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A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior

artículo científico publicado en 2016

A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases.

artículo científico publicado en 2017

A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia

artículo científico publicado en 2014

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

artículo científico publicado en 2018

A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1

artículo científico publicado en 2008

AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models

artículo científico publicado en 2018

Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1

artículo científico publicado en 2008

Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1.

artículo científico publicado en 2009

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

artículo científico publicado en 2016

Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex

artículo científico publicado en 2008

Distinct mechanisms govern the phosphorylation of different SR protein splicing factors

artículo científico publicado en 2018

Identification of influenza polymerase inhibitors targeting polymerase PB2 cap-binding domain through virtual screening.

artículo científico publicado en 2017

Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis.

artículo científico publicado en 2010

Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2.

artículo científico publicado en 2005

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.

artículo científico publicado en 2018

Nucleotide-induced conformational changes in the Saccharomyces cerevisiae SR protein kinase, Sky1p, revealed by X-ray crystallography

artículo científico publicado en 2003

Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.

artículo científico publicado en 2015

Primary structural features of SR-like protein acinusS govern the phosphorylation mechanism by SRPK2.

artículo científico publicado en 2014

Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1

artículo científico publicado en 2011

The ribosomal maturation factor P from Mycobacterium smegmatis facilitates the ribosomal biogenesis by binding to the small ribosomal protein S12

artículo científico publicado en 2018