" [Pestic. Biochem. Physiol. 146 (2018) 19-24]

scientific article published on 16 May 2018

Evaluation of commonly used tests to measure the effect of single-dose aspirin on mouse hemostasis

artículo científico publicado en 2019

Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells.

artículo científico publicado en 2014

Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis.

artículo científico publicado en 2013

Expression and characterization of recombinant protein S with the Ser 460 Pro mutation.

artículo científico publicado en 2000

FXa-α2-Macroglobulin Complex Neutralizes Direct Oral Anticoagulants Targeting FXa In Vitro and In Vivo

scientific article published on 02 August 2018

Forearm ischemia decreases endothelial colony-forming cell angiogenic potential

artículo científico publicado en 2013

Haemorrhagic complications of vitamin k antagonists in the elderly: risk factors and management

artículo científico publicado en 2006

Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study

artículo científico publicado en 2011

Hemolytic anemia, iron deficiency and personal history of deep vein thrombosis: consider paroxysmal nocturnal hemoglobinuria

artículo científico publicado en 2017

High on-clopidogrel platelet reactivity: Genotyping Can help to optimize antiplatelet treatment

artículo científico publicado en 2011

Human endoglin as a potential new partner involved in platelet-endothelium interactions

artículo científico publicado en 2017

Human thrombin variable region 1, including E39, is involved in interactions with alpha 1-antitrypsin M358R and protein C

scientific article published on 01 May 1995

Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers

scientific article published on 01 September 2006

Imbalance of circulating endothelial cells and progenitors in idiopathic pulmonary fibrosis

Imbalanced coagulation profile as a biomarker of migraine in children with sickle cell: Is this a link with cerebral ischemia?

artículo científico publicado en 2014

Impact of aspirin and clopidogrel interruption on platelet function in patients undergoing major vascular surgery

artículo científico publicado en 2014

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice.

artículo científico publicado en 2015

Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo.

artículo científico publicado en 2016

Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain

artículo científico publicado en 2001

In vitro plasma-induced endothelial oxidative stress and circulating markers of endothelial dysfunction in preeclampsia: an observational study

artículo científico publicado en 2009

Increase in both angiogenic and angiostatic mediators in patients with idiopathic pulmonary fibrosis

artículo científico publicado en 2014

Increase in expression and activity of thrombomodulin in term human syncytiotrophoblast microvilli.

artículo científico publicado en 1998

Increased VEGFR2 expression during human late endothelial progenitor cells expansion enhances in vitro angiogenesis with up-regulation of integrin alpha(6)

artículo científico publicado en 2007

Increased fibrinolytic mediators in IPF as potential contributors to pulmonary fibrosis and vascular remodeling

article

Inefficacy of platelet transfusion to reverse ticagrelor

artículo científico publicado en 2015

Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects

artículo científico publicado en 2007

Influence of genetic variations on levels of inflammatory markers of healthy subjects at baseline and one week after clopidogrel therapy; results of a preliminary study

artículo científico publicado en 2013

Interindividual variability in dabigatran and rivaroxaban exposure: contribution ofABCB1genetic polymorphisms and interaction with clarithromycin

artículo científico publicado en 2017

Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells.

artículo científico publicado en 2008

La cytokine fibrogénique TGF-β1 augmente les propriétés angiogéniques des progéniteurs endothéliaux circulants

Leucocytes platelets co-aggregates remain elevated in patients with perfusion defects after pulmonary embolism

article

MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease.

artículo científico publicado en 2016

Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood

artículo científico publicado en 2019

Multimodal assessment of non-specific hemostatic agents for apixaban reversal

artículo científico publicado en 2015

Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing

artículo científico publicado en 2019

No clear link between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease

scholarly article by Marie-Anne Loriot et al published 2008 in Thrombosis and Haemostasis

No impact of cancer and plague-relevant <i>FPR1</i> polymorphisms on COVID-19

artículo científico publicado en 2020

No influence of the VAMP8 rs1010 single nucleotide polymorphism on platelet functions in vitro.

artículo científico publicado en 2009

Optimizing the use of anticoagulants (heparins and oral anticoagulants) in the elderly

artículo científico publicado en 2013

P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease.

artículo científico publicado en 2012

P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study.

artículo científico publicado en 2003

P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation

scientific article published on 19 February 2020

PAR-1 activation has different effects on the angiogenic activity of endothelial progenitor cells derived from human adult and cord blood

artículo científico publicado en 2006

PAR-1 activation on human late endothelial progenitor cells enhances angiogenesis in vitro with upregulation of the SDF-1/CXCR4 system

artículo científico publicado en 2005

Peripheral Artery Disease Is Associated With a High CD163/TWEAK Plasma Ratio

Physiological Plasma Gas6 Levels Do Not Influence Platelet Aggregation

artículo científico publicado en 2006

Platelet Functions During Extracorporeal Membrane Oxygenation. Platelet-Leukocyte Aggregates Analyzed by Flow Cytometry as a Promising Tool to Monitor Platelet Activation

artículo científico publicado en 2020

Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. ⬇️

artículo científico publicado en 2016

Platelet dysfunction associated with the novel Trp29Cys thromboxane A₂ receptor variant.

artículo científico publicado en 2013

Platelet receptor gain-of-function single nucleotide polymorphisms in carotid and vertebral stenosis patients

scientific article published on 01 August 2011

Potential usefulness of activated charcoal (DOAC remove®) for dRVVT testing in patients receiving Direct Oral AntiCoagulants

artículo científico publicado en 2019

Pulsed cavitational therapy using high-frequency ultrasound for the treatment of deep vein thrombosis in an in vitro model of human blood clot

artículo científico publicado en 2017

Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism

artículo científico publicado en 2007

Recombinant activated factor VII and prothrombin complex concentrates have different effects on bleeding and arterial thrombosis in the haemodiluted rabbit

artículo científico publicado en 2012

Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel

artículo científico publicado en 2010

Response to DDAVP stimulation in thirteen patients with Buerger's disease

scientific article published on 01 April 1997

Role of the P2Y12 gene polymorphism in platelet responsiveness to clopidogrel in healthy subjects

scientific article published on 01 September 2006

Serum antibodies to distinct epitopes of the tissue-type plasminogen activator (t-PA) in patients with systemic lupus erythematosus

scientific article published on 01 June 1995

Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential.

artículo científico publicado en 2014

The Carmat Bioprosthetic Total Artificial Heart Is Associated With Early Hemostatic Recovery and no Acquired von Willebrand Syndrome in Calves

artículo científico publicado en 2017

The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers

artículo científico publicado en 2004

The Wnt antagonist Dickkopf-1 increases endothelial progenitor cell angiogenic potential

artículo científico publicado en 2010

The angiopoietin pathway is modulated by PAR-1 activation on human endothelial progenitor cells.

artículo científico publicado en 2006

The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation: An in-vitro study

artículo científico publicado en 2015

The formation of complexes between human plasminogen activator inhibitor-1 (PAI-1) and sodium dodecyl sulfate: possible implication in the functional properties of PAI-1

artículo científico publicado en 1991

The minor allele of GP6 T13254C is associated with decreased platelet activation and a reduced risk of recurrent cardiovascular events and mortality: results from the SMILE-Platelets project

artículo científico publicado en 2010

The profibrotic cytokine transforming growth factor-β1 increases endothelial progenitor cell angiogenic properties

artículo científico publicado en 2012

The role of extracorporeal removal of CO2 (ECCO2R) in the management of respiratory diseases

artículo científico publicado en 2017

The specific thromboxane receptor antagonist S18886: pharmacokinetic and pharmacodynamic studies.

artículo científico publicado en 2005

Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells

artículo científico publicado en 2008

Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanism.

artículo científico publicado en 2015

Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic properties

artículo científico publicado en 2011

Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome).

artículo científico publicado en 2008

Ticagrelor reversal: in vitro assessment of four haemostatic agents

artículo científico publicado en 2017

Tissue factor expression and P2Y gene polymorphism.

artículo científico publicado en 2004

Treprostinil increases the number and angiogenic potential of endothelial progenitor cells in children with pulmonary hypertension

artículo científico publicado en 2010

Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells

article

Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells

artículo científico publicado en 2015

Usefulness of initial plasma dabigatran concentration to predict rebound after reversal.

artículo científico publicado en 2018

Vascular endothelial growth factor, as compared with placental growth factor, is increased in severe sepsis but not in organ failure

artículo científico publicado en 2012

[Management of vitamin K antagonists in the elderly]

artículo científico publicado en 2014

[Proton pump inhibitors and clopidogrel: a hazardous association?]

artículo científico publicado en 2012

[Thrombopathy induced by selective serotonin reuptake inhibitors: a case report]

artículo científico publicado en 2014

Lista de obras de Pascale Gaussem

0130 : Endoglin is a new partner involved in platelet – endothelium interactions: role in microvessel stability?

0260 : Endoglin in adhesion between endothelial and mural cells

0304 : Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells

280: Circulating endothelial cell levels decrease after vasodilator therapy and are a biomarker of deterioration in pediatric pulmonary hypertension

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis

A monoclonal antibody recognizing the activation domain of protein C in its calcium-free conformation

Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects.

Amino acids 225-235** of the protein C serine-protease domain are important for the interaction with the thrombin-thrombomodulin complex

An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN.

Angiogenic potential of BM MSCs derived from patients with critical leg ischemia

Antiplaquettaires et transfusion

Arterial and venous thrombosis is associated with different angiogenic cytokine patterns in patients with antiphospholipid syndrome

Assessment of platelet function in man

Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban

Biphasic myosin II light chain activation during clot retraction

Blood outgrowth endothelial cells from cord blood and peripheral blood: angiogenesis-related characteristicsin vitro: a rebuttal

Bone marrow-derived mononuclear cell therapy induces distal angiogenesis after local injection in critical leg ischemia

Bone morphogenetic proteins 2 and 4 are selectively expressed by late outgrowth endothelial progenitor cells and promote neoangiogenesis.

Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential

Caractérisation des progéniteurs endothéliaux et stratégies d'expansionin vitro

Cerebral haemorrhagic risk in children with sickle-cell disease.

Circulating Endothelial Cells

Circulating endothelial cells in refractory pulmonary hypertension in children: markers of treatment efficacy and clinical worsening

Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy

Comparison of Endothelial Biomarkers According to Reversibility of Pulmonary Hypertension Secondary to Congenital Heart Disease

Cooperation between human fibrocytes and endothelial colony-forming cells increases angiogenesis via the CXCR4 pathway.

Correction: Circulating Endothelial Cells in Refractory Pulmonary Hypertension in Children: Markers of Treatment Efficacy and Clinical Worsening.

Current and Novel Antiplatelet Therapies for the Treatment of Cardiovascular Diseases ⬇️

Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects

Delivery management in a woman with thrombocytopenia of the May-Hegglin anomaly type.

Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status.

Distinct patterns of circulating endothelial cells in pulmonary hypertension

Dose-effect relationship for several coagulation markers during administration of the direct thrombin inhibitor S 18326 in healthy subjects

Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia

Effect of clopidogrel on circulating biomarkers of angiogenesis and endothelial activation

Effect of rivaroxaban and dabigatran on platelet functions: in vitro study

Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers

Egfl7 Represses the Vasculogenic Potential of Human Endothelial Progenitor Cells

Elevated plasma fibrin D-dimer as a risk factor for vascular dementia: the Three-City cohort study

Endogenous oestradiol as a positive correlate of plasma fibrinogen among older postmenopausal women: a population-based study (the Three-City cohort study).

Endoglin regulates mural cell adhesion in the circulatory system

Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis

Endothelial progenitor cells are selectively mobilised immediately after coronary artery bypass grafting or valve surgery

Endothelial progenitor cells: characterization, in vitro expansion, and prospects for autologous cell therapy.

Epinephrine restores platelet functions inhibited by ticagrelor: A mechanistic approach

Erratum to "Thrombin generation test: A reliable tool to evaluate the pharmacodynamics of vitamin K antagonist rodenticides in rats" [Pestic. Biochem. Physiol. 146 (2018) 19-24]

Evaluation of commonly used tests to measure the effect of single-dose aspirin on mouse hemostasis

Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells.

Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis.

Expression and characterization of recombinant protein S with the Ser 460 Pro mutation.

FXa-α2-Macroglobulin Complex Neutralizes Direct Oral Anticoagulants Targeting FXa In Vitro and In Vivo

Forearm ischemia decreases endothelial colony-forming cell angiogenic potential

Haemorrhagic complications of vitamin k antagonists in the elderly: risk factors and management

Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study

Hemolytic anemia, iron deficiency and personal history of deep vein thrombosis: consider paroxysmal nocturnal hemoglobinuria

High on-clopidogrel platelet reactivity: Genotyping Can help to optimize antiplatelet treatment

Human endoglin as a potential new partner involved in platelet-endothelium interactions

Human thrombin variable region 1, including E39, is involved in interactions with alpha 1-antitrypsin M358R and protein C

Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers

Imbalance of circulating endothelial cells and progenitors in idiopathic pulmonary fibrosis

Imbalanced coagulation profile as a biomarker of migraine in children with sickle cell: Is this a link with cerebral ischemia?

Impact of aspirin and clopidogrel interruption on platelet function in patients undergoing major vascular surgery

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice.

Impaired thromboxane receptor dimerization reduces signaling efficiency: A potential mechanism for reduced platelet function in vivo.

Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain

In vitro plasma-induced endothelial oxidative stress and circulating markers of endothelial dysfunction in preeclampsia: an observational study

Increase in both angiogenic and angiostatic mediators in patients with idiopathic pulmonary fibrosis

Increase in expression and activity of thrombomodulin in term human syncytiotrophoblast microvilli.

Increased VEGFR2 expression during human late endothelial progenitor cells expansion enhances in vitro angiogenesis with up-regulation of integrin alpha(6)

Increased fibrinolytic mediators in IPF as potential contributors to pulmonary fibrosis and vascular remodeling

Inefficacy of platelet transfusion to reverse ticagrelor

Influence of CYP2C19 and CYP3A4 gene polymorphisms on clopidogrel responsiveness in healthy subjects

Influence of genetic variations on levels of inflammatory markers of healthy subjects at baseline and one week after clopidogrel therapy; results of a preliminary study

Interindividual variability in dabigatran and rivaroxaban exposure: contribution ofABCB1genetic polymorphisms and interaction with clarithromycin

Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells.

La cytokine fibrogénique TGF-β1 augmente les propriétés angiogéniques des progéniteurs endothéliaux circulants

Leucocytes platelets co-aggregates remain elevated in patients with perfusion defects after pulmonary embolism

MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease.

Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood