Lista de obras - Kristopher A Sarosiek - Dominio Público Uruguay

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer

artículo científico publicado en 2022

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity

scientific article published on 13 September 2020

BCL-XL directly modulates RAS signalling to favour cancer cell stemness.

artículo científico publicado en 2017

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

artículo científico publicado en 2013

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

artículo científico publicado en 2016

Chemotherapy-treated cells go up in flames.

artículo científico publicado en 2017

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

artículo científico publicado en 2016

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

artículo científico publicado en 2016

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

artículo científico publicado en 2017

Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics

artículo científico publicado en 2016

Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas

artículo científico publicado en 2008

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage.

artículo científico publicado en 2018

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma

artículo científico publicado en 2015

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.

artículo científico publicado en 2016

Double trouble for CML

artículo científico publicado en 2017

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

artículo científico publicado en 2015

Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma

artículo científico publicado en 2010

Epigenetics make transient states of cancer therapy resistance permanent.

artículo científico publicado en 2017

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer

artículo científico publicado en 2018

Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers

artículo científico publicado en 2014

HSF1 phase transition mediates stress adaptation and cell fate decisions

artículo científico publicado en 2020

Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis.

artículo científico publicado en 2017

Interleukin 21 - its potential role in the therapy of B-cell lymphomas.

artículo científico publicado en 2016

Interleukin-4 distinctively modifies responses of germinal centre-like and activated B-cell-like diffuse large B-cell lymphomas to immuno-chemotherapy

scientific article published on 19 August 2009

Mitochondria: gatekeepers of response to chemotherapy

scientific article published on 21 September 2013

Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas.

artículo científico publicado en 2009

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling

artículo científico publicado en 2008

Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment.

artículo científico publicado en 2018

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

scientific article published on 01 March 2019

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

artículo científico publicado en 2013

T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6

artículo científico publicado en 2007

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance

artículo científico publicado en 2016

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

scientific article published on 13 September 2018

Lista de obras de Kristopher A Sarosiek

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity

BCL-XL directly modulates RAS signalling to favour cancer cell stemness.

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

Chemotherapy-treated cells go up in flames.

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL

Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics

Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage.

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.

Double trouble for CML

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma

Epigenetics make transient states of cancer therapy resistance permanent.

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer

Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers

HSF1 phase transition mediates stress adaptation and cell fate decisions

Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis.

Interleukin 21 - its potential role in the therapy of B-cell lymphomas.

Interleukin-4 distinctively modifies responses of germinal centre-like and activated B-cell-like diffuse large B-cell lymphomas to immuno-chemotherapy

Mitochondria: gatekeepers of response to chemotherapy

Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas.

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling

Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment.

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma