Lista de obras - Eduardo Henrique Silva Sousa

A Potential Visible-Light NO Releaser: Synthesis, Reactivity and Vasodilator Properties

scholarly article by Aurideia de Sousa et al published 2017 in Journal of the Brazilian Chemical Society

A bioinorganic chemistry perspective on the roles of metals as drugs and targets against Mycobacterium tuberculosis - a journey of opportunities

artículo científico publicado en 2020

A memory of oxygen binding explains the dose response of the heme-based sensor FixL.

artículo científico publicado en 2007

A proximal arginine R206 participates in switching of the Bradyrhizobium japonicum FixL oxygen sensor.

artículo científico publicado en 2006

A spectroelectrochemical investigation of the heme-based sensor DevS from Mycobacterium tuberculosis: a redox versus oxygen sensor

artículo científico publicado en 2019

A vanillin-based copper(ii) metal complex with a DNA-mediated apoptotic activity

scholarly article in RSC Advances, vol. 8 no. 30, 2018

Activity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infection

artículo científico publicado en 2012

An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.

artículo científico publicado en 2004

An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control.

artículo científico publicado en 2009

Anti-asthmatic effect of nitric oxide metallo-donor FOR811A [cis-[Ru(bpy)2(2-MIM)(NO)](PF6)3] in the respiratory mechanics of Swiss mice

artículo científico publicado en 2021

Antimicrobial activity and antibiotic synergy of a biphosphinic ruthenium complex against clinically relevant bacteria

artículo científico publicado en 2020

Aryl-Substituted Ruthenium(II) Complexes: A Strategy for Enhanced Photocleavage and Efficient DNA Binding

artículo científico publicado en 2017

Ascorbyl and hydroxyl radical generation mediated by a copper complex adsorbed on gold

scientific article published on 09 September 2019

Asymmetric heterobimetallic mixed-valence complex trans-[(SO3)Co(cyclam)(NCS)Ru(NH3)4(NCS)](BF4): Synthesis and characterization

Development of a spectrophotometric assay for cyclase activity.

artículo científico publicado en 2005

DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis

scientific journal article

Drug discovery targeting heme-based sensors and their coupled activities

artículo científico publicado en 2016

Effect of Crotalus basiliscus snake venom on the redox reaction of myoglobin

scientific article published on 23 January 2019

Electrochemical, mechanistic, and DFT studies of amine derived diphosphines containing Ru(II)-cymene complexes with potent in vitro cytotoxic activity against HeLa and triple-negative breast cancer cells MDA-MB-231

artículo científico publicado en 2020

Electrochemistry, surface plasmon resonance, and quartz crystal microbalance: an associative study on cytochrome c adsorption on pyridine tail-group monolayers on gold.

artículo científico publicado en 2013

Escherichia coli DosC and DosP: a role of c-di-GMP in compartmentalized sensing by degradosomes

scientific article published on 12 July 2019

Haem-Based Sensors of O2: Lessons and Perspectives.

artículo científico publicado en 2017

Hell's Gate globin I: an acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin

artículo científico publicado en 2011

Hydroxyl Radical Generation and DNA Nuclease Activity: A Mechanistic Study Based on a Surface-Immobilized Copper Thioether Clip-Phen Derivative

artículo científico publicado en 2016

In vitro and in vivo leishmanicidal activity of a ruthenium nitrosyl complex against Leishmania (Viannia) braziliensis

artículo científico publicado en 2019

Incorporation of Nitroprusside on Silica Nanoparticles-A Strategy for Safer Use of This NO Donor in Therapy

scientific article published on 24 May 2019

Insights into signal transduction by a hybrid FixL: Denaturation study of on and off states of a multi-domain oxygen sensor.

artículo científico publicado en 2017

Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

artículo científico publicado en 2018

Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.

artículo científico publicado en 2011

Mechanism and biological implications of the NO release of cis-[Ru(bpy)2L(NO)](n+) complexes: a key role of physiological thiols

artículo científico publicado en 2011

Nitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activities

scientific article published on 24 February 2020

Oxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structure

artículo científico publicado en 2019

Oxygen-sensing histidine-protein kinases: assays of ligand binding and turnover of response-regulator substrates.

scientific article published on January 2008

Photochemical studies of cis-[Ru(bpy)2(4-bzpy)(CO)](PF6)2 and cis-[Ru(bpy)2(4-bzpy)(Cl)](PF6): Blue light-induced nucleobase binding.

artículo científico publicado en 2017

Potential therapeutic approaches for a sleeping pathogen: tuberculosis a case for bioinorganic chemistry

artículo científico publicado en 2020

Preparation, characterization and structure of ruthenium phosphine complexes containing non-innocent ligands

Relaxant effect of a metal-based drug in human corpora cavernosa and its mechanism of action.

artículo científico publicado en 2015

Signal transduction and phosphoryl transfer by a FixL hybrid kinase with low oxygen affinity: importance of the vicinal PAS domain and receiver aspartate.

artículo científico publicado en 2013

Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex.

artículo científico publicado en 2006

Structural aspects and physiological implications of the hemoglobin of green iguana (Iguana iguana)

artículo científico publicado en 2018

Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy.

artículo científico publicado en 2017

Target DNA stabilizes Mycobacterium tuberculosis DevR/DosR phosphorylation by the full-length oxygen sensors DevS/DosS and DosT.

artículo científico publicado en 2017

The Heme-Based Oxygen Sensor Rhizobium etli FixL: Influence of Auxiliary Ligands on Heme Redox Potential and Implications on the Enzyme Activity.

artículo científico publicado en 2016

The nitric oxide donor cis-[Ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice--involvement of the soluble guanylate cyclase/K(ATP) pathway

artículo científico publicado en 2015

The potent anti-cancer activity of Dioclea lasiocarpa lectin

artículo científico publicado en 2017

The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory pain: involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway

artículo científico publicado en 2013

Thiocarbonyl-bound metallonitrosyl complexes with visible-light induced DNA cleavage and promising vasodilation activity

artículo científico publicado en 2018

[Fe(CN)5(isoniazid)](3-): an iron isoniazid complex with redox behavior implicated in tuberculosis therapy

artículo científico publicado en 2014

Lista de obras de Eduardo Henrique Silva Sousa

A Potential Visible-Light NO Releaser: Synthesis, Reactivity and Vasodilator Properties

A bioinorganic chemistry perspective on the roles of metals as drugs and targets against Mycobacterium tuberculosis - a journey of opportunities

A memory of oxygen binding explains the dose response of the heme-based sensor FixL.

A proximal arginine R206 participates in switching of the Bradyrhizobium japonicum FixL oxygen sensor.

A spectroelectrochemical investigation of the heme-based sensor DevS from Mycobacterium tuberculosis: a redox versus oxygen sensor

A vanillin-based copper(ii) metal complex with a DNA-mediated apoptotic activity

Activity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infection

An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.

An oxygen-sensing diguanylate cyclase and phosphodiesterase couple for c-di-GMP control.

Anti-asthmatic effect of nitric oxide metallo-donor FOR811A [cis-[Ru(bpy)2(2-MIM)(NO)](PF6)3] in the respiratory mechanics of Swiss mice

Antimicrobial activity and antibiotic synergy of a biphosphinic ruthenium complex against clinically relevant bacteria

Aryl-Substituted Ruthenium(II) Complexes: A Strategy for Enhanced Photocleavage and Efficient DNA Binding

Ascorbyl and hydroxyl radical generation mediated by a copper complex adsorbed on gold

Asymmetric heterobimetallic mixed-valence complex trans-[(SO3)Co(cyclam)(NCS)Ru(NH3)4(NCS)](BF4): Synthesis and characterization

Development of a spectrophotometric assay for cyclase activity.

DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis

Drug discovery targeting heme-based sensors and their coupled activities

Effect of Crotalus basiliscus snake venom on the redox reaction of myoglobin

Electrochemical, mechanistic, and DFT studies of amine derived diphosphines containing Ru(II)-cymene complexes with potent in vitro cytotoxic activity against HeLa and triple-negative breast cancer cells MDA-MB-231

Electrochemistry, surface plasmon resonance, and quartz crystal microbalance: an associative study on cytochrome c adsorption on pyridine tail-group monolayers on gold.

Escherichia coli DosC and DosP: a role of c-di-GMP in compartmentalized sensing by degradosomes

Haem-Based Sensors of O2: Lessons and Perspectives.

Hell's Gate globin I: an acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin

Hydroxyl Radical Generation and DNA Nuclease Activity: A Mechanistic Study Based on a Surface-Immobilized Copper Thioether Clip-Phen Derivative

In vitro and in vivo leishmanicidal activity of a ruthenium nitrosyl complex against Leishmania (Viannia) braziliensis

Incorporation of Nitroprusside on Silica Nanoparticles-A Strategy for Safer Use of This NO Donor in Therapy

Insights into signal transduction by a hybrid FixL: Denaturation study of on and off states of a multi-domain oxygen sensor.

Is IQG-607 a Potential Metallodrug or Metallopro-Drug With a Defined Molecular Target in Mycobacterium tuberculosis?

Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design.

Mechanism and biological implications of the NO release of cis-[Ru(bpy)2L(NO)](n+) complexes: a key role of physiological thiols

Nitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activities

Oxygen triggers signal transduction in the DevS (DosS) sensor of Mycobacterium tuberculosis by modulating the quaternary structure

Oxygen-sensing histidine-protein kinases: assays of ligand binding and turnover of response-regulator substrates.

Photochemical studies of cis-[Ru(bpy)2(4-bzpy)(CO)](PF6)2 and cis-[Ru(bpy)2(4-bzpy)(Cl)](PF6): Blue light-induced nucleobase binding.

Potential therapeutic approaches for a sleeping pathogen: tuberculosis a case for bioinorganic chemistry

Preparation, characterization and structure of ruthenium phosphine complexes containing non-innocent ligands

Relaxant effect of a metal-based drug in human corpora cavernosa and its mechanism of action.

Signal transduction and phosphoryl transfer by a FixL hybrid kinase with low oxygen affinity: importance of the vicinal PAS domain and receiver aspartate.

Slow-onset inhibition of 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis by an inorganic complex.

Structural aspects and physiological implications of the hemoglobin of green iguana (Iguana iguana)

Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy.

Target DNA stabilizes Mycobacterium tuberculosis DevR/DosR phosphorylation by the full-length oxygen sensors DevS/DosS and DosT.

The Heme-Based Oxygen Sensor Rhizobium etli FixL: Influence of Auxiliary Ligands on Heme Redox Potential and Implications on the Enzyme Activity.

The nitric oxide donor cis-[Ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice--involvement of the soluble guanylate cyclase/K(ATP) pathway

The potent anti-cancer activity of Dioclea lasiocarpa lectin

The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory pain: involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway

Thiocarbonyl-bound metallonitrosyl complexes with visible-light induced DNA cleavage and promising vasodilation activity

[Fe(CN)5(isoniazid)](3-): an iron isoniazid complex with redox behavior implicated in tuberculosis therapy